IL110972A - Pharmaceutical preparations for intravaginal administration of progesterone - Google Patents

Pharmaceutical preparations for intravaginal administration of progesterone

Info

Publication number
IL110972A
IL110972A IL110972A IL11097294A IL110972A IL 110972 A IL110972 A IL 110972A IL 110972 A IL110972 A IL 110972A IL 11097294 A IL11097294 A IL 11097294A IL 110972 A IL110972 A IL 110972A
Authority
IL
Israel
Prior art keywords
progesterone
levels
serum
preparation according
polymer
Prior art date
Application number
IL110972A
Other languages
English (en)
Other versions
IL110972A0 (en
Original Assignee
Columbia Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22402302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL110972(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Columbia Lab Inc filed Critical Columbia Lab Inc
Publication of IL110972A0 publication Critical patent/IL110972A0/xx
Publication of IL110972A publication Critical patent/IL110972A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
IL110972A 1993-09-15 1994-09-14 Pharmaceutical preparations for intravaginal administration of progesterone IL110972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/122,371 US5543150A (en) 1993-09-15 1993-09-15 Method of progesterone delivery and affect thereof

Publications (2)

Publication Number Publication Date
IL110972A0 IL110972A0 (en) 1994-11-28
IL110972A true IL110972A (en) 1998-03-10

Family

ID=22402302

Family Applications (1)

Application Number Title Priority Date Filing Date
IL110972A IL110972A (en) 1993-09-15 1994-09-14 Pharmaceutical preparations for intravaginal administration of progesterone

Country Status (27)

Country Link
US (1) US5543150A (lt)
EP (1) EP0719146B1 (lt)
JP (1) JP3143474B2 (lt)
KR (1) KR100278553B1 (lt)
AT (1) ATE174796T1 (lt)
BR (1) BR9407475A (lt)
CA (1) CA2171939C (lt)
CO (1) CO4290332A1 (lt)
DE (1) DE69415543T2 (lt)
DK (1) DK0719146T3 (lt)
ES (1) ES2126783T3 (lt)
FI (1) FI115444B (lt)
GR (1) GR3029314T3 (lt)
HU (1) HU221583B (lt)
IL (1) IL110972A (lt)
LT (1) LT4072B (lt)
LV (1) LV11527B (lt)
MA (1) MA23329A1 (lt)
MY (1) MY111484A (lt)
NO (1) NO308585B1 (lt)
NZ (1) NZ273816A (lt)
PE (1) PE50795A1 (lt)
PH (1) PH30813A (lt)
RU (1) RU2148393C1 (lt)
UA (1) UA37244C2 (lt)
WO (1) WO1995007699A1 (lt)
ZA (1) ZA947073B (lt)

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US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
US6248358B1 (en) * 1998-08-25 2001-06-19 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets and methods of making and using the same
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
DE69819748T2 (de) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen
EP1356806A1 (en) * 1997-09-12 2003-10-29 Columbia Laboratories (Bermuda) Limited A pharmaceutical composition for treating dysmenorrhea and premature labor
EP1021173A1 (en) * 1997-10-10 2000-07-26 Imperial College Innovations Limited Use of csaid?tm compounds for the management of uterine contractions
US6306914B1 (en) * 1997-10-21 2001-10-23 Columbia Laboratories, Inc. Progestin therapy for maintaining amenorrhea
AU4406899A (en) * 1998-05-20 1999-12-06 Bent Formby Progesterone treatment of cancer
US20070178139A1 (en) * 1998-11-18 2007-08-02 Yankov Vladimir I Vaginally administratable progesterone-containing tablets and method for preparing same
IL127129A (en) * 1998-11-18 2004-06-01 Ferring Bv Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared
US6479045B2 (en) 1999-12-22 2002-11-12 Columbia Laboratories, Inc. Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
US6544553B1 (en) 1999-12-28 2003-04-08 Watson Pharmaceuticals, Inc. Dosage forms and methods for oral delivery of progesterone
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US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
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ES2237298B1 (es) * 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
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BRPI0413200A (pt) 2003-09-03 2006-10-03 Miscon Trading S A método para tratamento de endometriose
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BRPI0711525A2 (pt) * 2006-06-02 2011-11-01 Pear Tree Women S Health Care composição farmacêutica e método para tratar sintomas de vaginite atrófica
US8828981B2 (en) * 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
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CN101970012A (zh) * 2007-09-14 2011-02-09 日东电工株式会社 药物载体
US12011423B2 (en) 2007-11-06 2024-06-18 Foraviset Ltd. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
GB0723882D0 (en) * 2007-12-07 2008-01-23 Univ Leicester Methods for the detection of a threatened miscarriage
PL2359807T3 (pl) 2008-02-04 2017-12-29 Ferring B.V. Monolityczne pierścienie dopochwowe zawierające progesteron oraz metody ich wytwarzania i stosowania
US9107696B2 (en) * 2008-08-06 2015-08-18 Emory University Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus
ES2344673B1 (es) 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
US8421747B2 (en) 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
ES2344675B1 (es) 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
CN107260745A (zh) * 2010-03-22 2017-10-20 利普生物药剂公司 用于抗孕酮的非毒性递送的组合物和方法
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
US8435972B2 (en) 2010-09-02 2013-05-07 Emory University Method for the treatment of central nervous system cancers and compositions related thereto
US9168303B2 (en) * 2011-07-15 2015-10-27 Universiteit Gent Intravaginal delivery system
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014018439A8 (pt) * 2012-01-26 2017-07-11 Therapeuticsmd Inc Terapias de reposição de hormônio transdérmica
CA2872644A1 (en) 2012-05-31 2013-12-05 Allergan Pharmaceuticals International Limited Formulations and methods for vaginal delivery of antiprogestins
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9545411B2 (en) 2012-11-02 2017-01-17 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN103239389A (zh) * 2013-06-03 2013-08-14 南京泽恒医药技术开发有限公司 一种治疗先兆性流产的黄体酮缓释凝胶的制备方法
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AU2016284459B2 (en) 2015-06-22 2021-12-23 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
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AU2018287513B2 (en) * 2017-06-22 2025-01-23 Viramal Limited Compositions for drug delivery and methods of use thereof
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Also Published As

Publication number Publication date
FI961221A0 (fi) 1996-03-15
AU7726194A (en) 1995-04-03
LV11527B (en) 1997-02-20
PE50795A1 (es) 1996-01-19
GR3029314T3 (en) 1999-05-28
MY111484A (en) 2000-06-30
UA37244C2 (uk) 2001-05-15
IL110972A0 (en) 1994-11-28
RU2148393C1 (ru) 2000-05-10
WO1995007699A1 (en) 1995-03-23
DK0719146T3 (da) 1999-08-23
HUT76824A (en) 1997-11-28
CA2171939A1 (en) 1995-03-23
DE69415543D1 (de) 1999-02-04
FI961221L (fi) 1996-05-14
ZA947073B (en) 1995-05-02
HU9600669D0 (en) 1996-05-28
CA2171939C (en) 2002-01-01
JPH09502724A (ja) 1997-03-18
NO308585B1 (no) 2000-10-02
NO961044D0 (no) 1996-03-14
LT96027A (en) 1996-07-25
KR100278553B1 (ko) 2001-01-15
NO961044L (no) 1996-05-14
EP0719146A1 (en) 1996-07-03
ATE174796T1 (de) 1999-01-15
PH30813A (en) 1997-10-17
US5543150A (en) 1996-08-06
HU221583B (hu) 2002-11-28
JP3143474B2 (ja) 2001-03-07
LT4072B (en) 1996-11-25
LV11527A (lv) 1996-10-20
FI115444B (fi) 2005-05-13
CO4290332A1 (es) 1996-04-17
EP0719146B1 (en) 1998-12-23
AU689133B2 (en) 1998-03-26
NZ273816A (en) 2007-09-28
DE69415543T2 (de) 1999-06-17
ES2126783T3 (es) 1999-04-01
MA23329A1 (fr) 1995-04-01
BR9407475A (pt) 1996-11-12

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