IL117602A0 - Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases - Google Patents

Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Info

Publication number
IL117602A0
IL117602A0 IL11760296A IL11760296A IL117602A0 IL 117602 A0 IL117602 A0 IL 117602A0 IL 11760296 A IL11760296 A IL 11760296A IL 11760296 A IL11760296 A IL 11760296A IL 117602 A0 IL117602 A0 IL 117602A0
Authority
IL
Israel
Prior art keywords
inhibition
treatment
compounds useful
proliferative diseases
protein function
Prior art date
Application number
IL11760296A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL117602A0 publication Critical patent/IL117602A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11760296A 1995-03-24 1996-03-21 Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases IL117602A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/410,443 US5700806A (en) 1995-03-24 1995-03-24 Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
IL117602A0 true IL117602A0 (en) 1996-07-23

Family

ID=23624755

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11760296A IL117602A0 (en) 1995-03-24 1996-03-21 Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Country Status (15)

Country Link
US (2) US5700806A (xx)
EP (1) EP0815099B1 (xx)
JP (1) JP3095781B2 (xx)
KR (1) KR19980703256A (xx)
AR (1) AR002722A1 (xx)
AT (1) ATE294791T1 (xx)
AU (1) AU711238B2 (xx)
CA (1) CA2216163C (xx)
DE (1) DE69634691T2 (xx)
ES (1) ES2238689T3 (xx)
HU (1) HUP9801331A3 (xx)
IL (1) IL117602A0 (xx)
NZ (1) NZ305137A (xx)
TW (1) TW349097B (xx)
WO (1) WO1996030362A1 (xx)

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US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US5945429A (en) * 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
CA2266014A1 (en) * 1996-09-13 1998-03-19 Schering Corporation Tricyclic compounds useful for inhibition of farnesyl protein transferase
BR9712035A (pt) * 1996-09-13 1999-08-24 Schering Corp Compostos Úteis para inibi-Æo de transferase de prote¡na farnesila
US6040305A (en) * 1996-09-13 2000-03-21 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
CN1104427C (zh) * 1996-09-13 2003-04-02 先灵公司 法呢基蛋白转移酶的三环抑制剂
US5994364A (en) * 1996-09-13 1999-11-30 Schering Corporation Tricyclic antitumor farnesyl protein transferase inhibitors
KR20000036111A (ko) * 1996-09-13 2000-06-26 둘락 노먼 씨. 파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물
US6071907A (en) * 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
US6030982A (en) * 1996-09-13 2000-02-29 Schering Corporationm Compounds useful for inhibition of farnesyl protein transferase
US5861395A (en) * 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
EP0927181A1 (en) * 1996-09-13 1999-07-07 Schering Corporation Tricyclic compounds useful as fpt inhibitors
US5985879A (en) * 1996-09-13 1999-11-16 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
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US5877177A (en) * 1997-06-17 1999-03-02 Schering Corporation Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
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Also Published As

Publication number Publication date
TW349097B (en) 1999-01-01
DE69634691T2 (de) 2006-02-23
AR002722A1 (es) 1998-04-29
EP0815099B1 (en) 2005-05-04
WO1996030362A1 (en) 1996-10-03
NZ305137A (en) 1999-04-29
JP3095781B2 (ja) 2000-10-10
JPH10505104A (ja) 1998-05-19
CA2216163A1 (en) 1996-10-03
MX9707232A (es) 1997-11-29
CA2216163C (en) 2001-06-05
US5807852A (en) 1998-09-15
DE69634691D1 (de) 2005-06-09
AU5307696A (en) 1996-10-16
US5700806A (en) 1997-12-23
HUP9801331A3 (en) 1999-06-28
AU711238B2 (en) 1999-10-07
EP0815099A1 (en) 1998-01-07
HUP9801331A2 (hu) 1999-05-28
ES2238689T3 (es) 2005-09-01
ATE294791T1 (de) 2005-05-15
KR19980703256A (ko) 1998-10-15

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