IL111273A - קרבמואיל אסטרים של-6-דהמתיל גלנתמיןותכשירי רוקחות המכילים אותם - Google Patents

קרבמואיל אסטרים של-6-דהמתיל גלנתמיןותכשירי רוקחות המכילים אותם

Info

Publication number
IL111273A
IL111273A IL111273A IL11127394A IL111273A IL 111273 A IL111273 A IL 111273A IL 111273 A IL111273 A IL 111273A IL 11127394 A IL11127394 A IL 11127394A IL 111273 A IL111273 A IL 111273A
Authority
IL
Israel
Prior art keywords
compound
hydrogen
demethyl
galanthamine
pharmaceutically acceptable
Prior art date
Application number
IL111273A
Other languages
English (en)
Other versions
IL111273A0 (en
Inventor
Raymond W Kosley Jr
Larry Davis
Veronica Taberna
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL111273A0 publication Critical patent/IL111273A0/xx
Publication of IL111273A publication Critical patent/IL111273A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL111273A 1993-10-15 1994-10-13 קרבמואיל אסטרים של-6-דהמתיל גלנתמיןותכשירי רוקחות המכילים אותם IL111273A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/137,443 US6323196B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number Publication Date
IL111273A0 IL111273A0 (en) 1994-12-29
IL111273A true IL111273A (he) 1998-04-05

Family

ID=22477457

Family Applications (1)

Application Number Title Priority Date Filing Date
IL111273A IL111273A (he) 1993-10-15 1994-10-13 קרבמואיל אסטרים של-6-דהמתיל גלנתמיןותכשירי רוקחות המכילים אותם

Country Status (24)

Country Link
US (1) US6323196B1 (he)
EP (2) EP0648771B1 (he)
JP (1) JP2718637B2 (he)
KR (1) KR100189043B1 (he)
CN (1) CN1039011C (he)
AT (1) ATE201687T1 (he)
AU (1) AU679560B2 (he)
CA (1) CA2118171C (he)
CZ (1) CZ283561B6 (he)
DE (1) DE69427332T2 (he)
DK (1) DK0648771T3 (he)
EG (1) EG20747A (he)
ES (1) ES2158876T3 (he)
FI (1) FI108724B (he)
GR (1) GR3036068T3 (he)
IL (1) IL111273A (he)
NO (1) NO307463B1 (he)
NZ (1) NZ264681A (he)
PL (1) PL177754B1 (he)
PT (1) PT648771E (he)
RO (1) RO114132B1 (he)
RU (1) RU2113438C1 (he)
TW (1) TW375615B (he)
ZA (1) ZA948060B (he)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
AU1738800A (en) 1998-11-23 2000-06-13 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
WO2000038686A1 (en) 1998-12-24 2000-07-06 Janssen Pharmaceutica N.V. Controlled release galantamine composition
CA2393301A1 (en) * 1999-12-10 2001-06-21 Bonnie Davis Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
CN1380883A (zh) 2000-03-31 2002-11-20 萨诺化学药物股份公司 雪花胺的新衍生物和类似物
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
WO2004041281A1 (en) * 2002-11-01 2004-05-21 Oregon Health And Science University Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) * 2003-07-11 2005-03-03 Jeroen Aerssens CHRNA2 genetic markers associated with galantamine response
US20050260613A1 (en) * 2003-10-28 2005-11-24 Genaissance Pharmaceuticals LRPAP1 genetic markers associated with galantamine
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US7250258B2 (en) * 2003-12-15 2007-07-31 Pgxhealth Llc CDK5 genetic markers associated with galantamine response
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
US20050142193A1 (en) * 2003-12-31 2005-06-30 Lijuan Tang Galantamine formulations
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
EP1895995A2 (en) * 2005-05-13 2008-03-12 Alza Corporation Multilayer drug system for the delivery of galantamine
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1777222A1 (en) * 2005-09-22 2007-04-25 Galantos Pharma GmbH Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1937226A2 (en) * 2005-09-23 2008-07-02 Alza Corporation Transdermal galantamine delivery system
KR100786371B1 (ko) * 2006-12-07 2007-12-17 한국화학연구원 갈란타민의 제조방법
JP5504253B2 (ja) 2008-04-14 2014-05-28 ニューロダイン ライフ サイエンス インコーポレイテッド ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体
CN102625700A (zh) * 2009-07-23 2012-08-01 夏尔有限责任公司 加兰他敏氨基酸和肽前药及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
AU632458B2 (en) * 1987-05-04 1993-01-07 Bonnie Davis Compounds for the treatment of alzheimer's disease
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
DK0584185T3 (da) 1991-05-14 2000-02-07 Ernir Snorrason Behandling af træthedssyndrom med cholinesteraseinhibitorer
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5231093A (en) * 1991-10-01 1993-07-27 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
NZ264681A (en) 1997-12-19
RU94036761A (ru) 1996-09-10
FI108724B (fi) 2002-03-15
PT648771E (pt) 2001-09-28
AU7581294A (en) 1995-05-04
CN1039011C (zh) 1998-07-08
US6323196B1 (en) 2001-11-27
NO943894D0 (no) 1994-10-14
ZA948060B (en) 1995-06-09
EG20747A (en) 2000-01-31
ATE201687T1 (de) 2001-06-15
AU679560B2 (en) 1997-07-03
PL305455A1 (en) 1995-04-18
RO114132B1 (ro) 1999-01-29
FI944822A0 (fi) 1994-10-13
PL177754B1 (pl) 2000-01-31
DK0648771T3 (da) 2001-08-27
DE69427332T2 (de) 2001-10-11
CN1108658A (zh) 1995-09-20
CZ254794A3 (en) 1995-05-17
JP2718637B2 (ja) 1998-02-25
CA2118171C (en) 1999-12-28
IL111273A0 (en) 1994-12-29
GR3036068T3 (en) 2001-09-28
EP0648771A1 (en) 1995-04-19
DE69427332D1 (de) 2001-07-05
TW375615B (en) 1999-12-01
ES2158876T3 (es) 2001-09-16
RU2113438C1 (ru) 1998-06-20
NO943894L (no) 1995-04-18
KR950011444A (ko) 1995-05-15
NO307463B1 (no) 2000-04-10
EP0648771B1 (en) 2001-05-30
CZ283561B6 (cs) 1998-05-13
FI944822A (fi) 1995-04-16
JPH07188238A (ja) 1995-07-25
EP1020469A3 (en) 2000-07-26
CA2118171A1 (en) 1995-04-16
KR100189043B1 (ko) 1999-06-01
EP1020469A2 (en) 2000-07-19

Similar Documents

Publication Publication Date Title
CA2118171C (en) Galanthamine derivatives, a process for their preparation and their use as medicaments
FI108723B (fi) Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin 6-esterijohdannaisten valmistamiseksi
CA2118172C (en) Galanthamine derivatives, a process for their preparation and their use as medicaments
FI90240C (fi) Menetelmä terapeuttisesti aktiivisten 8-aminosubstituoitu-7,8-dihydro-6,6-dimetyyli-6H-pyrano/2,3-f/bentso-2,1,3-oksadiatsolien valmistamiseksi
US5091541A (en) Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
CA2035397C (en) Hexahydropyrrolo¬2,3-b|indole carbamates, -ureas, -amides and related compounds, a process for their preparation and their use as medicaments

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
FF Patent granted
KB Patent renewed
EXP Patent expired