FI942419A0 - Menetelmä alfa-interferonin valmistamiseksi ja puhdistamiseksi - Google Patents

Menetelmä alfa-interferonin valmistamiseksi ja puhdistamiseksi

Info

Publication number
FI942419A0
FI942419A0 FI942419A FI942419A FI942419A0 FI 942419 A0 FI942419 A0 FI 942419A0 FI 942419 A FI942419 A FI 942419A FI 942419 A FI942419 A FI 942419A FI 942419 A0 FI942419 A0 FI 942419A0
Authority
FI
Finland
Prior art keywords
cleaning
producing
alpha interferon
interferon
alpha
Prior art date
Application number
FI942419A
Other languages
English (en)
Swedish (sv)
Other versions
FI942419A (fi
Inventor
Rudolf Hauptmann
Edgar Falkner
Gerhard Bodo
Tilman Voss
Ingrid Maurer-Fogy
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934329756 external-priority patent/DE4329756A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of FI942419A0 publication Critical patent/FI942419A0/fi
Publication of FI942419A publication Critical patent/FI942419A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI942419A 1993-05-26 1994-05-25 Menetelmä alfa-interferonin valmistamiseksi ja puhdistamiseksi FI942419A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4317459 1993-05-26
DE19934329756 DE4329756A1 (de) 1993-09-03 1993-09-03 Verfahren zur Herstellung und Reinigung von alpha-Interferon

Publications (2)

Publication Number Publication Date
FI942419A0 true FI942419A0 (fi) 1994-05-25
FI942419A FI942419A (fi) 1994-11-27

Family

ID=25926218

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942419A FI942419A (fi) 1993-05-26 1994-05-25 Menetelmä alfa-interferonin valmistamiseksi ja puhdistamiseksi

Country Status (8)

Country Link
US (1) US5710027A (fi)
EP (1) EP0626448A3 (fi)
JP (1) JPH07135992A (fi)
CN (1) CN1099799A (fi)
CA (1) CA2124271A1 (fi)
FI (1) FI942419A (fi)
HU (1) HUT70311A (fi)
IL (1) IL109773A0 (fi)

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CA2116774C (en) * 1991-09-19 2003-11-11 Paul J. Carter Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
ATE375363T1 (de) 1997-07-14 2007-10-15 Bolder Biotechnology Inc Derivate des wachstumshormons und verwandte proteine
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7390637B2 (en) * 1998-07-21 2008-06-24 Human Genome Sciences, Inc. Keratinocyte derived interferon
US6433145B1 (en) 1998-07-21 2002-08-13 Human Genome Sciences, Inc. Keratinocyte derived interferon
NZ509402A (en) * 1998-07-21 2003-08-29 Human Genome Sciences Inc Keratinocyte derived interferon
US6472512B1 (en) 1998-07-21 2002-10-29 Human Genome Sciences, Inc. Keratinocyte derived interferon
US6685933B1 (en) 1998-07-28 2004-02-03 The United States Of America As Represented By The Department Of Health And Human Services Interferon α hybrids
WO2000006596A2 (en) * 1998-07-28 2000-02-10 Us Health INTERFERON HYBRIDS- alpha
KR100316347B1 (ko) * 1998-09-15 2002-08-27 한미약품(주) 대장균엔테로톡신ⅱ신호펩티드의변형체와인체성장호르몬의융합단백질을발현하는재조합미생물및그를이용한인체성장호르몬의제조방법
WO2000039280A2 (en) * 1998-12-31 2000-07-06 Viragen, Inc. Leukocyte-derived interferon preparations
US8288126B2 (en) * 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
KR100356140B1 (ko) * 1999-07-08 2002-10-19 한미약품공업 주식회사 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법
AU2509900A (en) * 1999-07-21 2001-02-13 Human Genome Sciences, Inc. Keratinocyte derived interferon
GB9920906D0 (en) * 1999-09-03 1999-11-10 Glaxo Group Ltd Increased production of interferon-a
KR100360594B1 (ko) * 2000-01-19 2002-11-13 한미약품공업 주식회사 인간 인터페론 알파의 발현 분비벡터 및 이를 이용한인터페론 알파의 생산 방법
ATE321870T1 (de) * 2000-06-05 2006-04-15 Corixa Corp Leader-anteile zur erhöhung der sekretion von rekombinanten proteine aus einer wirtzelle
FR2817559B1 (fr) * 2000-12-06 2003-12-12 Genodyssee Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications
CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
US20050079579A1 (en) * 2001-02-28 2005-04-14 Guangwen Wei Uses of spatial configuration to modulate protein function
CA2445889A1 (en) 2001-05-02 2002-11-07 University Of South Florida Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
EP1539960B1 (en) * 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistant modified interferon alpha polypeptides
JP2007501622A (ja) * 2003-08-13 2007-02-01 サンド・アクチエンゲゼルシヤフト 組換えポリペプチドを精製するための方法
ATE353969T1 (de) * 2003-08-13 2007-03-15 Sandoz Ag Expressionsvektoren, transformierte wirtszellen und fermentationsverfahren zur herstellung rekombinanter polypeptide
GB0319601D0 (en) * 2003-08-20 2003-09-24 Sandoz Ag Production process
US7585647B2 (en) * 2003-08-28 2009-09-08 Guangwen Wei Nucleic acid encoding recombinant interferon
JP2007519422A (ja) 2004-02-02 2007-07-19 アンブレツクス・インコーポレイテツド 修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用
CN100460502C (zh) * 2005-01-28 2009-02-11 华东师范大学 一种高效表达重组人汗腺抗菌肽的基因工程菌及其构建方法和应用
KR101329878B1 (ko) * 2005-03-09 2013-11-22 광웬 위 재조합 슈퍼 화합물 인터페론의 용도
EP1931704B1 (en) 2005-10-04 2010-12-15 ZymoGenetics, L.L.C. Production and purification of il-29
US8852916B2 (en) * 2010-01-22 2014-10-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with microorganisms
CA2685596A1 (en) 2007-05-02 2008-11-13 Ambrx, Inc. Modified interferon beta polypeptides and their uses
PL2195338T3 (pl) * 2007-10-01 2014-05-30 Pharmaessentia Corp Interferon alfa zmodyfikowany na końcu N
CN107033233A (zh) * 2008-01-18 2017-08-11 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses
KR101340710B1 (ko) 2010-01-19 2013-12-12 한미사이언스 주식회사 지속형 과립구 콜로니 자극인자 결합체의 액상 제제
CN106317177A (zh) * 2015-06-23 2017-01-11 首都医科大学 Gly-Phe-Pro,其合成,活性和应用
CN107723290A (zh) * 2017-08-14 2018-02-23 蔡祥胜 一种重组人卵细胞透明带zp3蛋白及其制备方法
US11352445B2 (en) 2018-12-31 2022-06-07 Jecho Laboratories Inc. Method for preparing recombinant protein from bacterium and composition containing the same

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DE3247922A1 (de) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten
DE3587205T2 (de) * 1984-07-30 1993-08-26 Wakunaga Seiyaku Kk Verfahren zur herstellung eines proteins und dafuer zu verwendender vektor, rekombinante dns und transformierte zelle.
US4963495A (en) * 1984-10-05 1990-10-16 Genentech, Inc. Secretion of heterologous proteins
EP0177343B1 (en) * 1984-10-05 1992-07-22 Genentech, Inc. Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery
AU598455B2 (en) * 1984-12-27 1990-06-28 Suntory Limited Method for purifying an interferon
WO1986005812A1 (en) * 1985-03-29 1986-10-09 Biotechnica International, Inc. Secretion vector
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
IT1222427B (it) * 1987-07-31 1990-09-05 Sclavo Spa Procedimento per la purificazione di interferone
WO1989003225A1 (en) * 1987-10-06 1989-04-20 Interferon Sciences, Inc. Purification of monomeric interferon
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1992001055A1 (de) * 1990-07-10 1992-01-23 Boehringer Ingelheim International Gmbh O-glycosyliertes ifn-alpha
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin

Also Published As

Publication number Publication date
CN1099799A (zh) 1995-03-08
FI942419A (fi) 1994-11-27
JPH07135992A (ja) 1995-05-30
EP0626448A2 (de) 1994-11-30
HU9401580D0 (en) 1994-08-29
CA2124271A1 (en) 1994-11-27
US5710027A (en) 1998-01-20
HUT70311A (en) 1995-09-28
EP0626448A3 (de) 1998-01-14
IL109773A0 (en) 1994-08-26

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