HK1108701A1 - Inhibitor of stem cell proliferation and uses thereof - Google Patents

Inhibitor of stem cell proliferation and uses thereof

Info

Publication number
HK1108701A1
HK1108701A1 HK08102174.6A HK08102174A HK1108701A1 HK 1108701 A1 HK1108701 A1 HK 1108701A1 HK 08102174 A HK08102174 A HK 08102174A HK 1108701 A1 HK1108701 A1 HK 1108701A1
Authority
HK
Hong Kong
Prior art keywords
stem cell
cell proliferation
inhibitor
disclosed
accelerating
Prior art date
Application number
HK08102174.6A
Other languages
English (en)
Inventor
Vladimir Kozlov
Irena Tsyrlova
Stephen D Wolpe
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/316,424 external-priority patent/US6022848A/en
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of HK1108701A1 publication Critical patent/HK1108701A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/805Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04MTELEPHONIC COMMUNICATION
    • H04M11/00Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/002Telephonic communication systems specially adapted for combination with other electrical systems with telemetering systems
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04MTELEPHONIC COMMUNICATION
    • H04M11/00Telephonic communication systems specially adapted for combination with other electrical systems
    • H04M11/04Telephonic communication systems specially adapted for combination with other electrical systems with alarm systems, e.g. fire, police or burglar alarm systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
HK08102174.6A 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof HK1108701A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/316,424 US6022848A (en) 1993-03-31 1994-09-30 Inhibitor of stem cell proliferation and uses thereof
US08/535,882 US5939391A (en) 1993-03-31 1995-09-28 Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
HK98105855A HK1006642A1 (en) 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof

Publications (1)

Publication Number Publication Date
HK1108701A1 true HK1108701A1 (en) 2008-05-16

Family

ID=26980434

Family Applications (3)

Application Number Title Priority Date Filing Date
HK05104358A HK1071517A1 (en) 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof
HK98105855A HK1006642A1 (en) 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof
HK08102174.6A HK1108701A1 (en) 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK05104358A HK1071517A1 (en) 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof
HK98105855A HK1006642A1 (en) 1994-09-30 1998-06-22 Inhibitor of stem cell proliferation and uses thereof

Country Status (18)

Country Link
US (2) US5939391A (de)
EP (1) EP0784677B1 (de)
JP (3) JP3953511B2 (de)
CN (2) CN1328285C (de)
AT (1) ATE263236T1 (de)
CA (1) CA2201105C (de)
DE (1) DE69532813T2 (de)
DK (1) DK0784677T3 (de)
ES (1) ES2216019T3 (de)
FI (1) FI117468B (de)
HK (3) HK1071517A1 (de)
IL (1) IL115473A (de)
MX (1) MX9702266A (de)
NO (1) NO319575B1 (de)
NZ (2) NZ294446A (de)
PT (1) PT784677E (de)
RU (1) RU2186579C2 (de)
WO (1) WO1996010634A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
ES2185649T3 (es) 1993-03-31 2003-05-01 Wellstat Therapeutics Corp Inhibidores de la proliferacion de las celulas germinales y sus utilizaciones.
US6610654B2 (en) * 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
EP1897553A1 (de) * 1994-09-30 2008-03-12 Wellstat Therapeutics Corporation Stammzellenvermehrungsinhibitor und Verwendungen dafür
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
GB9700154D0 (en) 1997-01-07 1997-02-26 Primapharma Ltd Peptides
JP2000095794A (ja) * 1998-09-22 2000-04-04 Itoham Foods Inc エンケファリン分解酵素の阻害剤
US6488828B1 (en) * 2000-07-20 2002-12-03 Roche Diagnostics Corporation Recloseable biosensor
WO2005026380A2 (en) * 2003-09-10 2005-03-24 Southern Research Institute Bone marrow proliferation assay
NZ565394A (en) * 2005-07-26 2011-04-29 Cms Peptides Patent Holding Company Ltd Biologically active peptides comprising PTTKTYFPHF and their uses for non-therapeutically reducing fatigue
RU2317074C1 (ru) * 2006-03-16 2008-02-20 Общество с ограниченной ответственностью "МБФ" Ингибитор дифференцировки кроветворных клеток-предшественников
WO2008136699A1 (fr) * 2007-05-04 2008-11-13 Igor Alexandrovich Bazikov Patch transdermique à microcapsules et procédé de fabrication correspondant
US9782452B2 (en) * 2011-11-22 2017-10-10 Cornell University Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling
US9220706B2 (en) 2012-06-01 2015-12-29 National Institutes Of Health (Nih) Inhibition of leukemic stem cells by PP2A activating agents
WO2014078787A1 (en) * 2012-11-19 2014-05-22 Wellstat Therapeutics Corporation Stem cell mobilization and tissue repair and regeneration
RU2535972C2 (ru) * 2012-12-24 2014-12-20 Андрей Степанович БРЮХОВЕЦКИЙ Противоопухолевый индивидуальный протеом-основанный таргетный клеточный препарат, способ его получения и применение этого препарата для терапии рака и других злокачественных новообразований
RU2537141C1 (ru) * 2013-11-20 2014-12-27 государственное бюджетное образовательное учреждение высшего профессионального образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ определения способности клеток костного мозга к делению
CN104817622A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd04及其制备方法和应用
CN104817613A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd06及其制备方法和应用
CN104817625A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd03及其制备方法和应用
CN104817615A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd05及其制备方法和应用
CN105294830A (zh) * 2014-06-18 2016-02-03 陈光健 一种二肽分子及其制备方法和应用
WO2019241609A1 (en) * 2018-06-15 2019-12-19 Trustees Of Boston University Polypeptide compositions and methods for site-specific targeting of therapeutic agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1142466A (en) * 1979-01-09 1983-03-08 Cesar Milstein Cell lines
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
DE69034091T2 (de) * 1989-05-10 2004-04-22 Baxter Biotech Technology S.A.R.L. Herstellung von Hämoglobin und Analogen davon in Nicht-Erythrozytzellen
DK0494268T4 (da) * 1989-09-25 1999-11-08 Genetics Inst Fremgangsmåde til inhibering af stamcellers vækst
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
ATE206760T1 (de) * 1990-12-20 2001-10-15 Univ Alabama Res Found Transgenes, vernetztes hämoglobin
WO1992020369A1 (en) * 1991-05-14 1992-11-26 Dana Farber Cancer Institute Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5786334A (en) * 1992-08-14 1998-07-28 Technology Resources International, Inc. Hexapeptide having immunostimulatory activity
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof

Also Published As

Publication number Publication date
EP0784677A1 (de) 1997-07-23
EP0784677A4 (de) 2002-01-30
IL115473A0 (en) 1995-12-31
ATE263236T1 (de) 2004-04-15
RU2186579C2 (ru) 2002-08-10
WO1996010634A1 (en) 1996-04-11
JP3953511B2 (ja) 2007-08-08
JPH10509422A (ja) 1998-09-14
EP0784677B1 (de) 2004-03-31
CN1321688C (zh) 2007-06-20
FI971000A0 (fi) 1997-03-11
JP2004256553A (ja) 2004-09-16
DE69532813T2 (de) 2005-03-17
NO319575B1 (no) 2005-08-29
NZ335108A (en) 2000-11-24
ES2216019T3 (es) 2004-10-16
DE69532813D1 (de) 2004-05-06
NO971444D0 (no) 1997-03-26
IL115473A (en) 2005-08-31
HK1006642A1 (en) 1999-03-12
CA2201105A1 (en) 1996-04-11
CN1168695A (zh) 1997-12-24
JP4188279B2 (ja) 2008-11-26
DK0784677T3 (da) 2004-08-02
CN1565627A (zh) 2005-01-19
CA2201105C (en) 2009-11-24
NO971444L (no) 1997-05-26
NZ294446A (en) 1999-07-29
JP2008088186A (ja) 2008-04-17
US5939391A (en) 1999-08-17
MX9702266A (es) 1997-06-28
HK1071517A1 (en) 2005-07-22
CN1328285C (zh) 2007-07-25
US6090782A (en) 2000-07-18
PT784677E (pt) 2004-08-31
FI117468B (fi) 2006-10-31
FI971000A (fi) 1997-05-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130929