IL128535A - Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives - Google Patents

Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives

Info

Publication number
IL128535A
IL128535A IL12853597A IL12853597A IL128535A IL 128535 A IL128535 A IL 128535A IL 12853597 A IL12853597 A IL 12853597A IL 12853597 A IL12853597 A IL 12853597A IL 128535 A IL128535 A IL 128535A
Authority
IL
Israel
Prior art keywords
alpha
derivatives
dien
triol
acyloxy
Prior art date
Application number
IL12853597A
Other languages
English (en)
Other versions
IL128535A0 (en
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL128535(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of IL128535A0 publication Critical patent/IL128535A0/xx
Publication of IL128535A publication Critical patent/IL128535A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
IL12853597A 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives IL128535A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (2)

Publication Number Publication Date
IL128535A0 IL128535A0 (en) 2000-01-31
IL128535A true IL128535A (en) 2003-07-06

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12853597A IL128535A (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives

Country Status (18)

Country Link
US (1) US6787533B1 (ja)
EP (1) EP0929566B1 (ja)
JP (1) JP3807509B2 (ja)
AT (1) ATE229539T1 (ja)
AU (1) AU736840B2 (ja)
CA (1) CA2264863C (ja)
CL (1) CL2004001297A1 (ja)
CY (2) CY2454B1 (ja)
CZ (1) CZ298789B6 (ja)
DE (2) DE19635498A1 (ja)
DK (1) DK0929566T3 (ja)
EE (1) EE03927B1 (ja)
ES (1) ES2188984T3 (ja)
HU (1) HU228766B1 (ja)
IL (1) IL128535A (ja)
PL (1) PL186063B1 (ja)
PT (1) PT929566E (ja)
WO (1) WO1998009982A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
NZ525707A (en) * 2000-11-10 2004-11-26 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylene) bis(oxy)]-11,21-dihydroxy-pregna-1,4-diene-3,20-dione or its 21-isobutyrate by transketalisation
WO2004033478A2 (en) 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
AU2003293833B2 (en) 2002-12-12 2009-10-01 Covis Pharma B.V. Combination medicament
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
JP5618452B2 (ja) 2003-09-16 2014-11-05 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツングＴａｋｅｄａ ＧｍｂＨ 呼吸器疾患の治療のためのシクレソニドの使用
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
JP2009512733A (ja) * 2005-11-02 2009-03-26 シコール インコーポレイティド シクレソニドの改良された製造法
EP1904514A2 (en) * 2006-02-08 2008-04-02 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
NZ575549A (en) * 2006-09-19 2012-06-29 Cipla Ltd Processes for the preparation of ciclesonide and its crystal form
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
US20100331539A1 (en) * 2008-03-13 2010-12-30 Farmabios S.P.A. Process for the preparation of pregnane derivatives
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
SG11201810678WA (en) 2016-06-02 2018-12-28 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
TWI803542B (zh) 2017-12-01 2023-06-01 美商艾伯維有限公司 糖皮質激素受體激動劑及其免疫結合物
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (ja) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
EP0701565B1 (de) 1993-04-02 1998-10-28 Byk Gulden Lomberg Chemische Fabrik GmbH Neue prednisolonderivate
DE59508898D1 (de) * 1994-03-09 2001-01-18 Byk Gulden Lomberg Chem Fab Neue silylverbindungen und ihre verwendung

Also Published As

Publication number Publication date
US6787533B1 (en) 2004-09-07
ES2188984T3 (es) 2003-07-01
IL128535A0 (en) 2000-01-31
EP0929566A1 (en) 1999-07-21
CY2009010I1 (el) 2010-07-28
PL331699A1 (en) 1999-08-02
AU4456797A (en) 1998-03-26
DK0929566T3 (da) 2003-04-07
DE19635498A1 (de) 1998-03-26
JP3807509B2 (ja) 2006-08-09
EE9900079A (et) 1999-10-15
WO1998009982A1 (en) 1998-03-12
DE69717836D1 (de) 2003-01-23
CA2264863C (en) 2007-07-31
JP2000517330A (ja) 2000-12-26
CY2009010I2 (el) 2010-07-28
ATE229539T1 (de) 2002-12-15
EP0929566B1 (en) 2002-12-11
HU228766B1 (hu) 2013-05-28
HUP9904127A2 (hu) 2000-04-28
CZ72799A3 (cs) 1999-09-15
DE69717836T2 (de) 2003-09-18
EE03927B1 (et) 2002-12-16
CZ298789B6 (cs) 2008-01-30
CL2004001297A1 (es) 2005-04-15
AU736840B2 (en) 2001-08-02
CY2454B1 (en) 2005-06-03
PT929566E (pt) 2003-04-30
PL186063B1 (pl) 2003-09-30
CA2264863A1 (en) 1998-03-12
HUP9904127A3 (en) 2001-02-28

Similar Documents

Publication Publication Date Title
IL128535A (en) Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives
ES8705462A1 (es) Un procedimiento para la preparacion de 16,17-acetales de derivados de pregnano
DE122005000030I2 (de) Pregna-1,4-dien-3,20-dion-16-17-acetal-21-ester, Verfahren zur Herstellung, sowie diese enthaltende pharmazeutische Präparate
IL73521A (en) Preparation of 1,3,5-tri-o-acyl-2-deoxy-2-fluoroarabinofuranoside intermediate compounds for the synthesis of nucleosides and the 1,3,5-triaroyl esters thereof
BR9406724A (pt) Novos ligantes de receptores 1-fenilalcanona 5-ht4
HUT34513A (en) Process for production of 1-alkil-androsta-1,4-dien-3,17-dions and medical preparates consisting of such compounds
HUT61570A (en) Process for producing pregna-1,4-diene-3,20-dione derivatives
SI0929566T1 (en) Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives
IL74642A (en) Pharmaceutical composition constituted by 9alpha,11beta-dichloro-16alpha-methyl-21-oxycarbonyl dicyclohexylmethyloxy pregna-1,4-diene-3,20-dione,and an inert excipient
EP0276393A3 (en) Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives
HUT66162A (en) In 16-position quaternizated, substituted with amino-group androstane-derivatives and process for their production
EP0548895A3 (en) Process for the preparation of pure diasteroisomers of tetrahydrofolates
LV5274A3 (lv) 22(R,S)-11 beta,21-dihidroksi-16 alpha,17-butilidenbisoksipregna-1,4-dien-3,20-diona iegusanas panemiens
NO307052B1 (no) Fremgangsmåte for fremstilling av krystallinsk <beta>-laktam- monohydrat
HU9503063D0 (en) New 16-(substituted methyl)-pregna-1,4-diene-3,20-dione derivatives and process for producing them
ES8302458A1 (es) Procedimiento para preparar nuevas 1-substituido-6-n-propil-8-metilimidazo (1,5-d)-as-triazin-4(3h)-onas.
AR243199A1 (es) Procedimiento para elaborar compuestos de 9alfa,21-dihalogeno-llbeta- hidroxi-17alfa-alcanoiloxi-6alfa-fluor-16beta-metil- pregna-1,4-dien-3,20- diona
MX9701948A (es) Epimeros de (22rs-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-oxo-4-aza-5alfa-androst-1-e n-17beta-carboxamida.
SE8400145L (sv) Forfarande for framstellning av 17-estrar av klobetasol
ZA822301B (en) Derivatives of n.n-dimethyl 10-(1-aza bicyclo(2.2.2)3-octyl 10h)2-phenothiazinesulphonamide process for their preparation and use of the same as medicaments
HU9902345D0 (en) New pregna-1,4-diene-3,20-dione-derivatives
AR243200A1 (es) Procedimiento para la elaboracion de compuestos de 9alfa,21-dihalogeno-11 beta-hidroxi-17 alfa-alcanoiloxi-6alfa-fluor-16beta-metil-pregna-1,4-dien-3,20-diona.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired