IL140826A - Crystal changes of lipoic acid - Google Patents
Crystal changes of lipoic acidInfo
- Publication number
- IL140826A IL140826A IL14082699A IL14082699A IL140826A IL 140826 A IL140826 A IL 140826A IL 14082699 A IL14082699 A IL 14082699A IL 14082699 A IL14082699 A IL 14082699A IL 140826 A IL140826 A IL 140826A
- Authority
- IL
- Israel
- Prior art keywords
- lipoic acid
- solvent
- mixture
- crystalline
- toluene
- Prior art date
Links
- 235000019136 lipoic acid Nutrition 0.000 title claims abstract description 25
- 229960002663 thioctic acid Drugs 0.000 title claims abstract description 24
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 title description 5
- 230000004048 modification Effects 0.000 title description 4
- 238000012986 modification Methods 0.000 title description 4
- 239000011877 solvent mixture Substances 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 28
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 24
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 21
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 14
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims description 3
- 239000002778 food additive Substances 0.000 claims description 3
- 235000013373 food additive Nutrition 0.000 claims description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 9
- 239000000047 product Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 5
- 239000012043 crude product Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- AGBQKNBQESQNJD-ZETCQYMHSA-N (S)-lipoic acid Chemical compound OC(=O)CCCC[C@H]1CCSS1 AGBQKNBQESQNJD-ZETCQYMHSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- IVSZLXZYQVIEFR-UHFFFAOYSA-N m-xylene Chemical compound CC1=CC=CC(C)=C1 IVSZLXZYQVIEFR-UHFFFAOYSA-N 0.000 description 2
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 2
- ODLMAHJVESYWTB-UHFFFAOYSA-N propylbenzene Chemical compound CCCC1=CC=CC=C1 ODLMAHJVESYWTB-UHFFFAOYSA-N 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 1
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19834608A DE19834608A1 (de) | 1998-07-31 | 1998-07-31 | Kristallmodifikation der Liponsäure |
| PCT/EP1999/004870 WO2000008012A1 (de) | 1998-07-31 | 1999-07-12 | Kristallmodifikation der liponsäure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL140826A0 IL140826A0 (en) | 2002-02-10 |
| IL140826A true IL140826A (en) | 2004-06-01 |
Family
ID=7876020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14082699A IL140826A (en) | 1998-07-31 | 1999-07-12 | Crystal changes of lipoic acid |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6441024B1 (hu) |
| EP (1) | EP1100793B1 (hu) |
| JP (1) | JP2002522430A (hu) |
| KR (1) | KR20010072109A (hu) |
| CN (1) | CN1198815C (hu) |
| AT (1) | ATE224385T1 (hu) |
| AU (1) | AU751485B2 (hu) |
| BR (1) | BR9912622A (hu) |
| CA (1) | CA2338991A1 (hu) |
| DE (2) | DE19834608A1 (hu) |
| DK (1) | DK1100793T3 (hu) |
| ES (1) | ES2184475T3 (hu) |
| HU (1) | HUP0103405A3 (hu) |
| IL (1) | IL140826A (hu) |
| NO (1) | NO20010516L (hu) |
| RU (1) | RU2226528C2 (hu) |
| TW (1) | TWI250158B (hu) |
| WO (1) | WO2000008012A1 (hu) |
| ZA (1) | ZA200101609B (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000344739A (ja) * | 1999-06-01 | 2000-12-12 | Sumitomo Chem Co Ltd | Ｎ−保護−アゼチジン−２−カルボン酸の製造方法 |
| AU2001291677A1 (en) | 2000-08-02 | 2002-02-13 | Basf Aktiengesellschaft | Method for producing lipoic acid and dihydrolipoic acid |
| IT1319195B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Processo per la produzione dell'acido r(+)alfa-lipoico. |
| EP1339705B1 (de) * | 2000-11-30 | 2006-06-07 | Basf Aktiengesellschaft | Verfahren zur herstellung von liponsäure und dihydroliponsaüre |
| DE10137381A1 (de) * | 2001-07-31 | 2003-02-13 | Viatris Gmbh | Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung |
| DE10201464B4 (de) * | 2002-01-16 | 2005-06-16 | Viatris Gmbh & Co. Kg | Verfahren zur Herstellung reiner Thioctsäure |
| JP4849792B2 (ja) * | 2004-09-14 | 2012-01-11 | オリザ油化株式会社 | 美容用組成物 |
| US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
| CA2588709C (en) * | 2004-11-24 | 2015-07-14 | Hill's Pet Nutrition, Inc. | Use of lipoic acid to improve hepatic clearance of xenobiotic substances |
