IL131044A - Process for the production of semi synthetic statins via novel intermediates - Google Patents

Process for the production of semi synthetic statins via novel intermediates

Info

Publication number
IL131044A
IL131044A IL13104498A IL13104498A IL131044A IL 131044 A IL131044 A IL 131044A IL 13104498 A IL13104498 A IL 13104498A IL 13104498 A IL13104498 A IL 13104498A IL 131044 A IL131044 A IL 131044A
Authority
IL
Israel
Prior art keywords
production
novel intermediates
semi synthetic
via novel
synthetic statins
Prior art date
Application number
IL13104498A
Other languages
English (en)
Other versions
IL131044A0 (en
Original Assignee
Plus Chemicals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plus Chemicals Bv filed Critical Plus Chemicals Bv
Publication of IL131044A0 publication Critical patent/IL131044A0/xx
Publication of IL131044A publication Critical patent/IL131044A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
IL13104498A 1997-01-28 1998-01-27 Process for the production of semi synthetic statins via novel intermediates IL131044A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97200223 1997-01-28
EP97306809 1997-09-03
PCT/EP1998/000519 WO1998032751A1 (fr) 1997-01-28 1998-01-27 Procede de production de statines semi-synthetiques au moyen de nouveaux intermediaires

Publications (2)

Publication Number Publication Date
IL131044A0 IL131044A0 (en) 2001-01-28
IL131044A true IL131044A (en) 2003-07-31

Family

ID=26146080

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13104498A IL131044A (en) 1997-01-28 1998-01-27 Process for the production of semi synthetic statins via novel intermediates

Country Status (16)

Country Link
US (1) US6294680B1 (fr)
EP (2) EP1340752B1 (fr)
JP (1) JP2001508782A (fr)
KR (1) KR100538674B1 (fr)
AR (1) AR011780A1 (fr)
AT (2) ATE237605T1 (fr)
AU (1) AU747219C (fr)
CA (1) CA2278603A1 (fr)
DE (2) DE69834279T2 (fr)
DK (1) DK0971913T3 (fr)
ES (2) ES2197465T3 (fr)
IL (1) IL131044A (fr)
NO (1) NO318146B1 (fr)
NZ (1) NZ336993A (fr)
PT (1) PT971913E (fr)
WO (1) WO1998032751A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0940395A1 (fr) * 1998-03-05 1999-09-08 Synthon B.V. Procédé de production de simvastatine et/ou de ses dérivés
NO991045L (no) 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
CA2320163C (fr) * 1998-12-10 2008-09-23 Kaneka Corporation Procede de production de simvastatine
CO5140104A1 (es) 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
KR20010009846A (ko) * 1999-07-14 2001-02-05 구광시 심바스타틴 제조에 유용한 중간체 및 그의 제조방법
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
WO2001034590A1 (fr) * 1999-11-11 2001-05-17 Biocon India Limited Procede de fabrication de simvastatine et de nouveaux intermediaires
CN1446088A (zh) * 2000-07-27 2003-10-01 普拉斯化学品有限公司 高度纯化的辛伐他汀组合物
US6777552B2 (en) 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
US6472542B1 (en) 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
CA2515179A1 (fr) 2003-02-11 2004-08-26 Ferenc Korodi Procede de preparation de simvastatine ayant des gammes regulees de contenu de dimere de simvastatine
KR20060129196A (ko) * 2003-10-21 2006-12-15 다이버사 코포레이션 심바스타틴 및 중간체의 제조 방법
JP4621451B2 (ja) 2004-08-11 2011-01-26 富士フイルム株式会社 液浸露光用保護膜形成組成物及びそれを用いたパターン形成方法
WO2007030302A2 (fr) * 2005-09-01 2007-03-15 Prescient Medical, Inc. Medicaments enrobant un dispositif destine a traiter une plaque vulnerable
US8455640B2 (en) 2006-05-03 2013-06-04 Msn Laboratories Limited Process for statins and its pharmaceutically acceptable salts thereof
ES2567171T3 (es) * 2006-10-09 2016-04-20 Msn Laboratories Private Limited Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables
WO2010089770A2 (fr) 2009-01-19 2010-08-12 Msn Laboratories Limited Procédé amélioré d'élaboration d'acide (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophényl)quinolin-3-yl]-3,5-dihydroxy-6(e)-heptènoïque de haute pureté, y compris ses sels pharmaceutiquement acceptables
US8470805B2 (en) * 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
EP2526099B1 (fr) 2010-01-18 2016-03-30 MSN Laboratories Limited Procédé amélioré pour la préparation d'intermédiaires amides et leur utilisation
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN110483459A (zh) * 2019-09-10 2019-11-22 山东罗欣药业集团恒欣药业有限公司 一种辛伐他汀的合成方法
CN110563680A (zh) * 2019-09-10 2019-12-13 山东罗欣药业集团恒欣药业有限公司 一种治疗高脂血症药物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
EP0415488B1 (fr) * 1989-08-31 1994-04-20 Merck & Co. Inc. Inhibiteurs d'HMG-COA réductase substitués en 7
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
EP0940395A1 (fr) 1998-03-05 1999-09-08 Synthon B.V. Procédé de production de simvastatine et/ou de ses dérivés

Also Published As

Publication number Publication date
NZ336993A (en) 2000-05-26
NO993644D0 (no) 1999-07-27
DE69813538D1 (de) 2003-05-22
EP1340752A1 (fr) 2003-09-03
AR011780A1 (es) 2000-09-13
EP1340752B1 (fr) 2006-04-19
ES2266671T3 (es) 2007-03-01
AU747219C (en) 2003-11-20
DE69834279D1 (de) 2006-05-24
ATE237605T1 (de) 2003-05-15
WO1998032751A1 (fr) 1998-07-30
DE69834279T2 (de) 2007-01-04
AU6618398A (en) 1998-08-18
EP0971913A1 (fr) 2000-01-19
AU747219B2 (en) 2002-05-09
CA2278603A1 (fr) 1998-07-30
ES2197465T3 (es) 2004-01-01
DE69813538T2 (de) 2004-04-01
DK0971913T3 (da) 2003-08-04
KR100538674B1 (ko) 2005-12-26
KR20000070501A (ko) 2000-11-25
NO318146B1 (no) 2005-02-07
ATE323689T1 (de) 2006-05-15
EP0971913B1 (fr) 2003-04-16
JP2001508782A (ja) 2001-07-03
US6294680B1 (en) 2001-09-25
PT971913E (pt) 2003-08-29
NO993644L (no) 1999-09-28
IL131044A0 (en) 2001-01-28

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees