MX2021014965A - Conjugado de saponina y vacuna o composicion farmaceutica que comprende la misma. - Google Patents
Conjugado de saponina y vacuna o composicion farmaceutica que comprende la misma.Info
- Publication number
- MX2021014965A MX2021014965A MX2021014965A MX2021014965A MX2021014965A MX 2021014965 A MX2021014965 A MX 2021014965A MX 2021014965 A MX2021014965 A MX 2021014965A MX 2021014965 A MX2021014965 A MX 2021014965A MX 2021014965 A MX2021014965 A MX 2021014965A
- Authority
- MX
- Mexico
- Prior art keywords
- saponin
- glucuronic acid
- moiety
- attachment
- vaccine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención está dirigida a compuestos químicos novedosos en los cuales una porción lipofílica, tal como un lípido, ácido graso, polietilenglicol o terpeno, se une covalentemente a una saponina de triterpeno no acilada o desacilada a través de un grupo carboxilo presente en el ácido 3-O-glucurónico de la saponina de triterpeno. La unión de una porción lipofílica al ácido 3-O-glucurónico de una saponina tal como desacilosaponina Quillaja, luciósido P, o saponina de Gypsophila, Saponaria y Acanthophyllum mejora sus efectos coadyuvantes en la inmunidad humoral y mediada por células. Adicionalmente, la unión de una porción de lipófilos al residuo de ácido 3-O-glucurónico de no desacilsaponina produce un análogo de saponina que es más fácil de purificar, menos tóxico, químicamente más estable y posee iguales o mejores propiedades adyuvantes que la saponina original.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962856729P | 2019-06-03 | 2019-06-03 | |
| PCT/CN2020/093784 WO2020244483A1 (en) | 2019-06-03 | 2020-06-01 | Saponin conjugate and vaccine or pharmaceutical composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021014965A true MX2021014965A (es) | 2022-04-11 |
Family
ID=73652077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021014965A MX2021014965A (es) | 2019-06-03 | 2020-06-01 | Conjugado de saponina y vacuna o composicion farmaceutica que comprende la misma. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220323578A1 (es) |
| EP (1) | EP3976627A4 (es) |
| JP (1) | JP2022536296A (es) |
| KR (1) | KR20220009441A (es) |
| CN (1) | CN114040918A (es) |
| AU (1) | AU2020288770B2 (es) |
| BR (1) | BR112021024277A2 (es) |
| CA (1) | CA3140411C (es) |
| IL (1) | IL288645A (es) |
| MX (1) | MX2021014965A (es) |
| TW (1) | TWI768365B (es) |
| WO (1) | WO2020244483A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114644679B (zh) * | 2020-12-18 | 2024-01-09 | 百极优棠(广东)医药科技有限公司 | 葡萄糖醛酸糖苷类化合物、其制备方法及应用 |
| CN114644678B (zh) * | 2020-12-18 | 2023-12-12 | 百极优棠(广东)医药科技有限公司 | 葡萄糖醛酸糖苷类化合物、其制备方法及应用 |
| WO2024005485A1 (ko) * | 2022-06-26 | 2024-01-04 | 기초과학연구원 | 사포닌 유도체 화합물 및 이를 포함하는 코로나바이러스 감염증의 예방 또는 치료용 약학적 조성물 |
| CN115368428B (zh) * | 2022-08-02 | 2023-07-25 | 华南农业大学 | 马铃薯三糖桦木酸皂苷酯类衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| WO2004092329A2 (en) * | 2003-04-08 | 2004-10-28 | Galenica Pharmaceuticals, Inc. | Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines |
| US20150050319A1 (en) * | 2012-03-23 | 2015-02-19 | The Uab Research Foundation | Natural saponin-based synthetic immunoadjuvants |
| EP3389669B1 (en) * | 2015-12-17 | 2023-03-15 | Memorial Sloan-Kettering Cancer Center | Triterpene saponin variants, methods of synthesis and use thereof |
| US20210040143A1 (en) * | 2018-03-20 | 2021-02-11 | The Uab Research Foundation | Saponin-based vaccine adjuvants |
| CN114126419A (zh) * | 2019-03-19 | 2022-03-01 | Uab研究基金会 | 基于皂苷的疫苗佐剂 |
-
2020
- 2020-06-01 JP JP2021572368A patent/JP2022536296A/ja active Pending
- 2020-06-01 BR BR112021024277A patent/BR112021024277A2/pt unknown
- 2020-06-01 CA CA3140411A patent/CA3140411C/en active Active
- 2020-06-01 CN CN202080041297.XA patent/CN114040918A/zh active Pending
- 2020-06-01 KR KR1020217041156A patent/KR20220009441A/ko not_active Application Discontinuation
- 2020-06-01 EP EP20818336.8A patent/EP3976627A4/en active Pending
- 2020-06-01 US US17/616,213 patent/US20220323578A1/en active Pending
- 2020-06-01 AU AU2020288770A patent/AU2020288770B2/en active Active
- 2020-06-01 TW TW109118307A patent/TWI768365B/zh active
- 2020-06-01 WO PCT/CN2020/093784 patent/WO2020244483A1/en unknown
- 2020-06-01 MX MX2021014965A patent/MX2021014965A/es unknown
-
2021
- 2021-12-02 IL IL288645A patent/IL288645A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3140411A1 (en) | 2020-12-10 |
| IL288645A (en) | 2022-02-01 |
| EP3976627A1 (en) | 2022-04-06 |
| AU2020288770A1 (en) | 2022-01-06 |
| AU2020288770B2 (en) | 2023-09-28 |
| CN114040918A (zh) | 2022-02-11 |
| BR112021024277A2 (pt) | 2022-04-26 |
| WO2020244483A1 (en) | 2020-12-10 |
| CA3140411C (en) | 2024-01-02 |
| JP2022536296A (ja) | 2022-08-15 |
| TWI768365B (zh) | 2022-06-21 |
| EP3976627A4 (en) | 2023-07-19 |
| US20220323578A1 (en) | 2022-10-13 |
| KR20220009441A (ko) | 2022-01-24 |
| TW202110459A (zh) | 2021-03-16 |
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