IL109139A - Diamine salts of clavulanic acid, their preparation and pharmaceutical compositions containing them - Google Patents

Diamine salts of clavulanic acid, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL109139A
IL109139A IL109139A IL10913994A IL109139A IL 109139 A IL109139 A IL 109139A IL 109139 A IL109139 A IL 109139A IL 10913994 A IL10913994 A IL 10913994A IL 109139 A IL109139 A IL 109139A
Authority
IL
Israel
Prior art keywords
alkyl
cycloalkyl
clavulanic acid
preparation
pharmaceutical compositions
Prior art date
Application number
IL109139A
Other languages
English (en)
Other versions
IL109139A0 (en
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of IL109139A0 publication Critical patent/IL109139A0/xx
Publication of IL109139A publication Critical patent/IL109139A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrrole Compounds (AREA)
IL109139A 1993-03-26 1994-03-25 Diamine salts of clavulanic acid, their preparation and pharmaceutical compositions containing them IL109139A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93200872 1993-03-26
US08/457,985 US5719277A (en) 1993-03-26 1995-06-01 Diamine salts of clavulanic acid

Publications (2)

Publication Number Publication Date
IL109139A0 IL109139A0 (en) 1994-06-24
IL109139A true IL109139A (en) 1997-03-18

Family

ID=26133724

Family Applications (1)

Application Number Title Priority Date Filing Date
IL109139A IL109139A (en) 1993-03-26 1994-03-25 Diamine salts of clavulanic acid, their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US5719277A (zh)
EP (2) EP0719778A1 (zh)
CN (1) CN1041933C (zh)
AT (1) ATE140703T1 (zh)
AU (1) AU682030B2 (zh)
CA (1) CA2135671A1 (zh)
CY (1) CY1966A (zh)
CZ (1) CZ284855B6 (zh)
DE (2) DE647229T1 (zh)
DK (1) DK0647229T3 (zh)
ES (1) ES2070109T3 (zh)
FI (1) FI945510A0 (zh)
HK (1) HK217196A (zh)
HU (1) HUT69372A (zh)
IL (1) IL109139A (zh)
NO (1) NO301767B1 (zh)
NZ (1) NZ263564A (zh)
PL (1) PL306371A1 (zh)
RO (1) RO112113B1 (zh)
SK (1) SK279918B6 (zh)
WO (1) WO1994022873A1 (zh)
ZA (1) ZA942133B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
AU678752B3 (en) * 1992-06-11 1997-06-05 Smithkline Beecham Plc Process for the preparation of clavulanic acid
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
EP0729961B1 (en) * 1995-02-25 2001-12-19 Spurcourt Limited Clavulanic acid salt
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
EP1095046A1 (en) * 1998-07-16 2001-05-02 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
US6908663B1 (en) * 2000-11-15 2005-06-21 Awi Licensing Company Pigmented radiation cured wear layer
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes

Also Published As

Publication number Publication date
ES2070109T3 (es) 1996-12-01
DE69400334D1 (de) 1996-08-29
FI945510A (fi) 1994-11-23
NO301767B1 (no) 1997-12-08
DE69400334T2 (de) 1997-02-13
HUT69372A (en) 1995-09-28
EP0719778A1 (en) 1996-07-03
EP0647229B1 (en) 1996-07-24
FI945510A0 (fi) 1994-11-23
NO944531D0 (no) 1994-11-25
SK144294A3 (en) 1995-06-07
PL306371A1 (en) 1995-03-20
SK279918B6 (sk) 1999-05-07
CY1966A (en) 1997-07-04
AU6429494A (en) 1994-10-24
HU9403383D0 (en) 1995-02-28
CZ286394A3 (en) 1995-03-15
ATE140703T1 (de) 1996-08-15
DE647229T1 (de) 1996-01-18
EP0647229A1 (en) 1995-04-12
IL109139A0 (en) 1994-06-24
CA2135671A1 (en) 1994-10-13
HK217196A (en) 1996-12-27
NO944531L (no) 1994-11-25
WO1994022873A1 (en) 1994-10-13
ES2070109T1 (es) 1995-06-01
RO112113B1 (ro) 1997-05-30
DK0647229T3 (da) 1996-10-07
US5719277A (en) 1998-02-17
ZA942133B (en) 1995-02-21
AU682030B2 (en) 1997-09-18
CN1041933C (zh) 1999-02-03
CN1108029A (zh) 1995-09-06
NZ263564A (en) 1995-12-21
CZ284855B6 (cs) 1999-03-17

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HP Change in proprietorship
HC Change of name of proprietor(s)