IL122704A - Preparation of Dolastatin intermediates 15 - Google Patents
Preparation of Dolastatin intermediates 15Info
- Publication number
- IL122704A IL122704A IL12270496A IL12270496A IL122704A IL 122704 A IL122704 A IL 122704A IL 12270496 A IL12270496 A IL 12270496A IL 12270496 A IL12270496 A IL 12270496A IL 122704 A IL122704 A IL 122704A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- pro
- converting
- tert
- independently
- Prior art date
Links
- LQKSHSFQQRCAFW-UHFFFAOYSA-N Dolastatin 15 Natural products COC1=CC(=O)N(C(=O)C(OC(=O)C2N(CCC2)C(=O)C2N(CCC2)C(=O)C(C(C)C)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C)C(C)C)C1CC1=CC=CC=C1 LQKSHSFQQRCAFW-UHFFFAOYSA-N 0.000 title description 16
- LQKSHSFQQRCAFW-CCVNJFHASA-N [(2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2s)-1-[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxyl Chemical compound C([C@@H]1N(C(=O)C=C1OC)C(=O)[C@@H](OC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)C1=CC=CC=C1 LQKSHSFQQRCAFW-CCVNJFHASA-N 0.000 title description 16
- 108010045552 dolastatin 15 Proteins 0.000 title description 16
- 238000002360 preparation method Methods 0.000 title description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 7
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims abstract description 7
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- 125000001424 substituent group Chemical group 0.000 claims abstract description 7
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 6
- 150000002367 halogens Chemical class 0.000 claims abstract description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 6
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- VLJNHYLEOZPXFW-BYPYZUCNSA-N L-prolinamide Chemical compound NC(=O)[C@@H]1CCCN1 VLJNHYLEOZPXFW-BYPYZUCNSA-N 0.000 claims abstract description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 3
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- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
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- BLWYXBNNBYXPPL-YFKPBYRVSA-N methyl (2s)-pyrrolidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCCN1 BLWYXBNNBYXPPL-YFKPBYRVSA-N 0.000 description 2
- HQEIPVHJHZTMDP-JEDNCBNOSA-N methyl (2s)-pyrrolidine-2-carboxylate;hydrochloride Chemical compound Cl.COC(=O)[C@@H]1CCCN1 HQEIPVHJHZTMDP-JEDNCBNOSA-N 0.000 description 2
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 description 2
- 150000003147 proline derivatives Chemical class 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
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- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19527575A DE19527575A1 (de) | 1995-07-28 | 1995-07-28 | Verfahren zur Herstellung von peptidischer Wirkstoffe |
| PCT/EP1996/003073 WO1997005162A1 (de) | 1995-07-28 | 1996-07-12 | Verfahren zur herstellung von dolastatin 15 und deren zwischenprodukten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL122704A0 IL122704A0 (en) | 1998-08-16 |
| IL122704A true IL122704A (en) | 2001-06-14 |
Family
ID=7767995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12270496A IL122704A (en) | 1995-07-28 | 1996-07-12 | Preparation of Dolastatin intermediates 15 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5965700A (ja) |
| EP (1) | EP0842190B1 (ja) |
| JP (1) | JP3941883B2 (ja) |
| KR (1) | KR100445124B1 (ja) |
| AT (1) | ATE185349T1 (ja) |
| AU (1) | AU705143B2 (ja) |
| CA (1) | CA2223911C (ja) |
| CZ (1) | CZ293445B6 (ja) |
| DE (2) | DE19527575A1 (ja) |
| ES (1) | ES2138363T3 (ja) |
| HU (1) | HU227981B1 (ja) |
| IL (1) | IL122704A (ja) |
| TW (1) | TW418212B (ja) |
| WO (1) | WO1997005162A1 (ja) |
| ZA (1) | ZA966371B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010009901A1 (en) * | 1996-12-11 | 2001-07-26 | Basf Aktiengesellschaft Germany | Antineoplastic peptides |
| US6426331B1 (en) | 1998-07-08 | 2002-07-30 | Tularik Inc. | Inhibitors of STAT function |
| CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| WO2001083517A1 (en) * | 2000-05-03 | 2001-11-08 | Tularik Inc. | Stat4 and stat6 binding dipeptide derivatives |
| US6884782B2 (en) | 2000-11-08 | 2005-04-26 | Amgen Inc. | STAT modulators |
| AU2022338463A1 (en) | 2021-09-03 | 2024-03-21 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU180925B (en) * | 1979-06-28 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem |
| JPH03141298A (ja) * | 1989-10-25 | 1991-06-17 | M D Res Kk | 活性ペプチド |
| KR100286242B1 (ko) * | 1992-05-20 | 2001-04-16 | 스타르크, 카르크 | 돌라스타틴 유도체 |
-
1995
- 1995-07-28 DE DE19527575A patent/DE19527575A1/de not_active Withdrawn
-
1996
- 1996-07-12 JP JP50716097A patent/JP3941883B2/ja not_active Expired - Fee Related
- 1996-07-12 AU AU66154/96A patent/AU705143B2/en not_active Ceased
- 1996-07-12 EP EP96925744A patent/EP0842190B1/de not_active Expired - Lifetime
- 1996-07-12 US US08/983,460 patent/US5965700A/en not_active Expired - Lifetime
- 1996-07-12 WO PCT/EP1996/003073 patent/WO1997005162A1/de active IP Right Grant
- 1996-07-12 HU HU9802570A patent/HU227981B1/hu not_active IP Right Cessation
- 1996-07-12 ES ES96925744T patent/ES2138363T3/es not_active Expired - Lifetime
- 1996-07-12 CA CA002223911A patent/CA2223911C/en not_active Expired - Fee Related
- 1996-07-12 AT AT96925744T patent/ATE185349T1/de active
- 1996-07-12 IL IL12270496A patent/IL122704A/en not_active IP Right Cessation
- 1996-07-12 DE DE59603295T patent/DE59603295D1/de not_active Expired - Lifetime
- 1996-07-12 CZ CZ1998243A patent/CZ293445B6/cs not_active IP Right Cessation
- 1996-07-12 KR KR10-1998-0700636A patent/KR100445124B1/ko not_active IP Right Cessation
- 1996-07-19 TW TW085108763A patent/TW418212B/zh not_active IP Right Cessation
- 1996-07-26 ZA ZA9606371A patent/ZA966371B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59603295D1 (de) | 1999-11-11 |
| ATE185349T1 (de) | 1999-10-15 |
| AU6615496A (en) | 1997-02-26 |
| EP0842190B1 (de) | 1999-10-06 |
| ES2138363T3 (es) | 2000-01-01 |
| CA2223911A1 (en) | 1997-02-13 |
| EP0842190A1 (de) | 1998-05-20 |
| HU227981B1 (hu) | 2012-07-30 |
| ZA966371B (en) | 1998-01-26 |
| CA2223911C (en) | 2009-03-24 |
| DE19527575A1 (de) | 1997-01-30 |
| US5965700A (en) | 1999-10-12 |
| AU705143B2 (en) | 1999-05-13 |
| WO1997005162A1 (de) | 1997-02-13 |
| JP3941883B2 (ja) | 2007-07-04 |
| TW418212B (en) | 2001-01-11 |
| JPH11509850A (ja) | 1999-08-31 |
| CZ293445B6 (cs) | 2004-04-14 |
| KR19990035975A (ko) | 1999-05-25 |
| HUP9802570A3 (en) | 1999-06-28 |
| KR100445124B1 (ko) | 2004-11-16 |
| IL122704A0 (en) | 1998-08-16 |
| CZ24398A3 (cs) | 1998-07-15 |
| HUP9802570A2 (hu) | 1999-04-28 |
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Legal Events
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |