IL127099A0 - Modified factor vii - Google Patents
Modified factor viiInfo
- Publication number
- IL127099A0 IL127099A0 IL12709997A IL12709997A IL127099A0 IL 127099 A0 IL127099 A0 IL 127099A0 IL 12709997 A IL12709997 A IL 12709997A IL 12709997 A IL12709997 A IL 12709997A IL 127099 A0 IL127099 A0 IL 127099A0
- Authority
- IL
- Israel
- Prior art keywords
- factor vii
- modified factor
- modified
- vii
- factor
- Prior art date
Links
- 229940012413 factor vii Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/660,289 US5833982A (en) | 1991-02-28 | 1996-06-07 | Modified factor VII |
| PCT/DK1997/000251 WO1997047651A1 (en) | 1996-06-07 | 1997-06-06 | Modified factor vii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL127099A0 true IL127099A0 (en) | 1999-09-22 |
Family
ID=24648892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12709997A IL127099A0 (en) | 1996-06-07 | 1997-06-06 | Modified factor vii |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5833982A (Direct) |
| EP (1) | EP0910580A1 (Direct) |
| JP (1) | JP2000513720A (Direct) |
| KR (1) | KR20000016415A (Direct) |
| CN (2) | CN1515318A (Direct) |
| AU (1) | AU735012B2 (Direct) |
| BR (1) | BR9709661A (Direct) |
| CA (1) | CA2256761A1 (Direct) |
| CZ (1) | CZ394698A3 (Direct) |
| HU (1) | HUP0003077A3 (Direct) |
| IL (1) | IL127099A0 (Direct) |
| NO (1) | NO985668L (Direct) |
| PL (1) | PL330365A1 (Direct) |
| RU (1) | RU2211704C2 (Direct) |
| UA (1) | UA68333C2 (Direct) |
| WO (1) | WO1997047651A1 (Direct) |
| ZA (1) | ZA975013B (Direct) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040087498A1 (en) * | 1991-02-28 | 2004-05-06 | Novo Nordisk Health Care Ag | Modified factor VII |
| US5997864A (en) | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
| JP2001510168A (ja) * | 1997-07-18 | 2001-07-31 | ノボ ノルディスク アクティーゼルスカブ | FVIIa媒介性細胞内シグナル伝達経路に関連する反対条件の処理のためのFVIIa又はFVIIaiの使用 |
| US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6693075B1 (en) | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US6406488B1 (en) | 1998-08-27 | 2002-06-18 | Heartstent Corporation | Healing transmyocardial implant |
| EP0987274A1 (en) | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Factor VIIa Inhibitors |
| WO2001077137A1 (en) * | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1059302A1 (en) | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitors |
| US6924359B1 (en) * | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
| EP1095933A1 (en) | 1999-10-30 | 2001-05-02 | Aventis Pharma Deutschland GmbH | Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them |
| EP1982732A3 (en) | 2000-02-11 | 2011-06-08 | Bayer HealthCare LLC | Factor VII or VIIA-like conjugates |
| US7812132B2 (en) * | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| EP1162194A1 (en) | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| WO2001097752A2 (en) * | 2000-06-20 | 2001-12-27 | The Trustees Of The University Of Pennsylvania | Compositions comprising urokinase for modulating muscle contractility and angiogenisis |
| US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
| US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| US7160540B2 (en) * | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
| JP4274522B2 (ja) | 2000-12-06 | 2009-06-10 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Xa因子阻害剤としてのグアニジンおよびアミジン誘導体 |
| US6825323B2 (en) * | 2001-01-10 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Army | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same |
| US7235638B2 (en) | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
| EP1373493B1 (en) * | 2001-03-22 | 2013-07-31 | Novo Nordisk Health Care AG | Coagulation factor vii derivative |
| WO2002087605A2 (en) * | 2001-05-02 | 2002-11-07 | Novo Nordisk A/S | Modified fvii in treatment of ards |
| EP1270551A1 (en) | 2001-06-26 | 2003-01-02 | Aventis Pharma Deutschland GmbH | Urea derivatives with antiproteolytic activity |
| WO2003022122A2 (en) * | 2001-09-10 | 2003-03-20 | Florence Medical Ltd. | Individual ffr determination for lesions of a multi-lesioned blood vessel |
| ES2466024T3 (es) | 2001-10-10 | 2014-06-09 | Ratiopharm Gmbh | Remodelación y glicoconjugación de factor de crecimiento de fibroblastos (FGF) |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| AU2002336920A1 (en) * | 2001-11-02 | 2003-05-12 | Novo Nordisk Health Care Ag | Use of tissue factor agonist or tissue factor antagonist for treatment of conditions related to apoptosis |
| EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| PL370652A1 (en) * | 2001-12-21 | 2005-05-30 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
| EP1458407A1 (en) * | 2001-12-21 | 2004-09-22 | Novo Nordisk A/S | Liquid composition of modified factor vii polypeptides |
| NZ536340A (en) * | 2002-04-30 | 2006-09-29 | Maxygen Holdings Ltd | Factor VII or VIIa polypeptide variants with N-glycosylation |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| EP1503798B8 (en) * | 2002-05-03 | 2012-03-14 | Novo Nordisk Health Care AG | Stabilised solid compositions of modified factor vii |
| DK2283856T3 (da) | 2002-06-21 | 2017-11-20 | Novo Nordisk Healthcare Ag | Stabiliserede, faste sammensætninger af Faktor VIIa-polypeptider |
| ATE505487T1 (de) * | 2002-09-30 | 2011-04-15 | Bayer Healthcare Llc | Fvii- oder fviia-varianten mit erhöhter koagulationswirkung |
| US7358268B2 (en) | 2002-12-04 | 2008-04-15 | Sanofi-Aventis Deutschland Gmbh | Imidazole derivatives as factor Xa inhibitors |
| US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
| US20040176704A1 (en) * | 2003-03-04 | 2004-09-09 | Stevens Timothy A | Collection device adapted to accept cartridge for point of care system |
| AU2004222625A1 (en) * | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides |
| ES2327044T3 (es) * | 2003-03-20 | 2009-10-23 | Bayer Healthcare Llc | Variantes de fvii o fviia. |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US20040202726A1 (en) * | 2003-04-10 | 2004-10-14 | Deshay Samuel L. | Topical blood pressure composition |
| EP1479677A1 (en) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | New indole derivatives as factor xa inhibitors |
| EP1479675A1 (en) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Indazole-derivatives as factor Xa inhibitors |
| EP1479680A1 (en) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Azaindole derivatives as Factor Xa inhibitors |
| US7317027B2 (en) | 2003-05-19 | 2008-01-08 | Sanofi-Aventis Deutschland Gmbh | Azaindole-derivatives as factor Xa inhibitors |
| US7741341B2 (en) | 2003-05-19 | 2010-06-22 | Sanofi-Aventis Deutschland Gmbh | Benzimidazole-derivatives as factor Xa inhibitors |
| US7223780B2 (en) | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
| JP5627832B2 (ja) * | 2003-05-23 | 2014-11-19 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 溶液中におけるタンパク質の安定化 |
| US7029675B1 (en) * | 2003-06-04 | 2006-04-18 | Shu-Wha Lin | Hepsin antagonist and methods of use |
| WO2004111242A1 (en) * | 2003-06-19 | 2004-12-23 | Maxygen Holdings Ltd. | FACTOR VII OR VIIa GLA DOMAIN VARIANTS |
| WO2004112828A1 (en) | 2003-06-25 | 2004-12-29 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
| ES2335994T3 (es) * | 2003-07-01 | 2010-04-07 | Novo Nordisk Health Care Ag | Composicion farmaceutica liquida, acuosa de polipeptidos factor vii. |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| ES2574581T3 (es) | 2003-08-14 | 2016-06-20 | Novo Nordisk Health Care Ag | Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| AU2004298789A1 (en) * | 2003-12-19 | 2005-06-30 | Novo Nordisk Health Care Ag | Stabilised compositions of factor VII polypeptides |
| EP1568698A1 (en) | 2004-02-27 | 2005-08-31 | Aventis Pharma Deutschland GmbH | Pyrrole-derivatives as factor Xa inhibitors |
| EP1797180A2 (en) * | 2004-09-29 | 2007-06-20 | Novo Nordisk Health Care AG | Purification of a bulk of a factor vii polypeptide by fractionated elution from an anion-exchange material |
| ES2566670T3 (es) | 2004-10-29 | 2016-04-14 | Ratiopharm Gmbh | Remodelación y glucopegilación del factor de crecimiento de fibroblastos (FGF) |
| JP4951527B2 (ja) | 2005-01-10 | 2012-06-13 | バイオジェネリックス アーゲー | 糖peg化顆粒球コロニー刺激因子 |
| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| US20080248959A1 (en) | 2006-07-21 | 2008-10-09 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
| PL2144923T3 (pl) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Sposoby leczenia z użyciem glikopegilowanego G-CSF |
| EP2170919B8 (en) | 2007-06-12 | 2016-01-20 | ratiopharm GmbH | Improved process for the production of nucleotide sugars |
| EP2626079A3 (en) | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Conjungated factor VIII molecules |
| EP2379096B1 (en) | 2008-12-19 | 2019-10-30 | Baxalta GmbH | Tfpi inhibitors and methods of use |
| US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| DK2547355T3 (en) | 2010-03-19 | 2017-03-20 | Baxalta GmbH | TFPI INHIBITORS AND METHODS OF USE |
| KR101294351B1 (ko) * | 2010-05-27 | 2013-08-07 | 동국대학교 산학협력단 | 뇌혈전 형광영상기술을 이용한 뇌졸중 동물모델의 뇌경색 영역의 크기 예측 방법 |
| PT3564260T (pt) | 2012-02-15 | 2023-01-18 | Bioverativ Therapeutics Inc | Composições de fator viii e métodos de produção e utilização das mesmas |
| EP2822577B1 (en) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| NZ724133A (en) | 2012-03-21 | 2020-07-31 | Baxalta Inc | Tfpi inhibitors and methods of use |
| TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
| KR20180034518A (ko) * | 2015-07-22 | 2018-04-04 | 아이코닉 테라퓨틱스, 인코포레이티드 | 혈관신생 및 신혈관형성 관련 장애를 치료하는 방법 |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| AU2017206445B2 (en) | 2016-01-15 | 2019-07-18 | Rigshospitalet | Quantitative pet imaging of tissue factor expression using 18F-labled active site inhibited factor VII |
| WO2018091058A1 (en) | 2016-11-17 | 2018-05-24 | Rigshospitalet | 177-lu labeled active site inhibited factor vii |
| IL308416B2 (en) | 2016-12-02 | 2025-08-01 | Bioverativ Therapeutics Inc | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| EP0218713B1 (en) * | 1985-04-22 | 1992-03-25 | Genetics Institute, Inc. | High yield production of active factor ix |
| US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
| US4829052A (en) * | 1986-06-11 | 1989-05-09 | Monsanto Company | Serine protease inhibitors |
| US5258288A (en) * | 1986-07-25 | 1993-11-02 | Genzyme Corporation | Vector containing DNA encoding mature human protein S |
| JPS63290852A (ja) | 1987-02-10 | 1988-11-28 | グラクソ、グループ、リミテッド | 化合物 |
| FR2619314B1 (fr) * | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| US4994371A (en) * | 1987-08-28 | 1991-02-19 | Davie Earl W | DNA preparation of Christmas factor and use of DNA sequences |
| US5023236A (en) * | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
| US5258180A (en) * | 1988-09-02 | 1993-11-02 | Genetech, Inc. | Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment |
| EP0391999A4 (en) * | 1988-09-23 | 1991-03-13 | Corvas, Inc. | Peptidyl inhibitors of the initiation of coagulation |
| US5120537A (en) * | 1989-06-14 | 1992-06-09 | Oklahoma Medical Research Foundation | Factor xa based anticoagulant compositions |
| US5190919A (en) * | 1989-11-13 | 1993-03-02 | Board Of Regents, The University Of Texas System | Antihemostatic factor vii peptides |
| DE69131292T2 (de) | 1990-01-29 | 1999-09-30 | Zymogenetics, Inc. | Antikoagulierende proteine |
| US5278144A (en) * | 1990-09-04 | 1994-01-11 | Cor Therapeutics, Inc. | Antithrombosis agents |
| US5817788A (en) | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| ATE273393T1 (de) * | 1991-02-28 | 2004-08-15 | Zymogenetics Inc | Modifizierter faktor-vii |
| US5861374A (en) | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
| RU2022561C1 (ru) * | 1991-03-05 | 1994-11-15 | Харьковский государственный университет им.А.М.Горького | Противоишемическое средство |
| US5326559A (en) * | 1991-05-16 | 1994-07-05 | Miller D Douglas | Treatment of accelerated atheosclerosis with interleukin-2 receptor targeted molecules |
| US5419760A (en) * | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
| GB9301093D0 (en) * | 1993-01-20 | 1993-03-10 | Rca Thomson Licensing Corp | Digital video tape recorder for digital hdtv |
| ES2169074T3 (es) * | 1993-05-21 | 2002-07-01 | Novo Nordisk Healthcare Ag | Factor vii modificado para inhibir la reestenosis vascular o el deposito de plaquetas. |
| US5648331A (en) * | 1994-08-26 | 1997-07-15 | G.D. Searle & Co. | Method of inhibiting tissue ischemia and reperfusion injury |
-
1996
- 1996-06-07 US US08/660,289 patent/US5833982A/en not_active Expired - Fee Related
-
1997
- 1997-06-06 UA UA98126442A patent/UA68333C2/uk unknown
- 1997-06-06 ZA ZA9705013A patent/ZA975013B/xx unknown
- 1997-06-06 KR KR1019980709998A patent/KR20000016415A/ko not_active Ceased
- 1997-06-06 WO PCT/DK1997/000251 patent/WO1997047651A1/en not_active Ceased
- 1997-06-06 EP EP97925917A patent/EP0910580A1/en not_active Withdrawn
- 1997-06-06 CN CNA031066089A patent/CN1515318A/zh active Pending
- 1997-06-06 PL PL97330365A patent/PL330365A1/xx unknown
- 1997-06-06 HU HU0003077A patent/HUP0003077A3/hu unknown
- 1997-06-06 RU RU99100089/14A patent/RU2211704C2/ru not_active IP Right Cessation
- 1997-06-06 IL IL12709997A patent/IL127099A0/xx unknown
- 1997-06-06 CN CN97195294A patent/CN1131872C/zh not_active Expired - Fee Related
- 1997-06-06 AU AU30906/97A patent/AU735012B2/en not_active Ceased
- 1997-06-06 CZ CZ983946A patent/CZ394698A3/cs unknown
- 1997-06-06 JP JP10501082A patent/JP2000513720A/ja not_active Ceased
- 1997-06-06 CA CA002256761A patent/CA2256761A1/en not_active Abandoned
- 1997-06-06 BR BR9709661-0A patent/BR9709661A/pt not_active IP Right Cessation
-
1998
- 1998-11-10 US US09/189,607 patent/US6168789B1/en not_active Expired - Fee Related
- 1998-12-04 NO NO985668A patent/NO985668L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL330365A1 (en) | 1999-05-10 |
| BR9709661A (pt) | 2000-04-25 |
| RU2211704C2 (ru) | 2003-09-10 |
| US5833982A (en) | 1998-11-10 |
| JP2000513720A (ja) | 2000-10-17 |
| NO985668D0 (no) | 1998-12-04 |
| CN1515318A (zh) | 2004-07-28 |
| UA68333C2 (en) | 2004-08-16 |
| EP0910580A1 (en) | 1999-04-28 |
| CN1131872C (zh) | 2003-12-24 |
| CA2256761A1 (en) | 1997-12-18 |
| AU3090697A (en) | 1998-01-07 |
| HUP0003077A2 (hu) | 2000-12-28 |
| NO985668L (no) | 1999-02-04 |
| CZ394698A3 (cs) | 1999-04-14 |
| WO1997047651A1 (en) | 1997-12-18 |
| ZA975013B (en) | 1997-12-08 |
| KR20000016415A (ko) | 2000-03-25 |
| US6168789B1 (en) | 2001-01-02 |
| CN1221427A (zh) | 1999-06-30 |
| AU735012B2 (en) | 2001-06-28 |
| HUP0003077A3 (en) | 2003-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL127099A0 (en) | Modified factor vii | |
| DK0904360T3 (en) | Alpha-amylasemutanter | |
| DE59704951D1 (en) | Plättchenförmiges titandioxidpigment | |
| PL319813A1 (en) | Modified factor vii | |
| HU9700328D0 (en) | New heteroaryl-oxazolidinones | |
| DE59711450D1 (en) | Arylalkanoylpyridazine | |
| DE69737236D1 (en) | Verstärkter plastikcontainer | |
| GB9623184D0 (en) | Special X | |
| GB9609151D0 (en) | Cremators | |
| DE59711583D1 (en) | Heterocyclyluracile | |
| GB9622084D0 (en) | Transinduction | |
| GB9623079D0 (en) | Web-fingered swim-glove | |
| KR980002178U (ko) | 배선 보호용 그로밋(gromnet) | |
| GB9600193D0 (en) | Facibo | |
| AU128195S (en) | Campervan | |
| GB9605580D0 (en) | Baby-clear | |
| GB9607167D0 (en) | Autovision | |
| GB9607489D0 (en) | Protectatot/disc-cover | |
| GB9603928D0 (en) | Airjack | |
| GB9609238D0 (en) | Foam-flock | |
| GB9610864D0 (en) | Calyculinamides | |
| GB9611301D0 (en) | Trailorlock | |
| GB9611837D0 (en) | Televisor | |
| GB9612816D0 (en) | Smokemaster | |
| GB9613187D0 (en) | Wheelwrench |