IL115335A - Naphthyl compounds process for their preparation and pharmaceutical compositions thereof - Google Patents

Naphthyl compounds process for their preparation and pharmaceutical compositions thereof

Info

Publication number
IL115335A
IL115335A IL11533595A IL11533595A IL115335A IL 115335 A IL115335 A IL 115335A IL 11533595 A IL11533595 A IL 11533595A IL 11533595 A IL11533595 A IL 11533595A IL 115335 A IL115335 A IL 115335A
Authority
IL
Israel
Prior art keywords
alkyl
pyrrolidinyl
preparation
pharmaceutical compositions
ococ6h5
Prior art date
Application number
IL11533595A
Other languages
English (en)
Other versions
IL115335A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL12831095A priority Critical patent/IL128310A/en
Publication of IL115335A0 publication Critical patent/IL115335A0/xx
Priority to IL12831099A priority patent/IL128310A0/xx
Publication of IL115335A publication Critical patent/IL115335A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyrrole Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11533595A 1994-09-20 1995-09-18 Naphthyl compounds process for their preparation and pharmaceutical compositions thereof IL115335A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL12831095A IL128310A (en) 1994-09-20 1995-09-18 Intermediates for naphthyl compounds and processes for their preparation
IL12831099A IL128310A0 (en) 1994-09-20 1999-02-01 Intermediates for naphthyl compounds processes for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/309,525 US7501441B1 (en) 1994-09-20 1994-09-20 Naphthyl compounds, intermediates, processes, compositions, and methods

Publications (2)

Publication Number Publication Date
IL115335A0 IL115335A0 (en) 1995-12-31
IL115335A true IL115335A (en) 2000-07-26

Family

ID=23198583

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11533595A IL115335A (en) 1994-09-20 1995-09-18 Naphthyl compounds process for their preparation and pharmaceutical compositions thereof

Country Status (29)

Country Link
US (6) US7501441B1 (no)
EP (1) EP0703228B1 (no)
JP (1) JPH10506392A (no)
KR (1) KR970705983A (no)
AT (1) ATE214058T1 (no)
AU (1) AU697114B2 (no)
BR (1) BR9508967A (no)
CA (1) CA2200449A1 (no)
CO (1) CO4410318A1 (no)
CZ (1) CZ291207B6 (no)
DE (1) DE69525699T2 (no)
DK (1) DK0703228T3 (no)
ES (1) ES2173154T3 (no)
HU (1) HUT77919A (no)
IL (1) IL115335A (no)
MX (1) MX9702154A (no)
MY (1) MY132075A (no)
NO (1) NO307929B1 (no)
NZ (1) NZ294177A (no)
PE (1) PE47496A1 (no)
PL (1) PL319454A1 (no)
PT (1) PT703228E (no)
RU (1) RU2165924C2 (no)
SI (1) SI0703228T1 (no)
TR (1) TR199501135A2 (no)
TW (1) TW399036B (no)
WO (1) WO1996009039A1 (no)
YU (1) YU61595A (no)
ZA (1) ZA957857B (no)

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US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
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US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
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US20030083733A1 (en) * 1997-10-10 2003-05-01 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5998401A (en) * 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
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US5811421A (en) * 1995-07-31 1998-09-22 Eli Lilly And Company Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods
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US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
WO1998048806A1 (en) * 1997-04-25 1998-11-05 Eli Lilly And Company Indene compounds having activity as serms
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US6090843A (en) * 1997-08-11 2000-07-18 Eli Lilly And Company Benzothiophenes compounds which have useful pharmaceutical activity
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BRPI0407690A (pt) 2003-02-25 2006-03-01 Lilly Co Eli composto, e, métodos para tratar endometriose e para tratar leiomioma uterino
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US7655700B2 (en) 2005-08-25 2010-02-02 Michigan State University Transgenic mouse model and methods for treatment of neuro muscular disease by interfering with androgen-androgen receptor interaction in skeletal muscles
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Also Published As

Publication number Publication date
NO307929B1 (no) 2000-06-19
WO1996009039A1 (en) 1996-03-28
AU697114B2 (en) 1998-09-24
PE47496A1 (es) 1996-11-12
YU61595A (sh) 1998-09-18
EP0703228B1 (en) 2002-03-06
MY132075A (en) 2007-09-28
NO971278L (no) 1997-05-14
RU2165924C2 (ru) 2001-04-27
CO4410318A1 (es) 1997-01-09
TW399036B (en) 2000-07-21
ATE214058T1 (de) 2002-03-15
AU3686395A (en) 1996-04-09
KR970705983A (ko) 1997-11-03
BR9508967A (pt) 1997-12-30
CZ82297A3 (en) 1997-12-17
US6437137B1 (en) 2002-08-20
US7501441B1 (en) 2009-03-10
US5484796A (en) 1996-01-16
PL319454A1 (en) 1997-08-04
TR199501135A2 (tr) 1996-06-21
DE69525699T2 (de) 2002-11-21
US6410564B1 (en) 2002-06-25
US5484795A (en) 1996-01-16
NZ294177A (en) 1998-10-28
US5484797A (en) 1996-01-16
IL115335A0 (en) 1995-12-31
JPH10506392A (ja) 1998-06-23
EP0703228A1 (en) 1996-03-27
ZA957857B (en) 1997-03-18
PT703228E (pt) 2002-07-31
CA2200449A1 (en) 1996-03-28
SI0703228T1 (en) 2002-08-31
DK0703228T3 (da) 2002-05-21
ES2173154T3 (es) 2002-10-16
NO971278D0 (no) 1997-03-19
MX9702154A (es) 1997-06-28
CZ291207B6 (cs) 2003-01-15
DE69525699D1 (de) 2002-04-11
HUT77919A (hu) 1998-10-28

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