ES8106498A1 - Un procedimiento para la preparacion de derivados del pirrol - Google Patents
Un procedimiento para la preparacion de derivados del pirrolInfo
- Publication number
- ES8106498A1 ES8106498A1 ES494546A ES494546A ES8106498A1 ES 8106498 A1 ES8106498 A1 ES 8106498A1 ES 494546 A ES494546 A ES 494546A ES 494546 A ES494546 A ES 494546A ES 8106498 A1 ES8106498 A1 ES 8106498A1
- Authority
- ES
- Spain
- Prior art keywords
- diaryl
- polyfluoroalkanones
- methanols
- polyfluoroalkyl
- pyrrol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE PIRROL. CONSTA DE LAS SIGUIENTES ETAPAS: 1. REACCION DE UN COMPUESTO DE FORMULA GENERAL (I) CON UN COMPUESTO R4-CO-Q. SI SE DESEA, SE PUEDE HACER REACIONAR EL PRODUCTO OBTENIDO CON UN REACTIVO NUCLEOFILO. OPCIONALMENTE SE PUEDE HACER REACCIONAR EL PRODUCTO OBTENIDO CON UN QUIERA DE LAS ETAPAS ANTERIORES CON UN AGENTE ALQUILANTE O ACILANTE Y SI SE DESEA SE CONVIERTE EL PRODUCTO DE CUALQUIERA DE LAS ETAPAS ANTERIORES EN UNA SAL FARMACEUTICAMENTE ACEPTABLE. SE OBTIENE UN COMPUESTO DE FORMULA GENERAL (II). EL COMPUESTO OBTENIDO ES 4.5-BIS(4-FLUORFENIL)-ALFA,ALFA-BIS(TRIFLUORMETIL)-1H-PIRROL-2-METANOL O BIEN EL 4-(4-FLUORFENIL)-5-(4-DIMETILAMINOFENIL)-ALFA,ALFA-BIS(TRIFLUORMETIL)-1 H-PIRROL-2-METANOL. *FORMULA* E
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7032679A | 1979-08-27 | 1979-08-27 | |
US15923780A | 1980-06-20 | 1980-06-20 | |
US15923880A | 1980-06-20 | 1980-06-20 | |
US16680780A | 1980-07-17 | 1980-07-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES494546A0 ES494546A0 (es) | 1981-07-01 |
ES8106498A1 true ES8106498A1 (es) | 1981-07-01 |
Family
ID=27490817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES494546A Expired ES8106498A1 (es) | 1979-08-27 | 1980-08-27 | Un procedimiento para la preparacion de derivados del pirrol |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0025884A1 (es) |
DK (1) | DK350280A (es) |
ES (1) | ES8106498A1 (es) |
FI (1) | FI802693A (es) |
GR (1) | GR69839B (es) |
IL (1) | IL60917A0 (es) |
NO (1) | NO802528L (es) |
PT (1) | PT71748B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4267190A (en) * | 1980-04-18 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols |
EP0044485A1 (en) * | 1980-07-21 | 1982-01-27 | E.I. Du Pont De Nemours And Company | Antiinflammatory 2,3-diaryl-5(2,2,2-trifluoro-1-(trifluoromethyl)-ethyl)-1H-pyrroles |
US5599924A (en) * | 1992-08-14 | 1997-02-04 | Trustees Of The University Of Pennsylvania | Electron-deficient porphyrins and processes and intermediates for preparing same |
US6100392A (en) * | 1992-08-14 | 2000-08-08 | The Trustees Of The University Of Pennsylavania | Electron-deficient porphyrins and processes and intermediates for preparing same |
US5792778A (en) * | 1995-08-10 | 1998-08-11 | Merck & Co., Inc. | 2-substituted aryl pyrroles, compositions containing such compounds and methods of use |
US5837719A (en) * | 1995-08-10 | 1998-11-17 | Merck & Co., Inc. | 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use |
US5776954A (en) * | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
CA2316953A1 (en) | 1997-12-26 | 1999-07-08 | Nissin Food Products Co., Ltd. | 5-arylpyrrole derivatives |
GB0711776D0 (en) * | 2007-06-18 | 2007-07-25 | Syngenta Participations Ag | Substituted aromatic heterocyclic compounds as fungicides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3197480A (en) * | 1962-12-12 | 1965-07-27 | Du Pont | 2 and 2, 4-(alpha hydroxypolyperhalocycloalkyl)-thiophenes, pyrroles, and furans; 2 and 2, 4-[(alpha hydroxyalpha, alpha dipolyperhalo hydrocarbon) methyl]-thiophenes, pyrroles and furans and process for making them |
US3709906A (en) * | 1968-07-26 | 1973-01-09 | Sankyo Co | 2-alkyl-4,5-diphenylpyrrole derivatives |
US3918954A (en) * | 1973-03-11 | 1975-11-11 | Sterling Drug Inc | Herbicidal compositions containing halomethyl ketones and method of use thereof |
DK75779A (da) * | 1978-03-13 | 1979-09-14 | Du Pont | 4,5-diaryl-2- (substitueret thio) pyrroler og sulfoxider og sulfoner deraf samt fremgangsmaader til deres fremstilling og anvendelse |
-
1980
- 1980-08-13 DK DK350280A patent/DK350280A/da unknown
- 1980-08-22 EP EP80105006A patent/EP0025884A1/en not_active Withdrawn
- 1980-08-26 IL IL60917A patent/IL60917A0/xx unknown
- 1980-08-26 FI FI802693A patent/FI802693A/fi not_active Application Discontinuation
- 1980-08-26 NO NO802528A patent/NO802528L/no unknown
- 1980-08-26 GR GR62753A patent/GR69839B/el unknown
- 1980-08-27 ES ES494546A patent/ES8106498A1/es not_active Expired
- 1980-08-27 PT PT71748A patent/PT71748B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
GR69839B (es) | 1982-07-19 |
PT71748B (en) | 1982-04-07 |
NO802528L (no) | 1981-03-02 |
DK350280A (da) | 1981-02-28 |
ES494546A0 (es) | 1981-07-01 |
EP0025884A1 (en) | 1981-04-01 |
IL60917A0 (en) | 1980-10-26 |
FI802693A (fi) | 1981-02-28 |
PT71748A (en) | 1980-09-01 |
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