IL114779A - Estra-1,3,5(10)-triene derivatives, process for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Estra-1,3,5(10)-triene derivatives, process for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL114779A
IL114779A IL11477995A IL11477995A IL114779A IL 114779 A IL114779 A IL 114779A IL 11477995 A IL11477995 A IL 11477995A IL 11477995 A IL11477995 A IL 11477995A IL 114779 A IL114779 A IL 114779A
Authority
IL
Israel
Prior art keywords
estra
preparation
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL11477995A
Other languages
English (en)
Other versions
IL114779A0 (en
Original Assignee
Jenapharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm Gmbh filed Critical Jenapharm Gmbh
Publication of IL114779A0 publication Critical patent/IL114779A0/xx
Publication of IL114779A publication Critical patent/IL114779A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11477995A 1994-08-09 1995-07-30 Estra-1,3,5(10)-triene derivatives, process for the preparation thereof and pharmaceutical compositions containing the same IL114779A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4429397A DE4429397C2 (de) 1994-08-09 1994-08-09 Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (2)

Publication Number Publication Date
IL114779A0 IL114779A0 (en) 1995-11-27
IL114779A true IL114779A (en) 2003-06-24

Family

ID=6526060

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11477995A IL114779A (en) 1994-08-09 1995-07-30 Estra-1,3,5(10)-triene derivatives, process for the preparation thereof and pharmaceutical compositions containing the same

Country Status (21)

Country Link
US (1) US6080735A (xx)
EP (3) EP0775155B1 (xx)
JP (1) JP3814292B2 (xx)
CN (1) CN1057305C (xx)
AT (2) ATE482968T1 (xx)
AU (1) AU699701B2 (xx)
BR (1) BR9508864A (xx)
CA (1) CA2196694A1 (xx)
CZ (1) CZ288762B6 (xx)
DE (3) DE4429397C2 (xx)
DK (1) DK0775155T3 (xx)
ES (1) ES2220932T3 (xx)
FI (1) FI970526A0 (xx)
HU (1) HUT77610A (xx)
IL (1) IL114779A (xx)
NZ (1) NZ289793A (xx)
PL (1) PL186185B1 (xx)
PT (1) PT775155E (xx)
RU (1) RU2139885C1 (xx)
SG (1) SG47348A1 (xx)
WO (1) WO1996005216A1 (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
DE19753363A1 (de) * 1997-12-02 1999-06-10 Jenapharm Gmbh 15-Methyl-cyclopropanosteroide und Verfahren zu ihrer Herstellung
EA002707B1 (ru) * 1998-02-20 2002-08-29 Йенафарм Гмбх Унд Ко. Кг Фармацевтические композиции, предназначенные для направленного восполнения дефицита эстрогена в центральной нервной системе
US6245756B1 (en) 1998-02-27 2001-06-12 Jenapharm Gmbh & Co. Kg Pharmaceutical preparations for treatment of estrogen deficiency in the central nervous system
DE19834931A1 (de) * 1998-07-28 2000-02-24 Jenapharm Gmbh Verwendung von biogenen Estrogenen zur Hormonsubstitutionstherapie
DE19906152B4 (de) 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Wirkstoffhaltige Laminate für Transdermalsysteme
CA2383650A1 (en) 1999-08-31 2001-04-19 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
US6653298B2 (en) 2000-01-14 2003-11-25 Sterix Limited Composition
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
AU2002232509A1 (en) * 2000-11-03 2002-05-15 Washington University Estrone-derivatives having cytoprotective activity
US20020132802A1 (en) * 2000-11-17 2002-09-19 Washington Univeristy Cytoprotective polycyclic compounds
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
EP1603933A2 (en) * 2003-03-13 2005-12-14 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
US20060183725A1 (en) * 2005-02-15 2006-08-17 Thomas Graeser Pharmaceutical preparation for oral contraception
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
GB201302368D0 (en) * 2013-02-11 2013-03-27 Univ Bath Compound
US9745338B2 (en) 2013-07-11 2017-08-29 Evestra, Inc. Pro-drug forming compounds
CN105753924B (zh) * 2016-02-03 2017-11-10 中国药科大学 新型甾体类选择性雌激素受体调节剂、其制备方法及其医药用途
BR112020007673A2 (pt) 2017-10-19 2020-10-13 Evestra, Inc. contraceptivos pró-fármaco de progestina de ação prolongada

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2133484A2 (en) * 1969-04-29 1972-12-01 Jenapharm Veb 3-17 and 21-sulphonyloxy-steroids - with androgenic anabolic progestogenic and oestrogen activity of long duration
GB1317373A (en) * 1971-03-11 1973-05-16 Jenapharm Veb Steroid esters
US3697558A (en) * 1971-03-24 1972-10-10 Lilly Co Eli Preparation of 17alpha-ethynylestriol
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DD114806A1 (xx) * 1974-10-11 1975-08-20
DD145919B1 (de) * 1978-06-28 1982-06-30 Kurt Ponsold Verfahren zur herstellung von 14,1 -methylenderivaten der oestranreihe
DD201143B1 (de) * 1981-11-17 1986-12-17 Jenapharm Veb Verfahren zur herstellung von 9,11-tritiummarkierten gonatriensulfonaten
DD207447A3 (de) * 1982-04-02 1984-02-29 Jenapharm Veb Mittel zur chemosterilisation von schadnagetieren
FR2533570B1 (fr) * 1982-09-23 1985-07-12 Centre Nat Rech Scient Complexes organometalliques d'oestrogenes et leur application au dosage des recepteurs hormonaux
RU2087479C1 (ru) * 1989-11-29 1997-08-20 Шеринг Аг Эстратриены, содержащие мостик
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
DE4222316A1 (de) * 1992-07-03 1994-01-05 Schering Ag Verfahren zur Herstellung von Etheno- und Ethano-16â,17µ-Steroiddiolen und deren Derivaten

Also Published As

Publication number Publication date
DE4429397A1 (de) 1996-02-15
PL186185B1 (pl) 2003-11-28
BR9508864A (pt) 1997-11-11
CA2196694A1 (en) 1996-02-22
NZ289793A (en) 1998-11-25
CZ27497A3 (en) 1997-08-13
ES2220932T3 (es) 2004-12-16
CN1156998A (zh) 1997-08-13
FI970526A (fi) 1997-02-07
SG47348A1 (en) 1998-04-17
DE4429397C2 (de) 2003-11-20
RU2139885C1 (ru) 1999-10-20
AU2974195A (en) 1996-03-07
HUT77610A (hu) 1998-06-29
EP0775155A1 (de) 1997-05-28
EP1273590A2 (de) 2003-01-08
EP1284273A2 (de) 2003-02-19
US6080735A (en) 2000-06-27
CN1057305C (zh) 2000-10-11
AU699701B2 (en) 1998-12-10
ATE266038T1 (de) 2004-05-15
FI970526A0 (fi) 1997-02-07
EP1284273A3 (de) 2004-07-21
DE59510900D1 (de) 2004-06-09
PT775155E (pt) 2004-09-30
PL318525A1 (en) 1997-06-23
CZ288762B6 (cs) 2001-08-15
EP1273590A3 (de) 2004-07-28
DE59511110D1 (de) 2010-11-11
DK0775155T3 (da) 2004-08-30
EP0775155B1 (de) 2004-05-06
JPH10503180A (ja) 1998-03-24
JP3814292B2 (ja) 2006-08-23
ATE482968T1 (de) 2010-10-15
EP1284273B1 (de) 2010-09-29
IL114779A0 (en) 1995-11-27
WO1996005216A1 (de) 1996-02-22

Similar Documents

Publication Publication Date Title
IL114779A (en) Estra-1,3,5(10)-triene derivatives, process for the preparation thereof and pharmaceutical compositions containing the same
AP9701041A0 (en) Pyridylpyrrole compounds.
GEP20074251B (en) N-oxycarbonyl substituted 5'- deoxy-5-fluorocytidines
TW365604B (en) Anthracyclinone derivatives
CA2185192A1 (fr) Nouveaux acides et esters 2,2- dimethyl-w-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MY114282A (en) Anthracycline derivatives
ATE211137T1 (de) Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung
HUT55349A (en) Process for producing benzanilide derivatives and pharmaceutical compositions comprising same
CY2160B1 (en) Erburnane derivatives processes for their preparation and pharmaceutical compositions containing them
GR3033003T3 (en) Acronycin analogues, process for their preparation and pharmaceutical compositions containing them.
ATE132867T1 (de) 20,21-dinoreburnaminderivate, substituiert in position 15, verfahren zu deren herstellung und die auf diese weise erhaltenen zwischenverbindungen, deren anwendung als arzneimittel und diese enthaltende zusammensetzungen

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees