IL125003A - Process for the preparation of N-ACETYL- (L) - 4-CYANOPHENYLALANINE AC- (L) -PHE (4-CN) -OH and for the preparation of N-ACETYL- (L) -P- AMIDINOPHENYLALANINE- CYCLOHEXYLGYLCINE-3 C) - N-METHYLPYRID) ALANINE AC (L) -PAPH-CHG- PALME (3) -NH2 - Google Patents

Process for the preparation of N-ACETYL- (L) - 4-CYANOPHENYLALANINE AC- (L) -PHE (4-CN) -OH and for the preparation of N-ACETYL- (L) -P- AMIDINOPHENYLALANINE- CYCLOHEXYLGYLCINE-3 C) - N-METHYLPYRID) ALANINE AC (L) -PAPH-CHG- PALME (3) -NH2

Info

Publication number
IL125003A
IL125003A IL12500396A IL12500396A IL125003A IL 125003 A IL125003 A IL 125003A IL 12500396 A IL12500396 A IL 12500396A IL 12500396 A IL12500396 A IL 12500396A IL 125003 A IL125003 A IL 125003A
Authority
IL
Israel
Prior art keywords
compound
sufficient amount
reaction medium
appropriate
subtilisin
Prior art date
Application number
IL12500396A
Other languages
English (en)
Hebrew (he)
Other versions
IL125003A0 (en
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of IL125003A0 publication Critical patent/IL125003A0/xx
Publication of IL125003A publication Critical patent/IL125003A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
IL12500396A 1995-12-20 1996-11-25 Process for the preparation of N-ACETYL- (L) - 4-CYANOPHENYLALANINE AC- (L) -PHE (4-CN) -OH and for the preparation of N-ACETYL- (L) -P- AMIDINOPHENYLALANINE- CYCLOHEXYLGYLCINE-3 C) - N-METHYLPYRID) ALANINE AC (L) -PAPH-CHG- PALME (3) -NH2 IL125003A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57556995A 1995-12-20 1995-12-20
PCT/US1996/019005 WO1997022712A1 (en) 1995-12-20 1996-11-25 NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH¿2?

Publications (2)

Publication Number Publication Date
IL125003A0 IL125003A0 (en) 1999-01-26
IL125003A true IL125003A (en) 2001-12-23

Family

ID=24300839

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12500396A IL125003A (en) 1995-12-20 1996-11-25 Process for the preparation of N-ACETYL- (L) - 4-CYANOPHENYLALANINE AC- (L) -PHE (4-CN) -OH and for the preparation of N-ACETYL- (L) -P- AMIDINOPHENYLALANINE- CYCLOHEXYLGYLCINE-3 C) - N-METHYLPYRID) ALANINE AC (L) -PAPH-CHG- PALME (3) -NH2

Country Status (27)

Country Link
EP (1) EP0868526B1 (pt)
JP (1) JP4044614B2 (pt)
KR (1) KR100438879B1 (pt)
CN (1) CN1087349C (pt)
AR (1) AR005119A1 (pt)
AT (1) ATE222293T1 (pt)
AU (1) AU717995B2 (pt)
BR (1) BR9612059A (pt)
CA (1) CA2241210C (pt)
CZ (1) CZ295362B6 (pt)
DE (1) DE69623038T2 (pt)
DK (1) DK0868526T3 (pt)
EE (1) EE03698B1 (pt)
ES (1) ES2179957T3 (pt)
HK (1) HK1017384A1 (pt)
IL (1) IL125003A (pt)
MX (1) MX9804997A (pt)
NO (1) NO319678B1 (pt)
NZ (1) NZ324159A (pt)
PL (1) PL185541B1 (pt)
PT (1) PT868526E (pt)
RU (1) RU2170764C2 (pt)
SK (1) SK281432B6 (pt)
TR (1) TR199801107T2 (pt)
UA (1) UA48993C2 (pt)
WO (1) WO1997022712A1 (pt)
ZA (1) ZA9610600B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL349343A1 (en) 1999-01-02 2002-07-15 Aventis Pharma Gmbh Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity)
EP1016663A1 (en) * 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
RU2250212C2 (ru) * 2000-01-28 2005-04-20 Авентис Фарма Дойчланд Гмбх Способ получения ацетиламидиниофенилаланилциклогексилглицилпиридиниоаланинамидов
EP1127884A1 (en) 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
GB0306267D0 (en) * 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
CN106946724B (zh) * 2017-04-07 2019-03-22 苏州汉德创宏生化科技有限公司 单胺基抑制剂类中间体2-乙酰氨基-2-苄基丙二酸单乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
AU662522B2 (en) * 1991-05-13 1995-09-07 Fujisawa Pharmaceutical Co., Ltd. New peptide compound and a process for the preparation thereof
SI9520044B (sl) * 1994-04-26 2004-08-31 Aventis Pharmaceuticals Inc. Inhibitorji Xa faktorja

Also Published As

Publication number Publication date
DE69623038T2 (de) 2002-12-12
CZ195698A3 (cs) 1999-01-13
CN1087349C (zh) 2002-07-10
SK85598A3 (en) 1998-12-02
TR199801107T2 (xx) 1998-10-21
MX9804997A (es) 1998-09-30
DE69623038D1 (de) 2002-09-19
EP0868526B1 (en) 2002-08-14
PT868526E (pt) 2002-12-31
ES2179957T3 (es) 2003-02-01
IL125003A0 (en) 1999-01-26
KR100438879B1 (ko) 2004-07-16
AU1125197A (en) 1997-07-14
PL327314A1 (en) 1998-12-07
WO1997022712A1 (en) 1997-06-26
NO982868L (no) 1998-08-19
AR005119A1 (es) 1999-04-14
JP2000501618A (ja) 2000-02-15
ATE222293T1 (de) 2002-08-15
CZ295362B6 (cs) 2005-07-13
CA2241210C (en) 2002-05-14
CA2241210A1 (en) 1997-06-26
RU2170764C2 (ru) 2001-07-20
SK281432B6 (sk) 2001-03-12
BR9612059A (pt) 1999-02-23
NZ324159A (en) 1999-07-29
NO319678B1 (no) 2005-09-05
AU717995B2 (en) 2000-04-06
UA48993C2 (uk) 2002-09-16
JP4044614B2 (ja) 2008-02-06
CN1205742A (zh) 1999-01-20
PL185541B1 (pl) 2003-05-30
ZA9610600B (en) 1997-06-20
KR20000064486A (ko) 2000-11-06
EE03698B1 (et) 2002-04-15
EE9800188A (et) 1998-12-15
EP0868526A1 (en) 1998-10-07
NO982868D0 (no) 1998-06-19
DK0868526T3 (da) 2002-12-02
HK1017384A1 (en) 1999-11-19

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