IL115473A - Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapy - Google Patents
Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapyInfo
- Publication number
- IL115473A IL115473A IL11547395A IL11547395A IL115473A IL 115473 A IL115473 A IL 115473A IL 11547395 A IL11547395 A IL 11547395A IL 11547395 A IL11547395 A IL 11547395A IL 115473 A IL115473 A IL 115473A
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- stem cell
- cell proliferation
- medicaments
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04M—TELEPHONIC COMMUNICATION
- H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
- H04M11/002—Telephonic communication systems specially adapted for combination with other electrical systems with telemetering systems
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04M—TELEPHONIC COMMUNICATION
- H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
- H04M11/04—Telephonic communication systems specially adapted for combination with other electrical systems with alarm systems, e.g. fire, police or burglar alarm systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Signal Processing (AREA)
- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11547395A IL115473A (en) | 1994-03-30 | 1995-09-29 | Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapy |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL10917794A IL109177A (en) | 1993-03-31 | 1994-03-30 | Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor |
US08/316,424 US6022848A (en) | 1993-03-31 | 1994-09-30 | Inhibitor of stem cell proliferation and uses thereof |
US08/535,882 US5939391A (en) | 1993-03-31 | 1995-09-28 | Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation |
IL11547395A IL115473A (en) | 1994-03-30 | 1995-09-29 | Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
IL115473A0 IL115473A0 (en) | 1995-12-31 |
IL115473A true IL115473A (en) | 2005-08-31 |
Family
ID=26980434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11547395A IL115473A (en) | 1994-03-30 | 1995-09-29 | Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapy |
Country Status (18)
Country | Link |
---|---|
US (2) | US5939391A (de) |
EP (1) | EP0784677B1 (de) |
JP (3) | JP3953511B2 (de) |
CN (2) | CN1328285C (de) |
AT (1) | ATE263236T1 (de) |
CA (1) | CA2201105C (de) |
DE (1) | DE69532813T2 (de) |
DK (1) | DK0784677T3 (de) |
ES (1) | ES2216019T3 (de) |
FI (1) | FI117468B (de) |
HK (3) | HK1071517A1 (de) |
IL (1) | IL115473A (de) |
MX (1) | MX9702266A (de) |
NO (1) | NO319575B1 (de) |
NZ (2) | NZ294446A (de) |
PT (1) | PT784677E (de) |
RU (1) | RU2186579C2 (de) |
WO (1) | WO1996010634A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5939391A (en) * | 1993-03-31 | 1999-08-17 | Pro-Neuron, Inc. | Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation |
ES2185649T3 (es) | 1993-03-31 | 2003-05-01 | Wellstat Therapeutics Corp | Inhibidores de la proliferacion de las celulas germinales y sus utilizaciones. |
US6610654B2 (en) * | 1993-03-31 | 2003-08-26 | Wellstat Therapeutics Corporation | Inhibitor of stem cell proliferation and uses thereof |
EP1897553A1 (de) * | 1994-09-30 | 2008-03-12 | Wellstat Therapeutics Corporation | Stammzellenvermehrungsinhibitor und Verwendungen dafür |
US5861483A (en) | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
GB9700154D0 (en) | 1997-01-07 | 1997-02-26 | Primapharma Ltd | Peptides |
JP2000095794A (ja) * | 1998-09-22 | 2000-04-04 | Itoham Foods Inc | エンケファリン分解酵素の阻害剤 |
US6488828B1 (en) * | 2000-07-20 | 2002-12-03 | Roche Diagnostics Corporation | Recloseable biosensor |
WO2005026380A2 (en) * | 2003-09-10 | 2005-03-24 | Southern Research Institute | Bone marrow proliferation assay |
NZ565394A (en) * | 2005-07-26 | 2011-04-29 | Cms Peptides Patent Holding Company Ltd | Biologically active peptides comprising PTTKTYFPHF and their uses for non-therapeutically reducing fatigue |
RU2317074C1 (ru) * | 2006-03-16 | 2008-02-20 | Общество с ограниченной ответственностью "МБФ" | Ингибитор дифференцировки кроветворных клеток-предшественников |
WO2008136699A1 (fr) * | 2007-05-04 | 2008-11-13 | Igor Alexandrovich Bazikov | Patch transdermique à microcapsules et procédé de fabrication correspondant |
US9782452B2 (en) * | 2011-11-22 | 2017-10-10 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling |
US9220706B2 (en) | 2012-06-01 | 2015-12-29 | National Institutes Of Health (Nih) | Inhibition of leukemic stem cells by PP2A activating agents |
WO2014078787A1 (en) * | 2012-11-19 | 2014-05-22 | Wellstat Therapeutics Corporation | Stem cell mobilization and tissue repair and regeneration |
RU2535972C2 (ru) * | 2012-12-24 | 2014-12-20 | Андрей Степанович БРЮХОВЕЦКИЙ | Противоопухолевый индивидуальный протеом-основанный таргетный клеточный препарат, способ его получения и применение этого препарата для терапии рака и других злокачественных новообразований |
RU2537141C1 (ru) * | 2013-11-20 | 2014-12-27 | государственное бюджетное образовательное учреждение высшего профессионального образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ определения способности клеток костного мозга к делению |
CN104817622A (zh) * | 2014-01-30 | 2015-08-05 | 陈光健 | 寡肽cd04及其制备方法和应用 |
CN104817613A (zh) * | 2014-01-30 | 2015-08-05 | 陈光健 | 寡肽cd06及其制备方法和应用 |
CN104817625A (zh) * | 2014-01-30 | 2015-08-05 | 陈光健 | 寡肽cd03及其制备方法和应用 |
CN104817615A (zh) * | 2014-01-30 | 2015-08-05 | 陈光健 | 寡肽cd05及其制备方法和应用 |
CN105294830A (zh) * | 2014-06-18 | 2016-02-03 | 陈光健 | 一种二肽分子及其制备方法和应用 |
WO2019241609A1 (en) * | 2018-06-15 | 2019-12-19 | Trustees Of Boston University | Polypeptide compositions and methods for site-specific targeting of therapeutic agents |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1142466A (en) * | 1979-01-09 | 1983-03-08 | Cesar Milstein | Cell lines |
US4683194A (en) * | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
GB8711614D0 (en) * | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
US5545727A (en) * | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
DE69034091T2 (de) * | 1989-05-10 | 2004-04-22 | Baxter Biotech Technology S.A.R.L. | Herstellung von Hämoglobin und Analogen davon in Nicht-Erythrozytzellen |
DK0494268T4 (da) * | 1989-09-25 | 1999-11-08 | Genetics Inst | Fremgangsmåde til inhibering af stamcellers vækst |
US5239061A (en) * | 1990-06-20 | 1993-08-24 | Research Corporation Technologies, Inc. | Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin |
ATE206760T1 (de) * | 1990-12-20 | 2001-10-15 | Univ Alabama Res Found | Transgenes, vernetztes hämoglobin |
WO1992020369A1 (en) * | 1991-05-14 | 1992-11-26 | Dana Farber Cancer Institute | Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents |
US5334706A (en) * | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
US5786334A (en) * | 1992-08-14 | 1998-07-28 | Technology Resources International, Inc. | Hexapeptide having immunostimulatory activity |
DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
US5939391A (en) * | 1993-03-31 | 1999-08-17 | Pro-Neuron, Inc. | Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation |
US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
-
1995
- 1995-09-28 US US08/535,882 patent/US5939391A/en not_active Expired - Lifetime
- 1995-09-29 CA CA002201105A patent/CA2201105C/en not_active Expired - Fee Related
- 1995-09-29 NZ NZ294446A patent/NZ294446A/xx not_active IP Right Cessation
- 1995-09-29 IL IL11547395A patent/IL115473A/xx not_active IP Right Cessation
- 1995-09-29 DK DK95935119T patent/DK0784677T3/da active
- 1995-09-29 NZ NZ335108A patent/NZ335108A/xx unknown
- 1995-09-29 PT PT95935119T patent/PT784677E/pt unknown
- 1995-09-29 CN CNB951965557A patent/CN1328285C/zh not_active Expired - Fee Related
- 1995-09-29 ES ES95935119T patent/ES2216019T3/es not_active Expired - Lifetime
- 1995-09-29 DE DE69532813T patent/DE69532813T2/de not_active Expired - Lifetime
- 1995-09-29 AT AT95935119T patent/ATE263236T1/de not_active IP Right Cessation
- 1995-09-29 JP JP51195796A patent/JP3953511B2/ja not_active Expired - Fee Related
- 1995-09-29 MX MX9702266A patent/MX9702266A/es not_active IP Right Cessation
- 1995-09-29 RU RU97107644/14A patent/RU2186579C2/ru not_active IP Right Cessation
- 1995-09-29 WO PCT/US1995/012268 patent/WO1996010634A1/en active IP Right Grant
- 1995-09-29 CN CNB021561842A patent/CN1321688C/zh not_active Expired - Fee Related
- 1995-09-29 EP EP95935119A patent/EP0784677B1/de not_active Expired - Lifetime
-
1997
- 1997-03-11 FI FI971000A patent/FI117468B/fi active IP Right Grant
- 1997-03-26 NO NO19971444A patent/NO319575B1/no not_active IP Right Cessation
-
1998
- 1998-01-12 US US09/005,546 patent/US6090782A/en not_active Expired - Lifetime
- 1998-06-22 HK HK05104358A patent/HK1071517A1/xx not_active IP Right Cessation
- 1998-06-22 HK HK98105855A patent/HK1006642A1/xx unknown
- 1998-06-22 HK HK08102174.6A patent/HK1108701A1/xx not_active IP Right Cessation
-
2004
- 2004-05-17 JP JP2004147081A patent/JP4188279B2/ja not_active Expired - Fee Related
-
2007
- 2007-12-07 JP JP2007317741A patent/JP2008088186A/ja not_active Withdrawn
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |