IL128256A - Use of the history of hydroxylamine for the preparation of pharmaceutical preparations for the cure and prevention of diseases related to the dysfunction of endothelial cells in blood vessels, and pharmaceutical preparations - Google Patents
Use of the history of hydroxylamine for the preparation of pharmaceutical preparations for the cure and prevention of diseases related to the dysfunction of endothelial cells in blood vessels, and pharmaceutical preparationsInfo
- Publication number
- IL128256A IL128256A IL12825697A IL12825697A IL128256A IL 128256 A IL128256 A IL 128256A IL 12825697 A IL12825697 A IL 12825697A IL 12825697 A IL12825697 A IL 12825697A IL 128256 A IL128256 A IL 128256A
- Authority
- IL
- Israel
- Prior art keywords
- group
- refers
- formula
- carbon atoms
- active ingredient
- Prior art date
Links
- 150000002443 hydroxylamines Chemical class 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- 210000003556 vascular endothelial cell Anatomy 0.000 title description 7
- 239000000825 pharmaceutical preparation Substances 0.000 title description 4
- 229940127557 pharmaceutical product Drugs 0.000 title description 4
- 230000007257 malfunction Effects 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 119
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 15
- 210000002889 endothelial cell Anatomy 0.000 claims abstract description 13
- 125000002252 acyl group Chemical group 0.000 claims abstract description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 10
- 125000005843 halogen group Chemical group 0.000 claims abstract description 10
- 125000001424 substituent group Chemical group 0.000 claims abstract description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 9
- 125000004423 acyloxy group Chemical group 0.000 claims abstract description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 6
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 6
- 239000001301 oxygen Substances 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000005864 Sulphur Substances 0.000 claims abstract description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 5
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 4
- 230000006806 disease prevention Effects 0.000 claims abstract description 3
- 239000004615 ingredient Substances 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 17
- 230000008569 process Effects 0.000 claims description 16
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 7
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 7
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- SMXUVJJTNZTLOW-UHFFFAOYSA-N 1-hexyl-3-(3-piperidin-1-ylpropoxy)urea Chemical compound CCCCCCNC(=O)NOCCCN1CCCCC1 SMXUVJJTNZTLOW-UHFFFAOYSA-N 0.000 claims description 3
- ATIGGIJEVHORCN-UHFFFAOYSA-N n-(2-hydroxy-3-piperidin-1-ylpropoxy)-2-nitrobenzenecarboximidoyl chloride;hydrochloride Chemical compound Cl.C1CCCCN1CC(O)CON=C(Cl)C1=CC=CC=C1[N+]([O-])=O ATIGGIJEVHORCN-UHFFFAOYSA-N 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 150000004668 long chain fatty acids Chemical class 0.000 claims description 2
- HPJXQKQVNBUUPC-UHFFFAOYSA-N n-(3-piperidin-1-ylpropoxy)pyridine-3-carboximidoyl chloride;dihydrochloride Chemical compound Cl.Cl.C=1C=CN=CC=1C(Cl)=NOCCCN1CCCCC1 HPJXQKQVNBUUPC-UHFFFAOYSA-N 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- ZSRVLJCKFMSEEP-BTJKTKAUSA-N (Z)-but-2-enedioic acid N-(2-hydroxy-3-piperidin-1-ylpropoxy)pyridine-4-carboximidoyl chloride Chemical compound OC(=O)\C=C/C(O)=O.C1CCCCN1CC(O)CON=C(Cl)C1=CC=NC=C1 ZSRVLJCKFMSEEP-BTJKTKAUSA-N 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 22
- 238000012360 testing method Methods 0.000 description 16
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- 239000000126 substance Substances 0.000 description 10
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9602204A HUP9602204D0 (en) | 1996-08-09 | 1996-08-09 | Pharmaceutical compositions for treating diseases connected with the disfunction of the vascular endothelial cells |
| HU9701349A HUP9701349A1 (hu) | 1997-08-04 | 1997-08-04 | Gyógyászati készítmények a vaszkuláris endoteliális sejtek rendellenes működésével összefüggő betegségek gyógyítására vagy megelőzésére |
| PCT/HU1997/000044 WO1998006400A2 (en) | 1996-08-09 | 1997-08-06 | Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL128256A0 IL128256A0 (en) | 2000-02-17 |
| IL128256A true IL128256A (en) | 2004-05-12 |
Family
ID=90014231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12825697A IL128256A (en) | 1996-08-09 | 1997-08-06 | Use of the history of hydroxylamine for the preparation of pharmaceutical preparations for the cure and prevention of diseases related to the dysfunction of endothelial cells in blood vessels, and pharmaceutical preparations |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6143741A (ja) |
| EP (1) | EP0966283B1 (ja) |
| JP (1) | JP2001504446A (ja) |
| AT (1) | ATE329592T1 (ja) |
| AU (1) | AU739614B2 (ja) |
| BG (1) | BG64456B1 (ja) |
| CA (1) | CA2262997C (ja) |
| CZ (1) | CZ298542B6 (ja) |
| DE (1) | DE69736130T2 (ja) |
| DK (1) | DK0966283T3 (ja) |
| EE (1) | EE04044B1 (ja) |
| ES (1) | ES2267148T3 (ja) |
| HK (1) | HK1025506A1 (ja) |
| IL (1) | IL128256A (ja) |
| NO (1) | NO325109B1 (ja) |
| PT (1) | PT966283E (ja) |
| RS (1) | RS49719B (ja) |
| SK (1) | SK284301B6 (ja) |
| UA (1) | UA64716C2 (ja) |
| WO (1) | WO1998006400A2 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU9701081D0 (en) | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
| HU226617B1 (en) * | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| WO2003057664A1 (en) | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| TW200831479A (en) * | 2006-09-26 | 2008-08-01 | Cytrx Corp | Pharmaceutical compositions and methods for treating diseases |
| MX2009005798A (es) * | 2006-12-01 | 2009-08-12 | Cytrx Corp | Recuperacion de apoplejia. |
| TW200901958A (en) * | 2007-05-04 | 2009-01-16 | Cytrx Corp | Diabetic wound healing |
| JP5429865B2 (ja) * | 2009-09-15 | 2014-02-26 | 学校法人日本大学 | 生体外創傷治癒試験用用具または創傷作製方法 |
| HUP1100535A2 (en) * | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
| MX2023005954A (es) | 2020-11-19 | 2023-09-04 | Zevra Denmark As | Procesos para preparar citrato de arimoclomol e intermediarios del mismo. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| GB9017351D0 (en) * | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| WO1995030649A1 (en) * | 1994-05-06 | 1995-11-16 | Biorex Kutató És Fejleszto^' Rt. | Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same |
| HU218480B (hu) * | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
-
1997
- 1997-06-08 UA UA99020697A patent/UA64716C2/uk unknown
- 1997-08-06 PT PT97933813T patent/PT966283E/pt unknown
- 1997-08-06 RS YUP-51/99A patent/RS49719B/sr unknown
- 1997-08-06 SK SK154-99A patent/SK284301B6/sk not_active IP Right Cessation
- 1997-08-06 WO PCT/HU1997/000044 patent/WO1998006400A2/en active IP Right Grant
- 1997-08-06 AT AT97933813T patent/ATE329592T1/de active
- 1997-08-06 CA CA002262997A patent/CA2262997C/en not_active Expired - Fee Related
- 1997-08-06 DK DK97933813T patent/DK0966283T3/da active
- 1997-08-06 AU AU37049/97A patent/AU739614B2/en not_active Ceased
- 1997-08-06 IL IL12825697A patent/IL128256A/en not_active IP Right Cessation
- 1997-08-06 ES ES97933813T patent/ES2267148T3/es not_active Expired - Lifetime
- 1997-08-06 EE EEP199900044A patent/EE04044B1/xx not_active IP Right Cessation
- 1997-08-06 CZ CZ0043599A patent/CZ298542B6/cs not_active IP Right Cessation
- 1997-08-06 JP JP50952798A patent/JP2001504446A/ja not_active Ceased
- 1997-08-06 US US09/230,941 patent/US6143741A/en not_active Expired - Fee Related
- 1997-08-06 DE DE69736130T patent/DE69736130T2/de not_active Expired - Lifetime
- 1997-08-06 EP EP97933813A patent/EP0966283B1/en not_active Expired - Lifetime
-
1999
- 1999-02-05 NO NO19990547A patent/NO325109B1/no not_active IP Right Cessation
- 1999-02-22 BG BG103194A patent/BG64456B1/bg unknown
-
2000
- 2000-06-28 HK HK00103903A patent/HK1025506A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BG103194A (en) | 1999-09-30 |
| DE69736130T2 (de) | 2007-01-04 |
| BG64456B1 (bg) | 2005-03-31 |
| EP0966283B1 (en) | 2006-06-14 |
| NO990547D0 (no) | 1999-02-05 |
| AU739614B2 (en) | 2001-10-18 |
| CA2262997A1 (en) | 1998-02-19 |
| UA64716C2 (en) | 2004-03-15 |
| JP2001504446A (ja) | 2001-04-03 |
| ES2267148T3 (es) | 2007-03-01 |
| NO325109B1 (no) | 2008-02-04 |
| SK284301B6 (sk) | 2005-01-03 |
| CA2262997C (en) | 2008-07-29 |
| CZ298542B6 (cs) | 2007-10-31 |
| HK1025506A1 (en) | 2000-11-17 |
| EE9900044A (et) | 1999-08-16 |
| PT966283E (pt) | 2006-08-31 |
| NO990547L (no) | 1999-03-25 |
| WO1998006400A3 (en) | 1998-03-26 |
| RS49719B (sr) | 2007-12-31 |
| SK15499A3 (en) | 2000-02-14 |
| WO1998006400A2 (en) | 1998-02-19 |
| YU5199A (sh) | 2000-10-30 |
| EE04044B1 (et) | 2003-06-16 |
| US6143741A (en) | 2000-11-07 |
| DK0966283T3 (da) | 2006-10-09 |
| AU3704997A (en) | 1998-03-06 |
| IL128256A0 (en) | 2000-02-17 |
| CZ43599A3 (cs) | 1999-07-14 |
| DE69736130D1 (de) | 2006-07-27 |
| EP0966283A2 (en) | 1999-12-29 |
| ATE329592T1 (de) | 2006-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |