IL126418A0 - Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same - Google Patents
Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the sameInfo
- Publication number
- IL126418A0 IL126418A0 IL12641897A IL12641897A IL126418A0 IL 126418 A0 IL126418 A0 IL 126418A0 IL 12641897 A IL12641897 A IL 12641897A IL 12641897 A IL12641897 A IL 12641897A IL 126418 A0 IL126418 A0 IL 126418A0
- Authority
- IL
- Israel
- Prior art keywords
- modulating
- hormone
- pharmaceutical compositions
- same
- exogenous genes
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/75—Vector systems having a special element relevant for transcription from invertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62883096A | 1996-04-05 | 1996-04-05 | |
| PCT/US1997/005330 WO1997038117A1 (en) | 1996-04-05 | 1997-03-27 | Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL126418A0 true IL126418A0 (en) | 1999-05-09 |
Family
ID=24520484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12641897A IL126418A0 (en) | 1996-04-05 | 1997-03-27 | Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0910652B1 (de) |
| JP (1) | JP2000508895A (de) |
| CN (1) | CN1215432A (de) |
| AU (1) | AU734051B2 (de) |
| CA (1) | CA2251466A1 (de) |
| IL (1) | IL126418A0 (de) |
| WO (1) | WO1997038117A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900029A3 (en) | 1995-10-10 | 2001-02-28 | Novartis Ag | Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation |
| AUPP135698A0 (en) | 1998-01-15 | 1998-02-05 | Commonwealth Scientific And Industrial Research Organisation | Insectical modalities |
| US6342596B1 (en) | 1998-05-05 | 2002-01-29 | Hsf Pharmaceuticals S.A. | Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress |
| US6333318B1 (en) | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
| US6258603B1 (en) * | 1998-06-17 | 2001-07-10 | Rohm And Haas Company | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| FR2782732A1 (fr) * | 1998-08-28 | 2000-03-03 | Transgene Sa | Systeme d'expression inductible |
| US6117639A (en) | 1998-08-31 | 2000-09-12 | Vertex Pharmaceuticals Incorporated | Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity |
| WO2001036623A2 (en) * | 1999-11-05 | 2001-05-25 | Avigen, Inc. | Ecdysone-inducible adeno-associated virus expression vectors |
| AU2046801A (en) * | 1999-11-23 | 2001-06-04 | Mayo Foundation For Medical Education And Research | Gene expression by positive feedback activation of a cell type-specific promoter |
| AU2001241682A1 (en) * | 2000-02-24 | 2001-09-03 | The Salk Institute For Biological Studies | Gene expression system based on chimeric receptors |
| US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
| JP5031967B2 (ja) * | 2000-03-22 | 2012-09-26 | イントレキソン コーポレーション | 新規エクジソン受容体ベースの誘導性遺伝子発現系 |
| US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
| ES2317917T3 (es) | 2000-06-28 | 2009-05-01 | Amgen Inc. | Moleculas de receptor de linfopoyetina estromal timica y sus usos de las mismas. |
| US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
| CA2426818A1 (en) | 2000-10-24 | 2002-08-08 | Syngenta Participations Ag | Control of gene expression in plants |
| WO2002066613A2 (en) | 2001-02-20 | 2002-08-29 | Rheogene Holdings, Inc | Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system |
| ES2424812T3 (es) | 2001-02-20 | 2013-10-08 | Intrexon Corporation | Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso |
| EP1373470B1 (de) | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors |
| CA2438133C (en) | 2001-02-20 | 2015-01-27 | Rheogene, Inc. | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| CA2344208A1 (en) | 2001-04-30 | 2002-10-30 | Oxford Biomedica (Uk) Limited | Method |
| WO2003027289A1 (en) | 2001-09-26 | 2003-04-03 | Rheo Gene Holdings, Inc. | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| CA2459807C (en) | 2001-09-26 | 2013-09-03 | Jianzhong Zhang | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| US7662924B2 (en) | 2002-02-22 | 2010-02-16 | The Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
| WO2003072744A2 (en) * | 2002-02-25 | 2003-09-04 | University Of Rochester | Dna construct for inducible expression of angiogenic protein and use thereof |
| US7375093B2 (en) | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| CN101016518B (zh) * | 2006-09-12 | 2010-07-28 | 南方医科大学 | 一种生物杀虫剂筛选模型及其制备方法和应用 |
| CN104761466A (zh) | 2007-05-29 | 2015-07-08 | 英特拉克森公司 | 通过蜕皮素受体复合物调节外源性基因表达的手性二酰基肼配体 |
| US8852928B2 (en) | 2007-07-06 | 2014-10-07 | Temasek Life Sciences Laboratory Limited | LexA-based chemical-inducible gene expression system for use in transgenic animals |
| BRPI0817009A2 (pt) | 2007-09-17 | 2014-10-07 | Rohm & Haas | Sistema de expressão de gene para a expressão controlável de resposta ao etileno em uma célula de planta, composição, e, métodos para produzir uma planta transgênica, e para modular sensibilidade ao etileno em uma planta. |
| KR101666228B1 (ko) * | 2007-09-28 | 2016-10-13 | 인트렉손 코포레이션 | 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도 |
| EP2265116A4 (de) | 2008-03-14 | 2013-02-06 | Intrexon Corp | Steroid-liganden und ihre verwendung bei der gene-switch-modulation |
| ES2337973B8 (es) | 2008-05-16 | 2011-07-21 | Proyecto De Biomedicina Cima, S.L. | Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad. |
| ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
| MX2011009239A (es) | 2009-03-05 | 2011-09-15 | Rohm & Haas | Control de rotacion apuntada de proteina de ruta de señalizacion de hormona de etileno clave para modular la sensibilidad a etileno en plantas. |
| JP5733705B2 (ja) * | 2009-03-30 | 2015-06-10 | 国立大学法人 岡山大学 | 特異的プロモーターの活性を上昇させるシステム及び該システムを保持したベクター |
| EP2407534A1 (de) | 2010-07-14 | 2012-01-18 | Neo Virnatech, S.L. | Verfahren und Reagenzien zum Erhalt von transkriptionell aktiven virusähnlichen Artikeln und rekombinante Virionen |
| CN108192972B (zh) | 2010-10-06 | 2022-09-09 | 生物医学研究机构基金会 | 用于乳腺癌转移的诊断、预后和治疗的方法 |
| CN104378975A (zh) * | 2012-03-27 | 2015-02-25 | 转基因股份有限公司 | 人源化小鼠 |
| EP2650682A1 (de) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Asymmetrische Ester von als Schmiermittel geeigneten Fettsäuren |
| BR112014030750A2 (pt) | 2012-06-06 | 2017-08-22 | Inst Catalana Recerca Estudis Avancats | Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar |
| EP2687852A1 (de) | 2012-07-17 | 2014-01-22 | Laboratorios Del. Dr. Esteve, S.A. | Verfahren zur Diagnose und Behandlung des chronischen Erschöpfungssyndroms |
| ES2906586T3 (es) | 2012-10-12 | 2022-04-19 | Inbiomotion Sl | Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata |
| WO2014184679A2 (en) | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
| CA2906394A1 (en) | 2013-03-15 | 2014-09-18 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| ES2683329T3 (es) | 2013-03-15 | 2018-09-26 | Intrexon Corporation | Diacilhidrazinas que contienen boro |
| US20160040247A1 (en) | 2013-03-15 | 2016-02-11 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Method for the diagnosis, prognosis, and tratment of cancer metastasis |
| ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
| DK3055429T3 (en) | 2013-10-09 | 2019-04-23 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Procedure for the prognosis and treatment of metastatic bone cancer resulting from breast cancer |
| WO2015101666A1 (en) | 2014-01-03 | 2015-07-09 | Fundación Biofísica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
| WO2016044390A1 (en) | 2014-09-17 | 2016-03-24 | Intrexon Corporation | Boron-containing diacylhydrazine compounds |
| GB201619876D0 (en) | 2016-11-24 | 2017-01-11 | Cambridge Entpr Ltd | Controllable transcription |
| KR20190102259A (ko) | 2017-01-10 | 2019-09-03 | 인트렉손 코포레이션 | 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절 |
| EP3635132A4 (de) | 2017-06-07 | 2021-05-26 | Intrexon Corporation | Expression von neuartigen zellmarkern |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| WO2019173465A1 (en) | 2018-03-06 | 2019-09-12 | Intrexon Corporation | Human papillomavirus vaccines and uses of the same |
| EP3820484A4 (de) | 2018-07-10 | 2022-05-04 | Precigen, Inc. | Ror-1-spezifische chimäre antigenrezeptoren und verwendungen davon |
| US20210275589A1 (en) | 2018-07-13 | 2021-09-09 | Nanjing Legend Biotech Co. Ltd. | Co-receptor systems for treating infectious diseases |
| US20220152098A1 (en) | 2019-03-01 | 2022-05-19 | Achelois Biopharma, Inc. | Methods of modulating cd160 function in the antigen-specific immune cell and uses thereof |
| EP4371569A1 (de) | 2022-11-16 | 2024-05-22 | Universidad del País Vasco/Euskal Herriko Unibertsitatea | Vlps gegen akute myeloische leukämie |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492137B1 (en) * | 1989-11-16 | 2002-12-10 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
| DE69133064T2 (de) * | 1990-02-26 | 2003-03-06 | The Board Of Trustees Of The Leland Stanford Junior University, Stanford | Identifizierung und expression von insekten-steroidrezeptor-dns-sequenzen |
| ATE173295T1 (de) * | 1991-08-08 | 1998-11-15 | Genentech Inc | Ecdysteroid-abhängige gen regulierung in säugetier-zellen |
| WO1994001558A2 (en) * | 1992-07-02 | 1994-01-20 | The Salk Institute For Biological Studies | Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor |
-
1997
- 1997-03-27 AU AU25572/97A patent/AU734051B2/en not_active Ceased
- 1997-03-27 JP JP9536281A patent/JP2000508895A/ja active Pending
- 1997-03-27 CA CA002251466A patent/CA2251466A1/en not_active Abandoned
- 1997-03-27 IL IL12641897A patent/IL126418A0/xx unknown
- 1997-03-27 WO PCT/US1997/005330 patent/WO1997038117A1/en not_active Ceased
- 1997-03-27 CN CN97193597.1A patent/CN1215432A/zh active Pending
- 1997-03-27 EP EP97917146.9A patent/EP0910652B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2251466A1 (en) | 1997-10-16 |
| AU2557297A (en) | 1997-10-29 |
| AU734051B2 (en) | 2001-05-31 |
| JP2000508895A (ja) | 2000-07-18 |
| EP0910652A1 (de) | 1999-04-28 |
| CN1215432A (zh) | 1999-04-28 |
| WO1997038117A1 (en) | 1997-10-16 |
| EP0910652B1 (de) | 2014-10-08 |
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