DE69532813D1 - Inhibitor der stammzellenproliferation und dessen verwendung - Google Patents

Inhibitor der stammzellenproliferation und dessen verwendung

Info

Publication number
DE69532813D1
DE69532813D1 DE69532813T DE69532813T DE69532813D1 DE 69532813 D1 DE69532813 D1 DE 69532813D1 DE 69532813 T DE69532813 T DE 69532813T DE 69532813 T DE69532813 T DE 69532813T DE 69532813 D1 DE69532813 D1 DE 69532813D1
Authority
DE
Germany
Prior art keywords
stem cell
polliferation
inhibitor
disclosed
accelerating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532813T
Other languages
English (en)
Other versions
DE69532813T2 (de
Inventor
Vladimir Kozlov
Irena Tsyrlova
D Wolpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellstat Therapeutics Corp
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/316,424 external-priority patent/US6022848A/en
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of DE69532813D1 publication Critical patent/DE69532813D1/de
Application granted granted Critical
Publication of DE69532813T2 publication Critical patent/DE69532813T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/002—Telephonic communication systems specially adapted for combination with other electrical systems with telemetering systems
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04M—TELEPHONIC COMMUNICATION
    • H04M11/00—Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/04—Telephonic communication systems specially adapted for combination with other electrical systems with alarm systems, e.g. fire, police or burglar alarm systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
DE69532813T 1994-09-30 1995-09-29 Inhibitor der stammzellenproliferation und dessen verwendung Expired - Lifetime DE69532813T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/316,424 US6022848A (en) 1993-03-31 1994-09-30 Inhibitor of stem cell proliferation and uses thereof
US316424 1994-09-30
US535882 1995-09-28
US08/535,882 US5939391A (en) 1993-03-31 1995-09-28 Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
PCT/US1995/012268 WO1996010634A1 (en) 1994-09-30 1995-09-29 Inhibitor of stem cell proliferation and uses thereof

Publications (2)

Publication Number Publication Date
DE69532813D1 true DE69532813D1 (de) 2004-05-06
DE69532813T2 DE69532813T2 (de) 2005-03-17

Family

ID=26980434

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532813T Expired - Lifetime DE69532813T2 (de) 1994-09-30 1995-09-29 Inhibitor der stammzellenproliferation und dessen verwendung

Country Status (18)

Country Link
US (2) US5939391A (de)
EP (1) EP0784677B1 (de)
JP (3) JP3953511B2 (de)
CN (2) CN1321688C (de)
AT (1) ATE263236T1 (de)
CA (1) CA2201105C (de)
DE (1) DE69532813T2 (de)
DK (1) DK0784677T3 (de)
ES (1) ES2216019T3 (de)
FI (1) FI117468B (de)
HK (3) HK1108701A1 (de)
IL (1) IL115473A (de)
MX (1) MX9702266A (de)
NO (1) NO319575B1 (de)
NZ (2) NZ335108A (de)
PT (1) PT784677E (de)
RU (1) RU2186579C2 (de)
WO (1) WO1996010634A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US6610654B2 (en) 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
AU694111B2 (en) 1993-03-31 1998-07-16 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
EP1897553A1 (de) * 1994-09-30 2008-03-12 Wellstat Therapeutics Corporation Stammzellenvermehrungsinhibitor und Verwendungen dafür
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
GB9700154D0 (en) * 1997-01-07 1997-02-26 Primapharma Ltd Peptides
JP2000095794A (ja) * 1998-09-22 2000-04-04 Itoham Foods Inc エンケファリン分解酵素の阻害剤
US6488828B1 (en) * 2000-07-20 2002-12-03 Roche Diagnostics Corporation Recloseable biosensor
WO2005026380A2 (en) * 2003-09-10 2005-03-24 Southern Research Institute Bone marrow proliferation assay
EP1909815A4 (de) * 2005-07-26 2011-05-18 Cms Peptides Patent Holding Company Ltd Neuartige biologisch aktive peptide und neue verwendungen dafür
RU2317074C1 (ru) * 2006-03-16 2008-02-20 Общество с ограниченной ответственностью "МБФ" Ингибитор дифференцировки кроветворных клеток-предшественников
WO2008136699A1 (fr) * 2007-05-04 2008-11-13 Igor Alexandrovich Bazikov Patch transdermique à microcapsules et procédé de fabrication correspondant
WO2013078286A1 (en) * 2011-11-22 2013-05-30 Cornell University Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling
WO2013181488A2 (en) * 2012-06-01 2013-12-05 The Ohio State University Research Foundation Inhibition of leukemic stem cells by pp2a activating agents
US9428552B2 (en) * 2012-11-19 2016-08-30 Wellstat Therapeutics Corporation Stem cell mobilization and tissue repair and regeneration
RU2535972C2 (ru) * 2012-12-24 2014-12-20 Андрей Степанович БРЮХОВЕЦКИЙ Противоопухолевый индивидуальный протеом-основанный таргетный клеточный препарат, способ его получения и применение этого препарата для терапии рака и других злокачественных новообразований
RU2537141C1 (ru) * 2013-11-20 2014-12-27 государственное бюджетное образовательное учреждение высшего профессионального образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ определения способности клеток костного мозга к делению
CN104817613A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd06及其制备方法和应用
CN104817625A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd03及其制备方法和应用
CN104817622A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd04及其制备方法和应用
CN104817615A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd05及其制备方法和应用
CN105294830A (zh) * 2014-06-18 2016-02-03 陈光健 一种二肽分子及其制备方法和应用
WO2019241609A1 (en) * 2018-06-15 2019-12-19 Trustees Of Boston University Polypeptide compositions and methods for site-specific targeting of therapeutic agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1142466A (en) * 1979-01-09 1983-03-08 Cesar Milstein Cell lines
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
ES2204926T3 (es) * 1989-05-10 2004-05-01 Baxter Biotech Technology S. .R.L. Procedimiento de preparacion de hemoglobina y derivados de hemoglobina a partir de manipulacion de bacterias y levaduras.
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
EP0494268B2 (de) * 1989-09-25 1999-04-28 Genetics Institute, Inc. Verfahren zur wachstumshemmung von stammzellen
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
EP0668909B1 (de) * 1990-12-20 2001-10-10 The University Of Alabama Research Foundation Transgenes, vernetztes hämoglobin
AU2140492A (en) * 1991-05-14 1992-12-30 Biopure Corporation Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5786334A (en) * 1992-08-14 1998-07-28 Technology Resources International, Inc. Hexapeptide having immunostimulatory activity
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof

Also Published As

Publication number Publication date
CA2201105A1 (en) 1996-04-11
CA2201105C (en) 2009-11-24
NO971444L (no) 1997-05-26
MX9702266A (es) 1997-06-28
CN1328285C (zh) 2007-07-25
CN1168695A (zh) 1997-12-24
NZ294446A (en) 1999-07-29
JPH10509422A (ja) 1998-09-14
FI971000A (fi) 1997-05-28
US5939391A (en) 1999-08-17
HK1071517A1 (en) 2005-07-22
JP2004256553A (ja) 2004-09-16
ATE263236T1 (de) 2004-04-15
ES2216019T3 (es) 2004-10-16
NZ335108A (en) 2000-11-24
FI971000A0 (fi) 1997-03-11
IL115473A (en) 2005-08-31
DK0784677T3 (da) 2004-08-02
FI117468B (fi) 2006-10-31
US6090782A (en) 2000-07-18
EP0784677B1 (de) 2004-03-31
HK1006642A1 (en) 1999-03-12
HK1108701A1 (en) 2008-05-16
NO971444D0 (no) 1997-03-26
CN1321688C (zh) 2007-06-20
EP0784677A1 (de) 1997-07-23
JP2008088186A (ja) 2008-04-17
WO1996010634A1 (en) 1996-04-11
NO319575B1 (no) 2005-08-29
RU2186579C2 (ru) 2002-08-10
DE69532813T2 (de) 2005-03-17
IL115473A0 (en) 1995-12-31
PT784677E (pt) 2004-08-31
JP3953511B2 (ja) 2007-08-08
CN1565627A (zh) 2005-01-19
JP4188279B2 (ja) 2008-11-26
EP0784677A4 (de) 2002-01-30

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Legal Events

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