IL133508A - Pharmaceutical composition having enhanced antitumor activity and/or reduced side effects containingan antitumor agent and an hydroximic acid derivative - Google Patents
Pharmaceutical composition having enhanced antitumor activity and/or reduced side effects containingan antitumor agent and an hydroximic acid derivativeInfo
- Publication number
- IL133508A IL133508A IL13350898A IL13350898A IL133508A IL 133508 A IL133508 A IL 133508A IL 13350898 A IL13350898 A IL 13350898A IL 13350898 A IL13350898 A IL 13350898A IL 133508 A IL133508 A IL 133508A
- Authority
- IL
- Israel
- Prior art keywords
- containingan
- pharmaceutical composition
- side effects
- acid derivative
- reduced side
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- LEAWDHURBAHMCQ-UHFFFAOYSA-N (2-hydroxy-3-piperidin-1-ylpropyl) pyridine-3-carboxylate Chemical compound C1CCCCN1CC(O)COC(=O)C1=CC=CN=C1 LEAWDHURBAHMCQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical compound C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701081A HU9701081D0 (en) | 1997-06-23 | 1997-06-23 | Pharmaceutical composition of antitumoral activity |
| PCT/IB1998/000961 WO1998058676A1 (en) | 1997-06-23 | 1998-06-22 | Pharmaceutical composition having enhanced antitumor activity and/or reduced side effects, containing an antitumor agent and an hydroxamic acid derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL133508A0 IL133508A0 (en) | 2001-04-30 |
| IL133508A true IL133508A (en) | 2005-11-20 |
Family
ID=89995266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13350898A IL133508A (en) | 1997-06-23 | 1998-06-22 | Pharmaceutical composition having enhanced antitumor activity and/or reduced side effects containingan antitumor agent and an hydroximic acid derivative |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US6440998B1 (zh) |
| EP (1) | EP0993304B1 (zh) |
| JP (1) | JP2002508762A (zh) |
| KR (1) | KR20010020496A (zh) |
| CN (1) | CN1127984C (zh) |
| AT (1) | ATE235918T1 (zh) |
| AU (1) | AU735922B2 (zh) |
| BR (1) | BR9810312A (zh) |
| CA (1) | CA2294913C (zh) |
| CZ (1) | CZ298468B6 (zh) |
| DE (1) | DE69812949T2 (zh) |
| DK (1) | DK0993304T3 (zh) |
| ES (1) | ES2195344T3 (zh) |
| HK (1) | HK1029941A1 (zh) |
| HU (1) | HU9701081D0 (zh) |
| IL (1) | IL133508A (zh) |
| NO (1) | NO322206B1 (zh) |
| NZ (1) | NZ502039A (zh) |
| PL (1) | PL191718B1 (zh) |
| PT (1) | PT993304E (zh) |
| RU (2) | RU2254129C2 (zh) |
| SK (1) | SK282877B6 (zh) |
| TR (1) | TR199903214T2 (zh) |
| UA (1) | UA64757C2 (zh) |
| WO (1) | WO1998058676A1 (zh) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884424B2 (en) * | 1995-12-22 | 2005-04-26 | N-Gene Research Laboratories Inc. | Method for treating the pathological lesions of the skin that develop by ultraviolet radiation of the sunlight |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| CN104383542B (zh) | 2003-04-08 | 2017-09-26 | 普罗热尼奇制药公司 | 包含甲基纳曲酮的药物配方 |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| MX2007010833A (es) * | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
| US7763601B2 (en) * | 2006-11-02 | 2010-07-27 | N-Gene Research Laboratories, Inc. | Prevention and treatment of obesity |
| US20080108602A1 (en) * | 2006-11-02 | 2008-05-08 | N-Gene Research Laboratories, Inc. | Prevention of obesity in antipsychotic, antidepressant and antiepileptic medication |
| SI2139890T1 (sl) * | 2007-03-29 | 2014-12-31 | Wyeth Llc | Antagonisti perifernih opioidnih receptorjev in njih uporaba |
| MX351611B (es) | 2007-03-29 | 2017-10-20 | Wyeth Llc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
| PA8774201A1 (es) | 2007-03-29 | 2009-06-23 | Progenics Pharm Inc | Antagonista del receptor |
| WO2009092892A2 (fr) * | 2007-10-30 | 2009-07-30 | Trophos | Nouvelle composition pour traiter les effets secondaires des traitements anticancereux |
| US20090281143A1 (en) * | 2007-12-10 | 2009-11-12 | N-Gene Research Laboratories, Inc. | Dose Reduction of a Cannabinoid CB1 Receptor Antagonist in the Treatment of Overweight or Obesity |
