IL134894A - 2-substituted-1,3,4,5-tetrahydro-2h-gamma-carbolines, their preparation and pharmaceutical compositions containing them - Google Patents

2-substituted-1,3,4,5-tetrahydro-2h-gamma-carbolines, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL134894A
IL134894A IL13489498A IL13489498A IL134894A IL 134894 A IL134894 A IL 134894A IL 13489498 A IL13489498 A IL 13489498A IL 13489498 A IL13489498 A IL 13489498A IL 134894 A IL134894 A IL 134894A
Authority
IL
Israel
Prior art keywords
preparation
compositions containing
optionally substituted
carbolines
tetrahydro
Prior art date
Application number
IL13489498A
Other languages
English (en)
Other versions
IL134894A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL134894A0 publication Critical patent/IL134894A0/xx
Publication of IL134894A publication Critical patent/IL134894A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL13489498A 1997-09-08 1998-09-01 2-substituted-1,3,4,5-tetrahydro-2h-gamma-carbolines, their preparation and pharmaceutical compositions containing them IL134894A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202761A EP0905136A1 (fr) 1997-09-08 1997-09-08 Tétrahydro gamma-carbolines
PCT/EP1998/005710 WO1999012926A1 (fr) 1997-09-08 1998-09-01 Tetrahydro gamma-carbolines

Publications (2)

Publication Number Publication Date
IL134894A0 IL134894A0 (en) 2001-05-20
IL134894A true IL134894A (en) 2005-03-20

Family

ID=8228715

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13489498A IL134894A (en) 1997-09-08 1998-09-01 2-substituted-1,3,4,5-tetrahydro-2h-gamma-carbolines, their preparation and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (2) US6303614B1 (fr)
EP (2) EP0905136A1 (fr)
JP (1) JP2001515899A (fr)
KR (1) KR100603896B1 (fr)
CN (1) CN1110496C (fr)
AT (1) ATE243209T1 (fr)
AU (1) AU752410B2 (fr)
BR (1) BR9811769A (fr)
CA (1) CA2301807A1 (fr)
CZ (1) CZ297220B6 (fr)
DE (1) DE69815700T2 (fr)
EE (1) EE04496B1 (fr)
ES (1) ES2202902T3 (fr)
HK (1) HK1029107A1 (fr)
HR (1) HRP20000108A2 (fr)
HU (1) HUP0003577A3 (fr)
ID (1) ID23954A (fr)
IL (1) IL134894A (fr)
MY (1) MY129176A (fr)
NO (1) NO315236B1 (fr)
NZ (1) NZ503096A (fr)
PL (1) PL191863B1 (fr)
RU (1) RU2208614C2 (fr)
SK (1) SK285594B6 (fr)
TR (1) TR200000616T2 (fr)
TW (1) TW531539B (fr)
WO (1) WO1999012926A1 (fr)
ZA (1) ZA988161B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200801812A1 (ru) 2003-09-17 2009-06-30 Янссен Фармацевтика Н.В. Сопряженные гетероциклические соединения
CN101318961B (zh) * 2003-09-17 2012-11-28 詹森药业有限公司 稠合杂环化合物
EP1944306A1 (fr) * 2003-09-17 2008-07-16 Janssen Pharmaceutica, N.V. Composés hétérocycliques fusionnés
CN1972938B (zh) * 2004-04-12 2010-09-29 大正制药株式会社 环状胺化合物
JP2008530229A (ja) 2005-02-17 2008-08-07 ワイス シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
FR2885905A1 (fr) * 2005-05-23 2006-11-24 Trophos Sa Nouveaux composes chimiques et leurs utilisations comme medicament
WO2007009485A1 (fr) * 2005-07-22 2007-01-25 Pharma C S.A. Derives de 8-phenoxy-y-carboline substitues a activite 5ht1
WO2007058580A1 (fr) * 2005-11-15 2007-05-24 Astrazeneca Ab Nouveaux derives de 2-aminopyrimidinone et leur utilisation
US7637410B2 (en) * 2006-10-06 2009-12-29 Tyco Healthcare Group Lp Surgical instrument including a locking assembly
WO2009038764A1 (fr) * 2007-09-20 2009-03-26 D2E, Llc Dérivés à base de fluor de pyrido[4,3-b]indoles hydrogénés dotés de propriétés neuroprotectrices et favorisant la cognition, procédé de préparation et utilisation
WO2009082268A2 (fr) 2007-12-21 2009-07-02 Alla Chem, Llc Ligands dalpha-adrénorécepteurs, de récepteurs de dopamine, de l'histamine, d'imidazoline et de sérotonine ainsi que leurs procédés d'utilisation
RU2374245C1 (ru) 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
CN105399674B (zh) 2015-12-31 2017-02-15 青岛清原化合物有限公司 吡唑类化合物或其盐、制备方法、除草剂组合物及用途
CN106631941B (zh) * 2016-12-30 2018-09-28 青岛瀚生生物科技股份有限公司 一种2-甲基-3氯苯基甲硫醚的制备方法
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds
CN110698474B (zh) * 2019-11-14 2021-11-02 福州大学 一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
ATE247114T1 (de) * 1994-09-12 2003-08-15 Lilly Co Eli Serotonergische modulatoren

Also Published As

Publication number Publication date
DE69815700T2 (de) 2004-04-29
EP0905136A1 (fr) 1999-03-31
AU9742198A (en) 1999-03-29
SK2992000A3 (en) 2001-03-12
TW531539B (en) 2003-05-11
NZ503096A (en) 2001-11-30
EE200000059A (et) 2000-10-16
KR100603896B1 (ko) 2006-07-25
US20020103209A1 (en) 2002-08-01
NO20000737D0 (no) 2000-02-14
ES2202902T3 (es) 2004-04-01
ATE243209T1 (de) 2003-07-15
CA2301807A1 (fr) 1999-03-18
CN1269800A (zh) 2000-10-11
CZ297220B6 (cs) 2006-10-11
DE69815700D1 (en) 2003-07-24
RU2208614C2 (ru) 2003-07-20
MY129176A (en) 2007-03-30
HUP0003577A2 (hu) 2001-09-28
NO20000737L (no) 2000-05-08
SK285594B6 (sk) 2007-04-05
JP2001515899A (ja) 2001-09-25
TR200000616T2 (tr) 2000-07-21
CZ2000726A3 (cs) 2000-07-12
CN1110496C (zh) 2003-06-04
EP1015451A1 (fr) 2000-07-05
US6506768B2 (en) 2003-01-14
EE04496B1 (et) 2005-06-15
HUP0003577A3 (en) 2003-05-28
BR9811769A (pt) 2000-08-29
ID23954A (id) 2000-06-08
PL191863B1 (pl) 2006-07-31
KR20010022391A (ko) 2001-03-15
IL134894A0 (en) 2001-05-20
WO1999012926A1 (fr) 1999-03-18
AU752410B2 (en) 2002-09-19
HK1029107A1 (en) 2001-03-23
ZA988161B (en) 2000-03-22
HRP20000108A2 (en) 2000-12-31
PL339143A1 (en) 2000-12-04
NO315236B1 (no) 2003-08-04
EP1015451B1 (fr) 2003-06-18
US6303614B1 (en) 2001-10-16

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Legal Events

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