IL131798A - Device for continuous isotope ratio monitoring following fluorine based chemical reactions - Google Patents
Device for continuous isotope ratio monitoring following fluorine based chemical reactionsInfo
- Publication number
- IL131798A IL131798A IL13179898A IL13179898A IL131798A IL 131798 A IL131798 A IL 131798A IL 13179898 A IL13179898 A IL 13179898A IL 13179898 A IL13179898 A IL 13179898A IL 131798 A IL131798 A IL 131798A
- Authority
- IL
- Israel
- Prior art keywords
- sample
- mass spectrometer
- cri
- fluorine
- isotope ratio
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 34
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 34
- 239000011737 fluorine Substances 0.000 title claims abstract description 34
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims description 31
- 238000012544 monitoring process Methods 0.000 title description 6
- 238000000034 method Methods 0.000 claims abstract description 42
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- 230000000155 isotopic effect Effects 0.000 claims abstract description 17
- 238000005259 measurement Methods 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 7
- 239000013626 chemical specie Substances 0.000 claims abstract description 4
- 238000011896 sensitive detection Methods 0.000 claims abstract description 3
- 239000007789 gas Substances 0.000 claims description 44
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 42
- 229910052799 carbon Inorganic materials 0.000 claims description 32
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 29
- 239000000376 reactant Substances 0.000 claims description 29
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 239000000460 chlorine Substances 0.000 claims description 21
- 229910052801 chlorine Inorganic materials 0.000 claims description 18
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 15
- 229910052717 sulfur Inorganic materials 0.000 claims description 15
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 12
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- 229910052734 helium Inorganic materials 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 10
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- 239000002207 metabolite Substances 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 239000007791 liquid phase Substances 0.000 claims description 4
- 238000002663 nebulization Methods 0.000 claims description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 1
- 150000003464 sulfur compounds Chemical class 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 238000001514 detection method Methods 0.000 description 46
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- 229910052698 phosphorus Inorganic materials 0.000 description 14
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 13
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- 239000000126 substance Substances 0.000 description 9
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4071697P | 1997-03-14 | 1997-03-14 | |
| US09/038,017 US6031228A (en) | 1997-03-14 | 1998-03-11 | Device for continuous isotope ratio monitoring following fluorine based chemical reactions |
| PCT/US1998/004678 WO1998042006A1 (en) | 1997-03-14 | 1998-03-11 | A device for continuous isotope ratio monitoring following fluorine based chemical reactions |
Publications (2)
| Publication Number | Publication Date |
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| IL131798A0 IL131798A0 (en) | 2001-03-19 |
| IL131798A true IL131798A (en) | 2004-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13179898A IL131798A (en) | 1997-03-14 | 1998-03-11 | Device for continuous isotope ratio monitoring following fluorine based chemical reactions |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6031228A (ja) |
| EP (1) | EP1008167A4 (ja) |
| JP (1) | JP2002514302A (ja) |
| CN (1) | CN1127118C (ja) |
| AU (1) | AU745912B2 (ja) |
| CA (1) | CA2283177A1 (ja) |
| IL (1) | IL131798A (ja) |
| WO (1) | WO1998042006A1 (ja) |
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| DE19956632C1 (de) * | 1999-11-25 | 2001-06-28 | Finnigan Mat Gmbh | Verfahren und Vorrichtung zur Herstellung von Standardgasen für die Bestimmung von Isotopenverhältnissen |
| AU2001286665A1 (en) * | 2000-08-24 | 2002-03-04 | Newton Scientific, Inc. | Sample introduction interface for analytical processing |
| CN100408151C (zh) * | 2001-01-29 | 2008-08-06 | 美塔莱公司 | 自动同位素稀释质谱分析方法及装置 |
| US7001587B2 (en) * | 2001-10-24 | 2006-02-21 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
| WO2003044219A1 (en) * | 2001-11-20 | 2003-05-30 | Libraria, Inc. | Method of flexibly generating diverse reaction chemistries |
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| DE10216975B4 (de) * | 2002-04-16 | 2007-10-18 | Thermo Electron (Bremen) Gmbh | Verfahren und Vorrichtung zur Bereitstellung von Gas für die Isotopenverhältnisanalyse |
