IL117218A - ACTIN-RESISTANT VARIANTS OF HUMAN DNase I, NUCLEIC ACIDS ENCODING SUCH VARIANTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS - Google Patents

ACTIN-RESISTANT VARIANTS OF HUMAN DNase I, NUCLEIC ACIDS ENCODING SUCH VARIANTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS

Info

Publication number
IL117218A
IL117218A IL11721896A IL11721896A IL117218A IL 117218 A IL117218 A IL 117218A IL 11721896 A IL11721896 A IL 11721896A IL 11721896 A IL11721896 A IL 11721896A IL 117218 A IL117218 A IL 117218A
Authority
IL
Israel
Prior art keywords
actin
dnase
variant
human dnase
dna
Prior art date
Application number
IL11721896A
Other languages
English (en)
Other versions
IL117218A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL117218A0 publication Critical patent/IL117218A0/xx
Publication of IL117218A publication Critical patent/IL117218A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11721896A 1995-02-24 1996-02-21 ACTIN-RESISTANT VARIANTS OF HUMAN DNase I, NUCLEIC ACIDS ENCODING SUCH VARIANTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IL117218A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
US54052795A 1995-10-10 1995-10-10

Publications (2)

Publication Number Publication Date
IL117218A0 IL117218A0 (en) 1996-06-18
IL117218A true IL117218A (en) 2004-06-01

Family

ID=26789529

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11721896A IL117218A (en) 1995-02-24 1996-02-21 ACTIN-RESISTANT VARIANTS OF HUMAN DNase I, NUCLEIC ACIDS ENCODING SUCH VARIANTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS

Country Status (20)

Country Link
EP (2) EP1980618A2 (es)
JP (1) JP4549439B2 (es)
AR (1) AR003926A1 (es)
AT (1) ATE397073T1 (es)
AU (1) AU695863B2 (es)
BR (1) BR9607328A (es)
CA (1) CA2211413C (es)
DE (1) DE69637548D1 (es)
DK (1) DK0854927T3 (es)
ES (1) ES2308775T3 (es)
HU (1) HU222665B1 (es)
IL (1) IL117218A (es)
NO (1) NO326616B1 (es)
NZ (1) NZ334762A (es)
PL (1) PL184951B1 (es)
RO (1) RO118886B1 (es)
SI (1) SI9620043A (es)
SK (1) SK284191B6 (es)
TR (1) TR199700842T1 (es)
WO (1) WO1996026279A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391607B1 (en) * 1996-06-14 2002-05-21 Genentech, Inc. Human DNase I hyperactive variants
US20150010527A1 (en) * 2012-02-01 2015-01-08 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy
US10988745B2 (en) 2013-10-31 2021-04-27 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
CN104131093B (zh) * 2014-07-23 2015-12-09 哈尔滨工程大学 DNA蛋白结合位点的DNase高通测序检测信号处理方法
EP3240896A1 (en) 2015-01-04 2017-11-08 Protalix Ltd. Modified dnase and uses thereof
IL301970A (en) 2020-10-07 2023-06-01 Protalix Ltd A long-acting DNase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPS63502716A (ja) 1986-03-07 1988-10-13 マサチューセッツ・インステチュート・オブ・テクノロジー 糖タンパク安定性の強化方法
DE68929551T2 (de) * 1988-12-23 2008-03-06 Genentech, Inc., South San Francisco Menschliche DNase
US5464817A (en) 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I
US5279823A (en) 1992-06-08 1994-01-18 Genentech, Inc. Purified forms of DNASE
CA2147469C (en) 1992-11-02 2008-01-29 Ann L. Daugherty Compaction assay for assessment of respiratory disease therapy
JPH11505408A (ja) * 1995-02-24 1999-05-21 ジェネンテック インコーポレーテッド ヒトｄｎアーゼ変異体

Also Published As

Publication number Publication date
HUP9702147A2 (hu) 1999-07-28
JP4549439B2 (ja) 2010-09-22
RO118886B1 (ro) 2003-12-30
DE69637548D1 (de) 2008-07-10
CA2211413A1 (en) 1996-08-29
EP0854927B1 (en) 2008-05-28
JPH11503004A (ja) 1999-03-23
WO1996026279A1 (en) 1996-08-29
PL184951B1 (pl) 2003-01-31
ES2308775T3 (es) 2008-12-01
TR199700842T1 (xx) 1998-01-21
ATE397073T1 (de) 2008-06-15
PL322002A1 (en) 1998-01-05
AU5026396A (en) 1996-09-11
NO326616B1 (no) 2009-01-19
SI9620043A (sl) 1998-06-30
NO973877L (no) 1997-10-24
AU695863B2 (en) 1998-08-27
NO973877D0 (no) 1997-08-22
BR9607328A (pt) 1997-12-30
DK0854927T3 (da) 2008-09-08
SK284191B6 (sk) 2004-10-05
AR003926A1 (es) 1998-09-30
HU222665B1 (hu) 2003-09-29
EP1980618A2 (en) 2008-10-15
HUP9702147A3 (en) 1999-09-28
CA2211413C (en) 2010-06-22
IL117218A0 (en) 1996-06-18
SK114897A3 (en) 1998-03-04
EP0854927A1 (en) 1998-07-29
NZ334762A (en) 2000-10-27

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