| US8148325B2 (en) * | 2004-12-30 | 2012-04-03 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| JP2006219467A (ja) * | 2005-02-10 | 2006-08-24 | Oriza Yuka Kk | 脂肪蓄積阻害剤 |
| JP2006321732A (ja) * | 2005-05-18 | 2006-11-30 | Fancl Corp | 異常蛋白質除去及び８−ヒドロキシ２’−デオキシグアノシン増加抑制用組成物 |
| KR20110103987A (ko) * | 2008-12-01 | 2011-09-21 | 인베이스크 테라퓨틱, 인크. | 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도 |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| ITMI20111286A1 (it) * | 2011-07-11 | 2013-01-12 | Laboratorio Chimico Int Spa | Nuova forma cristallina |
| CN103880815A (zh) * | 2014-03-06 | 2014-06-25 | 南京海融医药科技有限公司 | ɑ-硫辛酸的多晶型物及其制备方法和应用 |
| EP3615023B1 (en) | 2017-04-25 | 2023-06-21 | Ischemix LLC | Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4037440A1 (de) | 1990-11-24 | 1992-05-27 | Basf Ag | Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern |
| JP3696233B2 (ja) | 1991-07-19 | 2005-09-14 | ミシガン、ステート、ユニバーシティー | ポリヒドロキシアルカノエートを生産するトランスジェニック植物 |
| DE4137773A1 (de) | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
| DE4229914A1 (de) | 1992-09-08 | 1994-03-10 | Basf Ag | Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure |
| DE59308496D1 (de) | 1992-09-08 | 1998-06-10 | Basf Ag | Verbessertes Verfahren zur Herstellung von R/S-gamma-Liponsäure oder R/S-alpha-Liponsäure |
| DE4235912C2 (de) | 1992-10-23 | 2002-12-05 | Viatris Gmbh | Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung |
| DE19810336A1 (de) * | 1998-03-11 | 1999-09-23 | Asta Medica Ag | Alpha-Liponsäure mit neuartiger Modifikation |
-
1998
- 1998-07-31 DE DE19834608A patent/DE19834608A1/de not_active Withdrawn
-
1999
- 1999-07-12 AU AU49094/99A patent/AU751485B2/en not_active Ceased
- 1999-07-12 AT AT99932864T patent/ATE224385T1/de not_active IP Right Cessation
- 1999-07-12 JP JP2000563645A patent/JP2002522430A/ja not_active Withdrawn
- 1999-07-12 IL IL14082699A patent/IL140826A/en not_active IP Right Cessation
- 1999-07-12 KR KR1020017001269A patent/KR20010072109A/ko not_active Application Discontinuation
- 1999-07-12 DK DK99932864T patent/DK1100793T3/da active
- 1999-07-12 HU HU0103405A patent/HUP0103405A3/hu unknown
- 1999-07-12 WO PCT/EP1999/004870 patent/WO2000008012A1/de not_active Application Discontinuation
- 1999-07-12 US US09/743,920 patent/US6441024B1/en not_active Expired - Fee Related
- 1999-07-12 DE DE59902779T patent/DE59902779D1/de not_active Expired - Fee Related
- 1999-07-12 CN CNB998092363A patent/CN1198815C/zh not_active Expired - Fee Related
- 1999-07-12 CA CA002338991A patent/CA2338991A1/en not_active Abandoned
- 1999-07-12 BR BR9912622-2A patent/BR9912622A/pt not_active Application Discontinuation
- 1999-07-12 ES ES99932864T patent/ES2184475T3/es not_active Expired - Lifetime
- 1999-07-12 EP EP99932864A patent/EP1100793B1/de not_active Expired - Lifetime
- 1999-07-12 RU RU2001105962/04A patent/RU2226528C2/ru not_active IP Right Cessation
- 1999-07-30 TW TW088113004A patent/TWI250158B/zh not_active IP Right Cessation
-
2001
- 2001-01-30 NO NO20010516A patent/NO20010516L/no not_active Application Discontinuation
- 2001-02-27 ZA ZA200101609A patent/ZA200101609B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE224385T1 (de) | 2002-10-15 |
| DK1100793T3 (da) | 2002-10-14 |
| CN1311784A (zh) | 2001-09-05 |
| ES2184475T3 (es) | 2003-04-01 |
| AU751485B2 (en) | 2002-08-15 |
| ZA200101609B (en) | 2002-06-27 |
| RU2226528C2 (ru) | 2004-04-10 |
| HUP0103405A2 (hu) | 2002-04-29 |
| NO20010516D0 (no) | 2001-01-30 |
| AU4909499A (en) | 2000-02-28 |
| US6441024B1 (en) | 2002-08-27 |
| NO20010516L (no) | 2001-01-30 |
| TWI250158B (en) | 2006-03-01 |
| EP1100793B1 (de) | 2002-09-18 |
| EP1100793A1 (de) | 2001-05-23 |
| BR9912622A (pt) | 2001-04-24 |
| WO2000008012A1 (de) | 2000-02-17 |
| JP2002522430A (ja) | 2002-07-23 |
| HUP0103405A3 (en) | 2003-01-28 |
| DE19834608A1 (de) | 2000-02-03 |
| IL140826A0 (en) | 2002-02-10 |
| KR20010072109A (ko) | 2001-07-31 |
| CN1198815C (zh) | 2005-04-27 |
| CA2338991A1 (en) | 2000-02-17 |
| DE59902779D1 (de) | 2002-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |