DK0696577T3 - Syntetiske excitatoriske aminosyrer - Google Patents

Syntetiske excitatoriske aminosyrer

Info

Publication number
DK0696577T3
DK0696577T3 DK95305632T DK95305632T DK0696577T3 DK 0696577 T3 DK0696577 T3 DK 0696577T3 DK 95305632 T DK95305632 T DK 95305632T DK 95305632 T DK95305632 T DK 95305632T DK 0696577 T3 DK0696577 T3 DK 0696577T3
Authority
DK
Denmark
Prior art keywords
amino acids
excitatory amino
synthetic excitatory
synthetic
acids
Prior art date
Application number
DK95305632T
Other languages
English (en)
Inventor
James Allen Monn
David R Helton
Darryle D Schoepp
Joseph P Tizzano
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,643 external-priority patent/US5750566A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0696577T3 publication Critical patent/DK0696577T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95305632T 1994-08-12 1995-08-11 Syntetiske excitatoriske aminosyrer DK0696577T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28995794A 1994-08-12 1994-08-12
US33734994A 1994-11-10 1994-11-10
US08/496,643 US5750566A (en) 1994-08-12 1995-06-29 Synthetic excitatory amino acids

Publications (1)

Publication Number Publication Date
DK0696577T3 true DK0696577T3 (da) 1999-06-23

Family

ID=27403949

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95305632T DK0696577T3 (da) 1994-08-12 1995-08-11 Syntetiske excitatoriske aminosyrer

Country Status (25)

Country Link
US (2) US5925782A (da)
EP (1) EP0696577B1 (da)
JP (1) JP2883297B2 (da)
CN (1) CN1066135C (da)
AP (1) AP758A (da)
AT (1) ATE172186T1 (da)
AU (2) AU3325195A (da)
BG (1) BG62728B1 (da)
CA (1) CA2156024C (da)
CZ (1) CZ291270B6 (da)
DE (1) DE69505318T2 (da)
DK (1) DK0696577T3 (da)
ES (1) ES2122456T3 (da)
FI (1) FI114861B (da)
HK (1) HK1013983A1 (da)
HU (1) HU223845B1 (da)
IL (2) IL114910A (da)
MY (1) MY115977A (da)
NO (1) NO306342B1 (da)
NZ (1) NZ272772A (da)
PL (1) PL182285B1 (da)
RO (1) RO119147B1 (da)
SK (1) SK281288B6 (da)
TW (1) TW438741B (da)
WO (1) WO1996005175A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
IL124487A (en) * 1995-11-16 2001-01-11 Lilly Co Eli Excitatory amino acid derivatives, their preparation and pharmaceutical compositions containing them
JP2000500752A (ja) 1995-11-16 2000-01-25 イーライ・リリー・アンド・カンパニー 興奮性アミノ酸受容体アンタゴニスト
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US5824662A (en) * 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
IL128718A0 (en) 1996-09-27 2000-01-31 Guildford Pharmaceuticals Inc Naaldase compositions
WO1998032436A1 (en) * 1997-01-29 1998-07-30 Eli Lilly And Company Treatment for premenstrual dysphoric disorder
ZA983930B (en) 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
EP1000015A1 (en) * 1997-07-18 2000-05-17 Georgetown University Bicyclic metabotropic glutamate receptor ligands
DE69804273T2 (de) * 1997-07-18 2002-10-31 F. Hoffmann-La Roche Ag, Basel 5h-Thiazolo[3,2-a]pyrimidinderivate
JP3727791B2 (ja) * 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
ATE236118T1 (de) 1998-01-28 2003-04-15 Taisho Pharmaceutical Co Ltd Fluorhaltige aminosäurederivate
US5933378A (en) * 1998-02-26 1999-08-03 Micron Technology, Inc. Integrated circuit having forced substrate test mode with improved substrate isolation
EP1396273A1 (en) * 1998-03-17 2004-03-10 Pfizer Products Inc. Bicyclo(2.2.1.)heptanes and related compounds
KR100372981B1 (ko) * 1998-03-17 2003-02-25 화이자 프로덕츠 인크. 비시클로[2.2.1]헵탄 및 관련 화합물
GB9815542D0 (en) * 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
DK1110943T3 (da) 1998-08-31 2004-10-11 Taisho Pharmaceutical Co Ltd 6-fluorbicyclo[3.1.0]hexanderivater
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
JP4783967B2 (ja) * 1999-07-21 2011-09-28 大正製薬株式会社 含フッ素アミノ酸誘導体を有効成分とする医薬
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
US7038077B2 (en) 2001-01-11 2006-05-02 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1310480A1 (en) * 2001-11-07 2003-05-14 Eli Lilly & Company Prodrugs of excitatory amino acids
US7256217B2 (en) * 2001-01-11 2007-08-14 Eli Lilly And Company Prodrugs of excitatory amino acids
AU2002353845A1 (en) * 2001-11-23 2003-06-10 Eli Lilly And Company Prodrugs of excitatory amino acids
AU2002361611A1 (en) * 2001-12-21 2003-07-24 Eli Lilly And Company Prodrugs of excitatory amino acids
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
JP4964593B2 (ja) * 2003-09-25 2012-07-04 セノメド バイオサイエンシーズ，エルエルシー 神経学的病状の治療用のテトラヒドロインドロン誘導体
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
EP2219648A4 (en) * 2007-11-09 2010-11-03 Cenomed Biosciences Llc TREATMENT OF POSTRAUMATIC STRESS WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
US5750566A (en) * 1994-08-12 1998-05-12 Eli Lilly And Company Synthetic excitatory amino acids

Also Published As

Publication number Publication date
US5925782A (en) 1999-07-20
HUT75524A (en) 1997-05-28
NO306342B1 (no) 1999-10-25
BG62728B1 (bg) 2000-06-30
DE69505318D1 (de) 1998-11-19
EP0696577A1 (en) 1996-02-14
FI953837A0 (fi) 1995-08-14
ES2122456T3 (es) 1998-12-16
AU692276B2 (en) 1998-06-04
FI114861B (fi) 2005-01-14
JPH08188561A (ja) 1996-07-23
CZ207495A3 (en) 1996-05-15
EP0696577B1 (en) 1998-10-14
MY115977A (en) 2003-10-31
HU9502380D0 (en) 1996-05-28
HK1013983A1 (en) 1999-09-17
ATE172186T1 (de) 1998-10-15
NO953191D0 (no) 1995-08-14
RO119147B1 (ro) 2004-04-30
HU223845B1 (hu) 2005-02-28
SK281288B6 (sk) 2001-02-12
WO1996005175A1 (en) 1996-02-22
NZ272772A (en) 1997-10-24
IL114910A0 (en) 1995-12-08
NO953191L (no) 1996-02-13
US5925680A (en) 1999-07-20
BG101213A (en) 1998-03-31
JP2883297B2 (ja) 1999-04-19
CZ291270B6 (cs) 2003-01-15
SK13397A3 (en) 1997-07-09
CA2156024A1 (en) 1996-02-13
AU2853095A (en) 1996-02-22
FI953837A (fi) 1996-02-13
CN1123272A (zh) 1996-05-29
CA2156024C (en) 2004-10-05
DE69505318T2 (de) 1999-03-25
TW438741B (en) 2001-06-07
AP758A (en) 1999-09-10
CN1066135C (zh) 2001-05-23
IL133493A0 (en) 2001-04-30
PL309972A1 (en) 1996-02-19
AP9700922A0 (en) 1997-01-31
PL182285B1 (pl) 2001-12-31
AU3325195A (en) 1996-03-07
IL114910A (en) 2000-06-29

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