IL138993A0 - Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors - Google Patents

Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors

Info

Publication number
IL138993A0
IL138993A0 IL13899399A IL13899399A IL138993A0 IL 138993 A0 IL138993 A0 IL 138993A0 IL 13899399 A IL13899399 A IL 13899399A IL 13899399 A IL13899399 A IL 13899399A IL 138993 A0 IL138993 A0 IL 138993A0
Authority
IL
Israel
Prior art keywords
methods
compositions
combination
leukotriene inhibitors
terfenadine
Prior art date
Application number
IL13899399A
Other languages
English (en)
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of IL138993A0 publication Critical patent/IL138993A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13899399A 1998-04-14 1999-04-13 Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors IL138993A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/059,570 US6194431B1 (en) 1998-04-14 1998-04-14 Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
PCT/US1999/008077 WO1999052554A1 (en) 1998-04-14 1999-04-13 Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors

Publications (1)

Publication Number Publication Date
IL138993A0 true IL138993A0 (en) 2001-11-25

Family

ID=22023833

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13899399A IL138993A0 (en) 1998-04-14 1999-04-13 Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
IL138993A IL138993A (en) 1998-04-14 2000-10-12 Preparations using trapenadin metabolites together with locotrian inhibitors and their uses

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138993A IL138993A (en) 1998-04-14 2000-10-12 Preparations using trapenadin metabolites together with locotrian inhibitors and their uses

Country Status (21)

Country Link
US (4) US6194431B1 (no)
EP (2) EP1707216A1 (no)
JP (1) JP2002511426A (no)
KR (1) KR100686297B1 (no)
CN (2) CN1768749A (no)
AT (1) ATE328608T1 (no)
AU (1) AU763979B2 (no)
BR (1) BR9909641A (no)
CA (1) CA2328074C (no)
CY (1) CY1106800T1 (no)
DE (1) DE69931771T2 (no)
DK (1) DK1071463T3 (no)
ES (1) ES2260910T3 (no)
HU (1) HU228035B1 (no)
IL (2) IL138993A0 (no)
NO (1) NO20005147L (no)
NZ (1) NZ507762A (no)
PL (1) PL343526A1 (no)
PT (1) PT1071463E (no)
WO (1) WO1999052554A1 (no)
ZA (1) ZA200005553B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194431B1 (en) * 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US20020198246A1 (en) * 1998-09-30 2002-12-26 Ono Pharmaceutical Co., Ltd. Agent for preventing and/or treating sinusitis
DE10007203A1 (de) * 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6440994B1 (en) 2000-03-29 2002-08-27 Richard J. Sanders, Jr. Method of treating acne
US20020198228A1 (en) * 2001-04-03 2002-12-26 Kaura Sita R. Composition and method for the treatment of respiratory desease
AU2003237253A1 (en) * 2002-05-29 2003-12-19 Aventis Pharmaceuticals Holdings Inc. Method of treating asthma using fexofenadine
US20040115647A1 (en) * 2002-12-12 2004-06-17 Paterson Thomas S. Apparatus and method for identifying biomarkers using a computer model
WO2009027852A2 (en) * 2007-08-28 2009-03-05 Agi Therapeutics, P.L.C. Methods and compositions for treating gastrointestinal conditions
WO2016011254A1 (en) * 2014-07-16 2016-01-21 Henry J. Legere Md, Pa Combinations of antihistamines and leukotriene antagonists and methods of use thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878217A (en) 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4254129A (en) 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4552899A (en) 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4783465A (en) 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4617407A (en) * 1984-08-30 1986-10-14 Merck Frosst Canada, Inc. Leukotriene antagonists
US4742175A (en) 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
US4800162A (en) 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
US4829064A (en) 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4996061A (en) 1987-10-07 1991-02-26 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol-decongestant combination
US4929605A (en) 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
US5057427A (en) 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US4990259A (en) 1988-12-16 1991-02-05 The Amalgamated Sugar Company Chromatographic separator sorbent bed preparation
US5019591A (en) 1989-02-17 1991-05-28 Pennsylvania Research Corporation Method for treating retinopathy and other small vessel disorders associated with diabetes
EP0639976B1 (en) 1992-05-11 2000-07-26 Merrell Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
WO1994003170A1 (en) 1992-08-03 1994-02-17 Sepracor Inc. Terfenadine metabolites and their optically pure isomers for treating allergic disorders
DK1026147T3 (da) 1993-06-24 2004-03-22 Albany Molecular Res Inc Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater
WO1995010278A1 (en) 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
ATE301457T1 (de) * 1995-06-12 2005-08-15 Searle & Co Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
CA2245162A1 (en) 1996-02-08 1997-08-14 Merck & Co., Inc. Method of treatment and pharmaceutical composition
CA2246265A1 (en) * 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
US5919776A (en) * 1996-12-20 1999-07-06 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
PL193131B1 (pl) * 1997-12-23 2007-01-31 Schering Corp Kompozycja farmaceutyczna zawierająca kombinację składników aktywnych i jej zastosowanie
US6194431B1 (en) * 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors

Also Published As

Publication number Publication date
HU228035B1 (en) 2012-08-28
DE69931771D1 (de) 2006-07-20
ES2260910T3 (es) 2006-11-01
AU3640999A (en) 1999-11-01
DK1071463T3 (da) 2006-09-25
AU763979B2 (en) 2003-08-07
WO1999052554A1 (en) 1999-10-21
IL138993A (en) 2011-01-31
HUP0102239A2 (hu) 2002-03-28
EP1071463B1 (en) 2006-06-07
CY1106800T1 (el) 2012-05-23
US20120149730A1 (en) 2012-06-14
JP2002511426A (ja) 2002-04-16
DE69931771T2 (de) 2006-10-12
CN1305385A (zh) 2001-07-25
US20030083343A1 (en) 2003-05-01
EP1707216A1 (en) 2006-10-04
US8404715B2 (en) 2013-03-26
HUP0102239A3 (en) 2002-06-28
ZA200005553B (en) 2001-05-17
KR100686297B1 (ko) 2007-02-23
CN1768749A (zh) 2006-05-10
NO20005147L (no) 2000-11-07
EP1071463A1 (en) 2001-01-31
US6194431B1 (en) 2001-02-27
US6509353B1 (en) 2003-01-21
PL343526A1 (en) 2001-08-27
KR20010042655A (ko) 2001-05-25
CA2328074A1 (en) 1999-10-21
BR9909641A (pt) 2000-12-19
NZ507762A (en) 2003-09-26
NO20005147D0 (no) 2000-10-13
CA2328074C (en) 2012-02-21
PT1071463E (pt) 2006-10-31
ATE328608T1 (de) 2006-06-15

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FF Patent granted