IL126969A - 2,4-diaminopyrimidine derivatives, a process for their preparation, their use for the preparation of dopamine d4 antagonist pharmaceutical compositions and their use in labeling dopamine d4 receptor - Google Patents
2,4-diaminopyrimidine derivatives, a process for their preparation, their use for the preparation of dopamine d4 antagonist pharmaceutical compositions and their use in labeling dopamine d4 receptorInfo
- Publication number
- IL126969A IL126969A IL12696997A IL12696997A IL126969A IL 126969 A IL126969 A IL 126969A IL 12696997 A IL12696997 A IL 12696997A IL 12696997 A IL12696997 A IL 12696997A IL 126969 A IL126969 A IL 126969A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- dopamine
- aryl
- hydrogen
- receptor
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 102000003962 Dopamine D4 receptors Human genes 0.000 title abstract 2
- 108090000357 Dopamine D4 receptors Proteins 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 239000005557 antagonist Substances 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 238000002372 labelling Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1
- -1 2,3-dihydro-1,4-benzodioxinyl Chemical group 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201283 | 1996-05-10 | ||
| PCT/EP1997/002506 WO1997043279A1 (fr) | 1996-05-10 | 1997-05-02 | Derives de la 2,4-diaminopyrimidine utilises comme antagonistes du recepteur d4 de la dopamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL126969A0 IL126969A0 (en) | 1999-09-22 |
| IL126969A true IL126969A (en) | 2003-01-12 |
Family
ID=8223971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12696997A IL126969A (en) | 1996-05-10 | 1997-05-02 | 2,4-diaminopyrimidine derivatives, a process for their preparation, their use for the preparation of dopamine d4 antagonist pharmaceutical compositions and their use in labeling dopamine d4 receptor |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6159982A (fr) |
| EP (1) | EP0912552B1 (fr) |
| JP (1) | JP4264135B2 (fr) |
| KR (1) | KR100462524B1 (fr) |
| CN (1) | CN1134431C (fr) |
| AT (1) | ATE264853T1 (fr) |
| CA (1) | CA2253429C (fr) |
| CZ (1) | CZ289250B6 (fr) |
| DE (1) | DE69728768T2 (fr) |
| ES (1) | ES2221052T3 (fr) |
| HU (1) | HUP9903445A3 (fr) |
| IL (1) | IL126969A (fr) |
| MY (1) | MY116114A (fr) |
| NO (1) | NO317179B1 (fr) |
| NZ (1) | NZ332308A (fr) |
| PL (1) | PL187769B1 (fr) |
| TW (1) | TW504510B (fr) |
| WO (1) | WO1997043279A1 (fr) |
| ZA (1) | ZA974050B (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265660A (zh) * | 1997-08-15 | 2000-09-06 | 辉瑞产品公司 | 2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物 |
| WO2000018763A2 (fr) * | 1998-09-29 | 2000-04-06 | Neurogen Corporation | 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles; ligands specifiques du sous-type du recepteur de dopamine |
| US6288230B1 (en) | 1998-09-29 | 2001-09-11 | Neurogen Corporation | 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
| US6284759B1 (en) | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
| US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
| GB9915616D0 (en) * | 1999-07-05 | 1999-09-01 | Knoll Ag | Therapeutic agents |
| KR100394083B1 (ko) * | 2000-12-04 | 2003-08-06 | 학교법인 성신학원 | 도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규4,5-디히드로이소옥사졸릴알킬피페라진 유도체와, 이의제조방법 |
| IL157363A0 (en) * | 2001-02-16 | 2004-02-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives and their use as dopamine d3 receptor ligands |
| EP1688412A3 (fr) * | 2001-02-16 | 2006-08-16 | Aventis Pharmaceuticals, Inc. | Nouveaux derives heterocycliques d'amides et leur utilisation comme ligands du recepteur de la dopamine D3 |
| EA005974B1 (ru) * | 2001-02-23 | 2005-08-25 | Мерк Энд Ко., Инк. | N-замещенные неарильные гетероциклические антагонисты nmda/nr2b |
| CA2489458A1 (fr) * | 2002-06-14 | 2003-12-24 | Altana Pharma Ag | Diaminopyrimidines substitues |
| EP1608652A1 (fr) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Composes pyrazolopyrimidines et leur utilisation en medecine |
| US7592360B2 (en) | 2003-06-04 | 2009-09-22 | Merck & Co., Inc. | 3-fluoro-piperidines as NMDA/NR2B antagonists |
| US7196928B2 (en) * | 2005-04-05 | 2007-03-27 | Sandisk Corporation | Compensating for coupling during read operations of non-volatile memory |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| US7855194B2 (en) * | 2006-03-27 | 2010-12-21 | Hoffmann-La Roche Inc. | Pyrimidine, quinazoline, pteridine and triazine derivatives |
| ES2389456T3 (es) | 2006-11-01 | 2012-10-26 | Purdue Pharma Lp | Compuestos de fenilpropionamida y uso de los mismos |
| JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| CA2683111A1 (fr) | 2007-04-23 | 2008-10-30 | Janssen Pharmaceutica N.V. | Derives de 4-alkoxypyridazine en tant qu'antagonistes du recepteur 2 de la dopamine a dissociation rapide |
| JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体 |
| CN102171189B (zh) | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶 |
| SG182351A1 (en) * | 2010-01-13 | 2012-08-30 | Glaxosmithkline Llc | Compounds and methods |
| CN107108601B (zh) | 2014-08-28 | 2021-08-20 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| CN106243088B (zh) | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| AU2017222964B2 (en) | 2016-02-25 | 2020-01-02 | Asceneuron S. A. | Glycosidase inhibitors |
| SG11201807012QA (en) | 2016-02-25 | 2018-09-27 | Asceneuron S A | Acid addition salts of piperazine derivatives |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| WO2017144633A1 (fr) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Inhibiteurs de glycosidases |
| WO2018226976A1 (fr) * | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Procédés et compositions d'inhibition de l'interaction de la ménine avec les protéines mll |
| WO2019037860A1 (fr) * | 2017-08-24 | 2019-02-28 | Asceneuron S.A. | Inhibiteurs linéaires de la glycosidase |
| WO2019060365A1 (fr) | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | Inhibiteurs substitués de ménine-mll et méthodes d'utilisation |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| MA53429A (fr) | 2018-08-22 | 2022-03-30 | Asceneuron Sa | Sels d'addition d'acide succinate et fumarate de dérivés de pipérazine utiles en tant qu'inhibiteurs de glycosidase |
| US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
| WO2020039029A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Composés spiro utilisés en tant qu'inhibiteurs de glycosidases |
| TWI716107B (zh) * | 2018-09-26 | 2021-01-11 | 美商美國禮來大藥廠 | 6-氟-2-甲基苯并[d]噻唑-5-基化合物 |
| WO2021178485A1 (fr) * | 2020-03-06 | 2021-09-10 | National Health Research Institutes | Composés de pyrimidine et leurs utilisations pharmaceutiques |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| GB9216298D0 (en) * | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
| SI9300097B (en) * | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
-
1997
- 1997-05-01 TW TW086105766A patent/TW504510B/zh active
- 1997-05-02 EP EP97923914A patent/EP0912552B1/fr not_active Expired - Lifetime
- 1997-05-02 HU HU9903445A patent/HUP9903445A3/hu unknown
- 1997-05-02 KR KR10-1998-0707915A patent/KR100462524B1/ko not_active Expired - Fee Related
- 1997-05-02 AT AT97923914T patent/ATE264853T1/de not_active IP Right Cessation
- 1997-05-02 PL PL97329850A patent/PL187769B1/pl not_active IP Right Cessation
- 1997-05-02 US US09/180,364 patent/US6159982A/en not_active Expired - Lifetime
- 1997-05-02 IL IL12696997A patent/IL126969A/xx not_active IP Right Cessation
- 1997-05-02 WO PCT/EP1997/002506 patent/WO1997043279A1/fr not_active Ceased
- 1997-05-02 DE DE69728768T patent/DE69728768T2/de not_active Expired - Lifetime
- 1997-05-02 CN CNB971945160A patent/CN1134431C/zh not_active Expired - Lifetime
- 1997-05-02 CA CA002253429A patent/CA2253429C/fr not_active Expired - Fee Related
- 1997-05-02 JP JP54053697A patent/JP4264135B2/ja not_active Expired - Lifetime
- 1997-05-02 ES ES97923914T patent/ES2221052T3/es not_active Expired - Lifetime
- 1997-05-02 NZ NZ332308A patent/NZ332308A/xx unknown
- 1997-05-02 CZ CZ19983627A patent/CZ289250B6/cs not_active IP Right Cessation
- 1997-05-07 MY MYPI97002019A patent/MY116114A/en unknown
- 1997-05-09 ZA ZA974050A patent/ZA974050B/xx unknown
-
1998
- 1998-11-09 NO NO19985228A patent/NO317179B1/no unknown
-
2000
- 2000-09-22 US US09/667,458 patent/US6395742B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CZ362798A3 (cs) | 1999-02-17 |
| NO985228L (no) | 1999-01-11 |
| AU708344B2 (en) | 1999-08-05 |
| CZ289250B6 (cs) | 2001-12-12 |
| DE69728768D1 (de) | 2004-05-27 |
| PL187769B1 (pl) | 2004-10-29 |
| CN1218466A (zh) | 1999-06-02 |
| TW504510B (en) | 2002-10-01 |
| DE69728768T2 (de) | 2005-04-28 |
| NZ332308A (en) | 1999-08-30 |
| CA2253429A1 (fr) | 1997-11-20 |
| CA2253429C (fr) | 2006-08-08 |
| ATE264853T1 (de) | 2004-05-15 |
| EP0912552A1 (fr) | 1999-05-06 |
| NO985228D0 (no) | 1998-11-09 |
| MY116114A (en) | 2003-11-28 |
| KR100462524B1 (ko) | 2005-06-13 |
| WO1997043279A1 (fr) | 1997-11-20 |
| US6159982A (en) | 2000-12-12 |
| HUP9903445A3 (en) | 2002-01-28 |
| CN1134431C (zh) | 2004-01-14 |
| JP4264135B2 (ja) | 2009-05-13 |
| EP0912552B1 (fr) | 2004-04-21 |
| US6395742B1 (en) | 2002-05-28 |
| HUP9903445A2 (hu) | 2000-05-28 |
| PL329850A1 (en) | 1999-04-12 |
| ZA974050B (en) | 1998-11-09 |
| IL126969A0 (en) | 1999-09-22 |
| JP2000512623A (ja) | 2000-09-26 |
| AU2956197A (en) | 1997-12-05 |
| KR20000005228A (ko) | 2000-01-25 |
| ES2221052T3 (es) | 2004-12-16 |
| NO317179B1 (no) | 2004-09-06 |
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