ES2132055T3 - Metodo para identificacion de compuestos para la inhibicion de lesiones neoplasicas. - Google Patents
Metodo para identificacion de compuestos para la inhibicion de lesiones neoplasicas.Info
- Publication number
- ES2132055T3 ES2132055T3 ES98304247T ES98304247T ES2132055T3 ES 2132055 T3 ES2132055 T3 ES 2132055T3 ES 98304247 T ES98304247 T ES 98304247T ES 98304247 T ES98304247 T ES 98304247T ES 2132055 T3 ES2132055 T3 ES 2132055T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibition
- compounds
- neoplasical
- injuries
- identification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000006378 damage Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 230000006882 induction of apoptosis Effects 0.000 abstract 1
- 230000017066 negative regulation of growth Effects 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ESTA INVENCION DESCRIBE UN PROCEDIMIENTO PARA IDENTIFICAR COMPUESTOS POTENCIALMENTE UTILES PARA EL TRATAMIENTO DE LA NEOPLASIA EN MAMIFEROS. LA ACTIVIDAD INHIBIDORA DE FOSFODIESTERASA DE UN COMPUESTO SE DETERMINA JUNTO CON LA ACTIVIDAD INHIBIDORA DE COX. TAMBIEN SE DETERMINAN LOS EFECTOS INHIBIDORES DEL CRECIMIENTO E INDUCTORES DE LA APOPTOSIS SOBRE CELULAS TUMORALES CULTIVADAS. RESULTAN DESEABLES COMPUESTOS QUE MUESTRAN UNA INHIBICION DE LA FOSFODIESTERASA, UNA INHIBICION DEL CRECIMIENTO Y UNA INDUCCION DE LA APOPTOSIS, PERO QUE NO MUESTREN UNA SUSTANCIAL ACTIVIDAD INHIBIDORA DE LA PROSTAGLANDINA, PARA EL TRATAMIENTO DE LA NEOPLASIA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/866,027 US5858694A (en) | 1997-05-30 | 1997-05-30 | Method for identifying compounds for inhibition of cancerous lesions |
US4673998A | 1998-03-24 | 1998-03-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2132055T1 ES2132055T1 (es) | 1999-08-16 |
ES2132055T3 true ES2132055T3 (es) | 2001-05-01 |
Family
ID=26724247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98304247T Expired - Lifetime ES2132055T3 (es) | 1997-05-30 | 1998-05-29 | Metodo para identificacion de compuestos para la inhibicion de lesiones neoplasicas. |
Country Status (16)
Country | Link |
---|---|
US (3) | US6500610B1 (es) |
EP (2) | EP0881300B1 (es) |
JP (3) | JP3053381B2 (es) |
KR (1) | KR100304859B1 (es) |
AT (1) | ATE198771T1 (es) |
AU (1) | AU709666B2 (es) |
CA (1) | CA2238283C (es) |
CZ (1) | CZ295868B6 (es) |
DE (2) | DE881300T1 (es) |
DK (1) | DK0881300T3 (es) |
ES (1) | ES2132055T3 (es) |
HK (1) | HK1012196A1 (es) |
IL (1) | IL124699A (es) |
NO (1) | NO321717B1 (es) |
TR (1) | TR199800960A2 (es) |
TW (1) | TW591111B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040009464A1 (en) * | 1998-10-15 | 2004-01-15 | Li Liu | Methods for identifying compounds for inhibition of neoplastic lesions, and pharmacetical compositions containing such compounds |
US20020009764A1 (en) * | 1999-10-08 | 2002-01-24 | W. Joseph Thompson | Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds |
IL132366A0 (en) * | 1998-10-15 | 2001-03-19 | Cell Pathways Inc | Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds |
US20050244914A1 (en) * | 1999-10-08 | 2005-11-03 | Li Liu | Methods for identifying compounds for inhibition of neoplastic lesions, and pharmaceutical compositions containing such compounds |
DE10060388A1 (de) * | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
FR2824334B1 (fr) | 2001-05-03 | 2003-10-10 | Coletica | Procede pour tester une substance eventuellement active dans le domaine de la lipolyse et son utilisation principalement cosmetique |
WO2003008578A2 (en) * | 2001-07-20 | 2003-01-30 | Board Of Trustees Of The University Of Illinois | Reagents and methods for identifying gene targets for treating cancer |
DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
ATE481497T1 (de) * | 2001-08-01 | 2010-10-15 | Univ Utah | Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a |
WO2003038430A1 (fr) * | 2001-10-29 | 2003-05-08 | Takeda Chemical Industries, Ltd. | Technique d'analyse |
US20050048573A1 (en) * | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
US7711584B2 (en) | 2003-09-04 | 2010-05-04 | Hartford Fire Insurance Company | System for reducing the risk associated with an insured building structure through the incorporation of selected technologies |
WO2005054181A1 (ja) * | 2003-12-01 | 2005-06-16 | Reverse Proteomics Research Institute Co., Ltd. | 抗癌剤の新規標的タンパク質および対応する新規抗癌剤(スプナール) |
US7585859B2 (en) * | 2004-05-06 | 2009-09-08 | Plexxikon, Inc. | PDE4B inhibitors and uses therefor |
JP2008512380A (ja) * | 2004-09-03 | 2008-04-24 | プレキシコン,インコーポレーテッド | Pde4b阻害剤 |
US20090074796A1 (en) | 2005-01-07 | 2009-03-19 | The John Hopkins University | Pde5 inhibitor compositions and methods for immunotherapy |
JP2008533090A (ja) * | 2005-03-14 | 2008-08-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 心血管疾患の防止方法 |
EA016323B1 (ru) | 2006-01-04 | 2012-04-30 | Саутерн Рисерч Инститьют | Производные сулиндака, их применение и получение |
JP2007224007A (ja) * | 2006-03-27 | 2007-09-06 | Univ De Santiago De Compostela | yessotoxinsのヒト腫瘍細胞増殖抑制剤としての治療的な使用 |
US8673914B2 (en) | 2011-03-28 | 2014-03-18 | St. John's University | Use of phosphodiesterase inhibitors for treating multidrug resistance |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
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1998
- 1998-05-20 CA CA002238283A patent/CA2238283C/en not_active Expired - Fee Related
- 1998-05-25 TW TW087108072A patent/TW591111B/zh not_active IP Right Cessation
- 1998-05-28 KR KR1019980019380A patent/KR100304859B1/ko not_active IP Right Cessation
- 1998-05-28 CZ CZ19981651A patent/CZ295868B6/cs not_active IP Right Cessation
- 1998-05-29 DK DK98304247T patent/DK0881300T3/da active
- 1998-05-29 EP EP98304247A patent/EP0881300B1/en not_active Expired - Lifetime
- 1998-05-29 DE DE0881300T patent/DE881300T1/de active Pending
- 1998-05-29 DE DE69800488T patent/DE69800488T2/de not_active Expired - Lifetime
- 1998-05-29 AU AU69794/98A patent/AU709666B2/en not_active Ceased
- 1998-05-29 AT AT98304247T patent/ATE198771T1/de not_active IP Right Cessation
- 1998-05-29 TR TR1998/00960A patent/TR199800960A2/xx unknown
- 1998-05-29 NO NO19982477A patent/NO321717B1/no unknown
- 1998-05-29 EP EP00112020A patent/EP1038523A3/en not_active Withdrawn
- 1998-05-29 IL IL12469998A patent/IL124699A/xx not_active IP Right Cessation
- 1998-05-29 JP JP10150033A patent/JP3053381B2/ja not_active Expired - Fee Related
- 1998-05-29 ES ES98304247T patent/ES2132055T3/es not_active Expired - Lifetime
- 1998-12-16 HK HK98113546A patent/HK1012196A1/xx not_active IP Right Cessation
-
1999
- 1999-07-02 JP JP18961599A patent/JP3234818B2/ja not_active Expired - Lifetime
- 1999-10-08 US US09/414,625 patent/US6500610B1/en not_active Expired - Fee Related
-
2000
- 2000-02-22 JP JP2000044184A patent/JP2000198746A/ja active Pending
-
2002
- 2002-01-07 US US10/040,776 patent/US20030004093A1/en not_active Abandoned
- 2002-09-24 US US10/252,983 patent/US20030190686A1/en not_active Abandoned
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