HUP0102239A2 - Terfenadin metabolitokat és leukotrién inhibitorokat tartalmazó gyógyásszati készítmények - Google Patents
Terfenadin metabolitokat és leukotrién inhibitorokat tartalmazó gyógyásszati készítményekInfo
- Publication number
- HUP0102239A2 HUP0102239A2 HU0102239A HUP0102239A HUP0102239A2 HU P0102239 A2 HUP0102239 A2 HU P0102239A2 HU 0102239 A HU0102239 A HU 0102239A HU P0102239 A HUP0102239 A HU P0102239A HU P0102239 A2 HUP0102239 A2 HU P0102239A2
- Authority
- HU
- Hungary
- Prior art keywords
- phenyl
- leukotriene inhibitors
- combination
- pharmaceutical compositions
- propyl
- Prior art date
Links
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical class C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title abstract 4
- 239000003199 leukotriene receptor blocking agent Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 4
- 230000001387 anti-histamine Effects 0.000 abstract 2
- 229940125715 antihistaminic agent Drugs 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 206010027654 Allergic conditions Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229940076372 protein antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960000351 terfenadine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgyát asztma, allergiás állapotok és gyulladás esetébenhatásos, antihisztaminokat és leukotriéninhibitorokat tartalmazókészítmények és ezek alkalmazása képezi. Az antihisztamin hatásúkomponens a terfenadin, a H1-hisztamin-receptor fehérjeantagonistája,amely a szokásos antihisztaminok által blokkolt választ továbbítja.Metabolitjai, például a fexofenadin - 4-/1-hidroxi-4-(4-hidroxi-difenil-metil-1-piperidinil)-butil/-a,a-dimetil-fenil-ecetsav -ugyancsak antihisztaminaktivitással rendelkeznek és a készítményekbenalkalmazhatók. A leukotriéninhibitorok közé tartozik például anátrium-1-/R-(3-(2-(6,7-difluor-2-kinolinil)-etinil)-fenil)-3-/2-(2-hidroxi-2-propil)-fenil/-tiometil-ciklopropán-acetát és az 1-/R-(3-(2-(2,3-diklór-tieno/3,2-b/piridin-5-il)-(E)-etenil)-fenil)-3-(2-(1-hidroxi-1-metil-etil)-fenil)-propil)-tiometi )-ciklopropán-ecetsavvagy sója. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/059,570 US6194431B1 (en) | 1998-04-14 | 1998-04-14 | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
PCT/US1999/008077 WO1999052554A1 (en) | 1998-04-14 | 1999-04-13 | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0102239A2 true HUP0102239A2 (hu) | 2002-03-28 |
HUP0102239A3 HUP0102239A3 (en) | 2002-06-28 |
HU228035B1 HU228035B1 (en) | 2012-08-28 |
Family
ID=22023833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102239A HU228035B1 (en) | 1998-04-14 | 1999-04-13 | Pharmaceutical compositions using terfenadine metabolites in combination with leukotriene inhibitors |
Country Status (21)
Country | Link |
---|---|
US (4) | US6194431B1 (hu) |
EP (2) | EP1071463B1 (hu) |
JP (1) | JP2002511426A (hu) |
KR (1) | KR100686297B1 (hu) |
CN (2) | CN1768749A (hu) |
AT (1) | ATE328608T1 (hu) |
AU (1) | AU763979B2 (hu) |
BR (1) | BR9909641A (hu) |
CA (1) | CA2328074C (hu) |
CY (1) | CY1106800T1 (hu) |
DE (1) | DE69931771T2 (hu) |
DK (1) | DK1071463T3 (hu) |
ES (1) | ES2260910T3 (hu) |
HU (1) | HU228035B1 (hu) |
IL (2) | IL138993A0 (hu) |
NO (1) | NO20005147L (hu) |
NZ (1) | NZ507762A (hu) |
PL (1) | PL343526A1 (hu) |
PT (1) | PT1071463E (hu) |
WO (1) | WO1999052554A1 (hu) |
ZA (1) | ZA200005553B (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194431B1 (en) | 1998-04-14 | 2001-02-27 | Paul D. Rubin | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
US20020198246A1 (en) * | 1998-09-30 | 2002-12-26 | Ono Pharmaceutical Co., Ltd. | Agent for preventing and/or treating sinusitis |
DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
US6440994B1 (en) | 2000-03-29 | 2002-08-27 | Richard J. Sanders, Jr. | Method of treating acne |
US20020198228A1 (en) * | 2001-04-03 | 2002-12-26 | Kaura Sita R. | Composition and method for the treatment of respiratory desease |
AU2003237253A1 (en) * | 2002-05-29 | 2003-12-19 | Aventis Pharmaceuticals Holdings Inc. | Method of treating asthma using fexofenadine |
US20040115647A1 (en) * | 2002-12-12 | 2004-06-17 | Paterson Thomas S. | Apparatus and method for identifying biomarkers using a computer model |
WO2009027852A2 (en) * | 2007-08-28 | 2009-03-05 | Agi Therapeutics, P.L.C. | Methods and compositions for treating gastrointestinal conditions |
WO2016011254A1 (en) * | 2014-07-16 | 2016-01-21 | Henry J. Legere Md, Pa | Combinations of antihistamines and leukotriene antagonists and methods of use thereof |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3878217A (en) | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4783465A (en) | 1984-04-09 | 1988-11-08 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
US4552899A (en) | 1984-04-09 | 1985-11-12 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
US4617407A (en) * | 1984-08-30 | 1986-10-14 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US4742175A (en) | 1986-05-07 | 1988-05-03 | Merrell Dow Pharmaceuticals Inc. | Preparation of polymorphically pure terfenadine |
US4800162A (en) | 1987-04-01 | 1989-01-24 | Sepracor, Inc. | Method for resolution of steroisomers in multiphase and extractive membrane reactors |
US4829064A (en) | 1987-06-08 | 1989-05-09 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
US4929605A (en) | 1987-10-07 | 1990-05-29 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol derivatives |
US4996061A (en) | 1987-10-07 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol-decongestant combination |
CN1053570C (zh) | 1987-10-07 | 2000-06-21 | 默尔多药物公司 | 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法 |
US5057427A (en) | 1988-04-07 | 1991-10-15 | Sepracor, Inc. | Method for resolution of stereoisomers |
US4990259A (en) | 1988-12-16 | 1991-02-05 | The Amalgamated Sugar Company | Chromatographic separator sorbent bed preparation |
US5019591A (en) | 1989-02-17 | 1991-05-28 | Pennsylvania Research Corporation | Method for treating retinopathy and other small vessel disorders associated with diabetes |
JPH07506828A (ja) | 1992-05-11 | 1995-07-27 | メレルダウファーマス−ティカルズ インコーポレイテッド | 肝臓が損われた患者での抗ヒスタミン剤としてのターフェナジン誘導体の用途 |
JP3041954B2 (ja) | 1992-08-03 | 2000-05-15 | セプラコア インコーポレーテッド | アレルギー疾患治療用のテルフェナジン代謝物及びその光学的に純粋な異性体 |
AU670004B2 (en) | 1993-06-24 | 1996-06-27 | Albany Molecular Research, Inc. | Piperidine derivatives and process for their production |
WO1995010278A1 (en) | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
JPH11507670A (ja) * | 1995-06-12 | 1999-07-06 | ジー.ディー.サール アンド カンパニー | シクロオキシゲナーゼ−2インヒビターと5−リポキシゲナーゼインヒビターの組合せによる炎症と炎症関連疾患の治療 |
CA2245162A1 (en) | 1996-02-08 | 1997-08-14 | Merck & Co., Inc. | Method of treatment and pharmaceutical composition |
ES2169351T3 (es) * | 1996-02-13 | 2002-07-01 | Searle & Co | Combinaciones que tienen efectos inmunosupresores, que contienen inhibidores de ciclooxigenasa-2 y 5-lipoxigenasa. |
US5919776A (en) * | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
US5900421A (en) * | 1997-02-11 | 1999-05-04 | Sepracor Inc. | Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine |
CA2315721C (en) * | 1997-12-23 | 2008-08-12 | Schering Corporation | Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine |
US6194431B1 (en) * | 1998-04-14 | 2001-02-27 | Paul D. Rubin | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
-
1998
- 1998-04-14 US US09/059,570 patent/US6194431B1/en not_active Expired - Lifetime
-
1999
- 1999-04-13 BR BR9909641-2A patent/BR9909641A/pt not_active Application Discontinuation
- 1999-04-13 CN CNA2005100832028A patent/CN1768749A/zh active Pending
- 1999-04-13 DE DE69931771T patent/DE69931771T2/de not_active Expired - Lifetime
- 1999-04-13 DK DK99918515T patent/DK1071463T3/da active
- 1999-04-13 WO PCT/US1999/008077 patent/WO1999052554A1/en not_active Application Discontinuation
- 1999-04-13 HU HU0102239A patent/HU228035B1/hu not_active IP Right Cessation
- 1999-04-13 NZ NZ507762A patent/NZ507762A/en not_active IP Right Cessation
- 1999-04-13 ES ES99918515T patent/ES2260910T3/es not_active Expired - Lifetime
- 1999-04-13 PT PT99918515T patent/PT1071463E/pt unknown
- 1999-04-13 AT AT99918515T patent/ATE328608T1/de active
- 1999-04-13 JP JP2000543164A patent/JP2002511426A/ja active Pending
- 1999-04-13 CN CN99807374A patent/CN1305385A/zh active Pending
- 1999-04-13 EP EP99918515A patent/EP1071463B1/en not_active Expired - Lifetime
- 1999-04-13 KR KR1020007011354A patent/KR100686297B1/ko not_active IP Right Cessation
- 1999-04-13 PL PL99343526A patent/PL343526A1/xx unknown
- 1999-04-13 EP EP06112687A patent/EP1707216A1/en active Pending
- 1999-04-13 AU AU36409/99A patent/AU763979B2/en not_active Ceased
- 1999-04-13 IL IL13899399A patent/IL138993A0/xx active IP Right Grant
- 1999-04-13 CA CA2328074A patent/CA2328074C/en not_active Expired - Fee Related
-
2000
- 2000-10-10 ZA ZA200005553A patent/ZA200005553B/xx unknown
- 2000-10-12 IL IL138993A patent/IL138993A/en not_active IP Right Cessation
- 2000-10-13 NO NO20005147A patent/NO20005147L/no not_active Application Discontinuation
- 2000-11-28 US US09/722,395 patent/US6509353B1/en not_active Expired - Lifetime
-
2002
- 2002-12-06 US US10/314,269 patent/US20030083343A1/en not_active Abandoned
-
2006
- 2006-09-05 CY CY20061101264T patent/CY1106800T1/el unknown
-
2012
- 2012-02-16 US US13/398,669 patent/US8404715B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
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FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU |
|
FH92 | Termination of representative |
Representative=s name: S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU |
|
MM4A | Lapse of definitive patent protection due to non-payment of fees |