IL116966A - Bicyclic isothiourea derivatives pharmaceutical compositions containing them and process for their preparation - Google Patents

Bicyclic isothiourea derivatives pharmaceutical compositions containing them and process for their preparation

Info

Publication number
IL116966A
IL116966A IL11696696A IL11696696A IL116966A IL 116966 A IL116966 A IL 116966A IL 11696696 A IL11696696 A IL 11696696A IL 11696696 A IL11696696 A IL 11696696A IL 116966 A IL116966 A IL 116966A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
isothiourea derivatives
bicyclic
Prior art date
Application number
IL11696696A
Other languages
English (en)
Other versions
IL116966A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9502670.4A external-priority patent/GB9502670D0/en
Priority claimed from GBGB9502669.6A external-priority patent/GB9502669D0/en
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL116966A0 publication Critical patent/IL116966A0/xx
Publication of IL116966A publication Critical patent/IL116966A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11696696A 1995-02-11 1996-01-30 Bicyclic isothiourea derivatives pharmaceutical compositions containing them and process for their preparation IL116966A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9502670.4A GB9502670D0 (en) 1995-02-11 1995-02-11 Pharmaceutically active compounds
GBGB9502669.6A GB9502669D0 (en) 1995-02-11 1995-02-11 Pharmaceutically active compounds

Publications (2)

Publication Number Publication Date
IL116966A0 IL116966A0 (en) 1996-05-14
IL116966A true IL116966A (en) 2000-02-17

Family

ID=26306479

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11696696A IL116966A (en) 1995-02-11 1996-01-30 Bicyclic isothiourea derivatives pharmaceutical compositions containing them and process for their preparation

Country Status (29)

Country Link
US (2) US5786364A (hu)
EP (1) EP0808307B1 (hu)
JP (1) JPH10513194A (hu)
KR (1) KR19980702114A (hu)
CN (1) CN1181070A (hu)
AR (1) AR002961A1 (hu)
AT (1) ATE188689T1 (hu)
AU (1) AU699546B2 (hu)
BR (1) BR9607264A (hu)
CA (1) CA2211299A1 (hu)
CZ (1) CZ237597A3 (hu)
DE (1) DE69606165T2 (hu)
DK (1) DK0808307T3 (hu)
EE (1) EE03439B1 (hu)
ES (1) ES2143181T3 (hu)
FI (1) FI973273A0 (hu)
GR (1) GR3033135T3 (hu)
HU (1) HUP9801363A3 (hu)
IL (1) IL116966A (hu)
IS (1) IS4528A (hu)
NO (1) NO309036B1 (hu)
NZ (1) NZ301831A (hu)
PL (1) PL321741A1 (hu)
PT (1) PT808307E (hu)
RU (1) RU2157802C2 (hu)
SK (1) SK281205B6 (hu)
TR (1) TR199700769T1 (hu)
TW (1) TW397812B (hu)
WO (1) WO1996024588A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
US6140322A (en) * 1995-11-07 2000-10-31 Astra Aktiebolag Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
TW458978B (en) * 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
WO1998016526A1 (en) * 1996-10-16 1998-04-23 Glaxo Group Limited Tetrahydro-6h-pyrazino[1,2-b]isoquinoline 1,4-diones as apoprotein b-100 inhibitors
US5929085A (en) * 1996-11-06 1999-07-27 Astra Aktiebolag Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase
SE9701681D0 (sv) 1997-05-05 1997-05-05 Astra Ab New compounds
GB9719530D0 (en) * 1997-09-12 1997-11-19 Smithkline Beecham Plc Novel compounds
DE19844291A1 (de) * 1998-09-18 2000-03-23 Schering Ag Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln
US6664293B2 (en) * 1999-02-26 2003-12-16 Fujiwawa Pharmaceutical Co., Ltd. Amide compounds for the potentiation of cholinergic activity
GB0016169D0 (en) * 2000-06-30 2000-08-23 Univ London Diagnostic method
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
RU2223952C2 (ru) * 2001-06-04 2004-02-20 Институт физиологически активных веществ РАН Производные n,s-замещенных n'-1-[(гетеро)арил]-n'-[(гетеро)арил]метилизотиомочевин или их солей с фармакологически приемлемыми кислотами нх, способы получения их солей и оснований, фармацевтическая композиция, способ лечения и способ изучения глутаматэргической системы
RU2252936C2 (ru) * 2002-12-05 2005-05-27 Институт физиологически активных веществ РАН S-замещенные n-1-[(гетеро)арил]алкил-n`-[(гетеро)арил]алкилизотиомочевины, способ их получения, фармацевтическая композиция, способ изучения глутаматэргической системы, способы лечения (варианты)
ITTO20040125A1 (it) 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1157626B (de) * 1959-06-27 1963-11-21 Hoechst Ag Verfahren zur Herstellung von N-p-Alkoxy-phenyl-N'-chinolylthioharnstoffen mit tuberkulostatischen Eigenschaften
GB1178242A (en) * 1966-02-05 1970-01-21 Wellcome Found Novel Biologically Active Bis-Isothioureas
BE792078A (fr) * 1971-12-01 1973-05-29 Wander Ag Dr A Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
NL7902993A (nl) * 1978-04-24 1979-10-26 Rhone Poulenc Ind Nieuwe isochinolinederivaten, de bereiding ervan en farmaceutische preparaten, die de nieuwe isochinoline- derivaten bevatten.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds
US4988688A (en) * 1989-08-02 1991-01-29 Warner-Lambert Company 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
CN1095710A (zh) * 1992-11-27 1994-11-30 惠尔康基金会集团公司 酶抑制剂
BR9407515A (pt) * 1993-08-12 1997-01-07 Astra Ab Composto formulação farmaceutica uso do composto processos para o tratamento de desordens neurodegenerativas ou de enxaqueca ou para a prevenção e a reversão da tolerância aos opiatos e diazepinas ou para o tratamento do vicio das drogas e para a preparação do composto
AU7705694A (en) * 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
PL321741A1 (en) 1997-12-22
EE03439B1 (et) 2001-06-15
DK0808307T3 (da) 2000-05-08
EP0808307A1 (en) 1997-11-26
NZ301831A (en) 1998-05-27
AU4734796A (en) 1996-08-27
NO973614L (no) 1997-09-29
TW397812B (en) 2000-07-11
HUP9801363A2 (hu) 1998-09-28
DE69606165D1 (de) 2000-02-17
RU2157802C2 (ru) 2000-10-20
DE69606165T2 (de) 2000-08-24
SK104097A3 (en) 1998-10-07
IS4528A (is) 1997-07-21
EE9700168A (et) 1998-02-16
KR19980702114A (ko) 1998-07-15
US6040314A (en) 2000-03-21
FI973273A (fi) 1997-08-08
IL116966A0 (en) 1996-05-14
NO309036B1 (no) 2000-12-04
FI973273A0 (fi) 1997-08-08
JPH10513194A (ja) 1998-12-15
HUP9801363A3 (en) 1999-01-28
GR3033135T3 (en) 2000-08-31
MX9705965A (es) 1997-11-29
ATE188689T1 (de) 2000-01-15
CZ237597A3 (cs) 1998-05-13
EP0808307B1 (en) 2000-01-12
PT808307E (pt) 2000-04-28
AR002961A1 (es) 1998-05-27
ES2143181T3 (es) 2000-05-01
TR199700769T1 (xx) 1998-03-21
WO1996024588A1 (en) 1996-08-15
US5786364A (en) 1998-07-28
AU699546B2 (en) 1998-12-03
SK281205B6 (sk) 2001-01-18
BR9607264A (pt) 1997-12-30
NO973614D0 (no) 1997-08-05
CN1181070A (zh) 1998-05-06
CA2211299A1 (en) 1996-08-15

Similar Documents

Publication Publication Date Title
SI1156049T1 (en) Substituted heterocyclic compounds, their process of preparation and pharmaceutical compositions containing them
HK1005136A1 (en) Amido-3-pyrazole derivatives process for their preparation and pharmaceutical compositions containing them
HUP9802200A3 (en) Rapamycin derivatives, process for their preparation, pharmaceutical compositions containing them and their use
IL110296A (en) Imidazole compounds process for their preparation and pharmaceutical compositions containing them
AU4821096A (en) Benzazepine-, benzoxazepine- and benzothiazepine-N-acetic derivatives, process for their preparation and pharmaceutical compositions containing them
IL117598A (en) Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them
HUT72639A (en) Substituted thiazolidinedione derivatives, pharmaceutical compositions containing them and process for their preparation
HUP9802300A3 (en) N-heteroaryl-pyridinesulfonamide derivatives, pharmaceutical compositions containing them, process for producing them and their use
IL117193A0 (en) Poly-pyrrolecarbox-amidenaphthalenic acid derivatives their preparation and pharmaceutical compositions containing them
IL122618A0 (en) Substituted imidazolylacetonitrile compounds their preparation and pharmaceutical compositions containing them
IL119559A0 (en) Purin -6- one derivatives their preparation and pharmaceutical compositions containing them
HUP9600071A3 (en) Indolo-piperidine derivatives, pharmaceutical compositions containing them, process for producing them and their use
HUP9602635A2 (en) 4-aciloxy-benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9702400A3 (en) Substituted camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9600876A3 (en) Benzonitril- and -fluoride derivatives, pharmaceutical compositions containing them, process for producing them and their use
HUP9801993A3 (en) Ascomycin derivatives and their use for preparation of pharmaceutical compositions, process for their preparation and pharmaceutical compositions containing them
IL116966A (en) Bicyclic isothiourea derivatives pharmaceutical compositions containing them and process for their preparation
HUP9901485A3 (en) Heterocyclylcarboxamide derivatives, pharmaceutical compositions containing the same, process for their preparation and their use
IL141955A0 (en) Benzothiazolone derivatives, process for their preparation and pharmaceutical compositions containing them
IL122377A (en) Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them
IL123900A0 (en) New phenylamidine derivatives processes for preparing them and their use as pharmaceutical compositions
CZ92295A3 (en) Boronpeptide derivatives, process of their preparation and pharmaceutical composition containing thereof
ZA9511029B (en) Substituted 4-phenylthiazole derivatives process for their preparation and pharmaceutical compositions containing them
HUP9601680A3 (en) Benzisothiazolyl-substituted aminomethyl-chromanes, pharmaceutical compositions containing the same, process for their preparation and use of the compounds
HUP9800631A3 (en) 4-aminotetrahydrobenzisoxazole or -isothiazole derivatives, pharmaceutical compositions containing them and their use for the preparation of pharmaceutical compositions

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees