IL123927A - Propanolamine derivatives processes for their preparation and pharmaceutical composition comprising them - Google Patents
Propanolamine derivatives processes for their preparation and pharmaceutical composition comprising themInfo
- Publication number
- IL123927A IL123927A IL12392798A IL12392798A IL123927A IL 123927 A IL123927 A IL 123927A IL 12392798 A IL12392798 A IL 12392798A IL 12392798 A IL12392798 A IL 12392798A IL 123927 A IL123927 A IL 123927A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical composition
- propanolamine derivatives
- derivatives processes
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Obesity (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19713865 | 1997-04-04 | ||
| DE1998102530 DE19802530A1 (de) | 1998-01-26 | 1998-01-26 | Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL123927A true IL123927A (en) | 2001-01-28 |
Family
ID=26035472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12392798A IL123927A (en) | 1997-04-04 | 1998-04-02 | Propanolamine derivatives processes for their preparation and pharmaceutical composition comprising them |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5874451A (ru) |
| EP (1) | EP0869121B1 (ru) |
| JP (1) | JP4234805B2 (ru) |
| KR (1) | KR19980081055A (ru) |
| CN (1) | CN1185217C (ru) |
| AR (1) | AR011210A1 (ru) |
| AT (1) | ATE268758T1 (ru) |
| AU (1) | AU730228B2 (ru) |
| BR (1) | BR9801150A (ru) |
| CA (1) | CA2233925A1 (ru) |
| CZ (1) | CZ293758B6 (ru) |
| DE (1) | DE59811528D1 (ru) |
| DK (1) | DK0869121T3 (ru) |
| ES (1) | ES2223091T3 (ru) |
| HK (1) | HK1015789A1 (ru) |
| HU (1) | HUP9800781A3 (ru) |
| ID (1) | ID20137A (ru) |
| IL (1) | IL123927A (ru) |
| MY (1) | MY114944A (ru) |
| NZ (1) | NZ330110A (ru) |
| PL (1) | PL325699A1 (ru) |
| PT (1) | PT869121E (ru) |
| RU (1) | RU2198876C2 (ru) |
| TR (1) | TR199800608A2 (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19845402B4 (de) * | 1998-10-02 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| US6417185B1 (en) | 1998-06-19 | 2002-07-09 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| DE19845406C2 (de) | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845403B4 (de) * | 1998-10-02 | 2005-02-10 | Aventis Pharma Deutschland Gmbh | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| IL156548A0 (en) * | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
| CN1638801A (zh) * | 2001-08-22 | 2005-07-13 | 安万特医药德国有限公司 | 芳基取代的丙醇胺衍生物与其他活性成分的联用产品及其应用 |
| AU2003241836A1 (en) | 2002-10-03 | 2004-04-23 | Ono Pharmaceutical Co., Ltd. | Lpa receptor antagonists |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| ATE528276T1 (de) * | 2003-12-19 | 2011-10-15 | Ono Pharmaceutical Co | Lysophosphatidylsäurerezeptor-antagonistische verbindungen und ihre anwendungen |
| CN1869002A (zh) * | 2005-05-27 | 2006-11-29 | 中国科学院上海药物研究所 | 一类非甾体雄激素受体调节剂、其制备方法和用途 |
| AU2007321719B2 (en) | 2006-11-15 | 2013-11-21 | Ym Biosciences Australia Pty Ltd | Inhibitors of kinase activity |
| EP2995317A1 (en) | 2010-05-26 | 2016-03-16 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| CN107375291A (zh) | 2011-10-28 | 2017-11-24 | 鲁美纳医药公司 | 用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂 |
| MX354242B (es) | 2011-10-28 | 2018-02-20 | Lumena Pharmaceuticals Inc | Nhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
| MX2015013193A (es) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Inhibidores del reciclaje de acidos biliares para el tratamiento de colangitis esclerosante primaria y enfermedad inflamatoria intestinal. |
| JP2016514678A (ja) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | バレット食道と胃食道逆流性疾患を処置するための胆汁酸再利用阻害剤 |
| CN105553262B (zh) * | 2015-08-24 | 2018-02-16 | 苏州瑞铬优电子科技有限公司 | 一种提高dc/dc升压变换器转换效率的方法 |
| JP2022519905A (ja) | 2019-02-12 | 2022-03-25 | ミルム ファーマシューティカルズ インコーポレイテッド | 胆汁酸塩排出ポンプ欠損症の患者における遺伝子型およびａｓｂｔｉに対する用量依存的反応 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI892341A (fi) * | 1988-06-10 | 1989-12-11 | Hoffmann La Roche | Propanolaminderivat. |
| DE59108326D1 (de) * | 1990-12-06 | 1996-12-12 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| EP0557879B1 (de) * | 1992-02-22 | 1997-01-08 | Hoechst Aktiengesellschaft | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
-
1998
- 1998-03-24 ES ES98105256T patent/ES2223091T3/es not_active Expired - Lifetime
- 1998-03-24 DK DK98105256T patent/DK0869121T3/da active
- 1998-03-24 DE DE59811528T patent/DE59811528D1/de not_active Expired - Lifetime
- 1998-03-24 AT AT98105256T patent/ATE268758T1/de not_active IP Right Cessation
- 1998-03-24 EP EP98105256A patent/EP0869121B1/de not_active Expired - Lifetime
- 1998-03-24 PT PT98105256T patent/PT869121E/pt unknown
- 1998-04-02 TR TR1998/00608A patent/TR199800608A2/xx unknown
- 1998-04-02 NZ NZ330110A patent/NZ330110A/xx unknown
- 1998-04-02 ID IDP980494A patent/ID20137A/id unknown
- 1998-04-02 IL IL12392798A patent/IL123927A/xx active IP Right Grant
- 1998-04-02 US US09/053,513 patent/US5874451A/en not_active Expired - Lifetime
- 1998-04-02 AR ARP980101512A patent/AR011210A1/es unknown
- 1998-04-03 HU HU9800781A patent/HUP9800781A3/hu unknown
- 1998-04-03 PL PL98325699A patent/PL325699A1/xx not_active Application Discontinuation
- 1998-04-03 CN CNB981082521A patent/CN1185217C/zh not_active Expired - Fee Related
- 1998-04-03 RU RU98106112/04A patent/RU2198876C2/ru not_active IP Right Cessation
- 1998-04-03 AU AU60624/98A patent/AU730228B2/en not_active Ceased
- 1998-04-03 MY MYPI98001488A patent/MY114944A/en unknown
- 1998-04-03 JP JP10716198A patent/JP4234805B2/ja not_active Expired - Fee Related
- 1998-04-03 CZ CZ19981025A patent/CZ293758B6/cs not_active IP Right Cessation
- 1998-04-03 KR KR1019980011750A patent/KR19980081055A/ko active IP Right Grant
- 1998-04-03 CA CA002233925A patent/CA2233925A1/en not_active Abandoned
- 1998-04-06 BR BR9801150A patent/BR9801150A/pt not_active IP Right Cessation
-
1999
- 1999-03-12 HK HK99101018A patent/HK1015789A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2223091T3 (es) | 2005-02-16 |
| CN1185217C (zh) | 2005-01-19 |
| US5874451A (en) | 1999-02-23 |
| EP0869121B1 (de) | 2004-06-09 |
| ATE268758T1 (de) | 2004-06-15 |
| JP4234805B2 (ja) | 2009-03-04 |
| CZ102598A3 (cs) | 1998-10-14 |
| DE59811528D1 (de) | 2004-07-15 |
| AU730228B2 (en) | 2001-03-01 |
| AR011210A1 (es) | 2000-08-02 |
| AU6062498A (en) | 1998-10-08 |
| CA2233925A1 (en) | 1998-10-04 |
| HUP9800781A3 (en) | 1999-07-28 |
| CN1199731A (zh) | 1998-11-25 |
| MY114944A (en) | 2003-02-28 |
| CZ293758B6 (cs) | 2004-07-14 |
| HUP9800781A2 (hu) | 1999-06-28 |
| TR199800608A3 (tr) | 1998-10-21 |
| KR19980081055A (ko) | 1998-11-25 |
| HU9800781D0 (en) | 1998-05-28 |
| NZ330110A (en) | 1999-03-29 |
| PT869121E (pt) | 2004-10-29 |
| EP0869121A1 (de) | 1998-10-07 |
| TR199800608A2 (en) | 1998-10-21 |
| RU2198876C2 (ru) | 2003-02-20 |
| ID20137A (id) | 1998-10-08 |
| PL325699A1 (en) | 1998-10-12 |
| JPH10287651A (ja) | 1998-10-27 |
| HK1015789A1 (en) | 1999-10-22 |
| BR9801150A (pt) | 2000-03-21 |
| DK0869121T3 (da) | 2004-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL123986A0 (en) | Antithombotic agents process for their preparation and pharmaceutical compositions comprising them | |
| ZA9810490B (en) | 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor | |
| HUP0100178A3 (en) | Tetrahydro-naphtiridinyl-imidazolydinyl-carboxylic acid derivatives and pharmaceutical compositions thereof | |
| HUP0103406A3 (en) | 1h-imidazopyridine derivatives and pharmaceutical compositions thereof | |
| HUP0001243A3 (en) | Nicotinamide derivatives and pharmaceutical compositions containing them | |
| HUP0001555A3 (en) | Tetrahydro-imidazo-naphthyridine derivatives, pharmaceutical compositions thereof and process for their preparation | |
| HUP0001508A3 (en) | 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them | |
| IL123927A (en) | Propanolamine derivatives processes for their preparation and pharmaceutical composition comprising them | |
| ZA9510146B (en) | Novel perhydroisoindole derivatives processes for their preparation and pharmaceutical compositions comprising them | |
| HUP0102990A3 (en) | Tetrahydroimidazo-naphtyridine derivatives and pharmaceutical compositions thereof | |
| HUP0104762A3 (en) | Pharmaceutical moxifloxacin compositions and process for their preparation | |
| HUP0100731A3 (en) | New oxazolidine-, thiazolidine-, pyrrolidine-and piperidin derivatives process for their preparation and pharmaceutical compositions containing them | |
| HUP9900424A2 (hu) | Tiazolil-benzfurán-származékok és a vegyületeket tartalmazó gyógyászati készítmények | |
| IL125710A0 (en) | Arylglycinamide derivatives their preparation and pharmaceutical compositions containing them | |
| HUP0101381A3 (en) | Benzofurylpyrone derivatives and pharmaceutical compositions containing them | |
| IL115905A0 (en) | Sordarin derivatives their preparation and pharmaceutical compositions containing them | |
| HUP0002272A3 (en) | Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use | |
| GB9710800D0 (en) | Pharmaceutical composition and method of preparing it | |
| HUP9800147A3 (en) | Isoxasol-and crotonoil-amide derivatives and pharmaceutical and diagnostical compositions containing them | |
| HUP0103203A3 (en) | Azaadamantane derivatives and pharmaceutical compositions thereof | |
| ZA967800B (en) | Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them | |
| HUP0100085A3 (en) | Biphenylamidine derivatives and pharmaceutical compositions containing them | |
| HUP0002331A3 (en) | 20-aralkyl-5alpha-pregnane derivatives and pharmaceutical compositions thereof | |
| HUP0101701A3 (en) | Substituted betha-alanines and pharmaceutical compositions comprising them | |
| HUP0003074A3 (en) | Pharmaceutical composition comprising ssri and betha-blocking agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |