IL126891A0 - Reparation and prevention of fibrotic lesions - Google Patents
Reparation and prevention of fibrotic lesionsInfo
- Publication number
- IL126891A0 IL126891A0 IL12689197A IL12689197A IL126891A0 IL 126891 A0 IL126891 A0 IL 126891A0 IL 12689197 A IL12689197 A IL 12689197A IL 12689197 A IL12689197 A IL 12689197A IL 126891 A0 IL126891 A0 IL 126891A0
- Authority
- IL
- Israel
- Prior art keywords
- reparation
- prevention
- fibrotic lesions
- fibrotic
- lesions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/647,006 US5716632A (en) | 1989-11-22 | 1996-05-09 | Compositions and methods for reparation and prevention of fibrotic lesions |
PCT/US1997/007468 WO1997041830A1 (en) | 1996-05-09 | 1997-05-03 | Reparation and prevention of fibrotic lesions |
Publications (1)
Publication Number | Publication Date |
---|---|
IL126891A0 true IL126891A0 (en) | 1999-09-22 |
Family
ID=24595333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12689197A IL126891A0 (en) | 1996-05-09 | 1997-05-03 | Reparation and prevention of fibrotic lesions |
Country Status (11)
Country | Link |
---|---|
US (1) | US5716632A (xx) |
EP (1) | EP0902680A4 (xx) |
JP (1) | JP2000510467A (xx) |
KR (1) | KR20000010676A (xx) |
AU (1) | AU725637B2 (xx) |
CA (1) | CA2253919A1 (xx) |
IL (1) | IL126891A0 (xx) |
NO (1) | NO985197L (xx) |
TR (1) | TR199802273T2 (xx) |
WO (1) | WO1997041830A1 (xx) |
ZA (1) | ZA974041B (xx) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962478A (en) * | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
DE69917248T2 (de) * | 1998-03-17 | 2005-05-04 | Margolin, Solomon B., Dallas | Topische antiseptische zusammensetzungen und verfahren |
DE69810518D1 (de) * | 1998-09-18 | 2003-02-06 | Mepha Ag Aesch | Topisch verabreichbare alkyl-, phenyl-pyridone-arzneimittel |
DE60029246D1 (de) * | 2000-01-24 | 2006-08-17 | Solomon B Margolin | Behandlung von brustkarzinomen, astrozytomen, melanomen und verwandten tumoren |
DE10053870A1 (de) * | 2000-10-31 | 2002-05-08 | Burchardt Elmar Reinhold | Procollagen (III)-Propeptide und verwandte Substanzen zur Behandlung von fibrotischen Erkrankungen |
WO2002060446A1 (en) | 2001-01-29 | 2002-08-08 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
JP2006502152A (ja) * | 2002-08-28 | 2006-01-19 | インターミューン インコーポレイテッド | 線維性疾患治療用の併用療法 |
TW200418516A (en) * | 2003-02-21 | 2004-10-01 | Shionogi & Co | Droplet dispersed ointment |
US20070072181A1 (en) * | 2003-02-28 | 2007-03-29 | Blatt Lawrence M | Combination therapy for treating alphavirus infection and liver fibrosis |
US20070092488A1 (en) * | 2003-05-16 | 2007-04-26 | Intermune Inc. | Methods of treating idiopathic pulmonary fibrosis |
WO2005016241A2 (en) | 2003-05-16 | 2005-02-24 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
WO2005037214A2 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
WO2005040758A2 (en) * | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
AU2003284808B2 (en) * | 2003-11-14 | 2009-01-22 | Catalyst Biosciences, Inc. | The derivatives of pyridone and the use of them |
JP2008513356A (ja) * | 2004-08-09 | 2008-05-01 | アリオス バイオファーマ インク. | 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法 |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
CN1846699A (zh) * | 2005-04-13 | 2006-10-18 | 中南大学湘雅医院 | 1-(取代苯基)-5-甲基-2-(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用 |
DK1928454T3 (da) * | 2005-05-10 | 2014-11-03 | Intermune Inc | Pyridonderivater til modulering af stress-aktiveret proteinkinasesystem |
JP5249028B2 (ja) | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新規大環状阻害剤 |
NZ591443A (en) * | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
AU2006303955A1 (en) * | 2005-10-11 | 2007-04-26 | Intermune, Inc. | Inhibitors of viral replication |
DE602006019323D1 (de) | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
AR061222A1 (es) * | 2006-06-05 | 2008-08-13 | Xenon Pharmaceuticals Inc | Derivados de 2-oxo-piridina, 2-oxo-quinolina y 2-oxo-isoquinolina, composiciones farmaceuticas que los comprenden y el uso de los mismos en medicamentos para tratar enfermedades mediadas por la scd. |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
JP2010518125A (ja) * | 2007-02-12 | 2010-05-27 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新規な阻害剤 |
WO2008131586A1 (en) * | 2007-04-27 | 2008-11-06 | Dieretech Investment Limited | Uses of 5-methyl-1-(substituted phenyl)-2(1h)-pyridones as anti-inflammatory and tnf-alpha-blocking agents |
CA2686138A1 (en) | 2007-05-03 | 2008-11-13 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
AR066528A1 (es) * | 2007-05-10 | 2009-08-26 | Array Biopharma Inc | Peptidos inhibidores de la replicacion del virus de la hepatitis c |
MX2007009796A (es) * | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
US9029385B2 (en) * | 2007-10-26 | 2015-05-12 | Ganesh Raghu | Compositions and methods for treating fibroproliferative disorders |
WO2009111785A2 (en) * | 2008-03-07 | 2009-09-11 | Solanan, Inc. | Treatment of sepsis with 5-ethyl-1-phenyl-2(1h)-pyridone and novel methods for synthesis |
EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
JP2012505897A (ja) | 2008-10-15 | 2012-03-08 | インターミューン・インコーポレーテッド | 治療用抗ウイルス性ペプチド |
US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
US7566729B1 (en) | 2008-11-10 | 2009-07-28 | Intermune, Inc. | Modifying pirfenidone treatment for patients with atypical liver function |
AU2010206543A1 (en) * | 2009-01-26 | 2011-07-07 | Intermune, Inc. | Methods for treating acute myocardial infarctions and associated disorders |
CN102149682B (zh) | 2009-05-25 | 2012-12-05 | 中南大学 | 1-(取代芳基)-5-三氟甲基-2-(1h)吡啶酮化合物及其盐的制备方法及其用途 |
WO2010135976A1 (zh) | 2009-05-25 | 2010-12-02 | 中南大学 | 1-(取代苄基)-5-三氟甲基-2-(1h)吡啶酮化合物及其盐,其制备方法及其用途 |
EA201290128A1 (ru) | 2009-09-28 | 2013-01-30 | Интермьюн, Инк. | Новые макроциклические ингибиторы репликации вируса гепатита с |
JP2013509869A (ja) | 2009-11-05 | 2013-03-21 | ノバルティス アーゲー | 線維症の進行の予測用バイオマーカー |
US7816383B1 (en) | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
US8084475B2 (en) * | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
AU2012212269B2 (en) | 2011-01-31 | 2016-05-19 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
WO2012107831A1 (en) | 2011-02-11 | 2012-08-16 | Signa S.A. De C.V. | Method of making a pyridone compound, 5-ethyl-1-phenyl-2-(1h)-pyridone, and intermediates thereof |
CA2819967C (en) | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
WO2015106150A1 (en) | 2014-01-10 | 2015-07-16 | Genoa Pharmaceuticals Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
CA3060514A1 (en) * | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
CN114716365B (zh) * | 2022-01-04 | 2024-03-01 | 大连理工大学 | 一类n-取代苯基-2-吡啶酮化合物或其可药用盐在治疗肺纤维化中的应用 |
CN114805333A (zh) * | 2022-05-09 | 2022-07-29 | 大连理工大学 | 一种主链含噁嗪和Cardo结构的双马来酰亚胺及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
JPH02215719A (ja) * | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
US5518729A (en) * | 1989-11-22 | 1996-05-21 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
US5310562A (en) * | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
DE69431433T2 (de) * | 1993-05-07 | 2003-12-04 | Solomon B Margolin | Zusammensetzungen und verfahren zur reparatur und vorbeugung fibrotischer verletzungen |
US5789426A (en) * | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
BR9607541A (pt) * | 1995-03-03 | 1997-12-23 | Solomon Begelfor Margolin | Tratamento de doenças que tem por causa o fator de crescimento da citoquina |
ATE360419T1 (de) * | 1995-09-19 | 2007-05-15 | Solomon B Margolin | Verwendung von n-substituierten pyridonen als tumornekrose-faktor alpha hemmer |
-
1996
- 1996-05-09 US US08/647,006 patent/US5716632A/en not_active Expired - Lifetime
-
1997
- 1997-05-03 AU AU27519/97A patent/AU725637B2/en not_active Ceased
- 1997-05-03 IL IL12689197A patent/IL126891A0/xx unknown
- 1997-05-03 KR KR1019980708678A patent/KR20000010676A/ko not_active Application Discontinuation
- 1997-05-03 EP EP97921495A patent/EP0902680A4/en not_active Withdrawn
- 1997-05-03 JP JP09540064A patent/JP2000510467A/ja active Pending
- 1997-05-03 WO PCT/US1997/007468 patent/WO1997041830A1/en not_active Application Discontinuation
- 1997-05-03 CA CA002253919A patent/CA2253919A1/en not_active Abandoned
- 1997-05-03 TR TR1998/02273T patent/TR199802273T2/xx unknown
- 1997-05-09 ZA ZA974041A patent/ZA974041B/xx unknown
-
1998
- 1998-11-06 NO NO985197A patent/NO985197L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO985197D0 (no) | 1998-11-06 |
NO985197L (no) | 1998-11-06 |
JP2000510467A (ja) | 2000-08-15 |
EP0902680A4 (en) | 2000-04-19 |
CA2253919A1 (en) | 1997-11-13 |
WO1997041830A1 (en) | 1997-11-13 |
US5716632A (en) | 1998-02-10 |
AU2751997A (en) | 1997-11-26 |
KR20000010676A (ko) | 2000-02-25 |
EP0902680A1 (en) | 1999-03-24 |
TR199802273T2 (xx) | 2000-11-21 |
AU725637B2 (en) | 2000-10-19 |
ZA974041B (en) | 1998-11-09 |
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