IL127971A - Preservation by creating foam - Google Patents
Preservation by creating foamInfo
- Publication number
- IL127971A IL127971A IL12797197A IL12797197A IL127971A IL 127971 A IL127971 A IL 127971A IL 12797197 A IL12797197 A IL 12797197A IL 12797197 A IL12797197 A IL 12797197A IL 127971 A IL127971 A IL 127971A
- Authority
- IL
- Israel
- Prior art keywords
- foam
- solution
- dispersion
- suspension
- temperature
- Prior art date
Links
- 239000006260 foam Substances 0.000 title claims abstract description 86
- 238000004321 preservation Methods 0.000 title claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 title description 13
- 238000000034 method Methods 0.000 claims abstract description 87
- 238000001035 drying Methods 0.000 claims abstract description 57
- 239000000243 solution Substances 0.000 claims abstract description 57
- 239000000725 suspension Substances 0.000 claims abstract description 43
- 239000011149 active material Substances 0.000 claims abstract description 29
- 239000006185 dispersion Substances 0.000 claims abstract description 27
- 238000009835 boiling Methods 0.000 claims abstract description 21
- 230000002706 hydrostatic effect Effects 0.000 claims abstract description 13
- 239000013543 active substance Substances 0.000 claims abstract description 5
- 238000003860 storage Methods 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 230000008020 evaporation Effects 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 6
- 235000000346 sugar Nutrition 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 235000014633 carbohydrates Nutrition 0.000 claims description 4
- 230000009477 glass transition Effects 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000002577 cryoprotective agent Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000001223 reverse osmosis Methods 0.000 claims 2
- 125000000185 sucrose group Chemical group 0.000 claims 2
- 239000000463 material Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 230000000694 effects Effects 0.000 description 16
- 239000012530 fluid Substances 0.000 description 10
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 8
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 8
- 230000004071 biological effect Effects 0.000 description 8
- 238000005187 foaming Methods 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 239000007983 Tris buffer Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000003801 milling Methods 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 238000013341 scale-up Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- 229940088623 biologically active substance Drugs 0.000 description 2
- 238000009529 body temperature measurement Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000006910 ice nucleation Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2179696P | 1996-07-15 | 1996-07-15 | |
| US08/785,473 US5766520A (en) | 1996-07-15 | 1997-01-17 | Preservation by foam formation |
| PCT/US1997/012156 WO1998002240A1 (fr) | 1996-07-15 | 1997-07-14 | Preservation par formation de mousse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127971A0 IL127971A0 (en) | 1999-11-30 |
| IL127971A true IL127971A (en) | 2001-09-13 |
Family
ID=26695104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12797197A IL127971A (en) | 1996-07-15 | 1997-07-14 | Preservation by creating foam |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5766520A (fr) |
| EP (1) | EP0914202A4 (fr) |
| JP (1) | JP2000515856A (fr) |
| KR (1) | KR100457748B1 (fr) |
| CN (1) | CN1116104C (fr) |
| AU (1) | AU714328B2 (fr) |
| BR (1) | BR9711808A (fr) |
| CA (1) | CA2260233A1 (fr) |
| CZ (1) | CZ7999A3 (fr) |
| DE (1) | DE914202T1 (fr) |
| EA (1) | EA001138B1 (fr) |
| HU (1) | HUP9903917A3 (fr) |
| IL (1) | IL127971A (fr) |
| NO (1) | NO990158D0 (fr) |
| NZ (1) | NZ333738A (fr) |
| PL (1) | PL331174A1 (fr) |
| TR (1) | TR199900127T2 (fr) |
| WO (1) | WO1998002240A1 (fr) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ257212A (en) * | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| JPH10508744A (ja) | 1994-09-22 | 1998-09-02 | クオドラント ホールディングス ケンブリッジ リミテッド | 運動競技の間の水分補給および栄養摂取の用途のための組成物ならびにその製造法 |
| US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| US6509146B1 (en) | 1996-05-29 | 2003-01-21 | Universal Preservation Technologies, Inc. | Scalable long-term shelf preservation of sensitive biological solutions and suspensions |
| US6468782B1 (en) * | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| GB9705588D0 (en) | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| US20060116330A1 (en) * | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
| US8563522B2 (en) * | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
| US20020035071A1 (en) * | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| DE69735600T2 (de) * | 1997-11-26 | 2007-01-25 | Universal Preservation Technologies, Inc., San Diego | Konservierung empfindlicher biologischer proben durch verglasung |
| US6306345B1 (en) * | 1998-05-06 | 2001-10-23 | Universal Preservation Technologies, Inc. | Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures |
| US6214054B1 (en) | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| CA2360112A1 (fr) | 1999-01-05 | 2000-07-13 | Victor Bronshtein | Systeme de commande de vide pour appareil de sechage de mousse |
| DK1175486T3 (da) * | 1999-05-04 | 2007-10-29 | Anhydro Ltd | Fremgangsmåde til konservering af virus og mycoplasma |
| US6692695B1 (en) | 1999-05-06 | 2004-02-17 | Quadrant Drug Delivery Limited | Industrial scale barrier technology for preservation of sensitive biological materials |
| CA2382061A1 (fr) * | 1999-08-19 | 2001-02-22 | Victor Bronshtein | Conservation de cellules bacteriennes a temperature ambiante |
| WO2001037804A2 (fr) * | 1999-11-22 | 2001-05-31 | Universal Preservation Technologies, Inc. | Conservation et preparation de matieres bioactives destinees au stockage et a l'administration dans des excipients hydrophobes |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| DK1280520T4 (en) | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| WO2001094867A1 (fr) | 2000-06-07 | 2001-12-13 | Universal Preservation Technologies, Inc. | Technologie d'isolation a echelle industrielle destinee a la preservation de matieres biologiques sensibles |
| HU229550B1 (en) * | 2000-06-27 | 2014-01-28 | Hoffmann La Roche | Method for preparing compositions |
| US6537666B1 (en) * | 2000-10-23 | 2003-03-25 | Universal Preservation Technologies, Inc. | Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals |
| US6872357B1 (en) * | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
| US7153472B1 (en) * | 2000-11-22 | 2006-12-26 | Quadrant Drug Delivery Limited | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers |
| AU2002305461A1 (en) * | 2001-05-07 | 2002-11-18 | Universal Preservation Technologies, Inc. | Preservation of competent cells at ambient temperatures |
| US6884866B2 (en) * | 2001-10-19 | 2005-04-26 | Avant Immunotherapeutics, Inc. | Bulk drying and the effects of inducing bubble nucleation |
| EP1458360B1 (fr) | 2001-12-19 | 2011-05-11 | Novartis AG | Administration pulmonaire d'aminoglycosides |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| CA2482448C (fr) * | 2002-04-11 | 2014-07-08 | Medimmune Vaccines, Inc. | Conservation de matieres bio-actives au moyen de mousse lyophilisee |
| US7927858B2 (en) | 2002-11-01 | 2011-04-19 | Glaxosmithkline Biologicals, S.A. | Drying process |
| US20050100559A1 (en) * | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
| US20050100636A1 (en) * | 2003-11-10 | 2005-05-12 | Megan Botteri | [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity] |
| US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| US8877178B2 (en) * | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US20050152884A1 (en) * | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
| US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
| US20050158294A1 (en) * | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US9744227B2 (en) | 2004-06-02 | 2017-08-29 | Universal Stabilization Technologies, Inc. | Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof |
| CA2569276C (fr) | 2004-06-02 | 2018-01-23 | Victor Bronshtein | Conservation par vaporisation |
| JP2007277094A (ja) * | 2004-06-29 | 2007-10-25 | Chemo Sero Therapeut Res Inst | 改変ダニ主要アレルゲン含有医薬組成物 |
| CA2571232C (fr) * | 2004-07-30 | 2010-02-16 | The University Of British Columbia | Procede permettant de produire des mousses hydrocolloides |
| AR052472A1 (es) * | 2005-05-31 | 2007-03-21 | Iams Company | Lactobacilos probioticos para felinos |
| EP1885383B1 (fr) * | 2005-05-31 | 2016-09-21 | IAMS Europe B.V. | Bifidobacteries de probiotiques felins |
| US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| WO2007079147A2 (fr) | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | Véhicule de délivrance pour bactéries probiotiques, comprenant une matrice sèche en polysaccharides, saccharides et polyols sous forme de verre, et son procédé de préparation |
| US9453675B2 (en) * | 2006-02-10 | 2016-09-27 | Sp Industries, Inc. | Method of inducing nucleation of a material |
| EP2077718B2 (fr) | 2006-10-27 | 2022-03-09 | Edwards Lifesciences Corporation | Tissu biologique pour implantation chirurgicale |
| CA2673120C (fr) | 2006-12-18 | 2012-08-07 | Advanced Bionutrition Corporation | Produit alimentaire sec contenant un probiotique vivant |
| WO2008093303A2 (fr) | 2007-02-01 | 2008-08-07 | The Iams Company | Procédé de réduction de l'inflammation et du stress chez un mammifère |
| US8617576B2 (en) * | 2007-05-18 | 2013-12-31 | Medimmune, Llc | Preservation of bioactive materials by freeze dried foam |
| US9101691B2 (en) * | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| JP2010534622A (ja) | 2007-07-26 | 2010-11-11 | サノフィ パストゥール リミテッド | 抗原−アジュバント組成物および方法 |
| CA2699120C (fr) * | 2007-09-13 | 2014-07-08 | Enwave Corporation | Appareil et procede pour deshydrater des matieres biologiques |
| US8357387B2 (en) * | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| CA2736317C (fr) | 2008-09-12 | 2015-06-16 | Enwave Corporation | Appareil et procede de deshydratation de matieres biologiques par congelation et micro-ondes |
| EP3266448B1 (fr) | 2009-03-27 | 2022-02-16 | Intervet International B.V. | Vaccins microparticulaires utilisables pour procéder à une vaccination et à des rappels par voie orale ou nasale chez les animaux, dont les poissons |
| CN102459568A (zh) | 2009-05-26 | 2012-05-16 | 先进生物营养公司 | 包含生物活性微生物和/或生物活性材料的稳定干粉组合物及其制造方法 |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| US20110064723A1 (en) * | 2009-09-14 | 2011-03-17 | Aridis Pharmaceuticals | Formulation for room temperature stabilization of a live attenuated bacterial vaccine |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
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| EP2549957B1 (fr) | 2010-03-23 | 2019-01-30 | Edwards Lifesciences Corporation | Méthodes de conditionnement d'un tissu bioprothétique en feuillets |
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1997
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- 1997-07-14 CZ CZ9979A patent/CZ7999A3/cs unknown
- 1997-07-14 EA EA199900268A patent/EA001138B1/ru not_active IP Right Cessation
- 1997-07-14 PL PL97331174A patent/PL331174A1/xx unknown
- 1997-07-14 TR TR1999/00127T patent/TR199900127T2/xx unknown
- 1997-07-14 HU HU9903917A patent/HUP9903917A3/hu not_active Application Discontinuation
- 1997-07-14 CN CN97196422A patent/CN1116104C/zh not_active Expired - Fee Related
- 1997-07-14 NZ NZ333738A patent/NZ333738A/xx unknown
- 1997-07-14 EP EP97933415A patent/EP0914202A4/fr not_active Withdrawn
- 1997-07-14 WO PCT/US1997/012156 patent/WO1998002240A1/fr not_active Application Discontinuation
- 1997-07-14 IL IL12797197A patent/IL127971A/en not_active IP Right Cessation
- 1997-07-14 JP JP10506201A patent/JP2000515856A/ja not_active Ceased
- 1997-07-14 KR KR10-1999-7000253A patent/KR100457748B1/ko not_active IP Right Cessation
- 1997-07-14 CA CA002260233A patent/CA2260233A1/fr not_active Abandoned
- 1997-07-14 AU AU36606/97A patent/AU714328B2/en not_active Ceased
- 1997-07-14 DE DE0914202T patent/DE914202T1/de active Pending
- 1997-07-14 BR BR9711808-7A patent/BR9711808A/pt unknown
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1999
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Also Published As
| Publication number | Publication date |
|---|---|
| EA001138B1 (ru) | 2000-10-30 |
| NO990158L (no) | 1999-01-14 |
| PL331174A1 (en) | 1999-06-21 |
| IL127971A0 (en) | 1999-11-30 |
| EA199900268A1 (ru) | 1999-10-28 |
| NO990158D0 (no) | 1999-01-14 |
| JP2000515856A (ja) | 2000-11-28 |
| CN1226842A (zh) | 1999-08-25 |
| CZ7999A3 (cs) | 1999-11-17 |
| EP0914202A4 (fr) | 2004-09-01 |
| US5766520A (en) | 1998-06-16 |
| WO1998002240A1 (fr) | 1998-01-22 |
| TR199900127T2 (xx) | 1999-04-21 |
| NZ333738A (en) | 2000-09-29 |
| HUP9903917A2 (hu) | 2000-03-28 |
| CA2260233A1 (fr) | 1998-01-22 |
| AU3660697A (en) | 1998-02-09 |
| BR9711808A (pt) | 2000-01-18 |
| KR100457748B1 (ko) | 2004-11-17 |
| DE914202T1 (de) | 2000-02-17 |
| KR20000023779A (ko) | 2000-04-25 |
| EP0914202A1 (fr) | 1999-05-12 |
| AU714328B2 (en) | 1999-12-23 |
| HUP9903917A3 (en) | 2000-06-28 |
| CN1116104C (zh) | 2003-07-30 |
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