IL126418A0 - Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same - Google Patents

Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same

Info

Publication number
IL126418A0
IL126418A0 IL12641897A IL12641897A IL126418A0 IL 126418 A0 IL126418 A0 IL 126418A0 IL 12641897 A IL12641897 A IL 12641897A IL 12641897 A IL12641897 A IL 12641897A IL 126418 A0 IL126418 A0 IL 126418A0
Authority
IL
Israel
Prior art keywords
modulating
hormone
pharmaceutical compositions
same
exogenous genes
Prior art date
Application number
IL12641897A
Other languages
English (en)
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of IL126418A0 publication Critical patent/IL126418A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/75—Vector systems having a special element relevant for transcription from invertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12641897A 1996-04-05 1997-03-27 Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same IL126418A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62883096A 1996-04-05 1996-04-05
PCT/US1997/005330 WO1997038117A1 (en) 1996-04-05 1997-03-27 Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto

Publications (1)

Publication Number Publication Date
IL126418A0 true IL126418A0 (en) 1999-05-09

Family

ID=24520484

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12641897A IL126418A0 (en) 1996-04-05 1997-03-27 Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same

Country Status (7)

Country Link
EP (1) EP0910652B1 (de)
JP (1) JP2000508895A (de)
CN (1) CN1215432A (de)
AU (1) AU734051B2 (de)
CA (1) CA2251466A1 (de)
IL (1) IL126418A0 (de)
WO (1) WO1997038117A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2232712A1 (en) 1995-10-10 1997-04-17 Lyle Dean Crossland Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation
AUPP135698A0 (en) * 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6342596B1 (en) 1998-05-05 2002-01-29 Hsf Pharmaceuticals S.A. Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) * 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
FR2782732A1 (fr) * 1998-08-28 2000-03-03 Transgene Sa Systeme d'expression inductible
US6117639A (en) * 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
AU3642601A (en) * 1999-11-05 2001-05-30 Avigen, Inc. Ecdysone-inducible adeno-associated virus expression vectors
EP1478750B1 (de) * 1999-11-23 2012-08-08 Mayo Foundation For Medical Education And Research Genexpression durch positive rückkopplungsaktivierung eines zelltypspezifischen promotors
AU2001241682A1 (en) * 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
CN1304578C (zh) 2000-03-22 2007-03-14 罗姆和哈斯公司 新的基于蜕皮激素受体的可诱导的基因表达系统
US7514239B2 (en) 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
WO2002000724A2 (en) 2000-06-28 2002-01-03 Amgen, Inc. Thymic stromal lymphopoietin receptor molecules and uses thereof
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
WO2002061102A2 (en) 2000-10-24 2002-08-08 Syngenta Participations Ag Control of gene expression in plants
AU2002247184B2 (en) 2001-02-20 2008-06-19 Intrexon Corporation Novel ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system
EP1534738B1 (de) 2001-02-20 2012-06-20 Intrexon Corporation Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionsystem auf grundlage eines nukleären rezeptors
ES2424812T3 (es) 2001-02-20 2013-10-08 Intrexon Corporation Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso
EP1373470B1 (de) 2001-02-20 2013-04-24 Intrexon Corporation Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors
CA2344208A1 (en) 2001-04-30 2002-10-30 Oxford Biomedica (Uk) Limited Method
US7919269B2 (en) 2001-09-26 2011-04-05 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7563879B2 (en) 2001-09-26 2009-07-21 Intrexon Corporation Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7662924B2 (en) 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
WO2003072744A2 (en) * 2002-02-25 2003-09-04 University Of Rochester Dna construct for inducible expression of angiogenic protein and use thereof
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20050164210A1 (en) * 2004-01-23 2005-07-28 Vivek Mittal Regulated polymerase III expression systems and related methods
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CN101016518B (zh) * 2006-09-12 2010-07-28 南方医科大学 一种生物杀虫剂筛选模型及其制备方法和应用
MX2009012834A (es) 2007-05-29 2010-05-17 Intrexon Corp Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona.
WO2009008837A1 (en) * 2007-07-06 2009-01-15 Temasek Life Sciences Laboratory Limited Lexa-based chemical-inducible gene expression system for use in transgenic animals
CN101848990B (zh) 2007-09-17 2013-07-31 罗门哈斯公司 改变植物生理学反应的组合物和方法
WO2009045370A2 (en) * 2007-09-28 2009-04-09 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
WO2009114201A2 (en) 2008-03-14 2009-09-17 Intrexon Corporation Steroidal ligands and their use in gene switch modulation
ES2337973B8 (es) 2008-05-16 2011-07-21 Proyecto De Biomedicina Cima, S.L. Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad.
ES2330826B1 (es) 2008-06-04 2010-07-26 Proyecto De Biomedicina Cima, S.L. Sistema para empaquetamiento de adenovirus de alta capacidad.
US9212373B2 (en) 2009-03-05 2015-12-15 Agrofresh Inc. Control of targeted turnover of key ethylene hormone signaling pathway proteins to modulate ethylene sensitivity in plants
JP5733705B2 (ja) * 2009-03-30 2015-06-10 国立大学法人 岡山大学 特異的プロモーターの活性を上昇させるシステム及び該システムを保持したベクター
EP2407534A1 (de) 2010-07-14 2012-01-18 Neo Virnatech, S.L. Verfahren und Reagenzien zum Erhalt von transkriptionell aktiven virusähnlichen Artikeln und rekombinante Virionen
DK3091085T3 (da) 2010-10-06 2019-05-06 Inst Catalana Recerca Estudis Avancats Fremgangsmåde til at designe en terapi mod brystcancermetastase
HK1202773A1 (en) * 2012-03-27 2015-10-09 Trans Genic Inc. Humanized mouse
EP2650682A1 (de) 2012-04-09 2013-10-16 Fundació Privada Institut de Recerca Biomèdica Asymmetrische Ester von als Schmiermittel geeigneten Fettsäuren
BR112014030750A2 (pt) 2012-06-06 2017-08-22 Inst Catalana Recerca Estudis Avancats Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar
EP2687852A1 (de) 2012-07-17 2014-01-22 Laboratorios Del. Dr. Esteve, S.A. Verfahren zur Diagnose und Behandlung des chronischen Erschöpfungssyndroms
ES2906586T3 (es) 2012-10-12 2022-04-19 Inbiomotion Sl Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata
WO2014140896A2 (es) 2013-03-15 2014-09-18 Fundacio Privada Institut De Recerca Biomedica Metodo para el diagnostico, pronostico y tratamiento de la metastasis de un cancer
WO2014184679A2 (en) 2013-03-15 2014-11-20 Inbiomotion S.L. Method for the prognosis and treatment of renal cell carcinoma metastasis
CN105283439B (zh) 2013-03-15 2018-02-02 英特瑞克斯顿股份有限公司 含硼的二酰基肼类化合物
KR20150122731A (ko) 2013-03-15 2015-11-02 펀다시오 인스티튜트 드 르세르카 바이오메디카 (아이알비 바르셀로나) 암 전이의 예후 및 치료 방법
ES2523016B1 (es) 2013-05-20 2015-09-09 3P Biopharmaceuticals Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes
AU2014333513B2 (en) 2013-10-09 2020-11-26 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Method for the prognosis and treatment of metastasizing cancer of the bone originating from breast cancer
WO2015101666A1 (en) 2014-01-03 2015-07-09 Fundación Biofísica Bizkaia VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF
WO2016044390A1 (en) 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds
GB201619876D0 (en) 2016-11-24 2017-01-11 Cambridge Entpr Ltd Controllable transcription
CA3049652A1 (en) 2017-01-10 2018-07-19 Intrexon Corporation Modulating expression of polypeptides via new gene switch expression systems
AU2018281316B2 (en) 2017-06-07 2024-05-30 Precigen, Inc. Expression of novel cell tags
US12404306B2 (en) 2018-03-06 2025-09-02 Precigen, Inc. Human papillomavirus vaccines and uses of the same
IL277128B2 (en) 2018-03-06 2025-11-01 Precigen Inc Hepatitis b vaccines and uses of the same
EP3820484A4 (de) 2018-07-10 2022-05-04 Precigen, Inc. Ror-1-spezifische chimäre antigenrezeptoren und verwendungen davon
KR20210031898A (ko) 2018-07-13 2021-03-23 난징 레전드 바이오테크 씨오., 엘티디. 전염병을 치료하기 위한 공동수용체 시스템
JP7810554B2 (ja) 2019-03-01 2026-02-03 アケロイス バイオファーマ， インコーポレイテッド 抗原特異的免疫細胞におけるｃｄ１６０機能をモジュレートする方法およびその使用
EP4371569A1 (de) 2022-11-16 2024-05-22 Universidad del País Vasco/Euskal Herriko Unibertsitatea Vlps gegen akute myeloische leukämie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492137B1 (en) * 1989-11-16 2002-12-10 The Salk Institute For Biological Studies Response element compositions and assays employing same
EP0517805B1 (de) * 1990-02-26 2002-07-10 The Board Of Trustees Of The Leland Stanford Junior University Identifizierung und expression von insekten-steroidrezeptor-dns-sequenzen
ATE173295T1 (de) * 1991-08-08 1998-11-15 Genentech Inc Ecdysteroid-abhängige gen regulierung in säugetier-zellen
WO1994001558A2 (en) * 1992-07-02 1994-01-20 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor

Also Published As

Publication number Publication date
CA2251466A1 (en) 1997-10-16
CN1215432A (zh) 1999-04-28
JP2000508895A (ja) 2000-07-18
EP0910652A1 (de) 1999-04-28
EP0910652B1 (de) 2014-10-08
AU2557297A (en) 1997-10-29
AU734051B2 (en) 2001-05-31
WO1997038117A1 (en) 1997-10-16

Similar Documents

Publication Publication Date Title
HUP9801207A3 (en) Therapeutic compositions for transfecting nucleic acids and use thereof
IL136454A0 (en) Compositions and methods for inducing gene expression
HUP0000969A3 (en) Heterocyclic esters and amides, their use and pharmaceutical compositions containing them
AU7678196A (en) Methods and compositions for the delivery of monomeric proteins
AU7275098A (en) Enhanced adenovirus-assisted transfection composition and method
IL135800A0 (en) Methods and pharmaceutical compositions for the closure of retinal breaks
HUP0003761A3 (en) Substituted alkanohydroxamic acids and pharmaceutical compositions containing them
HUP0000808A3 (en) Pharmaceutical composition of fenofibrate and method for preparing same
AU2557297A (en) Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
GB9615089D0 (en) Esters and compositions comprising them
HUP9900424A2 (hu) Tiazolil-benzfurán-származékok és a vegyületeket tartalmazó gyógyászati készítmények
AU5856898A (en) Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them
AU2259897A (en) Methods and compositions for the simultaneous control of rootdiseases
AU1390199A (en) Compositions and methods for inhibiting the activity of certain genes
AU3461095A (en) Compositions and methods for delivery of polypeptides
AU6819194A (en) Isolated dna elements that direct pistil-specific and anther-specific gene expression and methods of using same
IL115885A0 (en) Pharmaceutical compositions comprising carbazoles and cyclodextrins
AU6994298A (en) Method for discharge of liquid and liquid discharge head
ZA979295B (en) Methods and compositions for delivery and expression of interferon-Ó nucleic acids.
ZA963397B (en) Esters and pharmaceutical compositions
ZA9710934B (en) Compositions and methods for administering pneumococal dna
AU4895297A (en) Methods and compositions for enhancing the expression of genes in plants
AU753190C (en) Method for discharge of liquid and liquid discharge head
AUPO982097A0 (en) Methods and compositions for use therein
AU9247698A (en) Method for the identification of essential genes and therapeutic targets