IL127971A - Preservation by creating foam - Google Patents
Preservation by creating foamInfo
- Publication number
- IL127971A IL127971A IL12797197A IL12797197A IL127971A IL 127971 A IL127971 A IL 127971A IL 12797197 A IL12797197 A IL 12797197A IL 12797197 A IL12797197 A IL 12797197A IL 127971 A IL127971 A IL 127971A
- Authority
- IL
- Israel
- Prior art keywords
- foam
- solution
- dispersion
- suspension
- temperature
- Prior art date
Links
- 239000006260 foam Substances 0.000 title claims abstract description 86
- 238000004321 preservation Methods 0.000 title claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 title description 13
- 238000000034 method Methods 0.000 claims abstract description 87
- 238000001035 drying Methods 0.000 claims abstract description 57
- 239000000243 solution Substances 0.000 claims abstract description 57
- 239000000725 suspension Substances 0.000 claims abstract description 43
- 239000011149 active material Substances 0.000 claims abstract description 29
- 239000006185 dispersion Substances 0.000 claims abstract description 27
- 238000009835 boiling Methods 0.000 claims abstract description 21
- 230000002706 hydrostatic effect Effects 0.000 claims abstract description 13
- 239000013543 active substance Substances 0.000 claims abstract description 5
- 238000003860 storage Methods 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 230000008020 evaporation Effects 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 6
- 235000000346 sugar Nutrition 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 235000014633 carbohydrates Nutrition 0.000 claims description 4
- 230000009477 glass transition Effects 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000002577 cryoprotective agent Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000001223 reverse osmosis Methods 0.000 claims 2
- 125000000185 sucrose group Chemical group 0.000 claims 2
- 239000000463 material Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 230000000694 effects Effects 0.000 description 16
- 239000012530 fluid Substances 0.000 description 10
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 8
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 8
- 230000004071 biological effect Effects 0.000 description 8
- 238000005187 foaming Methods 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 239000007983 Tris buffer Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000003801 milling Methods 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 238000013341 scale-up Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- 229940088623 biologically active substance Drugs 0.000 description 2
- 238000009529 body temperature measurement Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000006910 ice nucleation Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2179696P | 1996-07-15 | 1996-07-15 | |
| US08/785,473 US5766520A (en) | 1996-07-15 | 1997-01-17 | Preservation by foam formation |
| PCT/US1997/012156 WO1998002240A1 (fr) | 1996-07-15 | 1997-07-14 | Preservation par formation de mousse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127971A0 IL127971A0 (en) | 1999-11-30 |
| IL127971A true IL127971A (en) | 2001-09-13 |
Family
ID=26695104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12797197A IL127971A (en) | 1996-07-15 | 1997-07-14 | Preservation by creating foam |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5766520A (fr) |
| EP (1) | EP0914202A4 (fr) |
| JP (1) | JP2000515856A (fr) |
| KR (1) | KR100457748B1 (fr) |
| CN (1) | CN1116104C (fr) |
| AU (1) | AU714328B2 (fr) |
| BR (1) | BR9711808A (fr) |
| CA (1) | CA2260233A1 (fr) |
| CZ (1) | CZ7999A3 (fr) |
| DE (1) | DE914202T1 (fr) |
| EA (1) | EA001138B1 (fr) |
| HU (1) | HUP9903917A3 (fr) |
| IL (1) | IL127971A (fr) |
| NO (1) | NO990158D0 (fr) |
| NZ (1) | NZ333738A (fr) |
| PL (1) | PL331174A1 (fr) |
| TR (1) | TR199900127T2 (fr) |
| WO (1) | WO1998002240A1 (fr) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9307141A (pt) * | 1992-09-29 | 1999-03-30 | Inhale Therapeutic Syst | Processo para a liberação sistência pulsátil de um fragmento ativo de hormônio de paratiróide (PTH) para um hospedeiro mamífero e para um paciente e composição farmacêutica |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| CZ88697A3 (en) | 1994-09-22 | 1997-09-17 | Quadrant Holdings Cambridge | Composition used for re-hydration and nourishment in the course of athletic outputs and processes for preparing thereof |
| US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| US6509146B1 (en) | 1996-05-29 | 2003-01-21 | Universal Preservation Technologies, Inc. | Scalable long-term shelf preservation of sensitive biological solutions and suspensions |
| US6468782B1 (en) * | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| GB9705588D0 (en) | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| US20060116330A1 (en) * | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
| US20020035071A1 (en) * | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
| US8563522B2 (en) * | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| EP1032647B1 (fr) * | 1997-11-26 | 2006-03-29 | Universal Preservation Technologies, Inc. | Conservation d'echantillons biologiques sensibles par vitrification |
| US6306345B1 (en) | 1998-05-06 | 2001-10-23 | Universal Preservation Technologies, Inc. | Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures |
| US6214054B1 (en) | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| EP1144930A1 (fr) | 1999-01-05 | 2001-10-17 | Universal Preservation Technologies, Inc. | Systeme de commande de vide pour appareil de sechage de mousse |
| AU776982B2 (en) * | 1999-05-04 | 2004-09-30 | Anhydro Limited | Method for the preservation of viruses and mycoplasma |
| US6692695B1 (en) | 1999-05-06 | 2004-02-17 | Quadrant Drug Delivery Limited | Industrial scale barrier technology for preservation of sensitive biological materials |
| CA2382061A1 (fr) * | 1999-08-19 | 2001-02-22 | Victor Bronshtein | Conservation de cellules bacteriennes a temperature ambiante |
| WO2001037804A2 (fr) * | 1999-11-22 | 2001-05-31 | Universal Preservation Technologies, Inc. | Conservation et preparation de matieres bioactives destinees au stockage et a l'administration dans des excipients hydrophobes |
| CA2382133C (fr) | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Poudres a base de phospholipides permettant de distribuer un medicament |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| AU2000264912A1 (en) | 2000-06-07 | 2001-12-17 | Universal Preservation Technologies, Inc. | Industrial scale barrier technology for preservation of sensitive biological materials |
| MXPA02012583A (es) * | 2000-06-27 | 2003-04-10 | Hoffmann La Roche | Metodo para preparacion de una composicion. |
| US6537666B1 (en) * | 2000-10-23 | 2003-03-25 | Universal Preservation Technologies, Inc. | Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals |
| US7153472B1 (en) * | 2000-11-22 | 2006-12-26 | Quadrant Drug Delivery Limited | Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers |
| US6872357B1 (en) * | 2000-11-22 | 2005-03-29 | Quadrant Drug Delivery Limited | Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying |
| AU2002305461A1 (en) * | 2001-05-07 | 2002-11-18 | Universal Preservation Technologies, Inc. | Preservation of competent cells at ambient temperatures |
| US6884866B2 (en) * | 2001-10-19 | 2005-04-26 | Avant Immunotherapeutics, Inc. | Bulk drying and the effects of inducing bubble nucleation |
| WO2003053411A1 (fr) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Administration pulmonaire d'aminoglycosides |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| CA2482448C (fr) | 2002-04-11 | 2014-07-08 | Medimmune Vaccines, Inc. | Conservation de matieres bio-actives au moyen de mousse lyophilisee |
| JP2006504801A (ja) * | 2002-11-01 | 2006-02-09 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥方法 |
| US20050100559A1 (en) * | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
| US20050100636A1 (en) * | 2003-11-10 | 2005-05-12 | Megan Botteri | [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity] |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US20050152884A1 (en) * | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
| US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
| US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US9744227B2 (en) | 2004-06-02 | 2017-08-29 | Universal Stabilization Technologies, Inc. | Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof |
| ES2644416T3 (es) * | 2004-06-02 | 2017-11-28 | Universal Stabilization Technologies, Inc. | Conservación mediante vaporización |
| JP2007277094A (ja) * | 2004-06-29 | 2007-10-25 | Chemo Sero Therapeut Res Inst | 改変ダニ主要アレルゲン含有医薬組成物 |
| AU2005266812B2 (en) * | 2004-07-30 | 2010-07-29 | Enwave Corporation | Method for producing hydrocolloid foams |
| DK1880001T3 (da) * | 2005-05-31 | 2011-09-12 | Iams Company | Feline probiotiske lactobacilli |
| ES2607988T3 (es) * | 2005-05-31 | 2017-04-05 | Iams Europe B.V. | Bifidobacterias probióticas felinas |
| US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| DK1973406T3 (da) | 2005-12-28 | 2014-06-23 | Advanced Bionutrition Corp | Fremføringsmiddel til probiotiske bakerier omfattende en tør blanding af polysaccharider, saccharider, polyoler i glasform |
| US9453675B2 (en) * | 2006-02-10 | 2016-09-27 | Sp Industries, Inc. | Method of inducing nucleation of a material |
| EP2077718B2 (fr) | 2006-10-27 | 2022-03-09 | Edwards Lifesciences Corporation | Tissu biologique pour implantation chirurgicale |
| CA2673120C (fr) | 2006-12-18 | 2012-08-07 | Advanced Bionutrition Corporation | Produit alimentaire sec contenant un probiotique vivant |
| BRPI0808391A2 (pt) | 2007-02-01 | 2014-07-08 | Lams Company | Método para diminuir a inflamação e o estresse em um mamífero, mediante o uso de antimetabólitos de glicose, abacate ou extratos de abacate. |
| WO2008143782A1 (fr) * | 2007-05-18 | 2008-11-27 | Medimmune, Llc | Conservation de substances biologiquement actives par mousse lyophilisée |
| US9101691B2 (en) * | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| WO2009012601A1 (fr) | 2007-07-26 | 2009-01-29 | Sanofi Pasteur Limited | Compositions antigène-adjuvant et procédés |
| WO2009033285A1 (fr) * | 2007-09-13 | 2009-03-19 | Enwave Corporation | Appareil et procédé pour déshydrater des matières biologiques |
| US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| CN102149813B (zh) | 2008-09-12 | 2015-05-27 | 能波公司 | 利用冷冻和微波使生物材料脱水的设备和方法 |
| CA2756883C (fr) | 2009-03-27 | 2018-01-09 | Advanced Bionutrition Corp. | Vaccins microparticulaires utilisables pour proceder a une vaccination et a des rappels par voie orale ou nasale chez les animaux, dont les poissons |
| CA2763074C (fr) | 2009-05-26 | 2021-02-23 | Moti Harel | Composition de poudre seche stable comprenant des micro-organismes biologiquement actifs et/ou des materiaux bioactifs et procedes de fabrication |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| WO2011032108A2 (fr) * | 2009-09-13 | 2011-03-17 | Vu Truong-Le | Formulation pour la stabilisation à température ambiante d'un vaccin bactérien atténué vivant |
| NZ601017A (en) | 2010-01-28 | 2014-07-25 | Advanced Bionutrition Corp | Dry glassy composition comprising a bioactive material |
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1997
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- 1997-07-14 JP JP10506201A patent/JP2000515856A/ja not_active Ceased
- 1997-07-14 CA CA002260233A patent/CA2260233A1/fr not_active Abandoned
- 1997-07-14 NZ NZ333738A patent/NZ333738A/xx unknown
- 1997-07-14 CZ CZ9979A patent/CZ7999A3/cs unknown
- 1997-07-14 IL IL12797197A patent/IL127971A/en not_active IP Right Cessation
- 1997-07-14 EA EA199900268A patent/EA001138B1/ru not_active IP Right Cessation
- 1997-07-14 DE DE0914202T patent/DE914202T1/de active Pending
- 1997-07-14 WO PCT/US1997/012156 patent/WO1998002240A1/fr not_active Application Discontinuation
- 1997-07-14 KR KR10-1999-7000253A patent/KR100457748B1/ko not_active IP Right Cessation
- 1997-07-14 TR TR1999/00127T patent/TR199900127T2/xx unknown
- 1997-07-14 BR BR9711808-7A patent/BR9711808A/pt unknown
- 1997-07-14 EP EP97933415A patent/EP0914202A4/fr not_active Withdrawn
- 1997-07-14 CN CN97196422A patent/CN1116104C/zh not_active Expired - Fee Related
- 1997-07-14 AU AU36606/97A patent/AU714328B2/en not_active Ceased
- 1997-07-14 PL PL97331174A patent/PL331174A1/xx unknown
- 1997-07-14 HU HU9903917A patent/HUP9903917A3/hu not_active Application Discontinuation
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1999
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|---|---|
| CN1226842A (zh) | 1999-08-25 |
| NO990158L (no) | 1999-01-14 |
| TR199900127T2 (xx) | 1999-04-21 |
| AU714328B2 (en) | 1999-12-23 |
| BR9711808A (pt) | 2000-01-18 |
| JP2000515856A (ja) | 2000-11-28 |
| PL331174A1 (en) | 1999-06-21 |
| EA199900268A1 (ru) | 1999-10-28 |
| NO990158D0 (no) | 1999-01-14 |
| HUP9903917A2 (hu) | 2000-03-28 |
| KR100457748B1 (ko) | 2004-11-17 |
| IL127971A0 (en) | 1999-11-30 |
| EP0914202A4 (fr) | 2004-09-01 |
| HUP9903917A3 (en) | 2000-06-28 |
| NZ333738A (en) | 2000-09-29 |
| DE914202T1 (de) | 2000-02-17 |
| CN1116104C (zh) | 2003-07-30 |
| KR20000023779A (ko) | 2000-04-25 |
| EP0914202A1 (fr) | 1999-05-12 |
| CZ7999A3 (cs) | 1999-11-17 |
| CA2260233A1 (fr) | 1998-01-22 |
| EA001138B1 (ru) | 2000-10-30 |
| WO1998002240A1 (fr) | 1998-01-22 |
| AU3660697A (en) | 1998-02-09 |
| US5766520A (en) | 1998-06-16 |
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