IL110828A - 10-BICYCLOHETEROALKYL OR ALKENYL-7-OXOPYRIDO £1, 2, 3-d, e| £1, 3, 4| BENZOXADIAZINE- 6-CARBOXYLIC ACID AND DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
10-BICYCLOHETEROALKYL OR ALKENYL-7-OXOPYRIDO £1, 2, 3-d, e| £1, 3, 4| BENZOXADIAZINE- 6-CARBOXYLIC ACID AND DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- IL110828A IL110828A IL110828A IL11082894A IL110828A IL 110828 A IL110828 A IL 110828A IL 110828 A IL110828 A IL 110828A IL 11082894 A IL11082894 A IL 11082894A IL 110828 A IL110828 A IL 110828A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- methyl
- hydroxyl
- optionally substituted
- alkyl
- Prior art date
Links
- WYFAFWRMEXHKPN-UHFFFAOYSA-N 2h-1,2,3-benzoxadiazine-6-carboxylic acid Chemical compound O1NN=CC2=CC(C(=O)O)=CC=C21 WYFAFWRMEXHKPN-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 12
- 239000001257 hydrogen Substances 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- -1 methoxy, amino, methylamino Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4329600A DE4329600A1 (de) | 1993-09-02 | 1993-09-02 | Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110828A0 IL110828A0 (en) | 1994-11-11 |
| IL110828A true IL110828A (en) | 1997-04-15 |
Family
ID=6496640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL110828A IL110828A (en) | 1993-09-02 | 1994-08-31 | 10-BICYCLOHETEROALKYL OR ALKENYL-7-OXOPYRIDO £1, 2, 3-d, e| £1, 3, 4| BENZOXADIAZINE- 6-CARBOXYLIC ACID AND DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5508278A (en, 2012) |
| EP (1) | EP0647644B1 (en, 2012) |
| JP (1) | JPH0782272A (en, 2012) |
| KR (1) | KR100342034B1 (en, 2012) |
| CN (1) | CN1041731C (en, 2012) |
| AT (1) | ATE159944T1 (en, 2012) |
| AU (1) | AU687833B2 (en, 2012) |
| CA (1) | CA2131103C (en, 2012) |
| CZ (1) | CZ211394A3 (en, 2012) |
| DE (2) | DE4329600A1 (en, 2012) |
| DK (1) | DK0647644T3 (en, 2012) |
| EG (1) | EG20425A (en, 2012) |
| ES (1) | ES2108348T3 (en, 2012) |
| FI (1) | FI943999A7 (en, 2012) |
| GR (1) | GR3025740T3 (en, 2012) |
| HR (1) | HRP940470B1 (en, 2012) |
| HU (1) | HUT71098A (en, 2012) |
| IL (1) | IL110828A (en, 2012) |
| JO (1) | JO1799B1 (en, 2012) |
| MY (1) | MY131768A (en, 2012) |
| NO (1) | NO943239L (en, 2012) |
| NZ (1) | NZ264334A (en, 2012) |
| PH (1) | PH31003A (en, 2012) |
| PL (1) | PL177249B1 (en, 2012) |
| RU (1) | RU2131430C1 (en, 2012) |
| SI (1) | SI0647644T1 (en, 2012) |
| SV (1) | SV1994000041A (en, 2012) |
| TW (1) | TW304196B (en, 2012) |
| UY (1) | UY23825A1 (en, 2012) |
| ZA (1) | ZA946700B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4416622A1 (de) * | 1994-05-11 | 1995-11-16 | Bayer Ag | 8-Amino-10-(azabicycloalkyl)-pyrido[1,2,3-d.e] [1,3,4]benzoxa-diazinderivate |
| DE4427530A1 (de) * | 1994-08-04 | 1996-02-08 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| DE4435479A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| KR100411620B1 (ko) * | 1995-12-29 | 2004-03-18 | 고려화학 주식회사 | Pvc프레임용불소도료조성물 |
| DE19652239A1 (de) * | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
| FR2928150A1 (fr) * | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
| EP2145891A1 (en) * | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0635458B2 (ja) * | 1985-02-15 | 1994-05-11 | 大日本製薬株式会社 | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| EP0259804B1 (de) * | 1986-09-12 | 1993-11-18 | F. Hoffmann-La Roche Ag | Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte |
| US4864023A (en) * | 1986-09-12 | 1989-09-05 | Hoffmann-La Roche Inc. | Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives |
| US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| JP2844079B2 (ja) * | 1988-05-23 | 1999-01-06 | 塩野義製薬株式会社 | ピリドンカルボン酸系抗菌剤 |
| DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| DE3910663A1 (de) * | 1989-04-03 | 1990-10-04 | Bayer Ag | 5-alkylchinoloncarbonsaeuren |
| GB9010941D0 (en) * | 1990-05-16 | 1990-07-04 | Erba Carlo Spa | Delta 2-cephem sulphones |
| DE4032560A1 (de) * | 1990-10-13 | 1992-04-16 | Bayer Ag | 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate |
| WO1992012146A1 (fr) * | 1990-12-27 | 1992-07-23 | Banyu Pharmaceutical Co., Ltd. | Derive d'acide pyridonecarboxylique |
| DE4120646A1 (de) * | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
| TW209865B (en, 2012) * | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| DK0680482T3 (da) * | 1993-01-23 | 1997-05-05 | Pfizer | Fremgangsmåde til fremstilling af en tricyclisk forbindelse |
-
1993
- 1993-09-02 DE DE4329600A patent/DE4329600A1/de not_active Withdrawn
-
1994
- 1994-08-18 HR HRP4329600.9A patent/HRP940470B1/xx not_active IP Right Cessation
- 1994-08-18 TW TW083107566A patent/TW304196B/zh active
- 1994-08-22 ES ES94113044T patent/ES2108348T3/es not_active Expired - Lifetime
- 1994-08-22 EP EP94113044A patent/EP0647644B1/de not_active Expired - Lifetime
- 1994-08-22 DE DE59404525T patent/DE59404525D1/de not_active Expired - Fee Related
- 1994-08-22 DK DK94113044T patent/DK0647644T3/da active
- 1994-08-22 AT AT94113044T patent/ATE159944T1/de not_active IP Right Cessation
- 1994-08-22 SI SI9430115T patent/SI0647644T1/xx unknown
- 1994-08-24 JO JO19941799A patent/JO1799B1/en active
- 1994-08-25 AU AU71485/94A patent/AU687833B2/en not_active Ceased
- 1994-08-26 US US08/296,944 patent/US5508278A/en not_active Expired - Fee Related
- 1994-08-29 EG EG53194A patent/EG20425A/xx active
- 1994-08-29 JP JP6226093A patent/JPH0782272A/ja active Pending
- 1994-08-29 KR KR1019940021421A patent/KR100342034B1/ko not_active Expired - Fee Related
- 1994-08-30 CA CA002131103A patent/CA2131103C/en not_active Expired - Fee Related
- 1994-08-30 NZ NZ264334A patent/NZ264334A/en unknown
- 1994-08-31 FI FI943999A patent/FI943999A7/fi unknown
- 1994-08-31 IL IL110828A patent/IL110828A/xx not_active IP Right Cessation
- 1994-09-01 CZ CZ942113A patent/CZ211394A3/cs unknown
- 1994-09-01 NO NO943239A patent/NO943239L/no unknown
- 1994-09-01 PH PH48892A patent/PH31003A/en unknown
- 1994-09-01 RU RU94031745A patent/RU2131430C1/ru active
- 1994-09-01 ZA ZA946700A patent/ZA946700B/xx unknown
- 1994-09-01 HU HU9402523A patent/HUT71098A/hu unknown
- 1994-09-01 SV SV1994000041A patent/SV1994000041A/es unknown
- 1994-09-02 CN CN94115644A patent/CN1041731C/zh not_active Expired - Fee Related
- 1994-09-02 UY UY23825A patent/UY23825A1/es not_active IP Right Cessation
- 1994-09-02 PL PL94304877A patent/PL177249B1/pl unknown
- 1994-09-02 MY MYPI94002293A patent/MY131768A/en unknown
-
1997
- 1997-12-23 GR GR970403390T patent/GR3025740T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |