IL109773A0 - Process for preparing and purifying alpha-interferon, a vector for its expression and transformed host organism containing the vector - Google Patents
Process for preparing and purifying alpha-interferon, a vector for its expression and transformed host organism containing the vectorInfo
- Publication number
- IL109773A0 IL109773A0 IL10977394A IL10977394A IL109773A0 IL 109773 A0 IL109773 A0 IL 109773A0 IL 10977394 A IL10977394 A IL 10977394A IL 10977394 A IL10977394 A IL 10977394A IL 109773 A0 IL109773 A0 IL 109773A0
- Authority
- IL
- Israel
- Prior art keywords
- vector
- interferon
- expression
- preparing
- host organism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4317459 | 1993-05-26 | ||
DE19934329756 DE4329756A1 (de) | 1993-09-03 | 1993-09-03 | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
Publications (1)
Publication Number | Publication Date |
---|---|
IL109773A0 true IL109773A0 (en) | 1994-08-26 |
Family
ID=25926218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10977394A IL109773A0 (en) | 1993-05-26 | 1994-05-25 | Process for preparing and purifying alpha-interferon, a vector for its expression and transformed host organism containing the vector |
Country Status (8)
Country | Link |
---|---|
US (1) | US5710027A (xx) |
EP (1) | EP0626448A3 (xx) |
JP (1) | JPH07135992A (xx) |
CN (1) | CN1099799A (xx) |
CA (1) | CA2124271A1 (xx) |
FI (1) | FI942419A (xx) |
HU (1) | HUT70311A (xx) |
IL (1) | IL109773A0 (xx) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7018809B1 (en) * | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
AU751898B2 (en) * | 1997-07-14 | 2002-08-29 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
US6433145B1 (en) | 1998-07-21 | 2002-08-13 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
US7390637B2 (en) * | 1998-07-21 | 2008-06-24 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
KR100688051B1 (ko) * | 1998-07-21 | 2007-02-28 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 각질세포-유래된 인터페론 |
US6472512B1 (en) | 1998-07-21 | 2002-10-29 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
WO2000006596A2 (en) * | 1998-07-28 | 2000-02-10 | Us Health | INTERFERON HYBRIDS- alpha |
US6685933B1 (en) | 1998-07-28 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Interferon α hybrids |
KR100316347B1 (ko) * | 1998-09-15 | 2002-08-27 | 한미약품(주) | 대장균엔테로톡신ⅱ신호펩티드의변형체와인체성장호르몬의융합단백질을발현하는재조합미생물및그를이용한인체성장호르몬의제조방법 |
WO2000039280A2 (en) * | 1998-12-31 | 2000-07-06 | Viragen, Inc. | Leukocyte-derived interferon preparations |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
KR100356140B1 (ko) * | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
AU2509900A (en) * | 1999-07-21 | 2001-02-13 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
GB9920906D0 (en) * | 1999-09-03 | 1999-11-10 | Glaxo Group Ltd | Increased production of interferon-a |
KR100360594B1 (ko) * | 2000-01-19 | 2002-11-13 | 한미약품공업 주식회사 | 인간 인터페론 알파의 발현 분비벡터 및 이를 이용한인터페론 알파의 생산 방법 |
ES2263626T3 (es) * | 2000-06-05 | 2006-12-16 | Corixa Corporation | Peptidos lider para potenciar la secrecion de proteina recombinante a partir de una celula hospedante. |
FR2817559B1 (fr) * | 2000-12-06 | 2003-12-12 | Genodyssee | Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications |
US20050079579A1 (en) * | 2001-02-28 | 2005-04-14 | Guangwen Wei | Uses of spatial configuration to modulate protein function |
CN1245215C (zh) | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
WO2002088325A2 (en) * | 2001-05-02 | 2002-11-07 | University Of South Florida | Vector system for selection of genes encoding secreted proteins and membrane-bound proteins |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US7785830B2 (en) * | 2003-08-13 | 2010-08-31 | Sandoz Ag | Expression vectors, transformed host cells and fermentation process for the production of recombinant polypeptides |
JP2007501622A (ja) * | 2003-08-13 | 2007-02-01 | サンド・アクチエンゲゼルシヤフト | 組換えポリペプチドを精製するための方法 |
GB0319601D0 (en) * | 2003-08-20 | 2003-09-24 | Sandoz Ag | Production process |
US7585647B2 (en) | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
WO2005074546A2 (en) * | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
CN100460502C (zh) * | 2005-01-28 | 2009-02-11 | 华东师范大学 | 一种高效表达重组人汗腺抗菌肽的基因工程菌及其构建方法和应用 |
MY167668A (en) * | 2005-03-09 | 2018-09-21 | Superlab Far East Ltd | Uses of recombinant super-compound interferons |
ATE491722T1 (de) * | 2005-10-04 | 2011-01-15 | Zymogenetics L L C | Herstellung und reinigung von il-29 |
US8852916B2 (en) * | 2010-01-22 | 2014-10-07 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with microorganisms |
JP2010525821A (ja) | 2007-05-02 | 2010-07-29 | アンブルックス,インコーポレイテッド | 修飾IFNβポリペプチドおよびこれらの使用 |
EP2195338B1 (en) * | 2007-10-01 | 2013-12-25 | Pharmaessentia Corp. | N-terminal modified interferon-alpha |
AU2009204998B2 (en) * | 2008-01-18 | 2014-03-27 | F. Hoffmann-La Roche Ag | Purification of non-glycosylated proteins |
CA2712606A1 (en) | 2008-02-08 | 2009-08-13 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
EP2525787B1 (en) | 2010-01-19 | 2017-03-15 | Hanmi Science Co., Ltd. | Liquid formulations for long-acting g-csf conjugate |
CN106317177A (zh) * | 2015-06-23 | 2017-01-11 | 首都医科大学 | Gly-Phe-Pro,其合成,活性和应用 |
CN107723290A (zh) * | 2017-08-14 | 2018-02-23 | 蔡祥胜 | 一种重组人卵细胞透明带zp3蛋白及其制备方法 |
US11352445B2 (en) | 2018-12-31 | 2022-06-07 | Jecho Laboratories Inc. | Method for preparing recombinant protein from bacterium and composition containing the same |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
DE3587205T2 (de) * | 1984-07-30 | 1993-08-26 | Wakunaga Seiyaku Kk | Verfahren zur herstellung eines proteins und dafuer zu verwendender vektor, rekombinante dns und transformierte zelle. |
DE3586386T2 (de) * | 1984-10-05 | 1993-01-14 | Genentech Inc | Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung. |
US4963495A (en) * | 1984-10-05 | 1990-10-16 | Genentech, Inc. | Secretion of heterologous proteins |
JPS63501471A (ja) * | 1984-12-27 | 1988-06-09 | サントリー株式会社 | インタ−フェロンの精製方法 |
EP0221923A4 (en) * | 1985-03-29 | 1990-03-22 | Bioteknika International | SECRETION VECTOR. |
US5196323A (en) * | 1985-04-27 | 1993-03-23 | Boehringer Ingelheim International Gmbh | Process for preparing and purifying alpha-interferon |
DE3607835A1 (de) * | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
IT1222427B (it) * | 1987-07-31 | 1990-09-05 | Sclavo Spa | Procedimento per la purificazione di interferone |
EP0396555B1 (en) * | 1987-10-06 | 1992-07-29 | Interferon Sciences, Inc. | Purification of monomeric interferon |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
KR930701601A (ko) * | 1990-07-10 | 1993-06-12 | 디이터 라우디엔, 루돌프 호프만 | O-글리코실화 ifn-알파 |
US5367060A (en) * | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
-
1994
- 1994-05-19 EP EP94107804A patent/EP0626448A3/de not_active Withdrawn
- 1994-05-25 JP JP6111150A patent/JPH07135992A/ja active Pending
- 1994-05-25 HU HU9401580A patent/HUT70311A/hu unknown
- 1994-05-25 FI FI942419A patent/FI942419A/fi unknown
- 1994-05-25 CA CA002124271A patent/CA2124271A1/en not_active Abandoned
- 1994-05-25 IL IL10977394A patent/IL109773A0/xx unknown
- 1994-05-26 US US08/249,671 patent/US5710027A/en not_active Expired - Fee Related
- 1994-05-26 CN CN94105930.8A patent/CN1099799A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2124271A1 (en) | 1994-11-27 |
FI942419A0 (fi) | 1994-05-25 |
US5710027A (en) | 1998-01-20 |
JPH07135992A (ja) | 1995-05-30 |
EP0626448A3 (de) | 1998-01-14 |
HUT70311A (en) | 1995-09-28 |
FI942419A (fi) | 1994-11-27 |
CN1099799A (zh) | 1995-03-08 |
EP0626448A2 (de) | 1994-11-30 |
HU9401580D0 (en) | 1994-08-29 |
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