IL137654A0 - Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors - Google Patents
Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitorsInfo
- Publication number
- IL137654A0 IL137654A0 IL13765499A IL13765499A IL137654A0 IL 137654 A0 IL137654 A0 IL 137654A0 IL 13765499 A IL13765499 A IL 13765499A IL 13765499 A IL13765499 A IL 13765499A IL 137654 A0 IL137654 A0 IL 137654A0
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- acid derivatives
- nitric oxide
- oxide synthase
- synthase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3828498A | 1998-03-11 | 1998-03-11 | |
| PCT/US1999/003728 WO1999046240A2 (en) | 1998-03-11 | 1999-03-04 | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137654A0 true IL137654A0 (en) | 2001-10-31 |
Family
ID=21899068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13765499A IL137654A0 (en) | 1998-03-11 | 1999-03-04 | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6344483B1 (de) |
| EP (2) | EP1415982A1 (de) |
| JP (1) | JP2002506056A (de) |
| KR (1) | KR20010034598A (de) |
| CN (1) | CN1171861C (de) |
| AP (1) | AP2000001900A0 (de) |
| AR (1) | AR018159A1 (de) |
| AT (1) | ATE277894T1 (de) |
| AU (1) | AU746235B2 (de) |
| BG (1) | BG104766A (de) |
| BR (1) | BR9908702A (de) |
| CA (1) | CA2322873A1 (de) |
| CU (1) | CU23047A3 (de) |
| DE (1) | DE69920670T2 (de) |
| EA (1) | EA200000826A1 (de) |
| EE (1) | EE200000519A (de) |
| ES (1) | ES2239839T3 (de) |
| GE (1) | GEP20043179B (de) |
| HR (1) | HRP20000595A2 (de) |
| HU (1) | HUP0101467A3 (de) |
| ID (1) | ID26208A (de) |
| IL (1) | IL137654A0 (de) |
| IS (1) | IS5583A (de) |
| NO (1) | NO20004531L (de) |
| NZ (1) | NZ506721A (de) |
| OA (1) | OA11901A (de) |
| PL (1) | PL343380A1 (de) |
| PT (1) | PT1062201E (de) |
| SI (1) | SI1062201T1 (de) |
| SK (1) | SK13012000A3 (de) |
| TR (1) | TR200002605T2 (de) |
| UA (1) | UA67767C2 (de) |
| WO (1) | WO1999046240A2 (de) |
| YU (1) | YU52200A (de) |
| ZA (1) | ZA991894B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE295832T1 (de) | 2000-03-24 | 2005-06-15 | Pharmacia Corp | Amidino-verbindung sowie salze davon verwendbar als hemmstoffe der stickstoffmonoxid-synthase |
| AR034120A1 (es) | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
| US6545170B2 (en) | 2000-04-13 | 2003-04-08 | Pharmacia Corporation | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
| US6787668B2 (en) | 2000-04-13 | 2004-09-07 | Pharmacia Corporation | 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
| AR030416A1 (es) | 2000-04-13 | 2003-08-20 | Pharmacia Corp | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |
| AR032318A1 (es) * | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
| US6956131B2 (en) | 2000-04-13 | 2005-10-18 | Pharmacia Corporation | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors |
| AR035585A1 (es) * | 2000-09-15 | 2004-06-16 | Pharmacia Corp | Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos |
| AR031609A1 (es) * | 2000-09-15 | 2003-09-24 | Pharmacia Corp | Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa |
| AR031129A1 (es) * | 2000-09-15 | 2003-09-10 | Pharmacia Corp | Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa |
| AR031608A1 (es) * | 2000-09-15 | 2003-09-24 | Pharmacia Corp | Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa |
| GB0031179D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
| US6582387B2 (en) * | 2001-03-20 | 2003-06-24 | Therox, Inc. | System for enriching a bodily fluid with a gas |
| US6613280B2 (en) * | 2001-03-20 | 2003-09-02 | Therox, Inc. | Disposable cartridge for producing gas-enriched fluids |
| US7012098B2 (en) | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
| WO2003097050A2 (en) * | 2002-05-16 | 2003-11-27 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
| US7638491B2 (en) * | 2004-12-22 | 2009-12-29 | Ambrx, Inc. | Therapies using non-natural amino acids and polypeptides |
| CA2601481C (en) * | 2005-03-14 | 2013-11-12 | Janssen Pharmaceutica N.V. | Process for the preparation of opioid modulators |
| AU2006311568B2 (en) * | 2005-11-08 | 2010-11-11 | Ambrx, Inc. | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
| US20080317670A1 (en) | 2005-12-14 | 2008-12-25 | Ambrx, Inc. | Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides |
| KR101103720B1 (ko) * | 2011-06-02 | 2012-01-11 | 한국건설기술연구원 | 자연환기에 의한 중공층의 온도제어가 가능한 일체형 다중유리 복합창짝 |
| CN105744944B (zh) | 2013-09-09 | 2020-07-07 | 卡尼姆盖德治疗学公司 | 免疫系统调节器 |
| ES2853582T3 (es) | 2015-03-06 | 2021-09-16 | Canimguide Therapeutics Ab | Moduladores del sistema inmune y composiciones |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
| EP0765308B1 (de) * | 1994-06-15 | 2000-04-05 | The Wellcome Foundation Limited | Enzymhemmer |
| GB9425701D0 (en) | 1994-12-20 | 1995-02-22 | Wellcome Found | Enzyme inhibitors |
| US5945408A (en) | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
| US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
-
1999
- 1999-03-04 GE GEAP19995542A patent/GEP20043179B/en unknown
- 1999-03-04 OA OA1200000239A patent/OA11901A/en unknown
- 1999-03-04 WO PCT/US1999/003728 patent/WO1999046240A2/en not_active Application Discontinuation
- 1999-03-04 EP EP20040001236 patent/EP1415982A1/de not_active Withdrawn
- 1999-03-04 AP APAP/P/2000/001900A patent/AP2000001900A0/en unknown
- 1999-03-04 PT PT99908324T patent/PT1062201E/pt unknown
- 1999-03-04 JP JP2000535621A patent/JP2002506056A/ja active Pending
- 1999-03-04 IL IL13765499A patent/IL137654A0/xx unknown
- 1999-03-04 SK SK1301-2000A patent/SK13012000A3/sk unknown
- 1999-03-04 CN CNB998037907A patent/CN1171861C/zh not_active Expired - Fee Related
- 1999-03-04 TR TR2000/02605T patent/TR200002605T2/xx unknown
- 1999-03-04 NZ NZ506721A patent/NZ506721A/en unknown
- 1999-03-04 EP EP99908324A patent/EP1062201B1/de not_active Expired - Lifetime
- 1999-03-04 YU YU52200A patent/YU52200A/sh unknown
- 1999-03-04 ES ES99908324T patent/ES2239839T3/es not_active Expired - Lifetime
- 1999-03-04 CA CA002322873A patent/CA2322873A1/en not_active Abandoned
- 1999-03-04 SI SI9930718T patent/SI1062201T1/xx unknown
- 1999-03-04 EE EEP200000519A patent/EE200000519A/xx unknown
- 1999-03-04 KR KR1020007010096A patent/KR20010034598A/ko not_active Application Discontinuation
- 1999-03-04 EA EA200000826A patent/EA200000826A1/ru unknown
- 1999-03-04 CU CU20000199A patent/CU23047A3/es unknown
- 1999-03-04 AU AU27786/99A patent/AU746235B2/en not_active Ceased
- 1999-03-04 DE DE69920670T patent/DE69920670T2/de not_active Expired - Fee Related
- 1999-03-04 US US09/402,953 patent/US6344483B1/en not_active Expired - Fee Related
- 1999-03-04 PL PL99343380A patent/PL343380A1/xx unknown
- 1999-03-04 BR BR9908702-2A patent/BR9908702A/pt not_active Application Discontinuation
- 1999-03-04 ID IDW20001739A patent/ID26208A/id unknown
- 1999-03-04 HU HU0101467A patent/HUP0101467A3/hu unknown
- 1999-03-04 AT AT99908324T patent/ATE277894T1/de not_active IP Right Cessation
- 1999-03-09 ZA ZA9901894A patent/ZA991894B/xx unknown
- 1999-03-11 AR ARP990101062A patent/AR018159A1/es unknown
- 1999-04-03 UA UA2000095233A patent/UA67767C2/uk unknown
-
2000
- 2000-08-04 IS IS5583A patent/IS5583A/is unknown
- 2000-09-08 HR HR20000595A patent/HRP20000595A2/hr not_active Application Discontinuation
- 2000-09-11 NO NO20004531A patent/NO20004531L/no not_active Application Discontinuation
- 2000-09-14 BG BG104766A patent/BG104766A/bg unknown
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