IL139848A0 - Vitamin b12 derivatives and methods for their preparation - Google Patents
Vitamin b12 derivatives and methods for their preparationInfo
- Publication number
- IL139848A0 IL139848A0 IL13984899A IL13984899A IL139848A0 IL 139848 A0 IL139848 A0 IL 139848A0 IL 13984899 A IL13984899 A IL 13984899A IL 13984899 A IL13984899 A IL 13984899A IL 139848 A0 IL139848 A0 IL 139848A0
- Authority
- IL
- Israel
- Prior art keywords
- vitamin
- derivatives
- preparation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP4050A AUPP405098A0 (en) | 1998-06-12 | 1998-06-12 | Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals |
PCT/AU1999/000462 WO1999065930A1 (en) | 1998-06-12 | 1999-06-11 | Vitamin b12 derivatives and methods for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
IL139848A0 true IL139848A0 (en) | 2002-02-10 |
Family
ID=3808296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13984899A IL139848A0 (en) | 1998-06-12 | 1999-06-11 | Vitamin b12 derivatives and methods for their preparation |
Country Status (10)
Country | Link |
---|---|
US (1) | US6150341A (ja) |
EP (1) | EP1086118A4 (ja) |
JP (1) | JP4794735B2 (ja) |
KR (1) | KR20010071450A (ja) |
AU (1) | AUPP405098A0 (ja) |
CA (1) | CA2334598A1 (ja) |
IL (1) | IL139848A0 (ja) |
NZ (1) | NZ538085A (ja) |
PL (1) | PL196047B1 (ja) |
WO (1) | WO1999065930A1 (ja) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5739313A (en) * | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
AUPQ071299A0 (en) * | 1999-06-02 | 1999-06-24 | Access Pharmaceuticals Australia Pty Limited | Vitamin directed dual targeting therapy |
MXPA02003771A (es) * | 1999-10-15 | 2005-04-28 | Mayo Foundation | Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes anti-tumor. |
US7591995B2 (en) * | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
EP1239887A1 (en) | 1999-10-15 | 2002-09-18 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
US20040028686A1 (en) * | 2001-06-28 | 2004-02-12 | Faulk Ward Page | Targeted delivery of cytotoxic drugs a) to activated lymphocytes in patients with transplated organs, b) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and c) in vitamin-binding proteins as drug carriers in the diagnosis and treatment of cancer |
JP2004501171A (ja) * | 2000-06-28 | 2004-01-15 | フォーク ワード ページ | A)臓器が移植された患者における活性化されたリンパ球への、b)放射線療法を受ける患者における、癌細胞への放射線増感剤としての、c)癌の診断および治療における薬物担体としてのビタミン結合タンパク質中の、細胞毒の標的指向型送達 |
EP1754712A3 (en) * | 2000-10-25 | 2009-01-14 | Mayo Foundation For Medical Education And Research | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
TWI228512B (en) * | 2000-10-25 | 2005-03-01 | Mayo Foundation | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
GB2374010B (en) * | 2001-02-26 | 2004-12-29 | Council Scient Ind Res | Novel vitamin B12 - biodegradable micro particulate conjugate carrier systems for peroral delivery of drugs, therapeutic peptides/proteins and vaccines |
AU2002312410A1 (en) * | 2001-06-08 | 2002-12-23 | Target Protein Technologies, Inc. | Tissue-specific endothelial membrane proteins |
JP2005508332A (ja) * | 2001-09-28 | 2005-03-31 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 |
US7232805B2 (en) * | 2003-09-10 | 2007-06-19 | Inflabloc Pharmaceuticals, Inc. | Cobalamin conjugates for anti-tumor therapy |
RU2394042C2 (ru) * | 2003-12-22 | 2010-07-10 | Золидаго Аг | Производные кобаламина, предназначенные для диагностики и лечения аномальной пролиферации клеток |
WO2006124870A1 (en) * | 2005-05-17 | 2006-11-23 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
CA2678646A1 (en) * | 2007-03-05 | 2008-09-12 | Syracuse University | A conjugate of insulin and vitamin b12 for oral delivery |
US20110092416A1 (en) * | 2007-03-05 | 2011-04-21 | Robert Patrick Doyle | Vitamine B12 - Peptide Conjugates for Oral Delivery |
WO2011130716A2 (en) | 2010-04-16 | 2011-10-20 | Access Pharmaceuticals, Inc. | A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers |
WO2012030745A1 (en) * | 2010-08-30 | 2012-03-08 | Access Pharmaecuticals, Inc | MULTIVITAMIN TARGETING OF RNAi THERAPEUTICS |
CN103501821A (zh) * | 2011-03-08 | 2014-01-08 | 艾克塞斯制药公司 | 用于递送活性剂穿过生物膜的靶向纳米载体系统 |
WO2014005601A1 (en) * | 2012-07-02 | 2014-01-09 | Pharmathen S.A. | A process for the preparation of solifenacin or a salt thereof |
CN103163306B (zh) * | 2013-02-05 | 2015-06-17 | 北京九强生物技术股份有限公司 | 25羟维生素d检测试剂盒及其制备方法 |
WO2015126841A1 (en) | 2014-02-18 | 2015-08-27 | Plasmatech Biopharmaceuticals, Inc. | Nutritional and therapeutic mucoadhesive formulations |
CN106749461B (zh) * | 2016-11-11 | 2020-10-27 | 暨南大学 | 可自主装形成纳米微粒的维生素b12衍生物及制备方法与应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209614A (en) * | 1978-05-30 | 1980-06-24 | E. R. Squibb & Sons, Inc. | Vitamin B12 derivative suitable for radiolabeling |
DK158224C (da) * | 1985-08-23 | 1990-09-24 | Danske Sukkerfab | Fremgangsmaade til fremstilling af indolderivater |
US5807832A (en) * | 1987-06-09 | 1998-09-15 | Biotech Australia Pty Limited | Oral delivery of biologically active substances bound to vitamin B12 |
DK0531497T3 (da) * | 1991-04-02 | 1998-03-23 | Biotech Australia Pty Ltd | Orale indgivelsessystemer til mikropartikler |
DE69233674T2 (de) * | 1991-05-22 | 2007-10-18 | Dade Behring Marburg Gmbh | Homogenes Testsystem zur Bestimmung eines Analytes |
US5294536A (en) * | 1992-04-23 | 1994-03-15 | Pb Diagnostic Systems, Inc. | Conjugates |
DE4239815A1 (de) * | 1992-11-26 | 1994-06-01 | Boehringer Mannheim Gmbh | Verbesserte B¶1¶¶2¶-Konjugate |
JPH08510260A (ja) * | 1993-05-20 | 1996-10-29 | バイオテック・オーストラリア・プロプライエタリー・リミテッド | Lhrh拮抗剤 |
US5548064A (en) * | 1993-05-24 | 1996-08-20 | Biotech Australia Pty Limited | Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions |
US5449720A (en) * | 1993-05-24 | 1995-09-12 | Biotech Australia Pty Limited | Amplification of the VB12 uptake system using polymers |
JPH06336494A (ja) * | 1993-05-27 | 1994-12-06 | Nippon Oil Co Ltd | 疎水性ビタミンb12誘導体 |
DE69528523T2 (de) * | 1994-04-08 | 2003-06-12 | Receptagen Corp | Rezeptor modulierendes mitteln und entsprechendes verfahren |
US5574018A (en) * | 1994-07-29 | 1996-11-12 | Amgen Inc. | Conjugates of vitamin B12 and proteins |
EP0856026A1 (en) * | 1995-10-19 | 1998-08-05 | Receptagen Corporation | Discrete-length polyethylene glycols |
JP3705657B2 (ja) * | 1996-09-05 | 2005-10-12 | 信越化学工業株式会社 | N,n−ジアルキルカルバミン酸2−ニトロベンジルエステル類の製造方法 |
AU6946998A (en) * | 1997-04-24 | 1998-11-13 | American Home Products Corporation | Process for the synthesis of 4-{6-(hexylcarbamoyloxy) hexylcarbamoyloxy}-piperidine-1- carboxylic acid 4-phenoxyphenyl ester |
US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
-
1998
- 1998-06-12 AU AUPP4050A patent/AUPP405098A0/en not_active Abandoned
-
1999
- 1999-06-11 US US09/330,167 patent/US6150341A/en not_active Expired - Lifetime
- 1999-06-11 IL IL13984899A patent/IL139848A0/xx unknown
- 1999-06-11 PL PL99344686A patent/PL196047B1/pl unknown
- 1999-06-11 NZ NZ538085A patent/NZ538085A/en not_active IP Right Cessation
- 1999-06-11 WO PCT/AU1999/000462 patent/WO1999065930A1/en not_active Application Discontinuation
- 1999-06-11 EP EP99927582A patent/EP1086118A4/en not_active Withdrawn
- 1999-06-11 CA CA002334598A patent/CA2334598A1/en not_active Abandoned
- 1999-06-11 KR KR1020007014046A patent/KR20010071450A/ko not_active Application Discontinuation
- 1999-06-11 JP JP2000554755A patent/JP4794735B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4794735B2 (ja) | 2011-10-19 |
PL196047B1 (pl) | 2007-11-30 |
WO1999065930A1 (en) | 1999-12-23 |
CA2334598A1 (en) | 1999-12-23 |
AUPP405098A0 (en) | 1998-07-02 |
NZ538085A (en) | 2006-10-27 |
JP2002518405A (ja) | 2002-06-25 |
PL344686A1 (en) | 2001-11-19 |
KR20010071450A (ko) | 2001-07-28 |
US6150341A (en) | 2000-11-21 |
EP1086118A1 (en) | 2001-03-28 |
EP1086118A4 (en) | 2002-05-02 |
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