IL124663A - תהליך לסינתזה של דיאוקסולאן נוקלאוסידים בעלי קונפיגורציה - b - Google Patents

תהליך לסינתזה של דיאוקסולאן נוקלאוסידים בעלי קונפיגורציה - b

Info

Publication number
IL124663A
IL124663A IL12466396A IL12466396A IL124663A IL 124663 A IL124663 A IL 124663A IL 12466396 A IL12466396 A IL 12466396A IL 12466396 A IL12466396 A IL 12466396A IL 124663 A IL124663 A IL 124663A
Authority
IL
Israel
Prior art keywords
group
process according
formula
hydrogen
alkyl
Prior art date
Application number
IL12466396A
Other languages
English (en)
Other versions
IL124663A0 (en
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Priority to IL14415596A priority Critical patent/IL144155A/xx
Publication of IL124663A0 publication Critical patent/IL124663A0/xx
Priority to IL14415501A priority patent/IL144155A0/xx
Publication of IL124663A publication Critical patent/IL124663A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12466396A 1995-12-14 1996-12-13 תהליך לסינתזה של דיאוקסולאן נוקלאוסידים בעלי קונפיגורציה - b IL124663A (he)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL14415596A IL144155A (en) 1995-12-14 1996-12-13 Process for the synthesis of dioxolane derivatives
IL14415501A IL144155A0 (en) 1995-12-14 2001-07-05 PROCESS FOR THE SYNTHESIS OF DIOXOLANE DERIVATIVES AND THE USE THEREOF IN THE PREPARATION OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
PCT/CA1996/000845 WO1997021706A1 (en) 1995-12-14 1996-12-13 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (2)

Publication Number Publication Date
IL124663A0 IL124663A0 (en) 1998-12-06
IL124663A true IL124663A (he) 2001-10-31

Family

ID=10785435

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12466396A IL124663A (he) 1995-12-14 1996-12-13 תהליך לסינתזה של דיאוקסולאן נוקלאוסידים בעלי קונפיגורציה - b
IL14415596A IL144155A (en) 1995-12-14 1996-12-13 Process for the synthesis of dioxolane derivatives
IL14415501A IL144155A0 (en) 1995-12-14 2001-07-05 PROCESS FOR THE SYNTHESIS OF DIOXOLANE DERIVATIVES AND THE USE THEREOF IN THE PREPARATION OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL14415596A IL144155A (en) 1995-12-14 1996-12-13 Process for the synthesis of dioxolane derivatives
IL14415501A IL144155A0 (en) 1995-12-14 2001-07-05 PROCESS FOR THE SYNTHESIS OF DIOXOLANE DERIVATIVES AND THE USE THEREOF IN THE PREPARATION OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Country Status (28)

Country Link
US (4) US5922867A (he)
EP (1) EP0970074B1 (he)
JP (1) JP3229990B2 (he)
KR (1) KR100406159B1 (he)
CN (1) CN1080263C (he)
AP (1) AP879A (he)
AT (1) ATE214699T1 (he)
AU (1) AU706328B2 (he)
BR (1) BR9612351A (he)
CA (1) CA2237730C (he)
DE (1) DE69620042T2 (he)
DK (1) DK0970074T3 (he)
EA (1) EA000844B1 (he)
ES (1) ES2172697T3 (he)
GB (1) GB9525606D0 (he)
HK (1) HK1017886A1 (he)
HU (1) HU224076B1 (he)
IL (3) IL124663A (he)
IN (1) IN187349B (he)
MX (1) MX9804701A (he)
NO (1) NO309901B1 (he)
NZ (1) NZ323855A (he)
OA (1) OA11094A (he)
PL (1) PL188447B1 (he)
PT (1) PT970074E (he)
TW (1) TW341574B (he)
WO (1) WO1997021706A1 (he)
ZA (1) ZA9610544B (he)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6898498A (en) 1997-04-07 1998-10-30 Triangle Pharmaceuticals, Inc. Use of mkc-442 in combination with other antiviral agents
KR100856416B1 (ko) 1998-08-12 2008-09-04 길리애드 사이언시즈, 인코포레이티드 1,3-옥사티올란 뉴클레오시드의 제조 방법
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
ATE254126T1 (de) 1998-12-23 2003-11-15 Shire Biochem Inc Antivirale nukleosidanaloga
JP2002538780A (ja) * 1999-02-11 2002-11-19 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
US6583149B1 (en) 1999-09-24 2003-06-24 Biochem Pharma Inc. Method for the treatment or prevention of viral infection using nucleoside analogues
US6566365B1 (en) * 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
WO2001058920A2 (fr) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Procede de production selective d'un anomere derive d'un sucre 1-phosphoryle
DE60127946D1 (de) 2000-02-11 2007-05-31 Shire Biochem Inc Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
AU2002335489B2 (en) * 2001-03-01 2008-06-05 Abbott Laboratories Polymorphic and other crystalline forms of cis-FTC
WO2003020222A2 (en) * 2001-09-04 2003-03-13 Merck & Co., Inc. PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
AU2002336864B2 (en) * 2001-11-02 2006-08-17 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
AU2002365234B2 (en) * 2001-12-14 2009-01-29 Pharmasset Inc N4-acylcytosine nucleosides for treatment of viral infections
CA2473736C (en) * 2002-01-25 2011-10-11 Shire Biochem Inc. Process for producing dioxolane nucleoside analogues
US6855821B2 (en) 2002-08-06 2005-02-15 Pharmasset, Ltd. Processes for preparing 1,3-dioxolane nucleosides
EP1620479B1 (en) 2002-10-15 2013-07-24 ExxonMobil Chemical Patents Inc. Polyolefin adhesive compositions and articles made therefrom
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
CN105039489A (zh) * 2004-02-03 2015-11-11 埃莫里大学 制备1,3-二氧戊环核苷的方法
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process

Also Published As

Publication number Publication date
CA2237730A1 (en) 1997-06-19
HUP9901050A3 (en) 2001-05-28
CN1080263C (zh) 2002-03-06
WO1997021706A1 (en) 1997-06-19
EP0970074B1 (en) 2002-03-20
NZ323855A (en) 1999-11-29
IL124663A0 (en) 1998-12-06
CN1208414A (zh) 1999-02-17
AU1089397A (en) 1997-07-03
TW341574B (en) 1998-10-01
BR9612351A (pt) 1999-07-13
DK0970074T3 (da) 2002-07-15
OA11094A (en) 2003-03-13
NO982716D0 (no) 1998-06-12
EA000844B1 (ru) 2000-06-26
ZA9610544B (en) 1997-07-29
HK1017886A1 (en) 1999-12-03
EA199800555A1 (ru) 1999-02-25
AP9801252A0 (en) 1998-06-30
PL188447B1 (pl) 2005-02-28
CA2237730C (en) 2001-12-04
US5922867A (en) 1999-07-13
HUP9901050A2 (hu) 2001-04-28
JP3229990B2 (ja) 2001-11-19
AP879A (en) 2000-10-02
KR100406159B1 (ko) 2004-11-16
US20020058670A1 (en) 2002-05-16
IN187349B (he) 2002-03-30
KR19990072141A (ko) 1999-09-27
PL327443A1 (en) 1998-12-07
IL144155A0 (en) 2002-05-23
PT970074E (pt) 2002-09-30
US6069250A (en) 2000-05-30
GB9525606D0 (en) 1996-02-14
NO309901B1 (no) 2001-04-17
ATE214699T1 (de) 2002-04-15
HU224076B1 (hu) 2005-05-30
ES2172697T3 (es) 2002-10-01
DE69620042D1 (de) 2002-04-25
DE69620042T2 (de) 2002-10-17
EP0970074A1 (en) 2000-01-12
JP2000501714A (ja) 2000-02-15
US20030060476A1 (en) 2003-03-27
AU706328B2 (en) 1999-06-17
MX9804701A (es) 1998-10-31
NO982716L (no) 1998-06-12
IL144155A (en) 2003-07-06

Similar Documents

Publication Publication Date Title
EP0970074B1 (en) Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration
EP0515156B1 (en) Processes for the diastereo-selective synthesis of nucleosides
RO118714B1 (ro) Analog nucleozidic
FI112078B (fi) Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä
CN102924454B (zh) 恩替卡韦的合成方法
KR20070085075A (ko) 1,3-디옥솔란 뉴클레오시드 제조방법
AU2003294212B2 (en) Processes for preparing 1,3-dioxolane nucleosides
WO2003040139A1 (en) Diastereoselective process for the preparation of the antiviral agent4-amino-1-(2r-hydroxymethyl-[1,3]oxathiolan-5s-yl)-1h-pyrimidin-2-one

Legal Events

Date Code Title Description
HP Change in proprietorship
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired