IL122220A - PROCESS FOR PREPARATION OF 8-[2'-(2H-TETRAZOL-5-YL) BIPHENYL-4-YL- METHYL]-5,8- DIHYDRO-6H- PYRIDO [2,3-d] PYRIMIDIN-7-ONES AND SIMILAR COMPOUNDS - Google Patents

PROCESS FOR PREPARATION OF 8-[2'-(2H-TETRAZOL-5-YL) BIPHENYL-4-YL- METHYL]-5,8- DIHYDRO-6H- PYRIDO [2,3-d] PYRIMIDIN-7-ONES AND SIMILAR COMPOUNDS

Info

Publication number
IL122220A
IL122220A IL12222096A IL12222096A IL122220A IL 122220 A IL122220 A IL 122220A IL 12222096 A IL12222096 A IL 12222096A IL 12222096 A IL12222096 A IL 12222096A IL 122220 A IL122220 A IL 122220A
Authority
IL
Israel
Prior art keywords
butyl
tert
solvent
reaction
compound
Prior art date
Application number
IL12222096A
Other languages
English (en)
Other versions
IL122220A0 (en
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/657,490 external-priority patent/US5760220A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL122220A0 publication Critical patent/IL122220A0/xx
Publication of IL122220A publication Critical patent/IL122220A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL12222096A 1995-06-07 1996-06-06 PROCESS FOR PREPARATION OF 8-[2'-(2H-TETRAZOL-5-YL) BIPHENYL-4-YL- METHYL]-5,8- DIHYDRO-6H- PYRIDO [2,3-d] PYRIMIDIN-7-ONES AND SIMILAR COMPOUNDS IL122220A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47859295A 1995-06-07 1995-06-07
US08/657,490 US5760220A (en) 1995-06-07 1996-06-04 Process for preparation of biphenyl derivatives
PCT/US1996/009117 WO1996040684A1 (en) 1995-06-07 1996-06-06 Process for preparation of biphenyl derivatives

Publications (2)

Publication Number Publication Date
IL122220A0 IL122220A0 (en) 1996-06-06
IL122220A true IL122220A (en) 2001-08-08

Family

ID=27045956

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12222096A IL122220A (en) 1995-06-07 1996-06-06 PROCESS FOR PREPARATION OF 8-[2'-(2H-TETRAZOL-5-YL) BIPHENYL-4-YL- METHYL]-5,8- DIHYDRO-6H- PYRIDO [2,3-d] PYRIMIDIN-7-ONES AND SIMILAR COMPOUNDS

Country Status (15)

Country Link
US (1) US5977372A (ja)
EP (1) EP0846117B1 (ja)
JP (1) JPH11507625A (ja)
CN (1) CN1073110C (ja)
AT (1) ATE240325T1 (ja)
AU (1) AU718553B2 (ja)
BR (1) BR9609403A (ja)
CA (1) CA2223783A1 (ja)
CZ (1) CZ390097A3 (ja)
DE (1) DE69628175D1 (ja)
EA (1) EA000622B1 (ja)
HU (1) HUP9900871A3 (ja)
IL (1) IL122220A (ja)
NZ (1) NZ310164A (ja)
WO (1) WO1996040684A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291356B1 (it) * 1997-05-13 1999-01-07 Zambon Spa Processo per la rimozione di metalli pesanti
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2372028T3 (es) 2000-10-23 2012-01-13 Glaxosmithkline Llc Nuevo compuesto de 8h-pirido[2,3-d]pirimidin-7-ona trisustituida para el tratamiento de enfermedades mediadas por la csbp/p38 quinasa.
GB0222056D0 (en) * 2002-09-23 2002-10-30 Novartis Ag Process for the manufacture of organic compounds
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
PE20061351A1 (es) * 2005-03-25 2007-01-14 Glaxo Group Ltd COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38
WO2008134890A1 (en) * 2007-05-07 2008-11-13 Valorisation-Recherche, Societe En Commandite Methods for preparing diorganozinc compounds
US20220396576A1 (en) * 2019-10-02 2022-12-15 Blueprint Medicines Corporation Process for preparing an activin receptor-like kinase inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5466692A (en) * 1993-03-24 1995-11-14 American Home Products Corporation Substituted pyridopyrimidines and antihypertensives

Also Published As

Publication number Publication date
EA000622B1 (ru) 1999-12-29
HUP9900871A3 (en) 2000-07-28
WO1996040684A1 (en) 1996-12-19
JPH11507625A (ja) 1999-07-06
BR9609403A (pt) 1999-05-11
AU718553B2 (en) 2000-04-13
CN1192214A (zh) 1998-09-02
IL122220A0 (en) 1996-06-06
CZ390097A3 (cs) 1998-06-17
HUP9900871A2 (hu) 1999-07-28
CA2223783A1 (en) 1996-12-19
CN1073110C (zh) 2001-10-17
EP0846117A1 (en) 1998-06-10
ATE240325T1 (de) 2003-05-15
US5977372A (en) 1999-11-02
EP0846117B1 (en) 2003-05-14
EA199800035A1 (ru) 1998-08-27
NZ310164A (en) 2000-01-28
DE69628175D1 (de) 2003-06-18
AU6090296A (en) 1996-12-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
MM9K Patent not in force due to non-payment of renewal fees