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| US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| JP2005181011A (ja) * | 2003-12-17 | 2005-07-07 | Yoshio Yamauchi | タンパク質解析方法 |
| TW200538738A (en) * | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| CA2559095A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| US20060054183A1 (en) * | 2004-08-27 | 2006-03-16 | Thomas Nowak | Method to reduce plasma damage during cleaning of semiconductor wafer processing chamber |
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| US20060090773A1 (en) * | 2004-11-04 | 2006-05-04 | Applied Materials, Inc. | Sulfur hexafluoride remote plasma source clean |
| JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
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| TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
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| US8492671B2 (en) * | 2006-04-28 | 2013-07-23 | Ge Healthcare Limited | Production of [18F]-F2 from [18F]-fluoride using a plasma induced scrambling procedure |
| US20070284523A1 (en) * | 2006-06-09 | 2007-12-13 | Sigma-Aldrich Co. | Process and apparatus for 15-nitrogen isotope determination of condensed phase samples |
| US8003936B2 (en) * | 2007-10-10 | 2011-08-23 | Mks Instruments, Inc. | Chemical ionization reaction or proton transfer reaction mass spectrometry with a time-of-flight mass spectrometer |
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| DE102007054419A1 (de) * | 2007-11-13 | 2009-05-14 | Thermo Fisher Scientific (Bremen) Gmbh | Verfahren und Vorrichtung zur Isotopenverhältnisanalyse |
| DE102008016583A1 (de) * | 2008-03-31 | 2009-10-01 | Thermo Fisher Scientific (Bremen) Gmbh | Vorrichtung und Verfahren zur Bildung von CO2, N2 und/oder SO2 aus einer Probe |
| US20110201126A1 (en) * | 2010-02-17 | 2011-08-18 | Graham John Hughes | Interface to a mass spectrometer |
| JP5808398B2 (ja) * | 2010-06-02 | 2015-11-10 | ジョンズ ホプキンズ ユニバーシティＪｏｈｎｓ Ｈｏｐｋｉｎｓ Ｕｎｉｖｅｒｓｉｔｙ | 微生物の薬物耐性を判定するシステムおよび方法 |
| JP2014526685A (ja) | 2011-09-08 | 2014-10-06 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 代謝流量測定、画像化、および顕微鏡法 |
| ES2668678T3 (es) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedimiento de determinación de la masa muscular esquelética corporal total |
| CN102590379B (zh) * | 2012-02-08 | 2013-10-16 | 中国地质科学院水文地质环境地质研究所 | 一种基于化学电离的有机单体氯或溴同位素在线分析方法 |
| CN102967648A (zh) * | 2012-11-20 | 2013-03-13 | 中国食品发酵工业研究院 | 基于稳定同位素比值鉴别有机辣椒的方法 |
| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
| CN103424462A (zh) * | 2013-08-23 | 2013-12-04 | 中国科学院寒区旱区环境与工程研究所 | 温室气体co2和n2o碳、氮元素富集分析仪 |
| GB2520067B (en) | 2013-11-08 | 2016-07-27 | Thermo Fisher Scient (Bremen) Gmbh | Gas inlet system for isotope ratio spectrometer |
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| GB2549248B (en) | 2016-01-12 | 2020-07-22 | Thermo Fisher Scient Bremen Gmbh | IRMS sample introduction system and method |
| GB2557891B (en) * | 2016-09-02 | 2021-05-12 | Thermo Fisher Scient Bremen Gmbh | Improved sample preparation apparatus and method for elemental analysis spectrometer |
| EP3497455A4 (en) | 2016-10-31 | 2020-04-22 | Hewlett-Packard Development Company, L.P. | ELECTRICAL PARAMETERS OF ISOTOPES |
| GB201701986D0 (en) * | 2017-02-07 | 2017-03-22 | Thermo Fisher Scient (Bremen) Gmbh | n |
| CN112730584A (zh) * | 2021-01-18 | 2021-04-30 | 天津师范大学 | 一种基于一氧化硫模式的bj-1小麦硫稳定同位素检测方法 |
| CN115266981B (zh) * | 2022-07-28 | 2023-06-13 | 四川阿格瑞新材料有限公司 | 一种用gc-ms检定物质氘代率的方法 |
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| US4933548A (en) * | 1985-04-24 | 1990-06-12 | Compagnie Generale Des Matieres Nucleaires | Method and device for introducing samples for a mass spectrometer |
| JPH05251038A (ja) * | 1992-03-04 | 1993-09-28 | Hitachi Ltd | プラズマイオン質量分析装置 |
| US5661038A (en) * | 1995-05-16 | 1997-08-26 | Cornell Research Foundation, Inc. | Interface system for isotopic analysis of hydrogen |
-
1998
- 1998-03-11 CN CN98803342.9A patent/CN1127118C/zh not_active Expired - Fee Related
- 1998-03-11 JP JP54058698A patent/JP2002514302A/ja not_active Ceased
- 1998-03-11 AU AU66962/98A patent/AU745912B2/en not_active Ceased
- 1998-03-11 EP EP98909090A patent/EP1008167A4/en not_active Withdrawn
- 1998-03-11 WO PCT/US1998/004678 patent/WO1998042006A1/en not_active Application Discontinuation
- 1998-03-11 US US09/038,017 patent/US6031228A/en not_active Expired - Fee Related
- 1998-03-11 IL IL13179898A patent/IL131798A/en active IP Right Grant
- 1998-03-11 CA CA002283177A patent/CA2283177A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1127118C (zh) | 2003-11-05 |
| AU745912B2 (en) | 2002-04-11 |
| EP1008167A1 (en) | 2000-06-14 |
| JP2002514302A (ja) | 2002-05-14 |
| US6031228A (en) | 2000-02-29 |
| EP1008167A4 (en) | 2006-08-23 |
| CA2283177A1 (en) | 1998-09-24 |
| CN1253660A (zh) | 2000-05-17 |
| IL131798A0 (en) | 2001-03-19 |
| AU6696298A (en) | 1998-10-12 |
| WO1998042006A1 (en) | 1998-09-24 |
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