IL116428A - Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof - Google Patents

Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof

Info

Publication number
IL116428A
IL116428A IL11642895A IL11642895A IL116428A IL 116428 A IL116428 A IL 116428A IL 11642895 A IL11642895 A IL 11642895A IL 11642895 A IL11642895 A IL 11642895A IL 116428 A IL116428 A IL 116428A
Authority
IL
Israel
Prior art keywords
intermediates
phthalimidopropanoyl
enkephalinase
dihydropyridine
tri
Prior art date
Application number
IL11642895A
Other languages
English (en)
Other versions
IL116428A0 (en
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/535,403 external-priority patent/US5641880A/en
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Priority to IL12899695A priority Critical patent/IL128996A/xx
Priority to IL13914295A priority patent/IL139142A/en
Priority to IL13914195A priority patent/IL139141A/xx
Publication of IL116428A0 publication Critical patent/IL116428A0/xx
Priority to IL12899699A priority patent/IL128996A0/xx
Priority to IL13914100A priority patent/IL139141A0/xx
Priority to IL13914200A priority patent/IL139142A0/xx
Publication of IL116428A publication Critical patent/IL116428A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL11642895A 1994-12-21 1995-12-18 Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof IL116428A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL12899695A IL128996A (en) 1994-12-21 1995-12-18 Process for preparing 1,2,3,4,6,7,8,12b-octahydro-6-oxo-7-phthalimido-pyrido ¬2,1-a¾ benzazepine-4-carboxylic acids and simlar compounds as intermediates for inhibitors of enkephalinase and angiotension converting enzyme and some novel 1-(3-aryl-2-phthalimidopropanolyl)-1,2,3,4-tetrahydropyridine-carbonitriles as intermediates therefor
IL13914295A IL139142A (en) 1994-12-21 1995-12-18 4-CYANO-1,2,3,4,6,7,8,12b-OCTAHYDRO-6- OXOPYRIDO [2,1-A] [2] BENZAZEPINE AND ANALOGS THEREOF INTERMEDIATES FOR PREPARING TRI- AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME
IL13914195A IL139141A (en) 1994-12-21 1995-12-18 7-Phthalimido-1,2,6,7,8,12b hexahydro-pyrido Ä2,1-aÜbenzazepin-6-one and analogs thereof intermediates for preparing tri-and tetracyclic inhibitors ofenkephalinase and angiotensin converting enzyme
IL12899699A IL128996A0 (en) 1994-12-21 1999-03-15 A novel process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
IL13914100A IL139141A0 (en) 1994-12-21 2000-10-19 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME
IL13914200A IL139142A0 (en) 1994-12-21 2000-10-19 4-CYANO-1,2,3,4,6,7,8,12B-OCTAHYDRO-6- OXOPYRIDO[2,1-a] [2] BENZAZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36091594A 1994-12-21 1994-12-21
US08/535,403 US5641880A (en) 1994-12-21 1995-10-24 Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof

Publications (2)

Publication Number Publication Date
IL116428A0 IL116428A0 (en) 1996-03-31
IL116428A true IL116428A (en) 2001-03-19

Family

ID=27001069

Family Applications (6)

Application Number Title Priority Date Filing Date
IL11642895A IL116428A (en) 1994-12-21 1995-12-18 Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof
IL13914195A IL139141A (en) 1994-12-21 1995-12-18 7-Phthalimido-1,2,6,7,8,12b hexahydro-pyrido Ä2,1-aÜbenzazepin-6-one and analogs thereof intermediates for preparing tri-and tetracyclic inhibitors ofenkephalinase and angiotensin converting enzyme
IL13914295A IL139142A (en) 1994-12-21 1995-12-18 4-CYANO-1,2,3,4,6,7,8,12b-OCTAHYDRO-6- OXOPYRIDO [2,1-A] [2] BENZAZEPINE AND ANALOGS THEREOF INTERMEDIATES FOR PREPARING TRI- AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME
IL12899699A IL128996A0 (en) 1994-12-21 1999-03-15 A novel process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
IL13914200A IL139142A0 (en) 1994-12-21 2000-10-19 4-CYANO-1,2,3,4,6,7,8,12B-OCTAHYDRO-6- OXOPYRIDO[2,1-a] [2] BENZAZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME
IL13914100A IL139141A0 (en) 1994-12-21 2000-10-19 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME

Family Applications After (5)

Application Number Title Priority Date Filing Date
IL13914195A IL139141A (en) 1994-12-21 1995-12-18 7-Phthalimido-1,2,6,7,8,12b hexahydro-pyrido Ä2,1-aÜbenzazepin-6-one and analogs thereof intermediates for preparing tri-and tetracyclic inhibitors ofenkephalinase and angiotensin converting enzyme
IL13914295A IL139142A (en) 1994-12-21 1995-12-18 4-CYANO-1,2,3,4,6,7,8,12b-OCTAHYDRO-6- OXOPYRIDO [2,1-A] [2] BENZAZEPINE AND ANALOGS THEREOF INTERMEDIATES FOR PREPARING TRI- AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME
IL12899699A IL128996A0 (en) 1994-12-21 1999-03-15 A novel process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
IL13914200A IL139142A0 (en) 1994-12-21 2000-10-19 4-CYANO-1,2,3,4,6,7,8,12B-OCTAHYDRO-6- OXOPYRIDO[2,1-a] [2] BENZAZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME
IL13914100A IL139141A0 (en) 1994-12-21 2000-10-19 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME

Country Status (22)

Country Link
US (1) US5734049A (da)
EP (1) EP0800527B1 (da)
JP (1) JP3658408B2 (da)
CN (2) CN1241924C (da)
AR (1) AR000378A1 (da)
AT (2) ATE190315T1 (da)
AU (1) AU689362B2 (da)
CA (2) CA2297134C (da)
DE (2) DE69533002T2 (da)
DK (2) DK0800527T3 (da)
ES (2) ES2216386T3 (da)
FI (1) FI121599B (da)
GR (1) GR3033329T3 (da)
HU (1) HU227675B1 (da)
IL (6) IL116428A (da)
MX (1) MX9704677A (da)
NO (2) NO308900B1 (da)
NZ (2) NZ298245A (da)
PT (2) PT800527E (da)
SI (2) SI0957109T1 (da)
TW (1) TW401413B (da)
WO (1) WO1996019492A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
EP2951154B1 (de) * 2013-01-30 2017-04-19 Basf Se 2,6-bis-(aminomethyl)piperidin- (2,6-bamp-), 2,6-bis-(isocyanomethyl)piperidin- (diisocyanat-) und 2,6-dicyanopiperidin-derivate (2,6-dcp-derivate) und ihre verwendung in der herstellung von epoxyharzen, polyurethanen, polyetherolen und polyamiden

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874107B (da) * 1986-06-13 1987-12-09
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DK0492369T3 (da) * 1990-12-21 1997-10-13 Merrell Pharma Inc Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam

Also Published As

Publication number Publication date
CN1241924C (zh) 2006-02-15
CA2297134C (en) 2004-02-10
DK0957109T3 (da) 2004-06-01
NO972875D0 (no) 1997-06-20
CN1170413A (zh) 1998-01-14
DK0800527T3 (da) 2000-06-05
HU227675B1 (en) 2011-11-28
EP0800527A1 (en) 1997-10-15
FI972620A0 (fi) 1997-06-18
CA2208569A1 (en) 1996-06-27
CA2297134A1 (en) 1996-06-27
NO972875L (no) 1997-08-20
IL139142A0 (en) 2001-11-25
NO308900B1 (no) 2000-11-13
ATE190315T1 (de) 2000-03-15
NO20001822L (no) 1997-08-20
IL139142A (en) 2004-07-25
SI0957109T1 (en) 2004-10-31
DE69515517D1 (de) 2000-04-13
JP3658408B2 (ja) 2005-06-08
GR3033329T3 (en) 2000-09-29
ATE266040T1 (de) 2004-05-15
DE69533002T2 (de) 2005-05-04
NZ334608A (en) 1999-07-29
DE69515517T2 (de) 2000-07-06
US5734049A (en) 1998-03-31
AU689362B2 (en) 1998-03-26
FI121599B (fi) 2011-01-31
ES2216386T3 (es) 2004-10-16
IL139141A0 (en) 2001-11-25
DE69533002D1 (de) 2004-06-09
IL139141A (en) 2005-11-20
HUT78073A (hu) 1999-08-30
CN1495186A (zh) 2004-05-12
NO20001822D0 (no) 2000-04-07
NO310025B1 (no) 2001-05-07
IL116428A0 (en) 1996-03-31
PT957109E (pt) 2004-09-30
IL128996A0 (en) 2000-02-17
CN1113894C (zh) 2003-07-09
HK1066009A1 (en) 2005-03-11
FI972620L (fi) 1997-06-18
MX9704677A (es) 1997-09-30
CA2208569C (en) 2000-07-11
EP0800527B1 (en) 2000-03-08
TW401413B (en) 2000-08-11
WO1996019492A1 (en) 1996-06-27
AR000378A1 (es) 1997-06-18
JPH10511348A (ja) 1998-11-04
NZ298245A (en) 1999-04-29
AU4368596A (en) 1996-07-10
PT800527E (pt) 2000-06-30
ES2147863T3 (es) 2000-10-01
SI0800527T1 (en) 2000-08-31

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees