HUP9900871A2 - Eljárás bifenilszármazékok előállítására - Google Patents

Eljárás bifenilszármazékok előállítására

Info

Publication number
HUP9900871A2
HUP9900871A2 HU9900871A HUP9900871A HUP9900871A2 HU P9900871 A2 HUP9900871 A2 HU P9900871A2 HU 9900871 A HU9900871 A HU 9900871A HU P9900871 A HUP9900871 A HU P9900871A HU P9900871 A2 HUP9900871 A2 HU P9900871A2
Authority
HU
Hungary
Prior art keywords
general formula
formula
atom
salt
compound
Prior art date
Application number
HU9900871A
Other languages
English (en)
Inventor
Giuseppe Barreca
Michael Bernatchez
Vincenzo Cannata
Graziano Castaldi
Pierre Giguere
Silvio Iera
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/657,490 external-priority patent/US5760220A/en
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of HUP9900871A2 publication Critical patent/HUP9900871A2/hu
Publication of HUP9900871A3 publication Critical patent/HUP9900871A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya új eljárás az (I) általánős képletű vegyületek - aképletben X jelentése védőcsőpőrt, R1, R2, R3 és R4 azőnős vagy eltérőjelentéssel hidrőgénatőmőt vagy 1-6 szénatőmőt tartalmazó alkil- vagy1-6 szénatőmőt tartalmazó perflűőr-alkil-csőpőrtőt jelent, R5jelentése hidrőgénatőm vagy - ha n értéke 1 - R5 és R3 együtt kettőskötést alkőt, m értéke 1, 2 vagy 3, n értéke 0 vagy 1, és p értéke 0,1 vagy 2 - előállítására. Az eljárás abban áll, hőgy valamely (II)általánős képletű vegyületet - a képletben R1-R5, m, n és p jelentéseaz (I) általánős képletnél megadőtt, és R6 jelentése klór-, bróm- vagyjódatőm, vagy triflűőr-metán-szűlfőnil-őxi-csőpőrt - vagy sójátvalamely (III) általánős képletű vegyülettel - a képletben X jelentésevédőcsőpőrt, és R7 jelentése cink- vagy ónmőlekűlarész[példáűl ZnCl,ZnBr vagy Sn (1-6 szénatőmőt tartalmazó alkil)3] - vagy sójávalreagáltatnak palládiűm- vagy nikkelkatalizátőr jelenlétében. ŕ
HU9900871A 1995-06-07 1996-06-06 Process for preparation of biphenyl derivatives HUP9900871A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47859295A 1995-06-07 1995-06-07
US08/657,490 US5760220A (en) 1995-06-07 1996-06-04 Process for preparation of biphenyl derivatives

Publications (2)

Publication Number Publication Date
HUP9900871A2 true HUP9900871A2 (hu) 1999-07-28
HUP9900871A3 HUP9900871A3 (en) 2000-07-28

Family

ID=27045956

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900871A HUP9900871A3 (en) 1995-06-07 1996-06-06 Process for preparation of biphenyl derivatives

Country Status (15)

Country Link
US (1) US5977372A (hu)
EP (1) EP0846117B1 (hu)
JP (1) JPH11507625A (hu)
CN (1) CN1073110C (hu)
AT (1) ATE240325T1 (hu)
AU (1) AU718553B2 (hu)
BR (1) BR9609403A (hu)
CA (1) CA2223783A1 (hu)
CZ (1) CZ390097A3 (hu)
DE (1) DE69628175D1 (hu)
EA (1) EA000622B1 (hu)
HU (1) HUP9900871A3 (hu)
IL (1) IL122220A (hu)
NZ (1) NZ310164A (hu)
WO (1) WO1996040684A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291356B1 (it) * 1997-05-13 1999-01-07 Zambon Spa Processo per la rimozione di metalli pesanti
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
EP1333833B1 (en) 2000-10-23 2011-08-24 GlaxoSmithKline LLC Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compound for the treatment of CSBP/p38 kinase mediated diseases
GB0222056D0 (en) * 2002-09-23 2002-10-30 Novartis Ag Process for the manufacture of organic compounds
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
AR053346A1 (es) 2005-03-25 2007-05-02 Glaxo Group Ltd Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
EP2155759A4 (en) * 2007-05-07 2012-10-17 Valorisation Rech Soc En Commandite METHODS FOR THE PREPARATION OF DIORGANOZINC COMPOUNDS
JP2022550451A (ja) * 2019-10-02 2022-12-01 ブループリント メディシンズ コーポレイション アクチビン受容体様キナーゼ阻害剤を調製するためのプロセス

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5466692A (en) * 1993-03-24 1995-11-14 American Home Products Corporation Substituted pyridopyrimidines and antihypertensives

Also Published As

Publication number Publication date
EA000622B1 (ru) 1999-12-29
WO1996040684A1 (en) 1996-12-19
CA2223783A1 (en) 1996-12-19
AU6090296A (en) 1996-12-30
US5977372A (en) 1999-11-02
CN1192214A (zh) 1998-09-02
EP0846117A1 (en) 1998-06-10
AU718553B2 (en) 2000-04-13
CZ390097A3 (cs) 1998-06-17
CN1073110C (zh) 2001-10-17
IL122220A0 (en) 1996-06-06
JPH11507625A (ja) 1999-07-06
ATE240325T1 (de) 2003-05-15
IL122220A (en) 2001-08-08
HUP9900871A3 (en) 2000-07-28
EP0846117B1 (en) 2003-05-14
BR9609403A (pt) 1999-05-11
DE69628175D1 (de) 2003-06-18
EA199800035A1 (ru) 1998-08-27
NZ310164A (en) 2000-01-28

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