IL124699A - Method for identifying compounds for inhibition of neoplastic lesions - Google Patents
Method for identifying compounds for inhibition of neoplastic lesionsInfo
- Publication number
- IL124699A IL124699A IL12469998A IL12469998A IL124699A IL 124699 A IL124699 A IL 124699A IL 12469998 A IL12469998 A IL 12469998A IL 12469998 A IL12469998 A IL 12469998A IL 124699 A IL124699 A IL 124699A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- activity
- inhibition
- identifying compounds
- cgmp
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000003902 lesion Effects 0.000 title 1
- 230000001613 neoplastic effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 2
- 230000009826 neoplastic cell growth Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/866,027 US5858694A (en) | 1997-05-30 | 1997-05-30 | Method for identifying compounds for inhibition of cancerous lesions |
| US4673998A | 1998-03-24 | 1998-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124699A0 IL124699A0 (en) | 1998-12-06 |
| IL124699A true IL124699A (en) | 2003-02-12 |
Family
ID=26724247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12469998A IL124699A (en) | 1997-05-30 | 1998-05-29 | Method for identifying compounds for inhibition of neoplastic lesions |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6500610B1 (xx) |
| EP (2) | EP1038523A3 (xx) |
| JP (3) | JP3053381B2 (xx) |
| KR (1) | KR100304859B1 (xx) |
| AT (1) | ATE198771T1 (xx) |
| AU (1) | AU709666B2 (xx) |
| CA (1) | CA2238283C (xx) |
| CZ (1) | CZ295868B6 (xx) |
| DE (2) | DE881300T1 (xx) |
| DK (1) | DK0881300T3 (xx) |
| ES (1) | ES2132055T3 (xx) |
| HK (1) | HK1012196A1 (xx) |
| IL (1) | IL124699A (xx) |
| NO (1) | NO321717B1 (xx) |
| TR (1) | TR199800960A2 (xx) |
| TW (1) | TW591111B (xx) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020009764A1 (en) * | 1999-10-08 | 2002-01-24 | W. Joseph Thompson | Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds |
| US20040009464A1 (en) * | 1998-10-15 | 2004-01-15 | Li Liu | Methods for identifying compounds for inhibition of neoplastic lesions, and pharmacetical compositions containing such compounds |
| IL132366A0 (en) * | 1998-10-15 | 2001-03-19 | Cell Pathways Inc | Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds |
| US20050244914A1 (en) * | 1999-10-08 | 2005-11-03 | Li Liu | Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds |
| DE10060388A1 (de) * | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
| FR2824334B1 (fr) | 2001-05-03 | 2003-10-10 | Coletica | Procede pour tester une substance eventuellement active dans le domaine de la lipolyse et son utilisation principalement cosmetique |
| JP2005516586A (ja) * | 2001-07-20 | 2005-06-09 | ボード オブ トラスティーズ オブ ザ ユニヴァースティ オブ イリノイ | 癌の処置に対する遺伝子標的を同定するための試薬および方法 |
| DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
| AU2002312543A1 (en) * | 2001-08-01 | 2003-02-17 | University Of Utah, Technology Transfer Office | Isoform-selective inhibitors and activators of pde3 cyclic |
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| JP2007224007A (ja) * | 2006-03-27 | 2007-09-06 | Univ De Santiago De Compostela | ｙｅｓｓｏｔｏｘｉｎｓのヒト腫瘍細胞増殖抑制剤としての治療的な使用 |
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-
1998
- 1998-05-20 CA CA002238283A patent/CA2238283C/en not_active Expired - Fee Related
- 1998-05-25 TW TW087108072A patent/TW591111B/zh not_active IP Right Cessation
- 1998-05-28 KR KR1019980019380A patent/KR100304859B1/ko not_active IP Right Cessation
- 1998-05-28 CZ CZ19981651A patent/CZ295868B6/cs not_active IP Right Cessation
- 1998-05-29 EP EP00112020A patent/EP1038523A3/en not_active Withdrawn
- 1998-05-29 DK DK98304247T patent/DK0881300T3/da active
- 1998-05-29 NO NO19982477A patent/NO321717B1/no unknown
- 1998-05-29 AT AT98304247T patent/ATE198771T1/de not_active IP Right Cessation
- 1998-05-29 IL IL12469998A patent/IL124699A/xx not_active IP Right Cessation
- 1998-05-29 JP JP10150033A patent/JP3053381B2/ja not_active Expired - Fee Related
- 1998-05-29 ES ES98304247T patent/ES2132055T3/es not_active Expired - Lifetime
- 1998-05-29 AU AU69794/98A patent/AU709666B2/en not_active Ceased
- 1998-05-29 EP EP98304247A patent/EP0881300B1/en not_active Expired - Lifetime
- 1998-05-29 TR TR1998/00960A patent/TR199800960A2/xx unknown
- 1998-05-29 DE DE0881300T patent/DE881300T1/de active Pending
- 1998-05-29 DE DE69800488T patent/DE69800488T2/de not_active Expired - Lifetime
- 1998-12-16 HK HK98113546A patent/HK1012196A1/xx not_active IP Right Cessation
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1999
- 1999-07-02 JP JP18961599A patent/JP3234818B2/ja not_active Expired - Lifetime
- 1999-10-08 US US09/414,625 patent/US6500610B1/en not_active Expired - Fee Related
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2000
- 2000-02-22 JP JP2000044184A patent/JP2000198746A/ja active Pending
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2002
- 2002-01-07 US US10/040,776 patent/US20030004093A1/en not_active Abandoned
- 2002-09-24 US US10/252,983 patent/US20030190686A1/en not_active Abandoned
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