IL141021A0 - Treatment of autoimmune conditions with copolymer 1 and related copolymers - Google Patents
Treatment of autoimmune conditions with copolymer 1 and related copolymersInfo
- Publication number
- IL141021A0 IL141021A0 IL14102199A IL14102199A IL141021A0 IL 141021 A0 IL141021 A0 IL 141021A0 IL 14102199 A IL14102199 A IL 14102199A IL 14102199 A IL14102199 A IL 14102199A IL 141021 A0 IL141021 A0 IL 141021A0
- Authority
- IL
- Israel
- Prior art keywords
- copolymer
- treatment
- autoimmune conditions
- related copolymers
- copolymers
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9385998P | 1998-07-23 | 1998-07-23 | |
US10182598P | 1998-09-25 | 1998-09-25 | |
US10296098P | 1998-10-02 | 1998-10-02 | |
US10635098P | 1998-10-30 | 1998-10-30 | |
US10818498P | 1998-11-12 | 1998-11-12 | |
US12367599P | 1999-03-09 | 1999-03-09 | |
PCT/US1999/016747 WO2000005250A1 (fr) | 1998-07-23 | 1999-07-23 | Traitement de maladies auto-immunes a l'aide du copolymere 1 et des copolymeres et peptides apparentes |
Publications (1)
Publication Number | Publication Date |
---|---|
IL141021A0 true IL141021A0 (en) | 2002-02-10 |
Family
ID=27557471
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14102199A IL141021A0 (en) | 1998-07-23 | 1999-07-23 | Treatment of autoimmune conditions with copolymer 1 and related copolymers |
IL141021A IL141021A (en) | 1998-07-23 | 2001-01-22 | Use of copolymer-like polypeptide-1 to prepare a drug to treat autoimmune diseases |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL141021A IL141021A (en) | 1998-07-23 | 2001-01-22 | Use of copolymer-like polypeptide-1 to prepare a drug to treat autoimmune diseases |
Country Status (5)
Country | Link |
---|---|
US (1) | US7279172B2 (fr) |
EP (1) | EP1098902A4 (fr) |
CA (1) | CA2337688C (fr) |
IL (2) | IL141021A0 (fr) |
WO (1) | WO2000005250A1 (fr) |
Families Citing this family (57)
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WO2000005249A2 (fr) | 1998-07-23 | 2000-02-03 | The President And Fellows Of Harvard College | Peptides synthetiques et procedes d'utilisation de ceux-ci dans des therapies de maladies auto-immunes |
ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
EP1098902A4 (fr) | 1998-07-23 | 2002-07-24 | Yeda Res & Dev | Traitement de maladies auto-immunes a l'aide du copolymere 1 et des copolymeres et peptides apparentes |
US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
CA2400374A1 (fr) * | 2000-02-18 | 2001-08-23 | Adrian Gilbert | Formes posologiques a administration par voie orale, nasale et pulmonaire du copolymere 1 |
US7022663B2 (en) | 2000-02-18 | 2006-04-04 | Yeda Research And Development Co., Ltd. | Oral, nasal and pulmonary dosage formulations of copolymer 1 |
US20020077278A1 (en) | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
WO2002076503A1 (fr) | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Traitement de maladies du systeme nerveux central au moyen d'anticorps diriges contre l'acetate de glatiramere |
US20040037828A1 (en) * | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
US20060258562A1 (en) * | 2000-07-31 | 2006-11-16 | Healor Ltd. | Methods and pharmaceutical compositions for healing wounds |
HUP0401863A3 (en) * | 2001-10-03 | 2012-09-28 | Harvard College | Amino acid-copolymers for suppression of autoimmune diseases, and methods of use |
US7429374B2 (en) | 2001-12-04 | 2008-09-30 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
ATE474851T1 (de) * | 2002-10-02 | 2010-08-15 | Hoffmann La Roche | Verfahren zur identifizierung antigener peptide |
EP1592384B1 (fr) * | 2003-01-21 | 2012-10-31 | Yeda Research And Development Co., Ltd. | Copolymere 1 pour le traitement de maladies enteriques inflammatoires |
ATE529125T1 (de) | 2003-08-07 | 2011-11-15 | Healor Ltd | Pharmazeutische zusammensetzungen und verfahren zur beschleunigung der wundheilung |
CA2546077C (fr) | 2003-11-12 | 2016-07-05 | Yeda Research And Development Co. Ltd. | Vaccin et procede pour traiter des maladies neurodegeneratives |
JP4808631B2 (ja) | 2003-12-09 | 2011-11-02 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 精神医学的障害の治療用のコポリマー1を含む方法及びワクチン |
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EP1778286A4 (fr) * | 2004-03-03 | 2009-04-08 | Teva Pharma | Therapie de combinaison avec acetate de glatiramer et riluzole |
US7655221B2 (en) | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
EP1750742A2 (fr) | 2004-05-07 | 2007-02-14 | Peptimmune, Inc. | Methodes de traitement de maladie a l'aide de copolymeres aleatoires |
ES2572811T3 (es) | 2004-09-09 | 2016-06-02 | Yeda Research And Development Co., Ltd. | Mezclas de polipéptidos, composiciones que las contienen y procedimientos para obtener los mismos, y usos de los mismos |
PT2361924E (pt) | 2004-09-09 | 2014-03-13 | Teva Pharma | Processo para a preparação de misturas de acetato de glatirâmero trifluoroacetiílico utilizando ácido bromídrico purificado |
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WO2006083608A1 (fr) * | 2005-02-02 | 2006-08-10 | Teva Pharmaceutical Industries, Ltd. | Procede de production de melanges de polypeptides par hydrogenolyse |
ES2420404T3 (es) * | 2005-02-17 | 2013-08-23 | Teva Pharmaceutical Industries Ltd. | Terapia de combinación con acetato de glatiramero y rasagilina para el tratamiento de esclerosis múltiple |
WO2006116602A2 (fr) * | 2005-04-25 | 2006-11-02 | Yeda Research And Development Company | Marqueurs associes a l'efficacite therapeutique d'acetate de glatiramere |
EP2016095A2 (fr) | 2006-04-13 | 2009-01-21 | Peptimmune, Inc. | Procédés de conception et de synthèse de compositions de polymères à séquence dirigée par expansion dirigée de la perméabilité épitopique |
EP2046366B1 (fr) | 2006-06-28 | 2016-08-31 | Yeda Research And Development Company Limited | Copolymer-1 pour le traitement de la dégénérescence maculaire liée à l'âge |
NZ582556A (en) * | 2007-07-30 | 2013-02-22 | Healor Ltd | Pharmaceutical composition for treating wounds and related methods |
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ES2449865T5 (es) | 2008-04-16 | 2022-11-18 | Momenta Pharmaceuticals Inc | Análisis de composiciones de copolímeros de aminoácidos |
AU2009347384B2 (en) * | 2009-06-04 | 2014-10-23 | Council Of Scientific & Industrial Research | A process for the preparation of copolymer - 1 (Cop-I), composed of L-alanine, L-lysine, L-glutamic acid and L-tyrosine-drug for the treatment of multiple sclerosis |
DK3199172T3 (en) | 2009-08-20 | 2018-10-08 | Yeda Res & Dev | DOSAGE regimen for multiple sclerosis |
KR20120097520A (ko) * | 2009-11-17 | 2012-09-04 | 아레스 트레이딩 에스.에이. | 랜덤 서열 중합체 조성물의 혈청 단백질기반 검출을 통한 랜덤 서열 중합체 조성물의 설계,생체이용률,및 효능을 개선시키는 방법 |
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US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
ES2602977T3 (es) | 2010-10-11 | 2017-02-23 | Teva Pharmaceutical Industries Ltd. | Biomarcadores de citocinas como biomarcadores predictivos de la respuesta clínica para acetato de glatirámero |
EP2675824B1 (fr) | 2011-02-14 | 2017-09-27 | USV Private Limited | Copolymère-1, son procédé de préparation et méthodes d'analyse de celui-ci |
ES2601892T3 (es) | 2011-04-21 | 2017-02-16 | Mapi Pharma Limited | Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes |
EA201490749A1 (ru) | 2011-10-10 | 2014-09-30 | Тева Фармасьютикал Индастриз Лтд. | Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат |
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KR20230097209A (ko) | 2014-03-12 | 2023-06-30 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
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EP3256852A1 (fr) * | 2015-02-12 | 2017-12-20 | Melamed Medical Ltd | Procédés de détermination de l'activité relative d'acétate de glatiramère et leur utilisation dans la préparation d'un lot d'acétate de glatiramère acceptable pour utilisation pharmaceutique |
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US5719296A (en) | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
KR100281867B1 (ko) | 1996-01-17 | 2001-02-15 | 고바야시 유키오 | 3-(비스-치환페닐메틸렌)옥신돌유도체 |
US6214791B1 (en) | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
IL119989A0 (en) | 1997-01-10 | 1997-04-15 | Yeda Res & Dev | Pharmaceutical compositions for oral treatment of multiple sclerosis |
US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
WO2000005249A2 (fr) | 1998-07-23 | 2000-02-03 | The President And Fellows Of Harvard College | Peptides synthetiques et procedes d'utilisation de ceux-ci dans des therapies de maladies auto-immunes |
EP1098902A4 (fr) | 1998-07-23 | 2002-07-24 | Yeda Res & Dev | Traitement de maladies auto-immunes a l'aide du copolymere 1 et des copolymeres et peptides apparentes |
US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
HU229289B1 (en) | 1998-09-25 | 2013-10-28 | Yeda Res & Dev | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
AU6281599A (en) | 1998-10-02 | 2000-04-26 | Yeda Research And Development Co. Ltd. | Alternate day administration of copolymer 1 for treating autoimmune diseases |
AU775073C (en) | 1998-11-12 | 2007-05-03 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating GVHD and HVGD |
MXPA02007106A (es) | 2000-01-20 | 2002-12-13 | Mcinnis Patricia A | El uso del copolimero 1 y peptidos y polipeptidos relacionados y celulas t tratadas con estos para terapia neuroprotectora. |
CA2400374A1 (fr) | 2000-02-18 | 2001-08-23 | Adrian Gilbert | Formes posologiques a administration par voie orale, nasale et pulmonaire du copolymere 1 |
US7022663B2 (en) | 2000-02-18 | 2006-04-04 | Yeda Research And Development Co., Ltd. | Oral, nasal and pulmonary dosage formulations of copolymer 1 |
AU2000261978B2 (en) | 2000-05-10 | 2006-07-06 | Mayo Foundation For Medical Education And Research | Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
US20020107388A1 (en) | 2000-05-12 | 2002-08-08 | Vandenbark Arthur A. | Methods of identifying and monitoring disease-associated T cells |
US20020077278A1 (en) | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
HUP0302333A3 (en) | 2000-06-05 | 2005-07-28 | Teva Pharma | The use of glatiramer acetate (copolymer 1) for the preparation of pharmaceutical compositions available in the treatment of central nervous system disorders |
NZ520282A (en) | 2000-06-07 | 2004-09-24 | Yeda Res & Dev | The use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy |
WO2002076503A1 (fr) | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Traitement de maladies du systeme nerveux central au moyen d'anticorps diriges contre l'acetate de glatiramere |
US7429374B2 (en) | 2001-12-04 | 2008-09-30 | Teva Pharmaceutical Industries, Ltd. | Process for the measurement of the potency of glatiramer acetate |
KR20060097020A (ko) | 2003-10-31 | 2006-09-13 | 테바 파마슈티컬 인더스트리즈 리미티드 | 약물 전달용 나노입자 |
ES2572811T3 (es) | 2004-09-09 | 2016-06-02 | Yeda Research And Development Co., Ltd. | Mezclas de polipéptidos, composiciones que las contienen y procedimientos para obtener los mismos, y usos de los mismos |
PT2361924E (pt) | 2004-09-09 | 2014-03-13 | Teva Pharma | Processo para a preparação de misturas de acetato de glatirâmero trifluoroacetiílico utilizando ácido bromídrico purificado |
-
1999
- 1999-07-23 EP EP99937423A patent/EP1098902A4/fr not_active Ceased
- 1999-07-23 CA CA2337688A patent/CA2337688C/fr not_active Expired - Lifetime
- 1999-07-23 IL IL14102199A patent/IL141021A0/xx unknown
- 1999-07-23 WO PCT/US1999/016747 patent/WO2000005250A1/fr active IP Right Grant
-
2001
- 2001-01-22 IL IL141021A patent/IL141021A/en not_active IP Right Cessation
- 2001-01-23 US US09/768,872 patent/US7279172B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1098902A1 (fr) | 2001-05-16 |
WO2000005250A1 (fr) | 2000-02-03 |
US7279172B2 (en) | 2007-10-09 |
EP1098902A4 (fr) | 2002-07-24 |
CA2337688C (fr) | 2016-04-05 |
WO2000005250A9 (fr) | 2000-10-12 |
CA2337688A1 (fr) | 2000-02-03 |
US20020055466A1 (en) | 2002-05-09 |
IL141021A (en) | 2013-09-30 |
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