| EP2730578A1 (en) | 2008-02-06 | 2014-05-14 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnal trexone |
| EP2278966B1 (en) * | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| ITMI20110792A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia. |
| ITMI20110791A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri in grado di metabolizzare gli ossalati. |
| ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
| HUP1100445A2 (en) * | 2011-08-17 | 2013-02-28 | Pharma Gene Sa | Pharmaceutical composition |
| HUP1100444A2 (en) | 2011-08-17 | 2013-02-28 | Pharma Gene Sa | Pharmaceutical composition |
| RU2522548C2 (ru) * | 2012-09-26 | 2014-07-20 | Федеральное государственное бюджетное учреждение науки Институт кристаллографии им. А.В. Шубникова Российской академии наук (ИК РАН) | Ингибитор уридинфосфорилаз |
| US9938279B2 (en) * | 2013-04-09 | 2018-04-10 | Energenesis Biomedical Co., Ltd | Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) |
| CN108703970A (zh) * | 2013-09-18 | 2018-10-26 | 华安医学股份有限公司 | 一种活化ampk的化合物及其用途 |
| RU2679136C1 (ru) * | 2018-03-13 | 2019-02-06 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" (ФИЦ КНЦ СО РАН, КНЦ СО РАН) | Способ получения препарата на основе взаимодействия цис-диамин(циклобутан-1,1-дикарбоксилат-о,о')платины(ii) с арабиногалактаном |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4308399A (en) * | 1977-08-30 | 1981-12-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HUT54347A (en) * | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| SK279471B6 (sk) * | 1993-03-31 | 1998-11-04 | Merck & Co. | Kompozícia zlúčenín, farmaceutické prostriedky s i |
| TW381025B (en) * | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| HU9502843D0 (en) * | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells |
-
1997
- 1997-06-23 HU HU9701081A patent/HU9701081D0/hu unknown
-
1998
- 1998-06-22 AU AU77837/98A patent/AU735922B2/en not_active Ceased
- 1998-06-22 UA UA2000010341A patent/UA64757C2/uk unknown
- 1998-06-22 RU RU2003101319/15A patent/RU2254129C2/ru not_active IP Right Cessation
- 1998-06-22 CZ CZ0462599A patent/CZ298468B6/cs not_active IP Right Cessation
- 1998-06-22 SK SK1764-99A patent/SK282877B6/sk not_active IP Right Cessation
- 1998-06-22 RU RU2000102359/14A patent/RU2214238C2/ru not_active IP Right Cessation
- 1998-06-22 EP EP98925873A patent/EP0993304B1/en not_active Expired - Lifetime
- 1998-06-22 DK DK98925873T patent/DK0993304T3/da active
- 1998-06-22 AT AT98925873T patent/ATE235918T1/de not_active IP Right Cessation
- 1998-06-22 PL PL337719A patent/PL191718B1/pl unknown
- 1998-06-22 US US09/446,064 patent/US6440998B1/en not_active Expired - Fee Related
- 1998-06-22 DE DE69812949T patent/DE69812949T2/de not_active Expired - Fee Related
- 1998-06-22 ES ES98925873T patent/ES2195344T3/es not_active Expired - Lifetime
- 1998-06-22 JP JP50404999A patent/JP2002508762A/ja not_active Withdrawn
- 1998-06-22 BR BR9810312-1A patent/BR9810312A/pt active Search and Examination
- 1998-06-22 PT PT98925873T patent/PT993304E/pt unknown
- 1998-06-22 KR KR1019997012198A patent/KR20010020496A/ko not_active Application Discontinuation
- 1998-06-22 TR TR1999/03214T patent/TR199903214T2/xx unknown
- 1998-06-22 WO PCT/IB1998/000961 patent/WO1998058676A1/en active IP Right Grant
- 1998-06-22 CN CN98807103A patent/CN1127984C/zh not_active Expired - Fee Related
- 1998-06-22 NZ NZ502039A patent/NZ502039A/xx unknown
- 1998-06-22 IL IL13350898A patent/IL133508A/xx not_active IP Right Cessation
- 1998-06-22 CA CA002294913A patent/CA2294913C/en not_active Expired - Fee Related
-
1999
- 1999-12-20 NO NO19996349A patent/NO322206B1/no unknown
-
2001
- 2001-02-09 HK HK01100914A patent/HK1029941A1/xx not_active IP Right Cessation
-
2002
- 2002-02-28 US US10/084,095 patent/US6838469B2/en not_active Expired - Fee Related
- 2002-02-28 US US10/084,183 patent/US6656955B2/en not_active Expired - Fee Related
- 2002-03-27 US US10/106,227 patent/US6720337B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |