HK1029107A1 - Tetrahydro gamma-carbolines - Google Patents

Tetrahydro gamma-carbolines

Info

Publication number
HK1029107A1
HK1029107A1 HK00107165A HK00107165A HK1029107A1 HK 1029107 A1 HK1029107 A1 HK 1029107A1 HK 00107165 A HK00107165 A HK 00107165A HK 00107165 A HK00107165 A HK 00107165A HK 1029107 A1 HK1029107 A1 HK 1029107A1
Authority
HK
Hong Kong
Prior art keywords
optionally substituted
6alkyl
aryl
carbolines
tetrahydro
Prior art date
Application number
HK00107165A
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1029107A1 publication Critical patent/HK1029107A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK00107165A 1997-09-08 2000-11-10 Tetrahydro gamma-carbolines HK1029107A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202761A EP0905136A1 (fr) 1997-09-08 1997-09-08 Tétrahydro gamma-carbolines
PCT/EP1998/005710 WO1999012926A1 (fr) 1997-09-08 1998-09-01 Tetrahydro gamma-carbolines

Publications (1)

Publication Number Publication Date
HK1029107A1 true HK1029107A1 (en) 2001-03-23

Family

ID=8228715

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00107165A HK1029107A1 (en) 1997-09-08 2000-11-10 Tetrahydro gamma-carbolines

Country Status (28)

Country Link
US (2) US6303614B1 (fr)
EP (2) EP0905136A1 (fr)
JP (1) JP2001515899A (fr)
KR (1) KR100603896B1 (fr)
CN (1) CN1110496C (fr)
AT (1) ATE243209T1 (fr)
AU (1) AU752410B2 (fr)
BR (1) BR9811769A (fr)
CA (1) CA2301807A1 (fr)
CZ (1) CZ297220B6 (fr)
DE (1) DE69815700T2 (fr)
EE (1) EE04496B1 (fr)
ES (1) ES2202902T3 (fr)
HK (1) HK1029107A1 (fr)
HR (1) HRP20000108A2 (fr)
HU (1) HUP0003577A3 (fr)
ID (1) ID23954A (fr)
IL (1) IL134894A (fr)
MY (1) MY129176A (fr)
NO (1) NO315236B1 (fr)
NZ (1) NZ503096A (fr)
PL (1) PL191863B1 (fr)
RU (1) RU2208614C2 (fr)
SK (1) SK285594B6 (fr)
TR (1) TR200000616T2 (fr)
TW (1) TW531539B (fr)
WO (1) WO1999012926A1 (fr)
ZA (1) ZA988161B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101318962A (zh) * 2003-09-17 2008-12-10 詹森药业有限公司 稠合杂环化合物
EP1944306A1 (fr) * 2003-09-17 2008-07-16 Janssen Pharmaceutica, N.V. Composés hétérocycliques fusionnés
AU2004283196B2 (en) 2003-09-17 2011-08-25 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds
MXPA06011777A (es) 2004-04-12 2007-01-16 Taisho Pharma Co Ltd Compuesto de amina ciclico.
CA2597616A1 (fr) 2005-02-17 2006-08-24 Wyeth Derive d'indole, benzothiophene, benzofurane et indene a fusion cycloalkyle
FR2885905A1 (fr) * 2005-05-23 2006-11-24 Trophos Sa Nouveaux composes chimiques et leurs utilisations comme medicament
WO2007009485A1 (fr) * 2005-07-22 2007-01-25 Pharma C S.A. Derives de 8-phenoxy-y-carboline substitues a activite 5ht1
EP1951680A4 (fr) * 2005-11-15 2011-08-10 Astrazeneca Ab Nouveaux derives de 2-aminopyrimidinone et leur utilisation
US7637410B2 (en) * 2006-10-06 2009-12-29 Tyco Healthcare Group Lp Surgical instrument including a locking assembly
MX2010003149A (es) * 2007-09-20 2010-11-10 D2E Llc Derivados que contienen fluor de pirido[4,3-b]indoles hidrogenados con propiedades neuroprotectoras y de mejoramiento de cognicion, proceso de preparacion y uso.
WO2009082268A2 (fr) 2007-12-21 2009-07-02 Alla Chem, Llc Ligands dalpha-adrénorécepteurs, de récepteurs de dopamine, de l'histamine, d'imidazoline et de sérotonine ainsi que leurs procédés d'utilisation
RU2374245C1 (ru) 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
CN105399674B (zh) 2015-12-31 2017-02-15 青岛清原化合物有限公司 吡唑类化合物或其盐、制备方法、除草剂组合物及用途
CN106631941B (zh) * 2016-12-30 2018-09-28 青岛瀚生生物科技股份有限公司 一种2-甲基-3氯苯基甲硫醚的制备方法
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds
CN110698474B (zh) * 2019-11-14 2021-11-02 福州大学 一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用
AU2021356875B2 (en) * 2020-10-09 2023-11-23 Jiangsu Nhwa Pharmaceutical Co., Ltd HETEROCYCLIC SUBSTITUTED FUSED γ-CARBOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
DE69531476T2 (de) * 1994-09-12 2004-06-09 Lilly Industries Ltd., Basingstoke Serotonergische Modulatoren

Also Published As

Publication number Publication date
SK285594B6 (sk) 2007-04-05
NO315236B1 (no) 2003-08-04
CN1269800A (zh) 2000-10-11
PL339143A1 (en) 2000-12-04
HRP20000108A2 (en) 2000-12-31
ES2202902T3 (es) 2004-04-01
BR9811769A (pt) 2000-08-29
US6506768B2 (en) 2003-01-14
ATE243209T1 (de) 2003-07-15
CZ297220B6 (cs) 2006-10-11
IL134894A0 (en) 2001-05-20
NO20000737D0 (no) 2000-02-14
CZ2000726A3 (cs) 2000-07-12
EP1015451B1 (fr) 2003-06-18
HUP0003577A3 (en) 2003-05-28
WO1999012926A1 (fr) 1999-03-18
IL134894A (en) 2005-03-20
US6303614B1 (en) 2001-10-16
TW531539B (en) 2003-05-11
EE04496B1 (et) 2005-06-15
US20020103209A1 (en) 2002-08-01
HUP0003577A2 (hu) 2001-09-28
ID23954A (id) 2000-06-08
EE200000059A (et) 2000-10-16
SK2992000A3 (en) 2001-03-12
NO20000737L (no) 2000-05-08
ZA988161B (en) 2000-03-22
KR20010022391A (ko) 2001-03-15
JP2001515899A (ja) 2001-09-25
EP0905136A1 (fr) 1999-03-31
NZ503096A (en) 2001-11-30
EP1015451A1 (fr) 2000-07-05
TR200000616T2 (tr) 2000-07-21
DE69815700T2 (de) 2004-04-29
KR100603896B1 (ko) 2006-07-25
PL191863B1 (pl) 2006-07-31
DE69815700D1 (en) 2003-07-24
AU9742198A (en) 1999-03-29
RU2208614C2 (ru) 2003-07-20
AU752410B2 (en) 2002-09-19
CN1110496C (zh) 2003-06-04
MY129176A (en) 2007-03-30
CA2301807A1 (fr) 1999-03-18

Similar Documents

Publication Publication Date Title
DE69815700D1 (en) Tetrahydro gamma-carboline
HU896723D0 (en) Process for preparation of guanidine-derivatives and insecticid compositions comprising these compounds as active ingredient
PH23607A (en) Amide derivatives and pharmaceutical composition containing said compounds
ZW290A1 (en) 2-aminopyrimidinone derivatives
NL300298I2 (nl) Nieuwe 3-piperidinyl-1,2-benzisoxazolen
DK1029853T3 (da) Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
MXPA03011244A (es) Nuevos derivados de indol con afinidad por el receptor 5-ht6.
HU9401974D0 (en) New intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them
EP0324387A3 (en) Composition for treatment of ischemic disorder in organs
NZ214156A (en) Quindone derivatives and pharmaceutical compositions
IL114785A0 (en) Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
IL96498A0 (en) Aminocarbonylcarbamates related to physostigmine,a process for their preparation and their use as medicaments
MY125562A (en) Hexahydro-pyrido (4,3-b) indole derivatives as antipsychotic drugs
NO910904L (no) Fremgangsmaate for fremstilling av en substituert aminforbindelse.
PT91613A (pt) Process for the preparation of antihypertensive 3-piperidinyl-indazole derivatives
TW275629B (fr)
BG105521A (en) Benzisoxazoles and phenons as alpha2-antagonists

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070901