IL114910A - Synthetic excitatory amino acids their preparation and pharmaceutical compositions containing them - Google Patents

Synthetic excitatory amino acids their preparation and pharmaceutical compositions containing them

Info

Publication number
IL114910A
IL114910A IL11491095A IL11491095A IL114910A IL 114910 A IL114910 A IL 114910A IL 11491095 A IL11491095 A IL 11491095A IL 11491095 A IL11491095 A IL 11491095A IL 114910 A IL114910 A IL 114910A
Authority
IL
Israel
Prior art keywords
preparation
amino acids
pharmaceutical compositions
compositions containing
excitatory amino
Prior art date
Application number
IL11491095A
Other languages
English (en)
Other versions
IL114910A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,643 external-priority patent/US5750566A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IL13349395A priority Critical patent/IL133493A/en
Publication of IL114910A0 publication Critical patent/IL114910A0/xx
Publication of IL114910A publication Critical patent/IL114910A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11491095A 1994-08-12 1995-08-11 Synthetic excitatory amino acids their preparation and pharmaceutical compositions containing them IL114910A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL13349395A IL133493A (en) 1994-08-12 1995-08-11 Derivatives of 2-Spiro -'- 5 Hydentoin in Cyclo [3.1.0] Hexane - 6 - Carboxylic acid

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28995794A 1994-08-12 1994-08-12
US33734994A 1994-11-10 1994-11-10
US08/496,643 US5750566A (en) 1994-08-12 1995-06-29 Synthetic excitatory amino acids

Publications (2)

Publication Number Publication Date
IL114910A0 IL114910A0 (en) 1995-12-08
IL114910A true IL114910A (en) 2000-06-29

Family

ID=27403949

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11491095A IL114910A (en) 1994-08-12 1995-08-11 Synthetic excitatory amino acids their preparation and pharmaceutical compositions containing them
IL13349399A IL133493A0 (en) 1994-08-12 1999-12-13 Intermediates for the preparation of synthetic excitatory amino acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL13349399A IL133493A0 (en) 1994-08-12 1999-12-13 Intermediates for the preparation of synthetic excitatory amino acids

Country Status (25)

Country Link
US (2) US5925782A (hu)
EP (1) EP0696577B1 (hu)
JP (1) JP2883297B2 (hu)
CN (1) CN1066135C (hu)
AP (1) AP758A (hu)
AT (1) ATE172186T1 (hu)
AU (2) AU692276B2 (hu)
BG (1) BG62728B1 (hu)
CA (1) CA2156024C (hu)
CZ (1) CZ291270B6 (hu)
DE (1) DE69505318T2 (hu)
DK (1) DK0696577T3 (hu)
ES (1) ES2122456T3 (hu)
FI (1) FI114861B (hu)
HK (1) HK1013983A1 (hu)
HU (1) HU223845B1 (hu)
IL (2) IL114910A (hu)
MY (1) MY115977A (hu)
NO (1) NO306342B1 (hu)
NZ (1) NZ272772A (hu)
PL (1) PL182285B1 (hu)
RO (1) RO119147B1 (hu)
SK (1) SK281288B6 (hu)
TW (1) TW438741B (hu)
WO (1) WO1996005175A1 (hu)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
TR199800877T2 (xx) * 1995-11-16 1998-09-21 Eli Lilly And Company Uyar�c� amino asit t�revleri.
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
BR9611521A (pt) 1995-11-16 1999-06-29 Lilly Co Eli Antagonistas de receptor de aminoácido excitador
US5824662A (en) * 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
CZ60499A3 (cs) 1996-09-27 1999-08-11 Guilford Pharmaceuticals Inc. Prostředky s účinkem na NAALADázy, způsoby léčení glutamátové abnormality a způsoby ovlivňování neuronální aktivity u živočichů
CA2275777A1 (en) * 1997-01-29 1998-07-30 Louise Richman Levine Treatment for premenstrual dysphoric disorder
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
JP2001515839A (ja) 1997-07-18 2001-09-25 ジョージタウン・ユニバーシティ 二環式向代謝性グルタミン酸受容体リガンド
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
EP0891978B1 (en) * 1997-07-18 2002-03-20 F. Hoffmann-La Roche Ag 5H-Thiazolo (3,2-a) pyrimidine derivatives
JP3727791B2 (ja) * 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
EP1052246B1 (en) * 1998-01-28 2003-04-02 Taisho Pharmaceutical Co., Ltd Fluorine-containing amino acid derivatives
US5933378A (en) * 1998-02-26 1999-08-03 Micron Technology, Inc. Integrated circuit having forced substrate test mode with improved substrate isolation
SI1064256T1 (en) * 1998-03-17 2004-10-31 Pfizer Products Inc. Bicyclo (2.2.1) heptanes and related compounds
US6136861A (en) * 1998-03-17 2000-10-24 Pfizer Inc Bicyclo[2.2.1]heptanes and related compounds
GB9815542D0 (en) * 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
EP1110943B1 (en) 1998-08-31 2004-06-16 Taisho Pharmaceutical Co. Ltd. 6-fluorobicyclo 3. 1.0]hexane derivatives
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
JP4783967B2 (ja) * 1999-07-21 2011-09-28 大正製薬株式会社 含フッ素アミノ酸誘導体を有効成分とする医薬
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
US7038077B2 (en) 2001-01-11 2006-05-02 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1310480A1 (en) * 2001-11-07 2003-05-14 Eli Lilly & Company Prodrugs of excitatory amino acids
HUP0400620A3 (en) * 2001-01-11 2012-09-28 Lilly Co Eli Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds
WO2003045898A1 (en) * 2001-11-23 2003-06-05 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1458671A1 (en) * 2001-12-21 2004-09-22 Eli Lilly And Company Prodrugs of excitatory amino acids
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
WO2005030148A2 (en) * 2003-09-25 2005-04-07 Cenomed, Inc. Tetrahydroindolone derivatives for treatment of neurological conditions
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
EP2219648A4 (en) * 2007-11-09 2010-11-03 Cenomed Biosciences Llc TREATMENT OF POSTRAUMATIC STRESS WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
US5750566A (en) * 1994-08-12 1998-05-12 Eli Lilly And Company Synthetic excitatory amino acids

Also Published As

Publication number Publication date
AP758A (en) 1999-09-10
WO1996005175A1 (en) 1996-02-22
HU223845B1 (hu) 2005-02-28
US5925680A (en) 1999-07-20
DE69505318T2 (de) 1999-03-25
MY115977A (en) 2003-10-31
US5925782A (en) 1999-07-20
HU9502380D0 (en) 1996-05-28
PL309972A1 (en) 1996-02-19
JP2883297B2 (ja) 1999-04-19
CA2156024A1 (en) 1996-02-13
CZ291270B6 (cs) 2003-01-15
TW438741B (en) 2001-06-07
SK281288B6 (sk) 2001-02-12
AU692276B2 (en) 1998-06-04
CZ207495A3 (en) 1996-05-15
BG62728B1 (bg) 2000-06-30
CA2156024C (en) 2004-10-05
AP9700922A0 (en) 1997-01-31
EP0696577B1 (en) 1998-10-14
HUT75524A (en) 1997-05-28
NZ272772A (en) 1997-10-24
EP0696577A1 (en) 1996-02-14
IL114910A0 (en) 1995-12-08
FI953837A (fi) 1996-02-13
BG101213A (en) 1998-03-31
NO953191D0 (no) 1995-08-14
SK13397A3 (en) 1997-07-09
FI953837A0 (fi) 1995-08-14
ES2122456T3 (es) 1998-12-16
DK0696577T3 (da) 1999-06-23
DE69505318D1 (de) 1998-11-19
NO306342B1 (no) 1999-10-25
IL133493A0 (en) 2001-04-30
AU2853095A (en) 1996-02-22
PL182285B1 (pl) 2001-12-31
NO953191L (no) 1996-02-13
FI114861B (fi) 2005-01-14
JPH08188561A (ja) 1996-07-23
AU3325195A (en) 1996-03-07
CN1066135C (zh) 2001-05-23
CN1123272A (zh) 1996-05-29
HK1013983A1 (en) 1999-09-17
RO119147B1 (ro) 2004-04-30
ATE172186T1 (de) 1998-10-15

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees