IL130024A - תרכובות -2 אימידאזולינלאמינואינדול שימושיות כאגוניסטים a - 2 - אדרינוצפטורים ותכשירי רוקחות המכילים אותן - Google Patents
תרכובות -2 אימידאזולינלאמינואינדול שימושיות כאגוניסטים a - 2 - אדרינוצפטורים ותכשירי רוקחות המכילים אותןInfo
- Publication number
- IL130024A IL130024A IL13002497A IL13002497A IL130024A IL 130024 A IL130024 A IL 130024A IL 13002497 A IL13002497 A IL 13002497A IL 13002497 A IL13002497 A IL 13002497A IL 130024 A IL130024 A IL 130024A
- Authority
- IL
- Israel
- Prior art keywords
- dosage range
- compounds
- compound
- unsubstituted
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3177796P | 1996-11-25 | 1996-11-25 | |
PCT/US1997/020801 WO1998023610A1 (en) | 1996-11-25 | 1997-11-21 | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
IL130024A0 IL130024A0 (en) | 2000-02-29 |
IL130024A true IL130024A (he) | 2002-12-01 |
Family
ID=21861336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13002497A IL130024A (he) | 1996-11-25 | 1997-11-21 | תרכובות -2 אימידאזולינלאמינואינדול שימושיות כאגוניסטים a - 2 - אדרינוצפטורים ותכשירי רוקחות המכילים אותן |
Country Status (23)
Country | Link |
---|---|
US (2) | US6162818A (he) |
EP (1) | EP0944621B1 (he) |
JP (1) | JP2001506981A (he) |
KR (1) | KR100395356B1 (he) |
CN (1) | CN1092652C (he) |
AR (1) | AR013875A1 (he) |
AT (1) | ATE275142T1 (he) |
AU (1) | AU735767B2 (he) |
BR (1) | BR9713542A (he) |
CA (1) | CA2271841C (he) |
CO (1) | CO4910149A1 (he) |
CZ (1) | CZ180599A3 (he) |
DE (1) | DE69730516T2 (he) |
ES (1) | ES2225998T3 (he) |
HU (1) | HUP9904215A3 (he) |
ID (1) | ID22812A (he) |
IL (1) | IL130024A (he) |
NO (1) | NO992470L (he) |
PE (1) | PE16299A1 (he) |
SK (1) | SK68399A3 (he) |
TR (1) | TR199901885T2 (he) |
WO (1) | WO1998023610A1 (he) |
ZA (1) | ZA9710577B (he) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5677321A (en) | 1996-02-29 | 1997-10-14 | Synaptic Pharmaceutical Corporation | 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands |
CZ180599A3 (cs) * | 1996-11-25 | 1999-11-17 | The Procter & Gamble Company | 2-Imidazolinylaminoindolová sloučenina, farmaceutický prostředek ji obsahující a její použití |
US5866579A (en) * | 1997-04-11 | 1999-02-02 | Synaptic Pharmaceutical Corporation | Imidazole and imidazoline derivatives and uses thereof |
AU5960300A (en) * | 1999-07-15 | 2001-02-05 | Nps Allelix Corp. | Heterocyclic compounds for the treatment of migraine |
WO2001040183A1 (en) * | 1999-12-03 | 2001-06-07 | Alcon Universal Ltd. | 1-aminoalkyl-1h-indoles for treating glaucoma |
US20030166732A1 (en) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity |
MXPA05000193A (es) * | 2002-06-24 | 2005-04-08 | Schering Corp | Derivados de indol utiles como antagonistas de la histamina h2. |
KR20050072812A (ko) | 2002-11-07 | 2005-07-12 | 악조 노벨 엔.브이. | 안드로겐-수용체와 관련된 질병의 치료에 효과적인 인돌 |
DE10332473A1 (de) * | 2003-07-16 | 2005-02-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol für die Behandlung von Epilepsie |
TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
AU2006311577B2 (en) | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
TWI417099B (zh) * | 2007-03-23 | 2013-12-01 | Neuraxon Inc | 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物 |
US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
US8293742B2 (en) * | 2008-08-01 | 2012-10-23 | Alpha Synergy Development, Inc. | Preferential vasoconstriction compositions and methods of use |
US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
WO2010065547A1 (en) * | 2008-12-01 | 2010-06-10 | Map Pharmaceuticals, Inc. | Inhalation delivery methods and devices |
US8555875B2 (en) | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
CN107628981B (zh) * | 2017-10-31 | 2019-07-30 | 威海市妇女儿童医院 | 一种肉桂酰基吲哚啉化合物及其制备青光眼药物的应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US4398028A (en) * | 1977-01-14 | 1983-08-09 | Sandoz Ltd. | Bicyclic heterocyclic amino derivatives |
CH632268A5 (de) * | 1977-01-14 | 1982-09-30 | Sandoz Ag | Verfahren zur herstellung von neuen heterocyclylaminoderivaten. |
US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
US5677321A (en) * | 1996-02-29 | 1997-10-14 | Synaptic Pharmaceutical Corporation | 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands |
CZ180599A3 (cs) * | 1996-11-25 | 1999-11-17 | The Procter & Gamble Company | 2-Imidazolinylaminoindolová sloučenina, farmaceutický prostředek ji obsahující a její použití |
-
1997
- 1997-11-21 CZ CZ991805A patent/CZ180599A3/cs unknown
- 1997-11-21 DE DE69730516T patent/DE69730516T2/de not_active Expired - Lifetime
- 1997-11-21 KR KR10-1999-7004535A patent/KR100395356B1/ko not_active IP Right Cessation
- 1997-11-21 HU HU9904215A patent/HUP9904215A3/hu unknown
- 1997-11-21 AT AT97948289T patent/ATE275142T1/de not_active IP Right Cessation
- 1997-11-21 AU AU54380/98A patent/AU735767B2/en not_active Ceased
- 1997-11-21 BR BR9713542-9A patent/BR9713542A/pt not_active IP Right Cessation
- 1997-11-21 JP JP52469398A patent/JP2001506981A/ja active Pending
- 1997-11-21 IL IL13002497A patent/IL130024A/he not_active IP Right Cessation
- 1997-11-21 ES ES97948289T patent/ES2225998T3/es not_active Expired - Lifetime
- 1997-11-21 SK SK683-99A patent/SK68399A3/sk unknown
- 1997-11-21 WO PCT/US1997/020801 patent/WO1998023610A1/en not_active Application Discontinuation
- 1997-11-21 CA CA002271841A patent/CA2271841C/en not_active Expired - Fee Related
- 1997-11-21 ID IDW990403D patent/ID22812A/id unknown
- 1997-11-21 EP EP97948289A patent/EP0944621B1/en not_active Expired - Lifetime
- 1997-11-21 CN CN97180036A patent/CN1092652C/zh not_active Expired - Fee Related
- 1997-11-21 TR TR1999/01885T patent/TR199901885T2/xx unknown
- 1997-11-24 CO CO97068609A patent/CO4910149A1/es unknown
- 1997-11-25 PE PE1997001069A patent/PE16299A1/es not_active Application Discontinuation
- 1997-11-25 AR ARP970105526A patent/AR013875A1/es unknown
- 1997-11-25 ZA ZA9710577A patent/ZA9710577B/xx unknown
-
1999
- 1999-04-13 US US09/290,731 patent/US6162818A/en not_active Expired - Lifetime
- 1999-05-21 NO NO992470A patent/NO992470L/no not_active Application Discontinuation
-
2000
- 2000-10-17 US US09/690,992 patent/US6395764B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR20000069088A (ko) | 2000-11-25 |
HUP9904215A2 (hu) | 2000-06-28 |
AU735767B2 (en) | 2001-07-12 |
WO1998023610A1 (en) | 1998-06-04 |
EP0944621A1 (en) | 1999-09-29 |
HUP9904215A3 (en) | 2002-01-28 |
CA2271841C (en) | 2003-07-08 |
AU5438098A (en) | 1998-06-22 |
ID22812A (id) | 1999-12-09 |
CZ180599A3 (cs) | 1999-11-17 |
NO992470L (no) | 1999-07-26 |
ZA9710577B (en) | 1998-06-25 |
EP0944621B1 (en) | 2004-09-01 |
SK68399A3 (en) | 2000-07-11 |
TR199901885T2 (xx) | 1999-10-21 |
PE16299A1 (es) | 1999-03-12 |
ATE275142T1 (de) | 2004-09-15 |
US6162818A (en) | 2000-12-19 |
BR9713542A (pt) | 2000-01-25 |
DE69730516D1 (de) | 2004-10-07 |
CA2271841A1 (en) | 1998-06-04 |
AR013875A1 (es) | 2001-01-31 |
ES2225998T3 (es) | 2005-03-16 |
CN1092652C (zh) | 2002-10-16 |
KR100395356B1 (ko) | 2003-08-21 |
IL130024A0 (en) | 2000-02-29 |
CO4910149A1 (es) | 2000-04-24 |
CN1238771A (zh) | 1999-12-15 |
US6395764B1 (en) | 2002-05-28 |
JP2001506981A (ja) | 2001-05-29 |
NO992470D0 (no) | 1999-05-21 |
DE69730516T2 (de) | 2005-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |