IL129556A0 - Pharmaceutical compositions and methods for stimulating neurite growth - Google Patents
Pharmaceutical compositions and methods for stimulating neurite growthInfo
- Publication number
- IL129556A0 IL129556A0 IL12955697A IL12955697A IL129556A0 IL 129556 A0 IL129556 A0 IL 129556A0 IL 12955697 A IL12955697 A IL 12955697A IL 12955697 A IL12955697 A IL 12955697A IL 129556 A0 IL129556 A0 IL 129556A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- pharmaceutical compositions
- neurite growth
- stimulating neurite
- stimulating
- Prior art date
Links
- 230000014511 neuron projection development Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/748,448 US5811434A (en) | 1996-11-13 | 1996-11-13 | Methods and compositions for stimulating neurite growth |
PCT/US1997/020867 WO1998020892A1 (en) | 1996-11-13 | 1997-11-13 | Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors |
Publications (1)
Publication Number | Publication Date |
---|---|
IL129556A0 true IL129556A0 (en) | 2000-02-29 |
Family
ID=25009490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12955697A IL129556A0 (en) | 1996-11-13 | 1997-11-13 | Pharmaceutical compositions and methods for stimulating neurite growth |
Country Status (21)
Country | Link |
---|---|
US (1) | US5811434A (instruction) |
EP (1) | EP0941112B1 (instruction) |
JP (1) | JP2001503777A (instruction) |
KR (1) | KR20000068963A (instruction) |
CN (1) | CN1239435A (instruction) |
AR (1) | AR013873A1 (instruction) |
AT (1) | ATE232395T1 (instruction) |
AU (1) | AU5439698A (instruction) |
BR (1) | BR9712947A (instruction) |
CA (1) | CA2270629A1 (instruction) |
CO (1) | CO4920219A1 (instruction) |
DE (1) | DE69719063T2 (instruction) |
DK (1) | DK0941112T3 (instruction) |
EA (1) | EA199900462A1 (instruction) |
ES (1) | ES2187832T3 (instruction) |
IL (1) | IL129556A0 (instruction) |
IN (1) | IN183279B (instruction) |
NZ (1) | NZ335395A (instruction) |
PL (1) | PL333242A1 (instruction) |
WO (1) | WO1998020892A1 (instruction) |
ZA (1) | ZA9710258B (instruction) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133456A (en) * | 1994-08-18 | 2000-10-17 | Ariad Gene Therapeutics, Inc. | Synthetic multimerizing agents |
US6150527A (en) * | 1994-08-18 | 2000-11-21 | Ariad Pharmaceuticals, Inc. | Synthetic multimerizing agents |
US20030036654A1 (en) | 1994-08-18 | 2003-02-20 | Holt Dennis A. | Synthetic multimerizing agents |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
US6514686B2 (en) | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
US20010049381A1 (en) | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
EA200001247A1 (ru) | 1998-06-03 | 2001-08-27 | Джи Пи Ай Нил Холдингс, Инк. | N-связанные сульфонамиды n-гетероциклических карбоновых кислот или изостеры карбоновых кислот |
ATE268772T1 (de) | 1998-07-17 | 2004-06-15 | Agouron Pharma | Verbindungen und zusammensetzungen um neurales wachstum und streckung zu stimulieren |
GB9815880D0 (en) | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6399648B1 (en) * | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
EP1196389A1 (en) | 1999-07-06 | 2002-04-17 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
WO2001004090A2 (en) * | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
US6734211B1 (en) * | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
EP1214293A1 (en) | 1999-09-08 | 2002-06-19 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
ES2269206T3 (es) * | 1999-11-12 | 2007-04-01 | Alcon, Inc. | Ligandos de neurofilina para tratar trastornos oculares. |
US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
DE60026568D1 (de) | 1999-12-21 | 2006-05-04 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
EP1257544B1 (en) * | 2000-02-11 | 2012-07-25 | Vertex Pharmaceuticals Incorporated | Piperazine and piperidine derivatives for treatment or prevention of neuronal damage |
US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
EP1360173A2 (en) | 2001-01-25 | 2003-11-12 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
EP1404325A2 (en) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
WO2003062773A1 (en) * | 2002-01-24 | 2003-07-31 | Pei Electronics, Inc. | Compact integrated infrared scene projector |
KR20040011237A (ko) * | 2002-07-29 | 2004-02-05 | 김윤희 | Pdgf, 그의 유도체 및 약학적으로 허용되는 그의 염을함유하는 신경세포 보호 및 재생용 조성물 |
US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
ATE425967T1 (de) * | 2002-10-03 | 2009-04-15 | Vertex Pharma | Piperazin und piperadin-derivate fur die behandlung von neurologischen krankheiten |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
IL115685A (en) * | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
US5726184A (en) * | 1995-05-19 | 1998-03-10 | Vertex Pharmaceuticals Incorporated | Tetralin compounds with improved MDR activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
-
1996
- 1996-11-13 US US08/748,448 patent/US5811434A/en not_active Expired - Lifetime
-
1997
- 1997-11-13 CN CN97180249A patent/CN1239435A/zh active Pending
- 1997-11-13 AU AU54396/98A patent/AU5439698A/en not_active Abandoned
- 1997-11-13 DK DK97948308T patent/DK0941112T3/da active
- 1997-11-13 PL PL97333242A patent/PL333242A1/xx unknown
- 1997-11-13 NZ NZ335395A patent/NZ335395A/xx unknown
- 1997-11-13 IL IL12955697A patent/IL129556A0/xx unknown
- 1997-11-13 AR ARP970105319A patent/AR013873A1/es unknown
- 1997-11-13 CA CA002270629A patent/CA2270629A1/en not_active Abandoned
- 1997-11-13 KR KR1019997004193A patent/KR20000068963A/ko not_active Withdrawn
- 1997-11-13 ZA ZA9710258A patent/ZA9710258B/xx unknown
- 1997-11-13 BR BR9712947-0A patent/BR9712947A/pt not_active Application Discontinuation
- 1997-11-13 IN IN2150CA1997 patent/IN183279B/en unknown
- 1997-11-13 JP JP52286698A patent/JP2001503777A/ja not_active Ceased
- 1997-11-13 AT AT97948308T patent/ATE232395T1/de not_active IP Right Cessation
- 1997-11-13 DE DE69719063T patent/DE69719063T2/de not_active Expired - Lifetime
- 1997-11-13 EP EP97948308A patent/EP0941112B1/en not_active Expired - Lifetime
- 1997-11-13 ES ES97948308T patent/ES2187832T3/es not_active Expired - Lifetime
- 1997-11-13 EA EA199900462A patent/EA199900462A1/ru unknown
- 1997-11-13 CO CO97066754A patent/CO4920219A1/es unknown
- 1997-11-13 WO PCT/US1997/020867 patent/WO1998020892A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU5439698A (en) | 1998-06-03 |
DK0941112T3 (da) | 2003-05-19 |
CA2270629A1 (en) | 1998-05-22 |
AR013873A1 (es) | 2001-01-31 |
IN183279B (instruction) | 1999-10-30 |
JP2001503777A (ja) | 2001-03-21 |
ES2187832T3 (es) | 2003-06-16 |
CN1239435A (zh) | 1999-12-22 |
US5811434A (en) | 1998-09-22 |
KR20000068963A (ko) | 2000-11-25 |
EA199900462A1 (ru) | 2000-02-28 |
DE69719063D1 (de) | 2003-03-20 |
BR9712947A (pt) | 2000-03-28 |
PL333242A1 (en) | 1999-11-22 |
ZA9710258B (en) | 1998-05-28 |
CO4920219A1 (es) | 2000-05-29 |
WO1998020892A1 (en) | 1998-05-22 |
ATE232395T1 (de) | 2003-02-15 |
EP0941112B1 (en) | 2003-02-12 |
NZ335395A (en) | 1999-07-29 |
DE69719063T2 (de) | 2003-07-31 |
EP0941112A1 (en) | 1999-09-15 |
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