IL132886A0 - A triterpene saponin-lipophile conjugate a pharmaceutical composition containing the same and a vaccine containing the same - Google Patents
A triterpene saponin-lipophile conjugate a pharmaceutical composition containing the same and a vaccine containing the sameInfo
- Publication number
- IL132886A0 IL132886A0 IL13288698A IL13288698A IL132886A0 IL 132886 A0 IL132886 A0 IL 132886A0 IL 13288698 A IL13288698 A IL 13288698A IL 13288698 A IL13288698 A IL 13288698A IL 132886 A0 IL132886 A0 IL 132886A0
- Authority
- IL
- Israel
- Prior art keywords
- saponin
- same
- glucuronic acid
- triterpene saponin
- lipophile
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4712997P | 1997-05-20 | 1997-05-20 | |
| US8038998P | 1998-04-02 | 1998-04-02 | |
| PCT/US1998/010280 WO1998052573A1 (en) | 1997-05-20 | 1998-05-20 | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132886A0 true IL132886A0 (en) | 2001-03-19 |
Family
ID=26724657
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13288698A IL132886A0 (en) | 1997-05-20 | 1998-05-20 | A triterpene saponin-lipophile conjugate a pharmaceutical composition containing the same and a vaccine containing the same |
| IL132886A IL132886A (en) | 1997-05-20 | 1999-11-11 | Tritarpin saponin-lipophilic coupling that does not include a noble or non-acylating group, a pharmaceutical preparation containing it and a vaccine containing it |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL132886A IL132886A (en) | 1997-05-20 | 1999-11-11 | Tritarpin saponin-lipophilic coupling that does not include a noble or non-acylating group, a pharmaceutical preparation containing it and a vaccine containing it |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5977081A (ja) |
| EP (1) | EP0996451B1 (ja) |
| JP (2) | JP4583511B2 (ja) |
| KR (1) | KR100578317B1 (ja) |
| AT (1) | ATE286399T1 (ja) |
| AU (1) | AU732856B2 (ja) |
| BR (1) | BR9809149A (ja) |
| CA (1) | CA2290646C (ja) |
| DE (1) | DE69828507T2 (ja) |
| DK (1) | DK0996451T3 (ja) |
| ES (1) | ES2235330T3 (ja) |
| IL (2) | IL132886A0 (ja) |
| NZ (1) | NZ500779A (ja) |
| PT (1) | PT996451E (ja) |
| WO (1) | WO1998052573A1 (ja) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| US20030027818A1 (en) | 2001-04-03 | 2003-02-06 | Redmond H. Paul | Treatment of cancers |
| ES2327693T3 (es) * | 1997-08-29 | 2009-11-02 | Antigenics Inc. | Composiciones que comprenden el adyvante qs-21 y polisorbato o ciclodextrina excipiente. |
| US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| ATE315405T1 (de) * | 1998-08-10 | 2006-02-15 | Antigenics Inc | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
| US20010034330A1 (en) * | 1998-08-10 | 2001-10-25 | Charlotte Kensil | Innate immunity-stimulating compositions of CpG and saponin and methods thereof |
| WO2000009075A2 (en) * | 1998-08-14 | 2000-02-24 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
| ES2572834T3 (es) | 1999-02-17 | 2016-06-02 | Csl Limited | Complejos inmunogénicos y métodos relacionados con los mismos |
| JP5111705B2 (ja) | 1999-08-20 | 2013-01-09 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | 新規な複合多糖、グリコアミノ酸、これらへの中間体、及びこれらの使用 |
| US7854934B2 (en) | 1999-08-20 | 2010-12-21 | Sloan-Kettering Institute For Cancer Research | Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof |
| US7824687B2 (en) * | 1999-08-20 | 2010-11-02 | Sloan-Kettering Institute For Cancer Research | Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof |
| AU7085400A (en) * | 1999-09-02 | 2001-03-26 | Antigenics, Inc. | Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof |
| NZ518999A (en) * | 1999-11-19 | 2002-12-20 | Csl Ltd | Vaccine compositions |
| US6905712B2 (en) * | 1999-12-08 | 2005-06-14 | Statens Veterinarmedicinska Anstalt | Vaccine adjuvants comprising ginseng plant extract and added aluminum salt |
| BR0109704A (pt) * | 2000-03-31 | 2003-04-29 | Purdue Research Foundation | Método de tratamento usando conjugados de imunógeno ligando |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| MXPA02001323A (es) | 2000-05-10 | 2004-07-16 | Alliance Pharma | Microgranulos con base fosfolipida para la liberacion de farmaco. |
| AU2001280934A1 (en) * | 2000-07-28 | 2002-02-13 | Alliance Pharmaceutical Corp. | Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds |
| US6951847B2 (en) | 2000-09-29 | 2005-10-04 | Regents Of The University Of Minnesota | Methods of treating fungal infections using lupeol |
| JP4868698B2 (ja) * | 2001-05-02 | 2012-02-01 | パーデュー・リサーチ・ファウンデーション | マクロファージが仲介する疾患の治療および診断 |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| EP1434603B1 (en) * | 2001-09-28 | 2009-12-16 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| JP5153990B2 (ja) * | 2001-12-21 | 2013-02-27 | シーエスエル、リミテッド | 免疫反応性試薬およびサポニンを含有する組成物、およびその使用方法 |
| CA2477191A1 (en) * | 2002-02-04 | 2003-08-28 | Sally Mossman | Immunostimulant compositions comprising aminoalkyl glucosaminide phosphates and saponins |
| US20030190333A1 (en) * | 2002-02-04 | 2003-10-09 | Corixa Corporation | Immunostimulant compositions comprising aminoalkyl glucosaminide phosphates and saponins |
| US7030094B2 (en) * | 2002-02-04 | 2006-04-18 | Corixa Corporation | Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21 |
| AU2003302235A1 (en) * | 2002-12-03 | 2004-06-23 | Sloan-Kettering Institute For Cancer Research | Gp120 specific antigens, conjugates thereof, methods for their preparation and uses thereof |
| WO2004060915A2 (en) * | 2002-12-03 | 2004-07-22 | Sloan-Kettering Institute For Cancer Research | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. |
| WO2004092329A2 (en) * | 2003-04-08 | 2004-10-28 | Galenica Pharmaceuticals, Inc. | Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines |
| JP2007505836A (ja) * | 2003-09-15 | 2007-03-15 | アイディー バイオメディカル コーポレイション オブ ケベック | 麻疹サブユニットワクチン |
| US20060257429A1 (en) * | 2003-10-23 | 2006-11-16 | Dreier Kimberly J | Vaccine for periodontal disease |
| EP1691831B1 (en) * | 2003-12-03 | 2013-05-15 | Pah Usa 15 Llc | In ovo vaccination of campylobacter in avian species |
| US8168164B2 (en) * | 2006-02-03 | 2012-05-01 | Purdue Research Foundation | Targeted conjugates and radiation |
| US8003314B2 (en) * | 2007-04-16 | 2011-08-23 | Diagnostic Hybrids, Inc. | Methods for direct fluorescent antibody virus detection in liquids |
| US8747861B2 (en) | 2007-08-02 | 2014-06-10 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope influenza vaccines |
| US20100272675A1 (en) * | 2007-11-15 | 2010-10-28 | Endocyte, Inc. | Method of administering conjugates |
| US20090186136A1 (en) * | 2008-01-18 | 2009-07-23 | Saponin Inc. | Process for seed and grain fractionation and recovery of bio-products |
| CN104710487A (zh) | 2008-04-08 | 2015-06-17 | 索隆-基特林癌症研究协会 | 三萜皂苷、其合成方法和用途 |
| KR101701198B1 (ko) | 2008-06-19 | 2017-02-01 | 배리에이션 바이오테크놀로지스 아이엔씨. | 인플루엔자를 치료하기 위한 조성물 및 방법 |
| EP2315771A4 (en) * | 2008-07-11 | 2012-02-01 | Sloan Kettering Inst Cancer | GLYCOPEPTIDE CONSTRUCTS AND ITS USE |
| AU2009323682A1 (en) | 2008-12-03 | 2010-06-10 | Protea Vaccine Technologies Ltd. | Glutamyl tRNA synthetase (GtS) fragments |
| US20110097418A1 (en) * | 2009-05-29 | 2011-04-28 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| JP6050227B2 (ja) | 2010-06-11 | 2016-12-21 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 多価糖ペプチド構築物およびその使用 |
| AU2011276223C1 (en) | 2010-07-06 | 2016-05-12 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| EP2663288B1 (en) | 2011-01-13 | 2022-12-21 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| CN103517713A (zh) | 2011-02-22 | 2014-01-15 | 彼昂德瓦克斯医药有限公司 | 在改善的季节性和大流行性流感疫苗中的多聚体多表位多肽 |
| WO2012154554A1 (en) * | 2011-05-06 | 2012-11-15 | Catabasis Pharmaceuticals, Inc. | Fatty acid triterpene derivatives and their uses |
| CN102329362B (zh) * | 2011-06-01 | 2012-11-21 | 福州大学 | 经聚乙二醇化学改性的熊果酸衍生物及其制备方法 |
| CN104302323A (zh) | 2012-01-12 | 2015-01-21 | 变异生物技术公司 | 用于治疗病毒感染的组合物和方法 |
| RU2698906C2 (ru) | 2012-01-27 | 2019-09-02 | Вэриэйшн Биотекнолоджиз, Инк. | Способы и композиции для терапевтических агентов |
| CA2865561C (en) | 2012-03-02 | 2019-09-10 | Institut National De La Sante Et De La Recherche Medicale | Use of a glycosylated-modified tetrafunctional non-ionic amphiphilic block copolymer as immune adjuvant |
| EP3492095A1 (en) | 2012-04-01 | 2019-06-05 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
| WO2014107652A2 (en) | 2013-01-04 | 2014-07-10 | Obi Pharma | Vaccines with higher carbohydrate antigen density and novel saponin adjuvant |
| CN103271891B (zh) * | 2013-04-28 | 2016-01-06 | 福建南方制药股份有限公司 | 人参皂苷纳米胶束及其制备方法、应用和药物组合物 |
| US10195257B2 (en) * | 2013-07-28 | 2019-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response |
| WO2015151103A1 (en) | 2014-04-03 | 2015-10-08 | Biondvax Pharmaceuticals Ltd. | Compositions of multimeric-multiepitope influenza polypeptides and their production |
| CA2948455C (en) | 2014-05-09 | 2023-09-19 | Universiteit Utrecht Holding B.V. | New cath2 derivatives |
| US20210230082A1 (en) * | 2018-06-26 | 2021-07-29 | Nutrifield Pty Ltd | Plant nutrient compositions |
| CN110680819A (zh) * | 2018-07-06 | 2020-01-14 | 云南民族大学 | 一种三萜皂苷类化合物的应用 |
| AU2019411278A1 (en) * | 2018-12-21 | 2021-08-12 | Sapreme Technologies B.V. | Saponin conjugates |
| KR20230043113A (ko) * | 2020-06-24 | 2023-03-30 | 사프렘 테크놀로지스 비.브이. | 의약용 사포닌 유도체 |
| WO2022060905A1 (en) | 2020-09-15 | 2022-03-24 | The University Of Montana | Compositions and methods targeting filamentous bacteriophage |
| CA3202622A1 (en) | 2020-12-18 | 2022-06-23 | Hendrik Peter HAAGSMAN | Cath2 derivatives for stimulating innate immune memory |
| KR20230146035A (ko) | 2021-02-05 | 2023-10-18 | 유니버시테이트 우트레크트 홀딩 비.브이. | 스트렙토코커스 수이스를 억제하는 cath2 및 유도체 |
| CN114019166B (zh) * | 2021-09-27 | 2024-02-27 | 浙江省食品药品检验研究院 | 一种检测龙葵素的试纸条及其应用 |
| WO2024065107A1 (en) * | 2022-09-26 | 2024-04-04 | Powin Biomedical Co., Ltd. | Novel compositions comprising terpenoid and macromolecule, and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) * | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| JPH0832637B2 (ja) * | 1985-02-14 | 1996-03-29 | アクゾ・エヌ・ヴエー | 合成免疫原 |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5583112A (en) * | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| KR100278157B1 (ko) * | 1992-06-25 | 2001-01-15 | 장 스테판느 | 보조약을 함유하는 백신 조성물 |
| US5650398A (en) * | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
| US5273965A (en) * | 1992-07-02 | 1993-12-28 | Cambridge Biotech Corporation | Methods for enhancing drug delivery with modified saponins |
| DE69306545T2 (de) * | 1992-10-01 | 1997-04-03 | Wellcome Found | Tucaresol als Mittel zur Immunopotentierung |
-
1998
- 1998-05-20 ES ES98923551T patent/ES2235330T3/es not_active Expired - Lifetime
- 1998-05-20 DE DE69828507T patent/DE69828507T2/de not_active Expired - Lifetime
- 1998-05-20 NZ NZ500779A patent/NZ500779A/en not_active IP Right Cessation
- 1998-05-20 DK DK98923551T patent/DK0996451T3/da active
- 1998-05-20 IL IL13288698A patent/IL132886A0/xx active IP Right Grant
- 1998-05-20 KR KR1019997010765A patent/KR100578317B1/ko not_active IP Right Cessation
- 1998-05-20 JP JP55055598A patent/JP4583511B2/ja not_active Expired - Fee Related
- 1998-05-20 PT PT98923551T patent/PT996451E/pt unknown
- 1998-05-20 AT AT98923551T patent/ATE286399T1/de active
- 1998-05-20 US US09/081,647 patent/US5977081A/en not_active Expired - Lifetime
- 1998-05-20 AU AU75818/98A patent/AU732856B2/en not_active Expired
- 1998-05-20 CA CA002290646A patent/CA2290646C/en not_active Expired - Fee Related
- 1998-05-20 BR BR9809149-2A patent/BR9809149A/pt not_active Application Discontinuation
- 1998-05-20 WO PCT/US1998/010280 patent/WO1998052573A1/en active IP Right Grant
- 1998-05-20 EP EP98923551A patent/EP0996451B1/en not_active Expired - Lifetime
-
1999
- 1999-11-11 IL IL132886A patent/IL132886A/en not_active IP Right Cessation
-
2010
- 2010-03-31 JP JP2010084524A patent/JP2010174031A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU7581898A (en) | 1998-12-11 |
| PT996451E (pt) | 2005-04-29 |
| DE69828507D1 (de) | 2005-02-10 |
| CA2290646C (en) | 2008-03-11 |
| BR9809149A (pt) | 2000-08-01 |
| JP2010174031A (ja) | 2010-08-12 |
| JP2002504099A (ja) | 2002-02-05 |
| EP0996451B1 (en) | 2005-01-05 |
| WO1998052573A1 (en) | 1998-11-26 |
| KR20010012802A (ko) | 2001-02-26 |
| EP0996451A4 (en) | 2001-04-18 |
| CA2290646A1 (en) | 1998-11-26 |
| DK0996451T3 (da) | 2005-05-23 |
| IL132886A (en) | 2007-02-11 |
| NZ500779A (en) | 2001-06-29 |
| AU732856B2 (en) | 2001-05-03 |
| DE69828507T2 (de) | 2006-01-05 |
| EP0996451A1 (en) | 2000-05-03 |
| WO1998052573A9 (en) | 1999-04-01 |
| ES2235330T3 (es) | 2005-07-01 |
| ATE286399T1 (de) | 2005-01-15 |
| US5977081A (en) | 1999-11-02 |
| JP4583511B2 (ja) | 2010-11-17 |
| KR100578317B1 (ko) | 2006-05-11 |
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