IL130528A - Aminoindan derivatives, pharmaceutical compositions comprising them and uses thereof - Google Patents
Aminoindan derivatives, pharmaceutical compositions comprising them and uses thereofInfo
- Publication number
- IL130528A IL130528A IL13052897A IL13052897A IL130528A IL 130528 A IL130528 A IL 130528A IL 13052897 A IL13052897 A IL 13052897A IL 13052897 A IL13052897 A IL 13052897A IL 130528 A IL130528 A IL 130528A
- Authority
- IL
- Israel
- Prior art keywords
- compound according
- methyl
- propargyl
- ethyl
- dementia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Centrifugal Separators (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13052897A IL130528A (en) | 1996-12-18 | 1997-12-18 | Aminoindan derivatives, pharmaceutical compositions comprising them and uses thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11985396A IL119853A0 (en) | 1996-12-18 | 1996-12-18 | Aminoindan derivatives |
| IL12051097A IL120510A0 (en) | 1997-03-24 | 1997-03-24 | Phenylethylamine derivatives |
| IL13052897A IL130528A (en) | 1996-12-18 | 1997-12-18 | Aminoindan derivatives, pharmaceutical compositions comprising them and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL130528A true IL130528A (en) | 2004-12-15 |
Family
ID=26323338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13052897A IL130528A (en) | 1996-12-18 | 1997-12-18 | Aminoindan derivatives, pharmaceutical compositions comprising them and uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6303650B1 (fr) |
| EP (2) | EP0966435B1 (fr) |
| JP (1) | JP4222632B2 (fr) |
| AT (2) | ATE292619T1 (fr) |
| AU (1) | AU5726898A (fr) |
| CA (1) | CA2275425C (fr) |
| DE (2) | DE69732984T2 (fr) |
| DK (1) | DK0966435T3 (fr) |
| ES (1) | ES2241064T3 (fr) |
| HU (1) | HU229507B1 (fr) |
| IL (1) | IL130528A (fr) |
| PT (1) | PT966435E (fr) |
| WO (1) | WO1998027055A1 (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4222632B2 (ja) * | 1996-12-18 | 2009-02-12 | テバ・ファーマシューティカル・インダストリーズ・リミテッド | アミノインダン誘導体 |
| WO1999062867A1 (fr) * | 1998-06-03 | 1999-12-09 | Nissan Chemical Industries, Ltd. | Derives d'indane |
| CA2387394C (fr) | 1999-10-27 | 2009-08-18 | Teva Pharmaceutical Industries, Ltd. | Utilisation de derives de 1-aminoindan pour le traitement de la manie liee a la psychose maniacodepressive |
| WO2003072055A2 (fr) * | 2002-02-27 | 2003-09-04 | Teva Pharmaceutical Industries, Ltd. | Derives de propargylaminoindane et derives de propargylaminotetraline utilises comme inhibiteurs de la mao cerebro-selectifs |
| US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| WO2004041151A2 (fr) * | 2002-11-07 | 2004-05-21 | Technion Research And Development Foundation Ltd. | Chelateurs du fer et compositions pharmaceutiques les renfermant |
| US8097608B2 (en) | 2003-11-25 | 2012-01-17 | Technion Research And Development Foundation Ltd. | Methods for treatment of cardiovascular disorders and diseases |
| EP2433626B1 (fr) | 2003-11-25 | 2015-11-04 | Technion Research & Development Foundation Ltd. | Compositions et procédés pour le traitement des troubles cardiovasculaires et maladies |
| JP2005232148A (ja) * | 2004-02-03 | 2005-09-02 | Technion Research & Development Foundation Ltd | 神経保護剤としてプロパルギルアミンの使用 |
| EP1574498A1 (fr) | 2004-02-19 | 2005-09-14 | PPG-Sipsy | Procédé de synthèse de derivés de alpha-aminoindane substitués |
| CA2574925A1 (fr) * | 2004-07-26 | 2006-02-09 | Teva Pharmaceutical Industries Ltd. | Dosages pharmaceutiques contenant de la rasagiline |
| WO2006014968A2 (fr) * | 2004-07-27 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Nitroxydes propargyle et nitroxydes indanyle et leur utilisation pour traiter les maladies et les troubles neurologiques |
| US7262326B2 (en) | 2004-09-08 | 2007-08-28 | Teva Pharmaceuticals Industries Ltd. | Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates |
| ES2420404T3 (es) * | 2005-02-17 | 2013-08-23 | Teva Pharmaceutical Industries Ltd. | Terapia de combinación con acetato de glatiramero y rasagilina para el tratamiento de esclerosis múltiple |
| CA2600008A1 (fr) | 2005-02-22 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Procede ameliore de synthese de derives d'indanylamine enantiomeres |
| KR20170023211A (ko) | 2005-02-23 | 2017-03-02 | 테바 파마슈티컬 인더스트리즈 리미티드 | 함량 균일성이 개선된 라사길린 제형 |
| AU2006216695A1 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof |
| JP2008531594A (ja) | 2005-02-24 | 2008-08-14 | テバ ファーマシューティカル インダストリーズ リミティド | 酒石酸ラドスチジルの製剤 |
| WO2006130726A2 (fr) * | 2005-06-01 | 2006-12-07 | Teva Pharmaceutical Industries, Ltd. | Utilisation du ladostigil pour traiter la sclerose en plaques |
| AU2006252540B2 (en) * | 2005-06-02 | 2011-12-01 | Jenrin Discovery | MAO-B inhibitors useful for treating obesity |
| US7539261B2 (en) * | 2005-08-22 | 2009-05-26 | Nec Laboratories America, Inc. | Multi-layer coded modulation for non-ergodic block fading channels |
| WO2007038677A2 (fr) * | 2005-09-28 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Procedes de preparation de ladostigil tartrate cristallise forme a1 |
| WO2007038676A2 (fr) * | 2005-09-28 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Formes polymorphiques de ladostigil tartrate |
| US8263655B2 (en) * | 2005-10-06 | 2012-09-11 | Technion Research And Development Foundation Ltd | Methods for treatment of renal failure |
| WO2007056403A2 (fr) * | 2005-11-04 | 2007-05-18 | Teva Pharmaceutical Industries Ltd. | Hydrogenation asymetrique d'enamides acyliques |
| WO2007056455A2 (fr) * | 2005-11-07 | 2007-05-18 | Teva Pharmaceutical Industries Ltd. | Aminoindanes n-proteges et leurs procedes de preparation |
| CN101622225B (zh) * | 2005-11-17 | 2015-04-15 | 泰华制药工业有限公司 | 炔丙基氨基茚分离方法 |
| US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
| ES2632638T3 (es) * | 2005-12-09 | 2017-09-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva |
| US20070135518A1 (en) * | 2005-12-09 | 2007-06-14 | Marta Weinstock-Rosin | Use of low-dose ladostigil for neuroprotection |
| ES2551481T3 (es) | 2006-02-21 | 2015-11-19 | Teva Pharmaceutical Industries, Ltd. | Uso de rasagilina para el tratamiento de atrofia multisistémica |
| TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| WO2007126898A2 (fr) * | 2006-03-31 | 2007-11-08 | Teva Pharmaceutical Industries, Ltd. | Utilisation de ladostigil pour le traitement de la schizophrénie |
| NZ571591A (en) | 2006-04-03 | 2011-09-30 | Teva Pharma | Use of rasagiline for the treatment of restless legs syndrome |
| EP1892233A1 (fr) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | De nouveaux sels de la substance active rasagiline |
| WO2008076315A1 (fr) | 2006-12-14 | 2008-06-26 | Teva Pharmaceutical Industries, Ltd. | Sel de tannate de rasagiline |
| HRP20110980T1 (hr) * | 2006-12-14 | 2012-02-29 | Teva Pharmaceutical Industries Ltd. | Kristalna kruta rasagilinska baza |
| EP1987816A1 (fr) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate d'un sel de rasagiline en combinaison avec un agent inactive soluble dans l'eau |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| NZ586025A (en) * | 2008-01-11 | 2012-08-31 | Teva Pharma | Rasagiline mesylate tablet coated with a composisiton comprising methacrylic acid - ethyl acrylate copolymer and triethyl citrate |
| WO2009151594A1 (fr) * | 2008-06-10 | 2009-12-17 | Teva Pharmaceutical Industries, Ltd. | Capsules molles de rasagiline |
| CA2727022A1 (fr) * | 2008-06-13 | 2009-12-17 | Teva Pharmaceutical Industries Ltd. | Administration de rasagiline a des fins de modification de l'evolution de la maladie de parkinson |
| EP2299993A4 (fr) * | 2008-06-19 | 2014-08-20 | Teva Pharma | Procédé de purification de la base de la rasagiline |
| JP2011524907A (ja) | 2008-06-19 | 2011-09-08 | テバ ファーマシューティカル インダストリーズ リミティド | 固体ラサギリン塩基を調製および乾燥する方法 |
| US20100189788A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline base formulation |
| DK2451771T3 (da) | 2009-07-09 | 2014-09-08 | Ratiopharm Gmbh | Salte af rasagilin og farmaceutiske fremstillingsmåder heraf |
| RU2607595C2 (ru) | 2010-02-03 | 2017-01-10 | Фарма Ту Б Лтд. | Составы разагилина с пролонгированным высвобождением и их применение |
| US8691872B2 (en) | 2010-07-27 | 2014-04-08 | Teva Pharmaceutical Industries Ltd. | Dispersions of rasagiline citrate |
| CA2806740A1 (fr) | 2010-07-27 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Utilisation de rasagiline pour le traitement d'un trouble olfactif |
| EP2766004A4 (fr) | 2011-10-10 | 2015-04-22 | Teva Pharma | R(+)-n-méthyl-propargyl-aminoindane |
| JP2014534196A (ja) | 2011-10-10 | 2014-12-18 | テバ ファーマシューティカル インダストリーズ リミティド | Ｒ（＋）−ｎ−ホルミル−プロパルギル−アミノインダン |
| EP2811995B1 (fr) * | 2012-02-12 | 2017-08-09 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Thérapie au ladostigil pour immunomodulation |
| BR112015003451A2 (pt) | 2012-08-17 | 2017-07-04 | Teva Pharma | formulação parentérica de rasagilina |
| JPWO2024204846A1 (fr) * | 2023-03-31 | 2024-10-03 |
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| WO1994007890A1 (fr) | 1992-10-05 | 1994-04-14 | Ube Industries, Ltd. | Compose pyrimidine |
| US5350762A (en) | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
| GB9315600D0 (en) | 1993-07-28 | 1993-09-08 | Smithkline Beecham Plc | Compounds |
| ATE187436T1 (de) | 1993-08-06 | 1999-12-15 | Upjohn Co | 2-aminoindane als selektive dopamin-d3-liganden |
| US5516943A (en) | 1993-09-14 | 1996-05-14 | Sepracor, Inc. | Process for preparing cyclic CIS-1-amino-2-alkanols |
| US5401758A (en) | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
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| JP4782252B2 (ja) * | 1994-01-10 | 2011-09-28 | テバ ファーマシューティカル インダストリーズ リミテッド | １−アミノインダン及びこれらの組成物 |
| US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| FR2717175B1 (fr) | 1994-03-11 | 1996-06-14 | Adir | Nouveaux composés alkylaminoindanes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| IT1271679B (it) | 1994-07-18 | 1997-06-04 | Mediolanum Farmaceutici Srl | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
| US5646188A (en) | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
| JP4222632B2 (ja) * | 1996-12-18 | 2009-02-12 | テバ・ファーマシューティカル・インダストリーズ・リミテッド | アミノインダン誘導体 |
| US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
| JP3002155B2 (ja) | 1997-06-25 | 2000-01-24 | 日本サーボ株式会社 | 景品懸吊装置 |
| US20040010038A1 (en) | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
-
1997
- 1997-12-18 JP JP52804898A patent/JP4222632B2/ja not_active Expired - Fee Related
- 1997-12-18 WO PCT/US1997/024155 patent/WO1998027055A1/fr not_active Ceased
- 1997-12-18 DE DE69732984T patent/DE69732984T2/de not_active Expired - Lifetime
- 1997-12-18 AT AT97953541T patent/ATE292619T1/de not_active IP Right Cessation
- 1997-12-18 DE DE69738275T patent/DE69738275T2/de not_active Expired - Lifetime
- 1997-12-18 EP EP97953541A patent/EP0966435B1/fr not_active Expired - Lifetime
- 1997-12-18 AT AT05002578T patent/ATE377585T1/de not_active IP Right Cessation
- 1997-12-18 AU AU57268/98A patent/AU5726898A/en not_active Abandoned
- 1997-12-18 EP EP05002578A patent/EP1535902B1/fr not_active Expired - Lifetime
- 1997-12-18 ES ES97953541T patent/ES2241064T3/es not_active Expired - Lifetime
- 1997-12-18 DK DK97953541T patent/DK0966435T3/da active
- 1997-12-18 HU HU0101130A patent/HU229507B1/hu unknown
- 1997-12-18 IL IL13052897A patent/IL130528A/en not_active IP Right Cessation
- 1997-12-18 PT PT97953541T patent/PT966435E/pt unknown
- 1997-12-18 CA CA002275425A patent/CA2275425C/fr not_active Expired - Lifetime
-
1999
- 1999-06-18 US US09/336,493 patent/US6303650B1/en not_active Expired - Lifetime
-
2001
- 2001-08-31 US US09/944,912 patent/US6538025B2/en not_active Ceased
- 2001-08-31 US US09/944,850 patent/US6462222B1/en not_active Expired - Lifetime
-
2005
- 2005-03-25 US US11/091,008 patent/USRE39616E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1076098A1 (en) | 2006-01-06 |
| US20020188020A1 (en) | 2002-12-12 |
| USRE39616E1 (en) | 2007-05-08 |
| DK0966435T3 (da) | 2005-08-15 |
| CA2275425C (fr) | 2009-08-04 |
| DE69732984T2 (de) | 2006-02-16 |
| HK1024462A1 (en) | 2000-10-13 |
| US6462222B1 (en) | 2002-10-08 |
| JP4222632B2 (ja) | 2009-02-12 |
| ES2241064T3 (es) | 2005-10-16 |
| JP2001506269A (ja) | 2001-05-15 |
| US6303650B1 (en) | 2001-10-16 |
| HUP0101130A3 (en) | 2003-02-28 |
| US6538025B2 (en) | 2003-03-25 |
| EP1535902B1 (fr) | 2007-11-07 |
| DE69738275D1 (de) | 2007-12-20 |
| PT966435E (pt) | 2005-06-30 |
| EP0966435A4 (fr) | 2003-04-16 |
| EP0966435A1 (fr) | 1999-12-29 |
| CA2275425A1 (fr) | 1998-06-25 |
| HUP0101130A2 (hu) | 2001-08-28 |
| EP1535902A1 (fr) | 2005-06-01 |
| DE69738275T2 (de) | 2008-08-28 |
| DE69732984D1 (de) | 2005-05-12 |
| WO1998027055A1 (fr) | 1998-06-25 |
| EP0966435B1 (fr) | 2005-04-06 |
| AU5726898A (en) | 1998-07-15 |
| ATE377585T1 (de) | 2007-11-15 |
| HU229507B1 (en) | 2014-01-28 |
| ATE292619T1 (de) | 2005-04-15 |
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| EXP | Patent expired |