IL110415A - Vitamin D analogues and pharmaceutical compositions containing them - Google Patents
Vitamin D analogues and pharmaceutical compositions containing themInfo
- Publication number
- IL110415A IL110415A IL11041594A IL11041594A IL110415A IL 110415 A IL110415 A IL 110415A IL 11041594 A IL11041594 A IL 11041594A IL 11041594 A IL11041594 A IL 11041594A IL 110415 A IL110415 A IL 110415A
- Authority
- IL
- Israel
- Prior art keywords
- alpha
- vitamin
- azide
- optionally substituted
- group
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
- 235000019166 vitamin D Nutrition 0.000 title abstract 2
- 239000011710 vitamin D Substances 0.000 title abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
- 229940046008 vitamin d Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001540 azides Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- -1 cyclohexylidene moiety Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939315253A GB9315253D0 (en) | 1993-07-23 | 1993-07-23 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110415A0 IL110415A0 (en) | 1996-03-31 |
| IL110415A true IL110415A (en) | 2000-01-31 |
Family
ID=10739292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11041594A IL110415A (en) | 1993-07-23 | 1994-07-22 | Vitamin D analogues and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5872140A (de) |
| EP (1) | EP0710227B1 (de) |
| JP (1) | JPH09500637A (de) |
| KR (1) | KR100321415B1 (de) |
| CN (1) | CN1043883C (de) |
| AT (1) | ATE172451T1 (de) |
| AU (1) | AU690565B2 (de) |
| CA (1) | CA2167837A1 (de) |
| CZ (1) | CZ20796A3 (de) |
| DE (1) | DE69414115T2 (de) |
| DK (1) | DK0710227T3 (de) |
| ES (1) | ES2125466T3 (de) |
| FI (1) | FI113535B (de) |
| GB (1) | GB9315253D0 (de) |
| HU (1) | HU221597B (de) |
| IL (1) | IL110415A (de) |
| NO (1) | NO314453B1 (de) |
| NZ (1) | NZ268659A (de) |
| WO (1) | WO1995003273A1 (de) |
| ZA (1) | ZA945427B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| CA2385755C (en) | 1999-09-29 | 2007-02-06 | Colotech A/S | Prevention of colorectal cancer |
| US6703380B2 (en) | 1999-09-29 | 2004-03-09 | Colotech A/S | Prevention of cancer |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6555573B2 (en) * | 2000-12-21 | 2003-04-29 | The Quigley Corporation | Method and composition for the topical treatment of diabetic neuropathy |
| US20030105031A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Methods for the treatment of skin disorders |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030118536A1 (en) * | 2001-11-06 | 2003-06-26 | Rosenbloom Richard A. | Topical compositions and methods for treatment of adverse effects of ionizing radiation |
| US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
| AU2003283101B2 (en) * | 2002-11-04 | 2008-12-11 | Dsm Nutritional Products Ag | Microcapsules having multiple shells and method for the preparation thereof |
| US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
| US8034450B2 (en) * | 2005-01-21 | 2011-10-11 | Ocean Nutrition Canada Limited | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
| CA2596023A1 (en) * | 2005-01-27 | 2006-11-09 | Ocean Nutrition Canada Ltd. | Fatty acid-benzenediol derivatives and methods of making and using thereof |
| CA2556520C (en) * | 2005-01-27 | 2008-10-28 | Ocean Nutrition Canada Ltd. | Chromium-fatty acid compounds and methods of making and using thereof |
| US9968120B2 (en) * | 2006-05-17 | 2018-05-15 | Dsm Nutritional Products Ag | Homogenized formulations containing microcapsules and methods of making and using thereof |
| EP2007224A2 (de) * | 2006-04-07 | 2008-12-31 | Ocean Nutrition Canada Limited | Emulsionen und mikrokapseln mit stoffen mit geringer grenzflächenspannung, herstellungsverfahren und verwendung |
| MX306461B (es) * | 2006-06-05 | 2013-01-07 | Ocean Nutrition Canada Ltd | Microcapsulas con cubiertas mejoradas |
| KR101454942B1 (ko) | 2007-01-10 | 2014-10-27 | 디에스엠 뉴트리셔널 프라덕츠 아게 | 채식주의용 마이크로캡슐 |
| US20090018151A1 (en) * | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
| WO2010088304A1 (en) | 2009-01-27 | 2010-08-05 | Cytotech Labs, Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| KR101880032B1 (ko) | 2009-08-14 | 2018-07-20 | 베르그 엘엘씨 | 탈모증 치료용 비타민 ｄ3 및 이의 유사체들 |
| WO2012158794A1 (en) | 2011-05-17 | 2012-11-22 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses |
| SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| CN104926739B (zh) * | 2015-06-09 | 2017-06-27 | 南京理工大学 | 基于氮杂环修饰的维生素d2衍生物、合成及应用 |
| US10548908B2 (en) | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2114570B (en) * | 1981-11-02 | 1985-08-07 | Res Inst Medicine Chem | Chemical compounds |
| DE4141746A1 (de) * | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| US5446635A (en) * | 1993-06-24 | 1995-08-29 | Quarton, Inc. | Laser assembly for marking a line on a workpiece for guiding a cutting tool |
-
1993
- 1993-07-23 GB GB939315253A patent/GB9315253D0/en active Pending
-
1994
- 1994-07-22 ES ES94921070T patent/ES2125466T3/es not_active Expired - Lifetime
- 1994-07-22 AT AT94921070T patent/ATE172451T1/de not_active IP Right Cessation
- 1994-07-22 CA CA002167837A patent/CA2167837A1/en not_active Abandoned
- 1994-07-22 EP EP94921070A patent/EP0710227B1/de not_active Expired - Lifetime
- 1994-07-22 NZ NZ268659A patent/NZ268659A/en unknown
- 1994-07-22 ZA ZA945427A patent/ZA945427B/xx unknown
- 1994-07-22 JP JP7505021A patent/JPH09500637A/ja not_active Ceased
- 1994-07-22 CN CN94193108A patent/CN1043883C/zh not_active Expired - Fee Related
- 1994-07-22 DE DE69414115T patent/DE69414115T2/de not_active Expired - Fee Related
- 1994-07-22 HU HU9600136A patent/HU221597B/hu not_active IP Right Cessation
- 1994-07-22 KR KR1019960700344A patent/KR100321415B1/ko not_active Expired - Fee Related
- 1994-07-22 DK DK94921070T patent/DK0710227T3/da active
- 1994-07-22 CZ CZ96207A patent/CZ20796A3/cs unknown
- 1994-07-22 WO PCT/GB1994/001587 patent/WO1995003273A1/en not_active Ceased
- 1994-07-22 AU AU71939/94A patent/AU690565B2/en not_active Ceased
- 1994-07-22 IL IL11041594A patent/IL110415A/xx not_active IP Right Cessation
- 1994-07-22 US US08/537,869 patent/US5872140A/en not_active Expired - Fee Related
-
1996
- 1996-01-22 NO NO19960251A patent/NO314453B1/no not_active IP Right Cessation
- 1996-01-22 FI FI960303A patent/FI113535B/fi not_active IP Right Cessation
-
1998
- 1998-10-20 US US09/175,311 patent/US6013814A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL110415A0 (en) | 1996-03-31 |
| DK0710227T3 (da) | 1999-06-28 |
| DE69414115T2 (de) | 1999-04-08 |
| FI113535B (fi) | 2004-05-14 |
| JPH09500637A (ja) | 1997-01-21 |
| US5872140A (en) | 1999-02-16 |
| WO1995003273A1 (en) | 1995-02-02 |
| CA2167837A1 (en) | 1995-02-02 |
| CZ20796A3 (en) | 1996-10-16 |
| CN1043883C (zh) | 1999-06-30 |
| NO314453B1 (no) | 2003-03-24 |
| EP0710227B1 (de) | 1998-10-21 |
| NO960251L (no) | 1996-03-22 |
| HU9600136D0 (en) | 1996-03-28 |
| FI960303L (fi) | 1996-03-22 |
| FI960303A0 (fi) | 1996-01-22 |
| HUT73846A (en) | 1996-09-30 |
| ZA945427B (en) | 1995-08-24 |
| CN1129441A (zh) | 1996-08-21 |
| US6013814A (en) | 2000-01-11 |
| EP0710227A1 (de) | 1996-05-08 |
| GB9315253D0 (en) | 1993-09-08 |
| ES2125466T3 (es) | 1999-03-01 |
| AU7193994A (en) | 1995-02-20 |
| ATE172451T1 (de) | 1998-11-15 |
| HU221597B (hu) | 2002-11-28 |
| NO960251D0 (no) | 1996-01-22 |
| DE69414115D1 (de) | 1998-11-26 |
| KR100321415B1 (ko) | 2002-11-13 |
| AU690565B2 (en) | 1998-04-30 |
| NZ268659A (en) | 1996-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |